Anti-protease Treatments Targeting Plasmin(ogen) and Neutrophil Elastase May Be Beneficial in Fighting COVID-19

An Ounce of Prevention May Prevent Hospitalization

(2020) Andrew B. Barker et al.   PHYSIOLOGICAL REVIEWS

Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility

(2020) Hong-Long Ji et al.   PHYSIOLOGICAL REVIEWS

DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma

(2019) Dayana Barbosa da Cruz et al.   FASEB JOURNAL

Thrombin and Plasmin Alter the Proteome of Neutrophil Extracellular Traps

(2018) Chun Hwee Lim et al.   Frontiers in Immunology

A Role for Neutrophils in Viral Respiratory Disease

(2017) Jeremy V. Camp et al.   Frontiers in Immunology

Elastase-mediated Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein at Discrete Sites within the S2 Domain

(2010) Sandrine Belouzard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α1-Antitrypsin Inhibits Epithelial Na+TransportIn VitroandIn Vivo

(2009) Ahmed Lazrak et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus with Cleaved S Protein as Revealed by Pseudotype Virus Bearing Cleaved S Protein

(2008) R. Watanabe et al.   JOURNAL OF VIROLOGY