Making sense of astrocytic calcium signals — from acquisition to interpretation

Improved tools to study astrocytes

(2020) Xinzhu Yu et al.   NATURE REVIEWS NEUROSCIENCE

Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

(2020) Michelle Corkrum et al.   NEURON

Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow

(2020) Nephtali Marina et al.   Nature Communications

Local Resting Ca2+ Controls the Scale of Astroglial Ca2+ Signals

(2020) Claire M. King et al.   Cell Reports

Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep

(2020) Laura Bojarskaite et al.   Nature Communications

Gi/o protein-coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

(2019) Caitlin A. Durkee et al.   GLIA

Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior

(2019) Yu Mu et al.   CELL

Distinct Mechanisms for Visual and Motor-Related Astrocyte Responses in Mouse Visual Cortex

(2019) Michal Slezak et al.   CURRENT BIOLOGY

Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology

(2019) Yizhi Wang et al.   NATURE NEUROSCIENCE

Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity

(2019) Audrey Denizot et al.   PLoS Computational Biology

Properties of human astrocytes and NG2 glia

(2019) Peter Bedner et al.   GLIA

On the special role of NCX in astrocytes: Translating Na+-transients into intracellular Ca2+ signals

(2019) Christine R. Rose et al.   CELL CALCIUM

Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons

(2018) Jillian L. Stobart et al.   NEURON

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Astrocytic Atrophy Following Status Epilepticus Parallels Reduced Ca2+ Activity and Impaired Synaptic Plasticity in the Rat Hippocampus

(2018) Alex Plata et al.   Frontiers in Molecular Neuroscience

Sodium–Calcium Exchanger Can Account for Regenerative Ca2+ Entry in Thin Astrocyte Processes

(2018) Alexey R. Brazhe et al.   Frontiers in Cellular Neuroscience

Astrocytic Coverage of Dendritic Spines, Dendritic Shafts, and Axonal Boutons in Hippocampal Neuropil

(2018) Nikolay Gavrilov et al.   Frontiers in Cellular Neuroscience

Disentangling astroglial physiology with a realistic cell model in silico

(2018) Leonid P. Savtchenko et al.   Nature Communications

Astrocytes in the mouse visual cortex reliably respond to visual stimulation

(2018) Keita Sonoda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inositol 1,4,5-trisphosphate receptor type 2-independent Ca2+ release from the endoplasmic reticulum in astrocytes

(2018) Yohei Okubo et al.   GLIA

Morphological profile determines the frequency of spontaneous calcium events in astrocytic processes

(2018) Yu-Wei Wu et al.   GLIA

Astrocytes Integrate Behavioral State and Vascular Signals during Functional Hyperemia

(2018) Cam Ha T. Tran et al.   NEURON

An Inconvenient Truth: Calcium Sensors Are Calcium Buffers

(2018) Shane M. McMahon et al.   TRENDS IN NEUROSCIENCES

Spatiotemporal pattern of calcium activity in astrocytic network

(2018) Alexey Semyanov   CELL CALCIUM

Astrocytic IP3Rs: Contribution to Ca2+signalling and hippocampal LTP

(2017) Mark William Sherwood et al.   GLIA

Fast Ca2+ responses in astrocyte end-feet and neurovascular coupling in mice

(2017) Barbara Lykke Lind et al.   GLIA

Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness

(2017) Thomas Papouin et al.   NEURON

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

Three-dimensional Ca2+imaging advances understanding of astrocyte biology

(2017) Erika Bindocci et al.   SCIENCE

Long-term In Vivo Calcium Imaging of Astrocytes Reveals Distinct Cellular Compartment Responses to Sensory Stimulation

(2016) Jillian L Stobart et al.   CEREBRAL CORTEX

Virtual reality systems for rodents

(2016) Kay Thurley et al.   Current Zoology

Subcellular calcium dynamics during juvenile development in mouse hippocampal astrocytes

