Review
Biochemistry & Molecular Biology
Joshua R. Brickner, Jada L. Garzon, Karlene A. Cimprich
Summary: R-loops, non-B DNA structures formed during transcription, can cause genomic instability but also have regulatory roles in maintaining genome integrity. They contribute to genomic instability during DNA replication and double-strand break repair, but also participate as intermediates in repair and influence pathway choice. Additionally, R-loops may be linked to disease.
Editorial Material
Oncology
Alexandre Puissant, Hind Medyouf
Summary: Ellegast and colleagues demonstrate that monocytic acute myeloid leukemias (AML) utilize the transcriptional repressor IRF2BP2 to suppress their cell-intrinsic inflammatory response. Disruption of IRF2BP2 leads to increased inflammatory signals and triggers apoptotic cell death in an NF-κB-IL1β-dependent manner, highlighting the potential therapeutic significance of targeting IRF2BP2 in monocytic AML.
Editorial Material
Biochemistry & Molecular Biology
George Yakoub, Martijn S. Luijsterburg
Summary: A recent study in Nature unveils the mechanism of how transcriptionally active RNA polymerase II clings to the genomic tightrope during replication, enabled by protein-protein interactions between the replication and transcription machineries.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Review
Anesthesiology
Theodoros Schizodimos, Vasiliki Soulountsi, Christina Iasonidou, Nikos Kapravelos
Summary: Venous thromboembolism is a common and potentially fatal complication in ICU patients, requiring careful consideration of individual risk factors and disease subgroups to select the appropriate form of thromboprophylaxis, whether pharmacologic or mechanical. Compliance with guidelines is essential for successful prevention in practice.
MINERVA ANESTESIOLOGICA
(2021)
Review
Oncology
Francesco Tarantini, Cosimo Cumbo, Luisa Anelli, Antonella Zagaria, Nicoletta Coccaro, Giuseppina Tota, Giorgina Specchia, Pellegrino Musto, Francesco Albano
Summary: This article reviews some challenging situations of clonal hematopoiesis in clinical practice, aiming to help doctors maintain balance in this tightrope.
LEUKEMIA & LYMPHOMA
(2022)
Article
Management
Matias Stahle, Tuomas Ahola
Summary: This study examines how a company manages the sales of tailored projects and standardized equipment under two concurrent sales logics, using a qualitative case study approach. The findings suggest that the company utilizes various segmenting, bridging, and demarcating practices to cope with conflicting demands and leverage synergies between the logics.
INTERNATIONAL JOURNAL OF PROJECT MANAGEMENT
(2022)
Article
Education, Scientific Disciplines
Leonid Minkin, Anthony C. Zable
Summary: Physics-related tricks using everyday materials can be entertaining and motivating for children, such as balancing a stick. Balancing a stick involves considerations of rotational dynamics and human responses, which are important for introductory physics courses.
Article
Business
Rajnish Rai, Devi R. Gnyawali, Himanshu Bhatt
Summary: This study addresses the lack of clarity and reliable measures for coopetition capability by conducting a three-phase research. It conceptualizes coopetition capability as a multidimensional construct and develops a valid scale for its measurement. The study provides a foundation for future theory development and empirical research on coopetition.
JOURNAL OF MANAGEMENT
(2023)
Review
Oncology
Aisling Barrett, Graham P. Collins
Summary: Since its initial description, classical Hodgkin lymphoma (cHL) has shown a good prognosis, with the goal of treatment being cure and minimal toxicity. However, older patients (>60 years old) have worse outcomes compared to younger patients, and cure is mostly achievable for those who can tolerate full doses of conventional chemotherapy. This review focuses on the difference in biology between younger and older cHL patients, and explores the impact of frailty and comorbidities on outcomes. The article also discusses the toxicities of conventional chemotherapy in different patient groups and highlights the potential of targeted therapies and checkpoint inhibitors as alternatives for those who cannot tolerate traditional chemotherapy. The treatment of older cHL patients remains an area in hematological research that requires further attention.
FRONTIERS IN ONCOLOGY
(2023)
Article
Business
Burcu Felekoglu, Serdar S. Durmusoglu, Anja M. Maier, James Moultrie
Summary: This study examines how technical and social drivers influence organic communication and top management involvement in new product development projects. The results show that active motivation and organic communication improve budget and schedule adherence, while providing guidance and stimulating a tolerant climate have detrimental effects on performance. The study's findings also emphasize the importance of top management involvement and the impact of technical and social drivers.
EUROPEAN JOURNAL OF INNOVATION MANAGEMENT
(2022)
Article
Sociology
Joseph A. Guzman
Summary: This article examines the solidarity and tensions within a middle-class Black men's social club. These organizations aim to maintain intra-racial ties, offer support for racial uplift, and provide an escape from societal pressures.
SOCIOLOGICAL QUARTERLY
(2022)
Review
Cardiac & Cardiovascular Systems
Davis Jones, Johny Nicolas, Frans Beerkens, Mohan Satish, Daniel Feldman, Davide Cao, Alessando Spirito, Roxana Mehran
Summary: As awareness of the impact of bleeding on prognosis increases, new treatment strategies are being sought to reduce bleeding risk without compromising ischemic protection. Patients at high bleeding risk are often underestimated in clinical trials and also at increased risk of ischemic events.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Immunology
Matthew Z. Dudley, Roger Bernier, Janesse Brewer, Daniel A. Salmon
Summary: Scientists are trained to be skeptical and cautious in their approach to evidence, which is valuable in research. However, when communicating with the public about urgent issues such as COVID-19 vaccines, they need to adjust their mindset to focus on brevity and clarity to foster public confidence in taking necessary actions.
Article
Business
Tim Heubeck
Summary: This study explores the relationship between CEOs and the board of directors in the context of ESG performance, and confirms the positive impact of dynamic CEO capabilities on ESG performance, as well as the moderating effect of board gender diversity on this relationship.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
Christopher Poppe, Martine Verwey, Tenzin Wangmo
Summary: Informal caregivers, mainly family members and friends, play a crucial role in providing supportive and palliative care for people with ALS. The theoretical understanding of ALS informal caregiving work emphasizes on the core category of 'holding the balance', which highlights the importance of ensuring care and normalcy for patients even as the disease progresses towards the end of life. This study accounts for the heterogeneity of ALS progression and takes into consideration various caregiving trajectories influenced by contextual factors.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Entomology
Simon C. Groen, Parris T. Humphrey, Daniela Chevasco, Frederick M. Ausubel, Naomi E. Pierce, Noah K. Whiteman
JOURNAL OF INSECT PHYSIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Kelsey M. Yule, Jennifer A. H. Koop, Nicolas M. Alexandre, Lauren R. Johnston, Noah K. Whiteman
Editorial Material
Multidisciplinary Sciences
Noah K. Whiteman, Andrew D. Gloss
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Ecology
Parris T. Humphrey, Andrew D. Gloss, Nicolas M. Alexandre, Martha M. Villalobos, Marcella R. Fremgen, Simon C. Groen, Lisa N. Meihls, Georg Jander, Noah K. Whiteman
ECOLOGY AND EVOLUTION
(2016)
Article
Biochemistry & Molecular Biology
Simon C. Groen, Erika R. LaPlante, Nicolas M. Alexandre, Anurag A. Agrawal, Susanne Dobler, Noah K. Whiteman
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Dario Copetti, Alberto Burquez, Enriquena Bustamante, Joseph L. M. Charboneau, Kevin L. Childs, Luis E. Eguiarte, Seunghee Lee, Tiffany L. Liu, Michelle M. McMahon, Noah K. Whiteman, Rod A. Wing, Martin F. Wojciechowski, Michael J. Sanderson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Entomology
David Giron, Geraldine Dubreuil, Alison Bennett, Franck Dedeine, Marcel Dicke, Lee A. Dyer, Matthias Erb, Marion O. Harris, Elisabeth Huguet, Isgouhi Kaloshian, Atsushi Kawakita, Carlos Lopez-Vaamonde, Todd M. Palmer, Theodora Petanidou, Michael Poulsen, Aurelien Salle, Jean-Christophe Simon, John S. Terblanche, Denis Thiery, Noah K. Whiteman, H. Arthur Woods, Sylvain Pincebourde
ENTOMOLOGIA EXPERIMENTALIS ET APPLICATA
(2018)
Article
Ecology
P. T. Humphrey, A. D. Gloss, J. Frazier, A. C. Nelson-Dittrich, S. Faries, N. K. Whiteman
Article
Ecology
Nicolas M. Alexandre, Parris T. Humphrey, Andrew D. Gloss, Jimmy Lee, Joseph Frazier, Henry A. Affeldt, Noah K. Whiteman
Editorial Material
Biochemistry & Molecular Biology
Marianthi Karageorgi, Teruyuki Matsunaga, Noah K. Whiteman
Article
Ecology
Timothy K. O'Connor, Robert G. Laport, Noah K. Whiteman
JOURNAL OF BIOGEOGRAPHY
(2019)
Article
Biochemistry & Molecular Biology
Kirsten Verster, Jennifer H. Wisecaver, Marianthi Karageorgi, Rebecca P. Duncan, Andrew D. Gloss, Ellie E. Armstrong, Donald K. Price, Aruna R. Menon, Zainab M. Ali, Noah K. Whiteman
MOLECULAR BIOLOGY AND EVOLUTION
(2019)
Review
Biology
Andrew D. Gloss, Patrick Abbot, Noah K. Whiteman
CURRENT OPINION IN INSECT SCIENCE
(2019)
Article
Multidisciplinary Sciences
Marianthi Karageorgi, Simon C. Groen, Fidan Sumbul, Julianne N. Pelaez, Kirsten I. Verster, Jessica M. Aguilar, Amy P. Hastings, Susan L. Bernstein, Teruyuki Matsunaga, Michael Astourian, Geno Guerra, Felix Rico, Susanne Dobler, Anurag A. Agrawal, Noah K. Whiteman
