Article
Pharmacology & Pharmacy
Osama A. A. Ahmed, Noura A. Hassan, Ahmad S. Azhar, Mahmoud M. El-Mas, Hany M. El-Bassossy
Summary: The quercetin loaded SNEDDS showed superior protection against cardiovascular complications of MetS compared to the standard suspension, by reversing various functional and histopathological manifestations of cardiac damage induced by MetS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Claire Mayer, Leo Richard, Martine Come, Lionel Ulmann, Hassan Nazih, Benoit Chenais, Khadija Ouguerram, Virginie Mimouni
Summary: The study demonstrated that the DHA-rich microalga Tisochrysis lutea can improve metabolic disturbances associated with obesity, enhance lipid and glucose metabolism, reduce fat accumulation and inflammation.
Article
Plant Sciences
Rongrong Zhou, Dan He, Haichao Zhang, Jing Xie, Shuihan Zhang, Xuefei Tian, Hongliang Zeng, Yuhui Qin, Luqi Huang
Summary: This study aimed to explore the insulin-sensitizing and anti-diabetic effects of ginsenoside Rb1 and its underlying mechanisms. Using a diabetes model, the study found that ginsenoside Rb1 reduces blood glucose and insulin levels, and improves gut microbiota dysbiosis and fecal metabolites. Antibiotic intervention showed that ginsenoside Rb1 fails to improve high-fat diet-induced diabetes.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell Biology
Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Veronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common chronic liver disease, especially in obese individuals. This study suggests that the nuclear receptor CAR may play a role in the pathogenesis of NAFLD and could be a potential therapeutic target. In mice, deletion of CAR led to a NASH-like hepatic transcriptomic signature and astrogliosis in the hypothalamus of female mice.
Article
Endocrinology & Metabolism
Ying Sun, Lei Zhao, Di Teng, Xiaoguang Shi, Yongze Li, Zhongyan Shan, Weiping Teng
Summary: Postprandial glucose dips are closely associated with metabolic disorders, metabolic syndrome, related component diseases, and cardiovascular disease risk. Glucose dips may serve as an indicator of underlying metabolic abnormalities.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Joe Eun Son, Zhengchao Dou, Kyoung-Han Kim, Chi-chung Hui
Summary: This study investigates the role of Irx5 gene in obesity and metabolic abnormalities. Using a mouse model, it was found that Irx5 regulates energy expenditure and intake, leading to resistance against diet-induced obesity. Additionally, Irx5 is shown to play a direct role in hypothalamic feeding control.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Immunology
Hussein Hamade, Jasmine T. Stamps, Dalton T. Stamps, Shyam K. More, Lisa S. Thomas, Anna Y. Blackwood, Nawele L. Lahcene, Sofi L. Castanon, Brenda C. Salumbides, Yosuke Shimodaira, Helen S. Goodridge, Stephan R. Targan, Kathrin S. Michelsen
Summary: Intestinal dendritic cells play an important role in metabolic syndrome by preserving beneficial microbiota and maintaining intestinal epithelial barrier function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Federica Scarano, Saverio Nucera, Miriam Scicchitano, Francesca Bosco, Stefano Ruga, Maria Caterina Zito, Roberta Macri, Rosamaria Bulotta, Carolina Muscoli, Vincenzo Mollace
Summary: Metabolic syndrome is a collection of cardiovascular disease risk factors, including obesity, hypertension, insulin resistance, and dyslipidemia. Insufficient autophagy may lead to metabolic imbalance and contribute to the onset of metabolic syndrome. Understanding the underlying mechanisms of this disease is crucial for developing effective treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Wenjuan Zhang, Qimeng Sun, Baixin Chen, Maria Basta, Chongtao Xu, Yun Li
Summary: The study revealed an association between insomnia symptoms and metabolic syndrome as well as insulin resistance in patients with severe psychiatric disorders. Insomnia symptoms may serve as independent clinical indicators of underlying metabolic syndrome in these patients.
Article
Cell Biology
Qiang Qin, Jia'nan Shou, Mengjie Li, Meidi Gu, Zhuoxian Meng, Pinglong Xu, Hua Meng, Xiaojian Wang
Summary: In this study, it was found that the expression of Stk24 is significantly downregulated in ATMs in obese individuals or those with type 2 diabetes, as well as in mice fed a high-fat diet. Stk24 deficiency exacerbates HFD-induced metabolic disorders and insulin insensitivity. Stk24 plays a role in regulating NLRP3 inflammasome assembly in ATMs, and its expression correlates negatively with body mass index and related indicators in human subjects.
Article
Veterinary Sciences
Martin Sillence, Alexandra Meier, Melody de Laat, Rebecca Klee, Dania Reiche
Summary: This study investigated the factors associated with the rate of improvement in hyperinsulinaemia-associated laminitis (HAL) in 37 naturally-occurring cases. The results showed that younger horses and a modest increase in blood glucose and insulin concentrations are associated with delayed improvement in laminitis.
