Article
Biochemistry & Molecular Biology
Syed Husain Mustafa Rizvi, Di Shao, Yuko Tsukahara, David Richard Pimentel, Robert M. Weisbrod, Naomi M. Hamburg, Mark E. McComb, Reiko Matsui, Markus Michael Bachschmid
Summary: The study showed that exposure to hydrogen peroxide induced S-glutathionylation and nuclear translocation of GAPDH in HEK 293T cells. Overexpression of Glrx or a redox dead mutant GAPDH inhibited S-glutathionylation and nuclear translocation. Nuclear GAPDH formed a complex with SirT1, transferring S-glutathionylation to SirT1 and inhibiting its deacetylase activity to initiate apoptotic signaling.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Xiaoxiao Zhu, Qiang Guo, Jing Zou, Bin Wang, Zhen Zhang, Ran Wei, Lin Zhao, Yunhong Zhang, Chu Chu, Xiaoxiao Fu, Xia Li
Summary: The study revealed that miR-19a-3p inhibits M1 macrophage polarization by targeting STAT1. This pathway can potentially be used for designing novel immunotherapy to modulate macrophage polarization and reduce inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ailing Wang, Xueli Kang, Jing Wang, Shi Zhang
Summary: This study identified IRF1 as a key molecule in regulating macrophage M1 polarization and the development of septic ARDS, through the analysis of high-throughput experiments on ARDS patients and macrophage polarization. The study also found that the 5 hub genes (IFIH1, IRF1, STAT1, IFIT3, GBP1) may have a synergistic effect on macrophage M1 polarization in septic ARDS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Yang Luo, Dan Mo, Hongjie Guo, Cuilian Ye, Bailin Chen, Hai Zhu, Chun Deng, Qin Deng, Chunbao Guo, Lin Qiu
Summary: This study evaluated the essential role of NF-kappa B in macrophage polarization in necrotizing enterocolitis (NEC), and found that NF-kappa B inactivation can alleviate NEC by promoting M1 to M2 macrophage polarization.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Xiaomin Sun, Cuilian Ye, Qin Deng, Jingyu Chen, Chunbao Guo
Summary: The study demonstrates that Grx1 plays a crucial role in regulating ethanol-induced liver injury, with Grx1-deficient mice showing more severe liver damage when exposed to ethanol. Grx1 ablation suppresses NF-kappa B and Akt signaling cascades, leading to increased Fas-induced apoptosis.
Article
Cell Biology
Qiao Ye, Fang Luo, Tingting Yan
Summary: This study revealed that transcription factor KLF4 promotes M1 polarization of macrophages by enhancing STAT1 transcription, thereby exacerbating the progression of RA and inflammatory response.
Article
Genetics & Heredity
Tuo Liang, Jiarui Chen, Guoyong Xu, Zide Zhang, Jiang Xue, Haopeng Zeng, Jie Jiang, Tianyou Chen, Zhaojie Qin, Hao Li, Zhen Ye, Yunfeng Nie, Chong Liu, Xinli Zhan
Summary: The flow cytometric analysis validated the correlation between M1 macrophage polarization and the pathogenesis of EPTB, with most DEGs involved in immune-related processes. The hub genes STAT1 and CXCL10 might be involved in M1 macrophage polarization and correlated with the pathogenesis of EPTB, potentially serving as biomarkers for diagnosis and targeted therapy.
Article
Immunology
Yongquan Han, Gaozhi Li, Zeyu Zhang, Xiaohua Zhang, Bing Zhao, Hua Yang
Summary: This study found that Axl plays a crucial role in the rupture of intracranial aneurysm (IA) and macrophage polarization. Inhibiting Axl can reduce the infiltration of M1 macrophages and prevent IA rupture. Therefore, pharmacological inhibition of Axl might be used to prevent the progression and rupture of IA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yosuke Watanabe, Takamitsu Nakamura, Manabu Uematsu, Daisuke Fujioka, Daichi Inomata, Yukio Saito, Takeo Horikoshi, Toru Yoshizaki, Tsuyoshi Kobayashi, Kazuto Nakamura, Kiyotaka Kugiyama
Summary: This study demonstrated that plasma levels of Glrx are associated with future adverse events in patients with cardiovascular disease. Higher levels of Glrx were found to predict a higher probability of adverse events, indicating its potential as a biomarker for prognosis in CVD patients.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Fernando T. Ogata, Vasco Branco, Filipa F. Vale, Lucia Coppo
Summary: Glutaredoxin (Grx) is a small protein with an active site cysteine pair that regulates redox reactions through glutathionylation, playing a crucial role in various physiological and pathological conditions.
Article
Biochemistry & Molecular Biology
Ajanta Chatterji, Arne Holmgren, Rajib Sengupta
Summary: Ribonucleotide reductases play a crucial role in DNA synthesis and are essential for maintaining cellular functions. Research suggests that S-glutathionylation can regulate RNR activity, with studies exploring deglutathionylation mechanisms. Additionally, the study revealed the role of S-glutathionylation in DNA damage and repair processes.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jing Li, Xuewen Tang, Xing Wen, Xiaoyuan Ren, Huihui Zhang, Yatao Du, Jun Lu
Summary: Acetaminophen overdose is a common cause of drug-induced liver injury. The reaction between APAP metabolite and thiol molecules is the main cause of APAP-induced hepatotoxicity, but the role of other thiol-related regulators is unclear. In this study, the deletion of the Glrx2 gene worsened APAP-induced liver damage by interrupting the thiol-redox compensatory response and enhancing the AIF pathway-mediated oxidative damage.
Review
Biochemistry & Molecular Biology
Yuh-Cherng Chai, John J. Mieyal
Summary: This Special Issue aims to advance the understanding of the roles of the GSH/Grx system in cellular homeostasis and disease processes. GSH is the most abundant non-enzymatic antioxidant/nucleophilic molecule in cells. The S-glutathionylation of proteins, a reversible post-translational modification, can act as a regulatory switch in cell signaling and redox homeostasis.
Article
Biochemistry & Molecular Biology
Allison M. Manuel, Cheryl van de Wetering, Maximilian MacPherson, Cuixia Erickson, Caliann Murray, Reem Aboushousha, Jos van Der Velden, Anne E. Dixon, Matthew E. Poynter, Charles G. Irvin, Douglas J. Taatjes, Albert van Der Vliet, Vikas Anathy, Yvonne M. W. Janssen-Heininger
Summary: Obesity is a risk factor for the development of asthma and targeting metabolism and protein oxidation may be a novel treatment strategy for obese allergic asthma, highlighting the potential role of PKM2 in regulating glycolytic reprogramming and airway inflammation in obese asthmatic mice.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Immunology
Hui Guo, Yan Song, Fanjian Li, Yan Fan, Yiman Li, Chaonan Zhang, Huijie Hou, Minmin Shi, Zilong Zhao, Zhe Chen
Summary: This study found that ACT001 significantly alleviates inflammation and limits the M1 phenotype of pulmonary macrophages by suppressing NF-Kappa B and STAT1 signaling pathways in acute lung injury (ALI).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Masashi Nishimura, Yoshifumi Kimizuka, Takunori Ogawa, Motohiro Tsuchiya, Yoshiki Kato, Akira Matsukida, Shunya Igarashi, Koki Ito, Yusuke Serizawa, Tomomi Tanigaki, Yuji Fujikura, Yuka Katsurada, Sho Ogata, Akihiko Kawana
Summary: This study reports a case of IgG4-related retroperitoneal fibrosis occurring after chemotherapy. The patient showed improvement after discontinuing immunotherapy and receiving steroid treatment.
Article
Oncology
Yuta Ohishi, Yoko Nakanishi, Yukari Hirotani, Atsuko Suzuki, Tomoyuki Tanino, Haruna Nishimaki-Watanabe, Hiroko Kobayashi, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Kentaro Hayashi, Yoshiko Nakagawa, Tetsuo Shimizu, Ichiro Tsujino, Noriaki Takahashi, Yasuhiro Gon, Shinobu Masuda
Summary: This study aimed to investigate the clinicopathological differences and therapeutic response of NSCLC patients with SDC4::ROS1 fusion to crizotinib. The study found that different ROS1 fusion partners may affect the efficacy of crizotinib and patient prognosis. In addition, higher expression levels of ROS1 and pERK1/2 in tumor cells of case 2 may be related to the therapeutic response and prognosis.
Review
Oncology
Zitong Zheng, Juanjuan Liu, Junling Ma, Runting Kang, Zhen Liu, Jiangyong Yu
Summary: Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited treatment options. Over the past decade, immunotherapy has made progress in the treatment of SCLC, but current immune checkpoint inhibitors have limited benefits for patient survival. Therefore, it is important to explore new targets and develop drugs with novel mechanisms for immunotherapy in SCLC.
Article
Oncology
Kazuto Sugai, Kojiro Nakaoka, Rika Tobita, Shinji Kikuchi, Kei Inoue, Midori Enokido, Moriyuki Kiyoshima
Summary: This article presents a case of multilocular mediastinal cyst leading to the development of thymic cancer. Resection of multilocular anterior mediastinal cysts should be considered due to the challenges in preoperative diagnosis, the potential for coexisting tumors with cysts, and the risk of malignant tumor development.