(2016) Ryota Nakayama et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ca2+transients in astrocyte fine processes occur via Ca2+influx in the adult mouse hippocampus

(2016) Ravi L. Rungta et al.   GLIA

Dopamine elevates and lowers astroglial Ca2+through distinct pathways depending on local synaptic circuitry

(2016) Alistair Jennings et al.   GLIA

Mechanisms of CO 2 /H + Sensitivity of Astrocytes

(2016) Egor Turovsky et al.   JOURNAL OF NEUROSCIENCE

Accurate detection of low signal-to-noise ratio neuronal calcium transient waves using a matched filter

(2016) Agnieszka F. Szymanska et al.   JOURNAL OF NEUROSCIENCE METHODS

Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour

(2016) Zhiguo Ma et al.   NATURE

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

Astrocytic GABA transporter activity modulates excitatory neurotransmission

(2016) Kim Boddum et al.   Nature Communications

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

(2016) Hiromu Monai et al.   Nature Communications

Virtual reality systems for rodents

(2016) Kay Thurley et al.   Current Zoology

Quantitative two-photon imaging of fluorescent biosensors

(2015) Gary Yellen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Functional Oxygen Sensitivity of Astrocytes

(2015) P. R. Angelova et al.   JOURNAL OF NEUROSCIENCE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Ca2+ signaling in astrocytes from Ip3r2 −/− mice in brain slices and during startle responses in vivo

(2015) Rahul Srinivasan et al.   NATURE NEUROSCIENCE

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Volume Transmission in Central Dopamine and Noradrenaline Neurons and Its Astroglial Targets

(2015) Kjell Fuxe et al.   NEUROCHEMICAL RESEARCH

Time-Resolved Imaging Reveals Heterogeneous Landscapes of Nanomolar Ca2+ in Neurons and Astroglia

(2015) Kaiyu Zheng et al.   NEURON

Buffer mobility and the regulation of neuronal calcium domains

(2015) Elizabeth A. Matthews et al.   Frontiers in Cellular Neuroscience

Astrocyte Calcium Signaling: From Observations to Functions and the Challenges Therein

(2015) Baljit S. Khakh et al.   Cold Spring Harbor Perspectives in Biology

Spatiotemporal calcium dynamics in single astrocytes and its modulation by neuronal activity

(2014) Yu-Wei Wu et al.   CELL CALCIUM

Isoform- and Species-specific Control of Inositol 1,4,5-Trisphosphate (IP3) Receptors by Reactive Oxygen Species

(2014) Száva Bánsághi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Subtype of Astrocytes Expressing TRPV4 (Transient Receptor Potential Vanilloid 4) Regulates Neuronal Excitability via Release of Gliotransmitters

(2014) Koji Shibasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytic Gq-GPCR-Linked IP3R-Dependent Ca2+ Signaling Does Not Mediate Neurovascular Coupling in Mouse Visual Cortex In Vivo

(2014) D. E. Bonder et al.   JOURNAL OF NEUROSCIENCE

In vivo imaging of oligodendrocytes with sulforhodamine 101

(2014) Robert A Hill et al.   NATURE METHODS

Calcium dynamics in astrocyte processes during neurovascular coupling

(2014) Yo Otsu et al.   NATURE NEUROSCIENCE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse

(2014) J. Michael Gee et al.   NEURON

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Volume transmission signalling via astrocytes

(2014) H. Hirase et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Glia selectively approach synapses on thin dendritic spines

(2014) N. Medvedev et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

In Vivo Visualization of Subtle, Transient, and Local Activity of Astrocytes Using an Ultrasensitive Ca2+ Indicator

(2014) Kazunori Kanemaru et al.   Cell Reports

Flat-floored Air-lifted Platform: A New Method for Combining Behavior with Microscopy or Electrophysiology on Awake Freely Moving Rodents

(2014) Mikhail Kislin et al.   Jove-Journal of Visualized Experiments

Calcium-induced outgrowth of astrocytic peripheral processes requires actin binding by Profilin-1

