Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner

Benzoquinone derivatives with antioxidant activity inhibit activated hepatic stellate cells and attenuate liver fibrosis in TAA-induced mice

(2020) Yu Miao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Neovascularization is a key feature of liver fibrosis progression: anti-angiogenesis as an innovative way of liver fibrosis treatment

(2020) Mariia Zadorozhna et al.   MOLECULAR BIOLOGY REPORTS

A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through Upregulating SIRT3

(2020) Yi Li et al.   Oxidative Medicine and Cellular Longevity

Mangiferin Attenuates LPS/D-GalN-Induced Acute Liver Injury by Promoting HO-1 in Kupffer Cells

(2020) Sen Yang et al.   Frontiers in Immunology

Total phenolic extract of Euscaphis konishii hayata Pericarp attenuates carbon tetrachloride (CCl4)-induced liver fibrosis in mice

(2020) Wei Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3

(2019) Xi Xu et al.   FASEB JOURNAL

Lonicera japonica Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Mice: Molecular Mechanisms of Action

(2019) Hui Miao et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Paeonol alleviates CCl4-induced liver fibrosis through suppression of hepatic stellate cells activation via inhibiting the TGF-β/Smad3 signaling

(2019) Shengwang Wu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Liquid chromatography-tandem mass spectrometry to assess the pharmacokinetics and tissue distribution of withaferin A in rats

(2019) Fan Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

(2019) Yong Liu et al.   Nature Communications

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblastsin Liver Fibrosis

(2019) Oliver Krenkel et al.   Cells

Withaferin A reverses bile duct ligation‐induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NFκB signaling

(2019) Nilofer Sayed et al.   BIOFACTORS

RAP-8 ameliorates liver fibrosis by modulating cell cycle and oxidative stress

(2019) Hongjiao Xu et al.   LIFE SCIENCES

Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways

(2019) Ning Liu et al.   MEDIATORS OF INFLAMMATION

Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug

(2019) Behrouz Hassannia et al.   BIOCHEMICAL PHARMACOLOGY

Withaferin A improves non-alcoholic steatohepatitis in mice

(2019) Daxesh P Patel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Astragaloside IV regulates NF‑κB‑mediated cellular senescence and apoptosis of hepatic stellate cells to suppress PDGF‑BB‑induced activation

(2019) Zhiwei Chen et al.   Experimental and Therapeutic Medicine

Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in Mice

(2019) Yue Ma et al.   Frontiers in Physiology

Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4‐ATF3‐CHOP axis

(2019) Qin Tang et al.   CELL PROLIFERATION

Comparative study on hepatoprotection of pine nut (Pinus koraiensis Sieb. et Zucc.) polysaccharide against different types of chemical-induced liver injury models in vivo

(2019) Hang Qu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Celastrol exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling

(2019) Yuqin Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Brassica rapa Polysaccharides Ameliorate CCl 4 ‐Induced Acute Liver Injury in Mice through Inhibiting Inflammatory Apoptotic Response and Oxidative Stress

(2019) Qiuyue Li et al.   CHEMISTRY & BIODIVERSITY

The Role of Sirtuins in Antioxidant and Redox Signaling

(2018) Chandra K. Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Dihydromyricetin Ameliorates Nonalcoholic Fatty Liver Disease by Improving Mitochondrial Respiratory Capacity and Redox Homeostasis Through Modulation of SIRT3 Signaling

(2018) Xianglong Zeng et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis

(2018) Zhaoguo Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats

(2018) Jinlin Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Current understanding and future perspectives of the roles of sirtuins in the reprogramming and differentiation of pluripotent stem cells

(2018) Yi-Chao Hsu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice

(2018) Min Li et al.   FASEB JOURNAL

Ursolic acid ameliorates CCl4-induced liver fibrosis through the NOXs/ROS pathway

(2018) Dakai Gan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Liver fibrosis: Direct antifibrotic agents and targeted therapies

(2018) Detlef Schuppan et al.   MATRIX BIOLOGY

SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction

(2018) Ping He et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Assessment of the possible roles of SB-269970 versus ketanserin on carbon tetrachloride-induced liver fibrosis in rats: Oxidative stress/TGF-β 1 -induced HSCs activation pathway

(2018) Marwa Ahmed Amin Atallah et al.   Pharmacological Reports

An Adaptogen: Withaferin A Ameliorates in Vitro and in Vivo Pulmonary Fibrosis by Modulating the Interplay of Fibrotic, Matricelluar Proteins, and Cytokines

(2018) Swarna Bale et al.   Frontiers in Pharmacology

Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy

(2018) Ruibing Li et al.   Redox Biology

Withaferin-A attenuates multiple low doses of Streptozotocin (MLD-STZ) induced type 1 diabetes

(2018) Sravani Tekula et al.   BIOMEDICINE & PHARMACOTHERAPY

Anthocyanins isolated from blueberry ameliorates CCl4 induced liver fibrosis by modulation of oxidative stress, inflammation and stellate cell activation in mice

(2018) Jianchao Sun et al.   FOOD AND CHEMICAL TOXICOLOGY

Dihydromyricetin Attenuates Myocardial Hypertrophy Induced by Transverse Aortic Constriction via Oxidative Stress Inhibition and SIRT3 Pathway Enhancement

(2018) Yun Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases

(2018) Dong-Yang Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tibetan Medical Formula Shi-Wei-Gan-Ning-Pill Protects Against Carbon Tetrachloride-Induced Liver Fibrosis – An NMR-Based Metabolic Profiling

(2018) Xin Feng et al.   Frontiers in Pharmacology

Sirtuin3 deficiency exacerbates carbon tetrachloride−induced hepatic injury in mice

(2018) Xinshuai Li et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury

(2018) Maria Ruart et al.   JOURNAL OF HEPATOLOGY

Withaferin A, a novel compound of Indian ginseng (Withania somnifera ), ameliorates Cerulein-induced acute pancreatitis: Possible role of oxidative stress and inflammation

(2018) Vijaya Lakshmi Tiruveedi et al.   PHYTOTHERAPY RESEARCH

γ-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis

(2018) Anqi Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition of YAP signaling contributes to senescence of hepatic stellate cells induced by tetramethylpyrazine

(2017) Huanhuan Jin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) induces hepatic stellate cell (HSC) activation and liver fibrosis in C57BL6 mouse via activating Akt and NF-κB signaling pathways

(2017) Ming Han et al.   TOXICOLOGY LETTERS

ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis

(2016) Zili Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms

(2016) Dushani L. Palliyaguru et al.   FREE RADICAL BIOLOGY AND MEDICINE

Withaferin-A Reduces Acetaminophen-Induced Liver Injury in Mice

(2015) Ravirajsinh N. Jadeja et al.   BIOCHEMICAL PHARMACOLOGY

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Determination of withaferin A and withanolide A in mice plasma using high-performance liquid chromatography-tandem mass spectrometry: Application to pharmacokinetics after oral administration of Withania somnifera aqueous extract

(2013) Dada Patil et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS