Withaferin-A Treatment Alleviates TAR DNA-Binding Protein-43 Pathology and Improves Cognitive Function in a Mouse Model of FTLD

Withaferin A alleviates traumatic brain injury induced secondary brain injury via suppressing apoptosis in endothelia cells and modulating activation in the microglia

(2020) Zixian Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitigation of ALS pathology by neuron-specific inhibition of nuclear factor kappa B signaling

(2020) Kallol Dutta et al.   JOURNAL OF NEUROSCIENCE

Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease

(2019) Niraj Kumar Jha et al.   JOURNAL OF NEUROCHEMISTRY

Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology

(2019) Silvia Pozzi et al.   JOURNAL OF CLINICAL INVESTIGATION

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

Concomitant Inhibition of Cytoprotective Autophagy Augments the Efficacy of Withaferin A in Hepatocellular Carcinoma

(2019) Sumit Siddharth et al.   Cancers

Radicava (edaravone) for amyotrophic lateral sclerosis: US experience at 1 year after launch

(2019) Carlayne Jackson et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Withaferin A protects against spinal cord injury by inhibiting apoptosis and inflammation in mice

(2017) Xianlei Yan et al.   PHARMACEUTICAL BIOLOGY

The frontotemporal dementia-motor neuron disease continuum

(2016) James R Burrell et al.   LANCET

Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration

(2016) Kallol Dutta et al.   Neurotherapeutics

TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion

(2015) Q. Xia et al.   EMBO JOURNAL

Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling

(2015) Shawn S. Jackson et al.   EXPERIMENTAL CELL RESEARCH

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ

(2014) Karen Heyninck et al.   BIOCHEMICAL PHARMACOLOGY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Early-Stage Treatment with Withaferin A Reduces Levels of Misfolded Superoxide Dismutase 1 and Extends Lifespan in a Mouse Model of Amyotrophic Lateral Sclerosis

(2014) Priyanka Patel et al.   Neurotherapeutics

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

(2012) I.-F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments

(2011) Vivek Swarup et al.   BRAIN

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways

(2011) Vivek Swarup et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1

(2010) Owen A. Brady et al.   JOURNAL OF NEUROCHEMISTRY

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells

(2009) Yan-Li Jia et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Autophagy: Basic Principles and Relevance to Disease

(2008) Mondira Kundu et al.   Annual Review of Pathology-Mechanisms of Disease

Potentiation of Amyotrophic Lateral Sclerosis (ALS)-associated TDP-43 Aggregation by the Proteasome-targeting Factor, Ubiquilin 1

(2008) Sang Hwa Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY