Review
Pathology
Priyanka Singh, Saba Naaz Ali, Sufian Zaheer, Mukul Singh
Summary: Interstitial lung diseases (ILDs) are a group of rare pulmonary pathologies that involve injury, inflammation, and scarring in the lungs. The exact causes of these diseases are largely unknown, but various cellular mechanisms play important roles in the development of fibrosis, influenced by occupational, environmental, and genetic factors. This study aims to provide new insights into the interactions and cellular contributions in the pathogenesis of idiopathic pulmonary fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Andrew Manley, Bahar I. Meshkat, Monica M. Jablonski, T. J. Hollingsworth
Summary: Inherited retinal dystrophies (IRDs) are congenital retinal degenerative diseases with various inheritance patterns caused by defects in retinal function, development, or both. Mutated genes associated with IRDs produce altered protein products that disrupt pathways critical to vision. This manuscript provides a comprehensive review of the molecular mechanisms underlying IRD pathogenesis by examining the genes, protein products, and pathways affected by genetic mutation.
Review
Environmental Sciences
Zhicheng Gao, Kangxin Luo, Qiuxiang Zhu, Jinghui Peng, Chang Liu, Xiaoyue Wang, Shoujun Li, Haiyang Zhang
Summary: This review summarizes the occurrence regularity, toxicity, toxic mechanisms, and management strategies of Fumonisin B1 (FB1). FB1 contamination is particularly serious in developing countries, humid and hot regions. FB1 exposure can produce different toxic effects on various systems, including the nervous, respiratory, digestive, and reproductive systems. The mechanism of toxic effects of FB1 is through interfering with sphingolipid de novo biosynthesis and causing oxidative stress and apoptosis. Detection methods for FB1 include lateral flow dipstick technology, enzyme-linked immunosorbent assay, high-performance liquid chromatography, and liquid chromatography-mass spectrometry. Natural plant extracts have been proven to inhibit the toxic effects of FB1 and protect livestock due to their antifungal and antioxidant effects. This review provides comprehensive information on FB1 and can serve as a reference for formulating treatment and management strategies in livestock production.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
Claudia Sirbe, Gelu Simu, Iulia Szabo, Alina Grama, Tudor Lucian Pop
Summary: Pediatric autoimmune liver disorders encompass autoimmune hepatitis, autoimmune sclerosing cholangitis, and de novo AIH after liver transplantation. The pathogenesis involves genetic variations, environmental factors, and epigenetic modifications. Current first-line therapy includes prednisolone plus azathioprine for clinical and biochemical remission induction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yashumati Ratan, Aishwarya Rajput, Sushmita Maleysm, Aaushi Pareek, Vivek Jain, Ashutosh Pareek, Ranjeet Kaur, Gurjit Singh
Summary: Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by cognitive decline, neurodegeneration, and the formation of amyloid-fi plaques and neurofibrillary tangles. Despite extensive research into the causes and molecular mechanisms of AD, a cure has not yet been found. Extensive disease modeling and understanding of the molecular mechanisms are crucial for the development of effective treatments.
Review
Biochemistry & Molecular Biology
Kaihui Lu
Summary: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome caused by metabolic disorders in the liver. It is characterized by hyperammonemia, EEG abnormalities, and disturbances in sensory, motor, and cognitive functions. The main mechanisms of HE include ammonia poisoning, oxidative/nitrosative stress, manganese toxicity, autophagy inhibition, mitochondrial damage, inflammation, and senescence.
Review
Biochemistry & Molecular Biology
Tanyalak Parimon, Miriam S. Hohmann, Changfu Yao
Summary: Pulmonary fibrosis is a chronic and fatal lung disease that predominantly affects the aging population globally. Understanding the mechanisms of cellular senescence may offer new pathways for treatment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Alexandra D. Dreyfuss, Anastasia Velalopoulou, Harris Avgousti, Brett I. Bell, Ioannis I. Verginadis
Summary: Radiation therapy is an important modality in cancer treatment, but incidental exposure of the heart to radiation can lead to the development of Radiation-Induced Heart Disease (RIHD), causing various cardiovascular complications. The pathogenesis of radiation-induced myocardial fibrosis (RIMF) is still largely unknown and there are currently no available clinical approaches to reverse it. Therefore, more clinically relevant preclinical models are needed to study the molecular and cellular mechanisms involved in RIMF.
FRONTIERS IN ONCOLOGY
(2022)
Review
Food Science & Technology
Suhuan Mei, Haile Ma, Xiumin Chen
Summary: Mangiferin, a C-glycosyl xanthone, has potential pharmacological activities in attenuating inflammation and preventing cancer by inhibiting inflammatory mediators, protecting intestinal barrier integrity, and targeting molecular pathways. Understanding the molecular targets of mangiferin is crucial for its better application in treating inflammation-related diseases and preventing cancer.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aurelian Anghelescu, Gelu Onose, Cristina Popescu, Mihai Baila, Simona Isabelle Stoica, Ruxandra Postoiu, Elena Bruma, Irina Raluca Petcu, Vlad Ciobanu, Constantin Munteanu
Summary: This article summarizes the current findings on the role of chronic neuroinflammation-mediated neurodegeneration in age-related neurodegenerative diseases and explores the impact of post-SARS-CoV-2 immune reactions on neurodegeneration. The study conducted a systematic literature review and meta-analysis, focusing on Parkinson's disease and the acute and chronic repercussions of COVID-19. Further clinical observations and prospective longitudinal cohort studies are needed to better understand the interplay between neuroinflammation, neurodegeneration, and COVID-19.
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Pharmacology & Pharmacy
Yunjing He, Jingrui Zheng, Binbin Ye, Yongzhao Dai, Ke Nie
Summary: Chemotherapy-induced gastrointestinal toxicity is a major concern for cancer patients, affecting their quality of life and treatment outcomes. The condition involves various factors such as gut microbiota disorders, inflammatory responses, and intestinal neurotoxicity. Traditional Chinese medicine has shown promise as a complementary therapy for managing gastrointestinal toxicity.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Environmental Sciences
Uzma Ramzan, Waqar Majeed, Abdul Ahad Hussain, Fasiha Qurashi, Safi Ur Rehman Qamar, Muhammad Naeem, Jalal Uddin, Ajmal Khan, Ahmed Al-Harrasi, Saiful Izwan Abd Razak, Tze Yan Lee
Summary: Silver nanoparticles (AgNPs) are widely used in consumer products, but their discharge pollutes the ecosystem and affects aquatic organisms. Managing the effects of AgNPs in aquatic ecosystems is highly important.
Review
Environmental Sciences
Mahesh Rachamalla, Joshi Chinthada, Sapana Kushwaha, Sravan Kumar Putnala, Chittaranjan Sahu, Gopabandhu Jena, Som Niyogi
Summary: Arsenic is a toxic metalloid that is harmful to both humans and animals. Drinking water contaminated with arsenic has been linked to the development of various diseases, including cancer, diabetes, cardiovascular disease, and neurological damage. Arsenic exposure negatively affects male reproductive systems, leading to infertility, sexual dysfunction, and poor sperm quality.
Article
Oncology
Weronika Maria Szejniuk, Martin Skovmos Nielsen, Zsuzsanna Takacs-Szabo, Jacek Pawlowski, Sahar Sulaiman Al-Saadi, Panagiotis Maidas, Martin Bogsted, Tine McCulloch, Jens Brondum Frokjaer, Ursula Gerda Falkmer, Oluf Dimitri Roe
Summary: This study aimed to evaluate the utility of a novel radiation-induced lung injury (RILI) grading scale (RGS) for predicting radiation pneumonitis (RP) after thoracic radiation therapy. Results showed that patients with RGS grades 2-3 had a significantly higher risk for developing RP, and RGS demonstrated good specificity in predicting symptomatic RP.
RADIATION ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fabienne Geiger, Sarah Zeitlmayr, Claudia A. Staab-Weijnitz, Suhasini Rajan, Andreas Breit, Thomas Gudermann, Alexander Dietrich
Summary: TRPA1 acts as an inhibitory factor in TGF-beta 1-driven fibroblast-to-myofibroblast differentiation and development of pulmonary fibrosis. Activation of TRPA1 channels can protect against the progression of pulmonary fibrosis by inhibiting TGF-beta receptor signaling.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Editorial Material
Cell Biology
Alexander Dietrich
Summary: Transient Receptor Potential (TRP) channels are nonselective cation channels that mainly allow the passage of Ca2+ and Na+, but some of them also permit the passage of Zn2+. A recent study discovered a Zn2+-dependent pathway involving the TRP member TRPC6 and alpha 1- as well as beta-adrenoceptors (AR) in rodent myocytes. This pathway, in which alpha 1-AR activation triggers Zn2+ influx through TRPC6 channels, enhances beta-AR-mediated positive inotropy and potentially benefits heart failure patients. This research highlights the importance of investigating the consequences of Zn2+ permeation through TRP channels in human health and disease.
Article
Radiology, Nuclear Medicine & Medical Imaging
Koen J. Nelissen, Eva Versteijne, Suresh Senan, Daan Hoffmans, Ben J. Slotman, Wilko F. A. R. Verbakel
Summary: A workflow involving preplanning on diagnostic CT imaging and online plan adaption using cone-beam CT scan was developed for single-visit radiotherapy. The study showed that this workflow can meet clinical goals and outperform initial treatment plans based on daily CT scan.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Oncology
Ishita Chen, Abraham J. Wu, Andrew Jackson, Purvi Patel, Lian Sun, Angela Ng, Aditi Iyer, Aditya Apte, Andreas Rimner, Daniel Gomez, Joseph O. Deasy, Maria Thor
Summary: Pulmonary toxicity is a limiting factor in SBRT for tumors near PBT, esophagus, or other mediastinal structures. Published models of pulmonary toxicity were explored in an independent cohort of patients. Seven NTCP models were identified and the Dmax model best described pulmonary toxicity in this cohort.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Andreas Rimner, Zachary R. Moore, Stephanie Lobaugh, Alexander Geyer, Daphna Y. Gelblum, Raja-Elie E. Abdulnour, Annemarie F. Shepherd, Narek Shaverdian, Abraham J. Wu, John Cuaron, Jamie E. Chaft, Marjorie G. Zauderer, Juliana Eng, Gregory J. Riely, Charles M. Rudin, Nicholas Vander Els, Mohit Chawla, Megan McCune, Henry Li, David R. Jones, Dennis M. Sopka, Charles B. Simone, Raymond Mak, Gerald L. Weinhouse, Zhongxing Liao, Daniel R. Gomez, Zhigang Zhang, Paul K. Paik
Summary: The purpose of the study was to investigate the efficacy and safety of nintedanib added to a prednisone taper in reducing pulmonary exacerbations in patients with radiation pneumonitis. The results showed that the addition of nintedanib to the treatment had a significant effect in reducing pulmonary exacerbations in RP patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moritz Rabe, Miguel A. Palacios, John van Sornsen R. de Koste, Chukwuka Eze, Martin Hillbrand, Claus Belka, Guillaume Landry, Suresh Senan, Christopher Kurz
Summary: This study compared the accumulated doses of MRgRT, non-adaptive IMPT, and online adaptive IMPT for central lung tumors, with a focus on the bronchial tree dose. The results showed that non-adaptive and online adaptive proton therapy achieved significant dose sparing for organs in close proximity to central lung tumors compared to MRgRT. Online adaptive IMPT achieved significantly lower doses to the bronchial tree compared to MRgRT.
Article
Oncology
Koen J. Nelissen, Eva Versteijne, Suresh Senan, Barbara Rijksen, Marjan Admiraal, Jorrit Visser, Sarah Barink, Amy L. de la Fuente, Daan Hoffmans, Ben J. Slotman, Wilko F. A. R. Verbakel
Summary: We developed a rapid palliative radiotherapy workflow using diagnostic imaging for pre-planning and on-couch target and plan adaptation based on a synthetic CT obtained from CBCT. The adapted treatment plans showed significant improvements in target coverage compared to the original plans. Most patients were satisfied with the workflow. The average treatment time, including consultation and on-couch adaptive treatment, was 85 minutes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Puneeth Iyengar, Sean All, Mark F. Berry, Thomas P. Boike, Lisa Brad fi Eld, Anne -Marie C. Dingemans, Jill Feldman, Daniel R. Gomez, Paul J. Hesketh, Salma K. Jabbour, Melenda Jeter, Mirjana Josipovic, Yolande Lievens, Fiona Mcdonald, Bradford A. Perez, Umberto Ricardi, Enrico Ruffini, Dirk De Ruysscher, Hina Saeed, Bryan J. Schneider, Suresh Senan, Joachim Widder, Matthias Guckenberger
Summary: This guideline aims to review the use of local therapy in the management of extracranial oligometastatic non-small cell lung cancer (NSCLC) and provide recommendations. Currently, data is limited, but with increasing evidence supporting the use of local therapy in NSCLC, this guideline attempts to provide recommendations based on the quality of available data.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Hilal Tekatli, Miguel A. Palacios, Famke L. Schneiders, Cornelis J. A. Haasbeek, Ben J. Slotman, Frank J. Lagerwaard, Suresh Senan
Summary: This study investigated the long-term clinical outcomes of MR-guided SF-SABR on a 0.35 T linac for lung tumors. The results showed that SF-SABR, using automatic beam gating during breath-holds, achieved good tumor control and low toxicity.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Christina Beck, Deepak Ramanujam, Paula Vaccarello, Florenc Widenmeyer, Martin Feuerherd, Cho-Chin Cheng, Anton Bomhard, Tatiana Abikeeva, Julia Schaedler, Jan-Peter Sperhake, Matthias Graw, Seyer Safi, Hans Hoffmann, Claudia A. A. Staab-Weijnitz, Roland Rad, Ulrike Protzer, Thomas Frischmuth, Stefan Engelhardt
Summary: The authors report on the development of a first-in-class, inhalable, carbohydrate-coupled microRNA-inhibitor that selectively targets macrophages and prevents pulmonary hyperinflammation. This inhibitor reverses pathological activation of macrophages and prevents pulmonary dysfunction and fibrosis in mice with acute lung damage. It also effectively prevents the exaggerated inflammatory response in human lung tissue infected with SARS-CoV-2 ex vivo.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Famke L. Schneiders, Claire van Vliet, Nicolas Giraud, Anna M. E. Bruynzeel, Ben J. Slotman, Miguel A. Palacios, Suresh Senan
Summary: This study retrospectively reviewed the outcomes of MR-guided adrenal SABR and found that this approach is well tolerated and achieves high local control rates. Further research using deformable dose accumulation is needed to better understand the dose-response relationship.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Computer Science, Interdisciplinary Applications
Aditi Iyer, Aditya P. Apte, Ethan Bendau, Maria Thor, Ishita Chen, Jacob Shin, Abraham Wu, Daniel Gomez, Andreas Rimner, Ellen Yorke, Joseph O. Deasy, Andrew Jackson
Summary: This study developed an open-source software tool for radiotherapy prescriptions that can help healthcare providers determine prescriptions based on personalized dose-response curves, providing various functions including visualizing predicted tumor control and normal tissue complications, batch-mode tools, etc.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
