Requirements for Animal Experiments: Problems and Challenges

Pre-screening the intrinsic angiogenic capacity of biomaterials in an optimised ex ovo chorioallantoic membrane model

(2020) Nupur Kohli et al.   Journal of Tissue Engineering

Zebrafish as a preclinical in vivo screening model for nanomedicines

(2019) Sandro Sieber et al.   ADVANCED DRUG DELIVERY REVIEWS

The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer

(2019) Styliani Melissaridou et al.   Cancer Cell International

Construction of a Quantitative Structure Activity Relationship (QSAR) Model to Predict the Absorption of Cephalosporins in Zebrafish for Toxicity Study

(2019) Ying Liu et al.   Frontiers in Pharmacology

Microfluidic platforms for cell cultures and investigations

(2019) Maria Laura Coluccio et al.   MICROELECTRONIC ENGINEERING

A Medicinal Chemist’s Perspective on Transitioning from Industry to Academic Drug Discovery

(2019) James C. Barrow   ACS Medicinal Chemistry Letters

Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine

(2019) M. R. Carvalho et al.   Science Advances

Survey of Clinical Translation of Cancer Nanomedicines—Lessons Learned from Successes and Failures

(2019) Hongliang He et al.   ACCOUNTS OF CHEMICAL RESEARCH

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

(2019) Sylvia E. Escher et al.   ARCHIVES OF TOXICOLOGY

Integrating in silico models and read-across methods for predicting toxicity of chemicals: A step-wise strategy

(2019) Emilio Benfenati et al.   ENVIRONMENT INTERNATIONAL

Improved Biocompatibility of Amino‐Functionalized Graphene Oxide in Caenorhabditis elegans

(2019) Corvin Rive et al.   Small

How Can Systematic Reviews Teach Us More about the Implementation of the 3Rs and Animal Welfare?

(2019) Merel Ritskes-Hoitinga et al.   Animals

Integrated Approaches to Testing and Assessment: OECD Activities on the Development and Use of Adverse Outcome Pathways and Case Studies

(2018) Yuki Sakuratani et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Integrated Approaches to Testing and Assessment

(2018) Silvia Casati   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Machine learning in chemoinformatics and drug discovery

(2018) Yu-Chen Lo et al.   DRUG DISCOVERY TODAY

Human skin in vivo has a higher skin barrier function than porcine skin ex vivo-comprehensive Raman microscopic study of the stratum corneum

(2018) ChunSik Choe et al.   Journal of Biophotonics

Recent advances in microfluidic technologies for cell-to-cell interaction studies

(2018) Mario Rothbauer et al.   LAB ON A CHIP

Guidelines on statistics for researchers using laboratory animals: the essentials

(2018) Romain-Daniel Gosselin   LABORATORY ANIMALS

Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries

(2018) Marcus C. Parrish et al.   Annual Review of Pharmacology and Toxicology

Translational in vitro research: integrating 3D drug discovery and development processes into the drug development pipeline

(2018) Jens M. Kelm et al.   DRUG DISCOVERY TODAY

Calcium phosphate nanoparticle-mediated transfection in 2D and 3D mono- and co-culture cell models

(2018) Viktoriya Sokolova et al.   Acta Biomaterialia

Cardiovascular disease models: A game changing paradigm in drug discovery and screening

(2018) Houman Savoji et al.   BIOMATERIALS

3D organ models—Revolution in pharmacological research?

(2018) Marie Weinhart et al.   PHARMACOLOGICAL RESEARCH

Laboratory Animal Laws, Regulations, Guidelines and Standards in China Mainland, Japan, and Korea

(2017) Bryan E Ogden et al.   ILAR JOURNAL

Modeling Physiological Events in 2D vs. 3D Cell Culture

(2017) Kayla Duval et al.   PHYSIOLOGY

Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications

(2017) Alicia Paini et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling

(2017) Alicia Paini et al.   TOXICOLOGY IN VITRO

From in vivo to in vitro: The medical device testing paradigm shift

(2017) Dayna Myers   ALTEX-Alternatives to Animal Experimentation

An enhanced C. elegans based platform for toxicity assessment

(2017) Huajiang Xiong et al.   Scientific Reports

In silico methods to address polypharmacology: current status, applications and future perspectives

(2016) Antonio Lavecchia et al.   DRUG DISCOVERY TODAY

Archiving of zebrafish lines can reduce animal experiments in biomedical research

(2016) Robert Geisler et al.   EMBO REPORTS

The animal experimentation quandary: stuck between legislation and scientific freedom

(2016) Bettina Bert et al.   EMBO REPORTS

TheC. elegansmodel in toxicity testing

(2016) Piper Reid Hunt   JOURNAL OF APPLIED TOXICOLOGY

Alternative Animal and Non-Animal Models for Drug Discovery and Development: Bonus or Burden?

(2016) Irlan Almeida Freires et al.   PHARMACEUTICAL RESEARCH

Chemotherapeutic efficiency of drugs in vitro: Comparison of doxorubicin exposure in 3D and 2D culture matrices

(2016) A. Casey et al.   TOXICOLOGY IN VITRO

A micromechanical comparison of human and porcine skin before and after preservation by freezing for medical device development

(2016) S. A. Ranamukhaarachchi et al.   Scientific Reports

Languages Are Still a Major Barrier to Global Science

(2016) Tatsuya Amano et al.   PLOS BIOLOGY

The chorioallantoic membrane (CAM) assay for the study of human bone regeneration: a refinement animal model for tissue engineering

(2016) Inés Moreno-Jiménez et al.   Scientific Reports

Chick embryo chorioallantoic membrane (CAM): an alternative predictive model in acute toxicological studies for anti-cancer drugs

(2015) Chin Siang KUE et al.   EXPERIMENTAL ANIMALS

Quantitative structure–activity relationship: promising advances in drug discovery platforms

(2015) Tao Wang et al.   Expert Opinion on Drug Discovery

Alternatives to animal testing: A review

(2015) Sonali K. Doke et al.   SAUDI PHARMACEUTICAL JOURNAL

Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980–2013

(2015) Jen-Yin Goh et al.   Toxicology Research

The top skin-associated genes: a comparative analysis of human and mouse skin transcriptomes

(2014) Peter Arne Gerber et al.   BIOLOGICAL CHEMISTRY

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

(2014) Knut Erik Tollefsen et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Animal models of human disease: Challenges in enabling translation

(2013) Paul McGonigle et al.   BIOCHEMICAL PHARMACOLOGY

Invertebrate Models for Biomedical Research, Testing, and Education

(2013) S. E. Wilson-Sanders   ILAR JOURNAL

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Rodent Models for Human Polycystic Ovary Syndrome1

(2012) Kirsty A. Walters et al.   BIOLOGY OF REPRODUCTION

Does Pet Arrival Trigger Prosocial Behaviors in Individuals with Autism?

(2012) Marine Grandgeorge et al.   PLoS One

In Vivo-In Vitro-In Silico Pharmacokinetic Modelling in Drug Development

(2011) Olavi Pelkonen et al.   CLINICAL PHARMACOKINETICS

Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery

(2011) U. B. Pandey et al.   PHARMACOLOGICAL REVIEWS

Zebrafish embryos as an alternative to animal experiments—A commentary on the definition of the onset of protected life stages in animal welfare regulations

(2011) Uwe Strähle et al.   REPRODUCTIVE TOXICOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Animal Models for Cartilage Regeneration and Repair

(2009) Constance R. Chu et al.   TISSUE ENGINEERING PART B-REVIEWS

Predictivity and sensitivity of animal models of arthritis

(2008) Rosanna Di Paola et al.   AUTOIMMUNITY REVIEWS

Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps

(2008) George Loizou et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Three-Dimensional Cell Culture Matrices: State of the Art

(2008) Jungwoo Lee et al.   TISSUE ENGINEERING PART B-REVIEWS