BMC VETERINARY RESEARCH
(2022)
Article
Nutrition & Dietetics
Vanessa Joy Timoteo, Kuang-Mao Chiang, Wen-Harn Pan
Summary: Iron overnutrition is associated with an increased risk of metabolic and cardiovascular diseases, while iron deficiency aggravates chronic conditions. Hemoglobin concentration can indicate the nutritional status of iron. Observational studies in two ethnic groups found that higher Hb concentrations were significantly associated with metabolic syndrome, while both high and low Hb concentrations were associated with increased odds of diabetes.
Article
Endocrinology & Metabolism
Dilnessa Fentie, Tariku Derese, Bekele Yazie, Yibeltal Getachew
Summary: The burden of metabolic syndrome is high in patients with psychiatric disorders, possibly due to factors such as reduced physical activity, use of psychotropic medication, psychological stress, excessive alcohol intake, and inadequate medical care. The study results highlight the increased burden of metabolic syndrome and its components among psychiatric patients in Eastern Ethiopia.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Cell Biology
Kumar Somyajit, Julian Spies, Fabian Coscia, Ufuk Kirik, Maj-Britt Rask, Ji-Hoon Lee, Kai John Neelsen, Andreas Mund, Lars Juhl Jensen, Tanya T. Paull, Matthias Mann, Jiri Lukas
Summary: The inhibition of ribonucleotide reductase leads to metabolic imbalance and accumulation of reactive oxygen species in cell nuclei, triggering a cascade of reactions involving ATM kinase and MRE11 nuclease. This process affects DNA replication and repair, impacting cancer evolution and tumor therapy.
DEVELOPMENTAL CELL
(2021)
Article
Endocrinology & Metabolism
Xuerui Wu, Cynthia Kwan Yui Cheung, Dewei Ye, Subrata Chakrabarti, Hema Mahajan, Sen Yan, Erfei Song, Wah Yang, Chi Ho Lee, Karen Siu Ling Lam, Cunchuan Wang, Aimin Xu
Summary: The study found that serum thrombospondin-2 (TSP2) is closely associated with the severity and progression of obesity-related metabolic syndrome (MetS) and metabolic associated fatty liver disease (MAFLD). Serum TSP2 is a promising noninvasive biomarker for differentiating metabolic associated steatohepatitis (MASH) and identifying at-risk patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Natasha Chidekel Bergmann, Melanie J. Davies, Ildiko Lingvay, Filip K. Knop
Summary: Obesity is a chronic disease with various complications and a significant impact on morbidity, mortality, and healthcare burden. The Semaglutide Treatment Effect in People with obesity (STEP) clinical trial program has shown that the use of once-weekly subcutaneous semaglutide 2.4 mg can lead to substantial weight loss in individuals with overweight or obesity. The trials demonstrated a mean weight loss of 14.9%-17.4% and a high proportion of participants achieving a weight loss of 10% or more with semaglutide 2.4 mg.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Juan P. Frias, Srikanth Deenadayalan, Lars Erichsen, Filip K. Knop, Ildiko Lingvay, Stanislava Macura, Chantal Mathieu, Sue Pedersen, Melanie Davies
Summary: This study assessed the efficacy and safety of co-administered semaglutide with cagrilintide in participants with type 2 diabetes. The results showed that the combination treatment resulted in clinically relevant improvements in glycemic control and weight loss compared to cagrilintide alone, and it was well tolerated.
Review
Endocrinology & Metabolism
Sofie Haedersdal, Andreas Andersen, Filip K. K. Knop, Tina Vilsboll
Summary: Insulin and glucagon have opposing effects on glucose metabolism, with the pancreatic islet beta-cells and alpha-cells acting as functional antagonists. The understanding of glucagon secretion has shifted towards the importance of alpha-cell-beta-cell crosstalk and the local paracrine actions on glucagon. Dysregulated glucagon secretion plays a role in metabolic diseases such as obesity, non-alcoholic fatty liver disease, and type 2 diabetes mellitus, and targeting glucagon holds clinical potential.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Mads M. Helsted, Laerke S. Gasbjerg, Tina Vilsboll, Casper K. Nielsen, Julie L. Forman, Mikkel B. Christensen, Filip K. Knop
Summary: Due to the reduced insulinotropic effect of GIP in type 2 diabetes, GIP has not been considered as a therapeutic option. However, tirzepatide, a dual incretin receptor agonist, has shown more significant glucose and weight-lowering effects compared to GLP-1 receptor agonist therapy. The role of GIP receptor activation in the efficacy of tirzepatide remains unknown. This study aims to evaluate the glucose-lowering effect of exogenous GIP in patients with type 2 diabetes under pharmacological GLP-1 receptor activation.
Article
Endocrinology & Metabolism
Pernille H. Hellmann, Jonatan Bagger, Katrine R. Carlander, Katrine B. Hansen, Julie L. Forman, Joachim Storling, Elizaveta Chabanova, Jens Holst, Tina Vilsboll, Filip K. Knop
Summary: This study aimed to evaluate the effect of curcumin combined with prednisolone on glucocorticoid-induced insulin resistance in healthy overweight or obese men. The results showed that curcumin had no protective effect on insulin resistance and other glucometabolic perturbations.
ENDOCRINE CONNECTIONS
(2023)
Article
Psychiatry
Bolette Skjodt Rafn, Martin Faerch Andersen, Victor Sorensen, Eik Dybboe Bjerre, Lone Baandrup, Ditte Lammers Vernal, Ole Mors, Filip Krag Knop, Rasmus Trap Wolf, Anders Tolver, Joseph Firth, Nikolaj Nohr, Soren T. Skou, Bjorn H. Ebdrup, Julie Midtgaard
Summary: Exercise is recommended for individuals with severe mental illness to protect physical health and facilitate recovery. This study aims to examine the effectiveness of a gym-based exercise intervention (Vega Exercise Community) tailored to young adults on antipsychotic treatment. The results may have important implications for promoting exercise as part of mental health treatment.
Article
Endocrinology & Metabolism
Signe Foghsgaard, Louise Vedtofte, Emilie S. Andersen, Emilie Bahne, Camilla Andreasen, Anne L. Sorensen, Julie L. Forman, Elisabeth R. Mathiesen, Jens A. Svare, Tine D. Clausen, Peter Damm, Jens J. Holst, Filip K. Knop, Tina Vilsboll
Summary: A 52-week treatment with liraglutide improved glucose tolerance, fasting plasma glucose, glycated hemoglobin, and bodyweight in women with overweight/obesity and previous gestational diabetes mellitus. However, the effects disappeared after a 1-week drug wash-out.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Vanita R. Aroda, Jens Aberle, Lars Bardtrum, Erik Christiansen, Filip K. Knop, Sanaz Gabery, Sue Pedersen, John B. Buse
Summary: This study investigated the efficacy of oral semaglutide at higher doses in patients with inadequately controlled type 2 diabetes and found that the doses of 25 mg and 50 mg were superior to the approved dose of 14 mg in reducing HbA1c and bodyweight. No new safety concerns were identified in the study.
Article
Nutrition & Dietetics
Soumia Majait, Emma C. E. Meessen, Frederic Maxime Vaz, E. Marleen Kemper, Samuel van Nierop, Steven W. Olde Damink, Frank G. Schaap, Johannes A. Romijn, Max Nieuwdorp, Aad Verrips, Filip Krag Knop, Maarten R. Soeters
Summary: This study examined the plasma profiles of bile acids, glucose, insulin, GLP-1, and FGF19 in CTX patients and healthy controls. The results showed that CTX patients had lower levels of bile acids and FGF19, abnormal postprandial glucose and insulin profiles, and elevated postprandial GLP-1 responses.
Review
Oncology
Yasemin Ceyhan, Nina Marie G. Garcia, James Alvarez
Summary: Tumor recurrence is a major challenge in achieving cures for cancer patients. Residual cancer cells, also known as minimal residual disease or persister cells, survive therapy and persist for extended periods before causing tumor relapse. While progress has been made in understanding the tumor-intrinsic pathways regulating the survival of residual cancer cells, the impact of the tumor microenvironment on persister cells and tumor recurrence remains less understood. This review highlights recent studies on the regulation and function of immune cells in residual disease and discusses therapeutic opportunities for targeting immune cells in residual tumors.
Article
Endocrinology & Metabolism
Sondre Meling, Erling Tjora, Heike Eichele, Rasmus B. Nedergaard, Filip K. Knop, Niels Ejskjaer, Siri Carlsen, Pal R. Njolstad, Christina Brock, Eirik Softeland
Summary: This study investigated the association between the incretin effect and autonomic neuropathy in type 2 diabetes patients. It found that rectal hyposensitivity was present in both longstanding and early diabetes, and was associated with gastrointestinal-mediated glucose disposal (GIGD) but not the incretin effect. Both the incretin effect and GIGD were correlated with the degree of dysglycemia and the duration of diabetes.
ENDOCRINOLOGY DIABETES & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Nina Lon, Sara Engel, Anders Damholt, Brynjulf Mortensen, Anne B. Haaber, Anja Wellejus, Filip K. Knop
Summary: Oral administration of the bacterial strain Bifidobacterium breve Bif195 can reduce the risk of aspirin-induced gastric mucosal damage. This study suggests that Bif195 may serve as a safe supplement during multiple-dosing aspirin treatment.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Manqi Zhang, Yasemin Ceyhan, Shenglin Mei, Taghreed Hirz, David B. Sykes, Irina U. Agoulnik
Summary: Prostate cancer is driven by multiple genetic alterations, and the loss of INPP4B and PTEN is a common tumor suppressor loss in prostate cancer. The loss of INPP4B and PTEN triggers different compensatory responses in prostate tissue.
Article
Endocrinology & Metabolism
Julio Rosenstock, Bertrand Cariou, Johanna Eliasson, Guillaume Frappin, Margit S. Kaltoft, Eduard Montanya, Filip K. Knop
Summary: The aim of this study was to assess the duration and likelihood of achieving HbA1c less than 7.0% in participants with type 2 diabetes using oral semaglutide compared to other medications.
DIABETES OBESITY & METABOLISM
(2023)