End Processing Factor APLF Promotes NHEJ Efficiency and Contributes to TMZ- and Ionizing Radiation-Resistance in Glioblastoma Cells

DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancer

(2018) Yunxiao Meng et al.   CANCER LETTERS

Enhanced expression of histone chaperone APLF associate with breast cancer

(2018) Aditi Majumder et al.   Molecular Cancer

The pendulum of the Ku-Ku clock

(2018) Atsushi Shibata et al.   DNA REPAIR

miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancer

(2018) Jing Sun et al.   ONCOGENE

DHS (trans−4,4′-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2)

(2018) Chi-Wei Chen et al.   ONCOGENE

SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV

(2016) George E. Greco et al.   DNA REPAIR

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex

(2016) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Augmented HR Repair Mediates Acquired Temozolomide Resistance in Glioblastoma

(2016) C. R. Gil del Alcazar et al.   MOLECULAR CANCER RESEARCH

DNA repair mechanisms and their clinical impact in glioblastoma

(2016) Hélène Erasimus et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

TDP1 promotes assembly of non-homologous end joining protein complexes on DNA

(2015) Jinho Heo et al.   DNA REPAIR

Contemporary murine models in preclinical astrocytoma drug development

(2014) Robert S. McNeill et al.   NEURO-ONCOLOGY

Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising

(2014) Christian Jekimovs et al.   Frontiers in Oncology

DNA DSB repair pathway choice: an orchestrated handover mechanism

(2013) A Kakarougkas et al.   BRITISH JOURNAL OF RADIOLOGY

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

(2013) B. E. Johnson et al.   SCIENCE

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

Inhibition of Histone Deacetylation Potentiates the Evolution of Acquired Temozolomide Resistance Linked to MGMT Upregulation in Glioblastoma Xenografts

(2012) G. J. Kitange et al.   CLINICAL CANCER RESEARCH

APLF promotes the assembly and activity of non-homologous end joining protein complexes

(2012) Gabrielle J Grundy et al.   EMBO JOURNAL

Emerging insights into the molecular and cellular basis of glioblastoma

(2012) G. P. Dunn et al.   GENES & DEVELOPMENT

Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas

(2011) Jörg Felsberg et al.   INTERNATIONAL JOURNAL OF CANCER

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells

(2010) Farjana Fattah et al.   PLoS Genetics

Analysis of DNA Double-strand Break (DSB) Repair in Mammalian Cells

(2010) Andrei Seluanov et al.   Jove-Journal of Visualized Experiments

MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance

(2009) S. Yip et al.   CLINICAL CANCER RESEARCH

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Homologous recombination in DNA repair and DNA damage tolerance

(2008) Xuan Li et al.   CELL RESEARCH

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation

(2008) Chloe J. Macrae et al.   DNA REPAIR

Comparison of nonhomologous end joining and homologous recombination in human cells

(2008) Z MAO et al.   DNA REPAIR

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients

(2008) G. Minniti et al.   JOURNAL OF NEURO-ONCOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE