DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma

Neutrophils: back in the thrombosis spotlight

(2019) Denis F. Noubouossie et al.   BLOOD

A Novel Assay for Neutrophil Extracellular Traps (NETs) Formation Independently Predicts Disseminated Intravascular Coagulation and Mortality in Critically Ill Patients

(2019) Simon T Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Quantification of NETs formation in neutrophil and its correlation with the severity of sepsis and organ dysfunction

(2019) Sanni Kumar et al.   CLINICA CHIMICA ACTA

Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke

(2018) Celina Ducroux et al.   STROKE

Evidence of Netosis in Septic Shock-Induced Disseminated Intravascular Coagulation

(2017) Xavier Delabranche et al.   SHOCK

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

The new sepsis consensus definitions (Sepsis-3): the good, the not-so-bad, and the actually-quite-pretty

(2016) Mervyn Singer   INTENSIVE CARE MEDICINE

Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in SepsisSignificance

(2015) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium

(2015) Julia Riegger et al.   EUROPEAN HEART JOURNAL

Basic mechanisms and regulation of fibrinolysis

(2015) C. Longstaff et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

DNA, histones and neutrophil extracellular traps exert anti-fibrinolytic effects in a plasma environment

(2015) Imre Varjú et al.   THROMBOSIS AND HAEMOSTASIS

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

(2015) Elzbieta Kolaczkowska et al.   Nature Communications

von Willebrand Factor Directly Interacts With DNA From Neutrophil Extracellular Traps

(2014) S. Grassle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins

(2014) M. P. Thomas et al.   JOURNAL OF IMMUNOLOGY

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones

(2013) Colin Longstaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis

(2012) Tobias A. Fuchs et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Crystal structure of the native plasminogen reveals an activation-resistant compact conformation

(2012) Y. XUE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction

(2012) Xiaofei Li et al.   THROMBOSIS AND HAEMOSTASIS

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens