Article
Biochemistry & Molecular Biology
Kyoung Ah Kang, Mei Jing Piao, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Joo Mi Yi, Jin Won Hyun
Summary: This study investigates whether Korean red ginseng (KRG) can inhibit PM2.5-induced senescence in skin keratinocytes. The results show that KRG can suppress PM2.5-induced cellular senescence and protect skin keratinocytes by epigenetic regulation of the p16(INK4A) gene.
Article
Plant Sciences
Huijeong Ahn, Byung-Cheol Han, Eui-Ju Hong, Beum-Soo An, Eunsong Lee, Seung-Ho Lee, Geun-Shik Lee
Summary: The study found that RGE and its saponins can inhibit the secretion of IL-1 beta in response to UV exposure in skin keratinocytes and macrophages, with RGE primarily interrupting the priming step in keratinocytes.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marta Karkoszka, Jakub Rok, Klaudia Banach, Justyna Kowalska, Zuzanna Rzepka, Dorota Wrzesniok
Summary: This study evaluated the influence of Meloxicam and UVAR on skin cell homeostasis. The results showed that co-treatment with Meloxicam and UVAR inhibited skin cell proliferation and caused morphological changes. Additionally, Meloxicam and UVAR disrupted redox homeostasis by lowering the intracellular level of reduced thiols. The study revealed that the phototoxic activity of Meloxicam is associated with oxidative stress induction and disruptions in cell homeostasis.
Article
Dermatology
Weixue Jia, Yuanyuan Zhang, Xue Wang, Lingling Luo, Heng Sun, Yiqun Jiang, Jianbo Wang, Qiuxia Mao, Youming Guo, Lingzhuo Kong, Ran Mo, Chengrang Li
Summary: This study reveals that the downregulation of KRT5 in keratinocytes affects melanogenesis in melanocytes through the Notch signaling pathway. The findings provide insights into the molecular mechanism of KRT5-Notch signaling pathway in the regulation of melanocytes and shed light on the mechanism of DDD pigment abnormality caused by KRT5 mutation. These findings identify potential therapeutic targets of the Notch signaling pathway for the treatment of skin pigment disorders.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Cell Biology
Jin Cheol Kim, Tae Jun Park, Hee Young Kang
Summary: Skin aging is caused by chronological aging and photoaging, resulting in pigmentation. Cellular senescence plays a crucial role in the process of skin aging, and the interaction between melanocytes and other aged skin cells affects pigmentation.
Article
Multidisciplinary Sciences
Pau-Ring Wong, Nur Fatin Nabilah Mohd Sahardi, Jen-Kit Tan, Kien-Hui Chua, Wan Zurinah Wan Ngah, Suzana Makpol
Summary: This study successfully isolated keratinocytes, fibroblasts, and melanocytes from human foreskin and characterized their purity using gene markers.
Article
Immunology
Sevda Cordier-Dirikoc, Nathalie Pedretti, Julien Garnier, Sandrine Clarhaut-Charreau, Bernhard Ryffel, Franck Morel, Francois-Xavier Bernard, Valerie Hamon de Almeida, Jean-Claude Lecron, Jean-Francois Jegou
Summary: In this study, dermal fibroblasts were identified as key sensors of IL-1 released by injured keratinocytes, showing high IL-1 responsiveness. Fibroblasts attract neutrophils for tissue repair by increasing the expression of chemokines in response to low concentrations of IL-1.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Shuang-Hai Hu, Shan Jiang, Fang Miao, Tie-Chi Lei
Summary: The release of sPmel17 protein from melanocytes (MCs) after exposure to UVB weakens cell-cell adhesions in keratinocytes (KCs), facilitating the migration of MCs to areas devoid of MCs. The upregulation of FHL2 in KCs requires stimulation by sPmel17 released from UVB-exposed MCs, and the activation of the sPmel17-FHL2-E-cadherin axis offers a potential therapeutic target to expedite repigmentation in patients with vitiligo.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Tiancheng Wang, Zhenwei Zhou, Enjing Luo, Jinghong Zhong, Daqing Zhao, Haisi Dong, Baojin Yao
Summary: This study compared the gene expression patterns between keratinocytes and fibroblasts, identifying a large number of differentially expressed genes. Keratinocytes and fibroblasts have distinct molecular characteristics, providing a resource for investigating novel biomarkers related to skin diseases.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Sullim Lee, Yea Jung Choi, Seulah Lee, Ki Sung Kang, Tae Su Jang, Ki Hyun Kim
Summary: Human skin relies on proteins like collagen and elastin for strength and elasticity. Damage to collagen, caused by factors like tumor necrosis factor (TNF)-alpha, leads to skin issues. This study finds that a compound called withagenin A diglucoside (WAD) from Withania somnifera can protect human skin cells from TNF-alpha-induced damage by inhibiting the generation of reactive oxygen species (ROS) and collagen-degrading enzymes. WAD works by inhibiting certain signaling pathways and suppressing the secretion of pro-inflammatory cytokines. These findings suggest that WAD has potential applications in cosmetics and pharmaceuticals related to skin aging.
Article
Multidisciplinary Sciences
Hellen Paula Valerio, Felipe Gustavo Ravagnani, Graziella Eliza Ronsein, Paolo Di Mascio
Summary: UVA induces proteome remodeling and senescence in primary keratinocytes, eliciting potent antioxidant and pro-inflammatory responses. Additionally, UVA modulates the secretory phenotype of these cells to the extent of inducing paracrine oxidative stress and immune system activation in pre-malignant keratinocytes.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Safa Tahri, Manira Maarof, Syafira Masri, Rohaina Che Man, Hatem Masmoudi, Mh Busra Fauzi
Summary: In this study, the potential of gelatin hydrogel crosslinked with genipin at different concentrations to promote human skin cell culture and develop a 3D in-vitro skin model was investigated. The crosslinked scaffolds showed improved physical properties, and genipin was found to enhance these properties. However, the selected formulations of 5% and 8% crosslinked gelatin hydrogel were not suitable for creating a bi-layer 3D in-vitro skin model. Further research is needed to address the challenges associated with gelatin hydrogels in developing 3D skin models.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Sun Mee Shin, Eun Joo Baek, Kwang Ho Kim, Kwang Joong Kim, Eun Joo Park
Summary: Polydeoxyribonucleotide (PDRN) is a mixture of deoxyribonucleotides with anti-inflammatory and tissue-regenerating properties. It regulates cell growth, collagen accumulation, and inflammation by modulating the mitogen-activated protein kinase pathway. In this study, the effects of PDRN on skin keratinocytes and fibroblasts were investigated to understand its molecular mechanism in skin healing. The results showed that PDRN promotes cell proliferation and migration, increases collagen synthesis in fibroblasts, and decreases inflammatory cytokine expression in keratinocytes via the extracellular signal-regulated kinase (ERK) pathway. Overall, PDRN has a positive effect on skin regeneration, but its mechanism varies among different cell types.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Plant Sciences
Eunsoo Park, Yun-Soo Kim, Mohammad Akbar Faqeerzada, Moon S. Kim, Insuck Baek, Byoung-Kwan Cho
Summary: In this study, a non-destructive method for early detection of root rot in ginseng was developed using crop phenotyping and HSI technique to analyze biochemical information. The results showed that root rot caused a decrease in nutrient absorption, photosynthetic activity, and levels of carotenoids, starch, and sucrose. This technique can be used for early and non-destructive detection of root rot in ginseng.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Dermatology
Hafeez Rahman, Dileep Kumar, Tong Liu, Nwanneka Okwundu, David Lum, Scott R. Florell, Christin E. Burd, Kenneth M. Boucher, Matthew W. VanBrocklin, Douglas Grossman
Summary: Aspirin can reduce UVB-induced DNA damage and skin cancer, decrease inflammation and DNA damage lesions, and delay the onset of non-melanoma and squamous cell carcinoma while translating into greater chemopreventive efficacy than melanoma in mouse models.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Horticulture
Lei Wu, Gongcheng Wang, Ting Shen, Long You, Weicheng Hu, Chuan-Ling Si
HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY
(2017)
Article
Food Science & Technology
Ting Shen, Gongcheng Wang, Long You, Liang Zhang, Haiwei Ren, Weicheng Hu, Qian Qiang, Xinfeng Wang, Lilian Jia, Zhengzhong Gu, Xiangxiang Zhao
FOOD & NUTRITION RESEARCH
(2017)
Article
Plant Sciences
Jeong-Oog Lee, So-Hyeon Hwang, Ting Shen, Ji Hye Kim, Long You, Weicheng Hu, Jae Youl Cho
Summary: PPT enhances skin barrier function and hydration by promoting the expression of filaggrin, transglutaminase, claudin, hyaluronic acid synthase, and activating Src/AKT/NF-kappa B and MAPK signaling pathways.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Anh Thu Ha, Laily Rahmawati, Long You, Mohammad Amjad Hossain, Jong-Hoon Kim, Jae Youl Cho
Summary: Quercetin 3-O-beta-D-glucuronide (Q-3-G) has been found to have anti-inflammatory, antioxidant, moisturizing, and antimelanogenesis effects in the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
Long You, Seunghwa Cha, Mi-Yeon Kim, Jae Youl Cho
Summary: The immune system plays a crucial role in the human body, with immunomodulation being its main function. Ginsenosides, derived from ginseng, have both immunostimulatory and immunosuppressive effects.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Plant Sciences
Kon Kuk Shin, Sang Hee Park, Hye Yeon Lim, Laura Rojas Lorza, Nurinanda Prisky Qomaladewia, Long You, Nur Aziz, Soo Ah Kim, Jong Sub Lee, Eui Su Choung, Jin Kyung Noh, Dong-Keun Yie, Deok Jeong, Jongsung Lee, Jae Youl Cho
Summary: Lm-ME has potential in skin protection due to its antioxidative, moisturizing, cytoprotective, and skin-lightening properties.
Article
Plant Sciences
Long You, Lei Huang, Jiwon Jang, Yo Han Hong, Han Gyung Kim, Hongxi Chen, Chae Yun Shin, Ji Hye Yoon, Philaxay Manilack, Bounthan Sounyvong, Woo-Shin Lee, Mi-Jeong Jeon, Sarah Lee, Byoung-Hee Lee, Jae Youl Cho
Summary: This study investigated the anti-inflammatory mechanisms of Callerya atropurpurea ethanol extract (Ca-EE) both in vitro and in vivo. The results showed that Ca-EE significantly reduced the production of inflammatory cytokines, protected cells from damage, and inhibited multiple signaling pathways. Gastritis and septic shock were also alleviated by Ca-EE. These findings suggest that Ca-EE has the potential to be used as a treatment for inflammatory diseases.
Article
Plant Sciences
Hwa Pyoung Lee, Wooram Choi, Ki Woong Kwon, Long You, Laily Rahmawati, Van Dung Luong, Wonhee Kim, Byoung-Hee Lee, Sarah Lee, Ji Hye Kim, Jae Youl Cho
Summary: This study evaluates the anti-allergic and anti-topical dermatitis activity of Grewia tomentosa Juss. ethanol extract (Gt-EE). The results show that Gt-EE suppressed allergic responses and inflammation, indicating its potential as a medicinal herb.
Article
Plant Sciences
Lei Huang, Long You, Nur Aziz, Seung Hui Yu, Jong Sub Lee, Eui Su Choung, Van Dung Luong, Mi-Jeong Jeon, Moonsuk Hur, Sarah Lee, Byoung-Hee Lee, Han Gyung Kim, Jae Youl Cho
Summary: Ardisia silvestris, a traditional medicinal herb, has skin-protective properties. Ethanol extract of A. silvestris can prevent UV-induced skin aging, enhance the skin barrier, and has no harmful effects on skin cells. These findings are important for the cosmetics and dermatology sectors.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Biochemistry & Molecular Biology
Long You, Mi-Yeon Kim, Jae Youl Cho
Summary: Maintaining skin homeostasis is crucial for skin health and UVB-induced skin photoaging can disrupt it, but Pg-EE has been found to strengthen the skin barrier, improve hydration, and possess anti-inflammatory properties, making it a valuable natural ingredient for treating skin disorders.
Article
Biochemistry & Molecular Biology
Young Jin, Long You, Hye Jeong Kim, Han-Woong Lee
MOLECULES AND CELLS
(2018)
Article
Biochemistry & Molecular Biology
Xueqin Li, Jun Shen, Yunyao Jiang, Ting Shen, Long You, Xiaobo Sun, Xudong Xu, Weicheng Hu, Haifeng Wu, Gongcheng Wang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)