(2013) Dmitry Molotkov et al.   CELL CALCIUM

Subcellular location of astrocytic calcium stores favors extrasynaptic neuron–astrocyte communication

(2013) Ilya Patrushev et al.   CELL CALCIUM

α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice

(2013) Fengfei Ding et al.   CELL CALCIUM

Astrocyte calcium microdomains are inhibited by Bafilomycin A1 and cannot be replicated by low-level Schaffer collateral stimulation in situ

(2013) Min-Yu Sun et al.   CELL CALCIUM

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices

(2013) Takahiro Takano et al.   GLIA

Theta rhythm and the encoding and retrieval of space and time

(2013) Michael E. Hasselmo et al.   NEUROIMAGE

TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses

(2013) K. M. Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses

(2013) Mika Tanaka et al.   Molecular Brain

A Deconvolution-Based Method with High Sensitivity and Temporal Resolution for Detection of Spontaneous Synaptic Currents In Vitro and In Vivo

(2012) Alejandro Javier Pernía-Andrade et al.   BIOPHYSICAL JOURNAL

Astrocyte Calcium Signal and Gliotransmission in Human Brain Tissue

(2012) M. Navarrete et al.   CEREBRAL CORTEX

Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

(2012) J. Akerboom et al.   JOURNAL OF NEUROSCIENCE

Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition

(2012) Sébastien Royer et al.   NATURE NEUROSCIENCE

Monitoring local synaptic activity with astrocytic patch pipettes

(2012) Christian Henneberger et al.   Nature Protocols

Primary Cultures of Astrocytes: Their Value in Understanding Astrocytes in Health and Disease

(2012) Sofie C. Lange et al.   NEUROCHEMICAL RESEARCH

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex

(2012) A. S. Thrane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-Scale Calcium Waves Traveling through Astrocytic Networks In Vivo

(2011) N. Kuga et al.   JOURNAL OF NEUROSCIENCE

Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo

(2011) N. Takata et al.   JOURNAL OF NEUROSCIENCE

Local Ca2+ detection and modulation of synaptic release by astrocytes

(2011) Maria Amalia Di Castro et al.   NATURE NEUROSCIENCE

Development of a Method for the Purification and Culture of Rodent Astrocytes

(2011) Lynette C. Foo et al.   NEURON

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition

(2010) Pavel I Ortinski et al.   NATURE NEUROSCIENCE

A genetically targeted optical sensor to monitor calcium signals in astrocyte processes

(2010) Eiji Shigetomi et al.   NATURE NEUROSCIENCE

Connectivity reflects coding: a model of voltage-based STDP with homeostasis

(2010) Claudia Clopath et al.   NATURE NEUROSCIENCE

Thinned-skull cranial window technique for long-term imaging of the cortex in live mice

(2010) Guang Yang et al.   Nature Protocols

Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons

(2010) J. Kang et al.   NEUROSCIENCE

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Transgenic mice expressing a cameleon fluorescent Ca2+ indicator in astrocytes and Schwann cells allow study of glial cell Ca2+ signals in situ and in vivo

(2009) Stan D. Atkin et al.   JOURNAL OF NEUROSCIENCE METHODS

Automated Analysis of Cellular Signals from Large-Scale Calcium Imaging Data

(2009) Eran A. Mukamel et al.   NEURON

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Superoxide Flashes in Single Mitochondria

(2008) Wang Wang et al.   CELL

The timing of the conscious intention to move

(2008) Masao Matsuhashi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Loss of IP3 Receptor-Dependent Ca2+ Increases in Hippocampal Astrocytes Does Not Affect Baseline CA1 Pyramidal Neuron Synaptic Activity

(2008) J. Petravicz et al.   JOURNAL OF NEUROSCIENCE

Endocannabinoids Mediate Neuron-Astrocyte Communication

(2008) Marta Navarrete et al.   NEURON

Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex

(2008) J. Schummers et al.   SCIENCE