Divergent synthesis of complex diterpenes through a hybrid oxidative approach

A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs

(2020) Jennifer J. Schmidt et al.   ACS Chemical Biology

Merging chemoenzymatic and radical-based retrosynthetic logic for rapid and modular synthesis of oxidized meroterpenoids

(2020) Jian Li et al.   Nature Chemistry

Engineering new catalytic activities in enzymes

(2020) Kai Chen et al.   Nature Catalysis

Two-Phase Synthesis of Taxol

(2020) Yuzuru Kanda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Late-Stage Diversification of Natural Products

(2020) Benke Hong et al.   ACS Central Science

Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis

(2019) Liao-Bin Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a Terpene Feedstock-Based Oxidative Synthetic Approach to the Illicium Sesquiterpenes

(2019) Kevin Hung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of (−)-Mitrephorone A via a Bioinspired Late Stage C–H Oxidation of (−)-Mitrephorone B

(2019) Lukas Anton Wein et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Syntheses of (−)-Tripterifordin and (−)-Neotripterifordin from Stevioside

(2018) Shoji Kobayashi et al.   JOURNAL OF ORGANIC CHEMISTRY

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

An Engineered Self-Sufficient Biocatalyst Enables Scalable Production of Linear α-Olefins from Carboxylic Acids

(2018) Chen Lu et al.   ACS Catalysis

Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis

(2018) Jeffrey D. Rudolf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes

(2018) Aitor Hernandez-Ortega et al.   Scientific Reports

Total Synthesis of (−)-Mitrephorone A

(2018) Matthieu J. R. Richter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isolation, Structure Elucidition, and Immunosuppressive Activity of Diterpenoids from Ligularia fischeri

(2017) Fekadu-Roge Gobu et al.   JOURNAL OF NATURAL PRODUCTS

Scalable, Electrochemical Oxidation of Unactivated C–H Bonds

(2017) Yu Kawamata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C—H Functionalization

(2017) Andrew N. Lowell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diterpenoids from Isodon species: an update

(2017) Miao Liu et al.   NATURAL PRODUCT REPORTS

Functional Diversification of Kaurene Synthase-Like Genes in Isodon rubescens

(2017) Baolong Jin et al.   PLANT PHYSIOLOGY

A Concise Route to the Strongylophorines

(2016) Wanwan Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nineteen-step total synthesis of (+)-phorbol

(2016) Shuhei Kawamura et al.   NATURE

Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution

(2016) Ryan S Nett et al.   Nature Chemical Biology

New Non-Toxic Semi-Synthetic Derivatives from Natural Diterpenes Displaying Anti-Tuberculosis Activity

(2015) Priscilla Matos et al.   MOLECULES

New avenues for the synthesis of ent-kaurene diterpenoids

(2015) Paul S. Riehl et al.   TETRAHEDRON

The Total Synthesis ofIsodonDiterpenes

(2014) Kiel E. Lazarski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Unified Approach to ent-Atisane Diterpenes and Related Alkaloids: Synthesis of (−)-Methyl Atisenoate, (−)-Isoatisine, and the Hetidine Skeleton

(2014) Emily C. Cherney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Remarkable Structural Diversity Achieved in ent-Kaurane Diterpenes by Fungal Biotransformations

(2014) Jacqueline Takahashi et al.   MOLECULES

Biochemical characterization of the castor bean ent -kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization

(2014) Alana J. Jackson et al.   PHYTOCHEMISTRY

Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells

(2014) Y-J Liao et al.   Cell Death & Disease

Synthesis of Skeletally Diverse and Stereochemically Complex Library Templates Derived from Isosteviol and Steviol

(2013) Oliver E. Hutt et al.   ORGANIC LETTERS

Tuning P450 Enzymes as Oxidation Catalysts

(2012) Rudi Fasan   ACS Catalysis

Innate and Guided C–H Functionalization Logic

(2011) Tobias Brückl et al.   ACCOUNTS OF CHEMICAL RESEARCH

P450BM3(CYP102A1): connecting the dots

(2011) Christopher J. C. Whitehouse et al.   CHEMICAL SOCIETY REVIEWS

P450 Fingerprinting Method for Rapid Discovery of Terpene Hydroxylating P450 Catalysts with Diversified Regioselectivity

(2011) Kaidong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution

(2011) Sabrina Kille et al.   Nature Chemistry

Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis

(2011) M. J. Smanski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LICRED: A Versatile Drop-In Vector for Rapid Generation of Redox-Self-Sufficient Cytochrome P450s

(2010) Federico Sabbadin et al.   CHEMBIOCHEM

Combinatorial Alanine Substitution Enables Rapid Optimization of Cytochrome P450BM3 for Selective Hydroxylation of Large Substrates

(2010) Jared C. Lewis et al.   CHEMBIOCHEM

Aiming for the Ideal Synthesis

(2010) Tanja Gaich et al.   JOURNAL OF ORGANIC CHEMISTRY

Formation of Beyerene, Kaurene, Trachylobane, and Atiserene Diterpenes by Rearrangements That Avoid Secondary Carbocations

(2010) Young J. Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diterpene Glycosides from the Seeds ofPharbitis nil

(2009) Ki Hyun Kim et al.   JOURNAL OF NATURAL PRODUCTS

Bioactive Constituents of the Stem Bark ofMitrephora glabra

(2009) Chen Li et al.   JOURNAL OF NATURAL PRODUCTS

Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein

(2007) Harshica Fernando et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS