Spastin depletion increases tubulin polyglutamylation and impairs kinesin-mediated neuronal transport, leading to working and associative memory deficits

Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons

(2020) Satish Bodakuntla et al.   JOURNAL OF CELL SCIENCE

New Hypothesis for the Etiology of SPAST‐ based Hereditary Spastic Paraplegia

(2019) Liang Qiang et al.   Cytoskeleton

Competition between microtubule-associated proteins directs motor transport

(2018) Brigette Y. Monroy et al.   Nature Communications

Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation

(2018) Annapurna Vemu et al.   SCIENCE

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport

(2018) Maria M Magiera et al.   EMBO JOURNAL

Truncating mutations inSPASTpatients are associated with a high rate of psychiatric comorbidities in hereditary spastic paraplegia

(2017) Viorica Chelban et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Of microtubules and memory: implications for microtubule dynamics in dendrites and spines

(2017) Erik W. Dent   MOLECULAR BIOLOGY OF THE CELL

Graded Control of Microtubule Severing by Tubulin Glutamylation

(2016) Max L. Valenstein et al.   CELL

Microtubule plus-end tracking proteins in neuronal development

(2016) Dieudonnée van de Willige et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

How Do Microtubule Dynamics Relate to the Hallmarks of Learning and Memory?

(2016) Konstantin Kaganovsky et al.   JOURNAL OF NEUROSCIENCE

Genetic Demonstration of a Role for Stathmin in Adult Hippocampal Neurogenesis, Spinogenesis, and NMDA Receptor-Dependent Memory

(2016) G. Martel et al.   JOURNAL OF NEUROSCIENCE

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

(2016) Monika S. Brill et al.   NEURON

Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation

(2016) Matthias Kneussel et al.   TRENDS IN NEUROSCIENCES

The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory

(2016) Mary Muhia et al.   Cell Reports

Hereditary spastic paraplegia SPG4: what is known and not known about the disease

(2015) Joanna M. Solowska et al.   BRAIN

Building the Neuronal Microtubule Cytoskeleton

(2015) Lukas C. Kapitein et al.   NEURON

SnapShot: Receptor Dynamics at Plastic Synapses

(2014) Matthias Kneussel et al.   CELL

Molecular aspects of hereditary spastic paraplegia

(2014) Anne Noreau et al.   EXPERIMENTAL CELL RESEARCH

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites

(2014) Frank F. Heisler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dynamic Synapse

(2013) Daniel Choquet et al.   NEURON

Age-Related Behavioral Phenotype of an Astrocytic Monoamine Oxidase-B Transgenic Mouse Model of Parkinson’s Disease

(2013) Christopher A. Lieu et al.   PLoS One

LTP requires a reserve pool of glutamate receptors independent of subunit type

(2012) Adam J. Granger et al.   NATURE

Sonic Hedgehog Expression in Corticofugal Projection Neurons Directs Cortical Microcircuit Formation

(2012) Corey C. Harwell et al.   NEURON

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

(2011) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Muskelin Regulates Actin Filament- and Microtubule-Based GABAA Receptor Transport in Neurons

(2011) Frank F. Heisler et al.   NEURON

Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay

(2010) Lukas C. Kapitein et al.   BIOPHYSICAL JOURNAL

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

(2010) Benjamin Lacroix et al.   JOURNAL OF CELL BIOLOGY

Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin

(2010) Alison E. Twelvetrees et al.   NEURON

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton

(2010) Carsten Janke et al.   TRENDS IN NEUROSCIENCES

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

(2010) Austen J. Milnerwood et al.   TRENDS IN NEUROSCIENCES

A Selective Filter for Cytoplasmic Transport at the Axon Initial Segment

(2009) Ai-hong Song et al.   CELL

Pleiotropic effects of spastin on neurite growth depending on expression levels

(2009) Elena Riano et al.   JOURNAL OF NEUROCHEMISTRY

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

(2009) Paul R. Kasher et al.   JOURNAL OF NEUROCHEMISTRY

Dementia in SPG4 hereditary spastic paraplegia: Clinical, genetic, and neuropathologic evidence

(2009) S. Murphy et al.   NEUROLOGY

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo

(2009) C. Maas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia

(2008) J. M. Solowska et al.   JOURNAL OF NEUROSCIENCE

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

(2008) Antonina Roll-Mecak et al.   NATURE