Creating CRISPR-responsive smart materials for diagnostics and programmable cargo release

Enhanced Cas12a editing in mammalian cells and zebrafish

(2019) Pengpeng Liu et al.   NUCLEIC ACIDS RESEARCH

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

(2019) Benjamin P. Kleinstiver et al.   NATURE BIOTECHNOLOGY

Detection of unamplified target genes via CRISPR–Cas9 immobilized on a graphene field-effect transistor

(2019) Reza Hajian et al.   Nature Biomedical Engineering

SHERLOCK: nucleic acid detection with CRISPR nucleases

(2019) Max J. Kellner et al.   Nature Protocols

Programmable CRISPR-responsive smart materials

(2019) Max A. English et al.   SCIENCE

Rapid molecular diagnosis of infectious viruses in microfluidics using DNA hydrogel formation

(2018) Wonhwi Na et al.   BIOSENSORS & BIOELECTRONICS

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

(2018) Shi-Yuan Li et al.   CELL RESEARCH

Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a)

(2018) Digvijay Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Field-deployable viral diagnostics using CRISPR-Cas13

(2018) Cameron Myhrvold et al.   SCIENCE

Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens

(2018) Stephen Baker et al.   SCIENCE

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

(2018) Janice S. Chen et al.   SCIENCE

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

(2018) Jonathan S. Gootenberg et al.   SCIENCE

Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a

(2018) Isabel Strohkendl et al.   MOLECULAR CELL

Engineering the Direct Repeat Sequence of crRNA for Optimization of FnCpf1-Mediated Genome Editing in Human Cells

(2018) Li Lin et al.   MOLECULAR THERAPY

CRISPR-Cas guides the future of genetic engineering

(2018) Gavin J. Knott et al.   SCIENCE

Modular DNA strand-displacement controllers for directing material expansion

(2018) Joshua Fern et al.   Nature Communications

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

(2018) Lucas B. Harrington et al.   SCIENCE

DNA sequence–directed shape change of photopatterned hydrogels via high-degree swelling

(2017) Angelo Cangialosi et al.   SCIENCE

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

(2016) Manju Kanamala et al.   BIOMATERIALS

Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components

(2016) Keith Pardee et al.   CELL

Functional nucleic acid-based hydrogels for bioanalytical and biomedical applications

(2016) Juan Li et al.   CHEMICAL SOCIETY REVIEWS

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

Designing hydrogels for controlled drug delivery

(2016) Jianyu Li et al.   Nature Reviews Materials

Bioresponsive materials

(2016) Yue Lu et al.   Nature Reviews Materials

Target-Responsive DNA Hydrogel Mediated “Stop-Flow” Microfluidic Paper-Based Analytic Device for Rapid, Portable and Visual Detection of Multiple Targets

(2015) Xiaofeng Wei et al.   ANALYTICAL CHEMISTRY

CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems

(2015) Wenyan Jiang et al.   Annual Review of Microbiology

Biodegradable DNA-enabled poly(ethylene glycol) hydrogels prepared by copper-free click chemistry

(2015) Karolyn Barker et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Programmable polymer-DNA hydrogels with dual input and multiscale responses

(2013) Giovanna Sicilia et al.   Biomaterials Science

Maleimide Cross-Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross-Linking for Cell Encapsulation and In Situ Delivery

(2011) Edward A. Phelps et al.   ADVANCED MATERIALS

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Toehold of dsDNA exchange affects the hydrogel swelling kinetics of a polymer–dsDNA hybrid hydrogel

(2010) Ming Gao et al.   Soft Matter

Nucleic Acid Therapeutic Carriers with On-Demand Triggered Release

(2009) Siddarth Venkatesh et al.   BIOCONJUGATE CHEMISTRY

The changing economics of DNA synthesis

(2009) Robert Carlson   NATURE BIOTECHNOLOGY

Complexity in biomaterials for tissue engineering

(2009) Elsie S. Place et al.   NATURE MATERIALS

MicroRNA Expression, Survival, and Response to Interferon in Liver Cancer

(2009) Junfang Ji et al.   NEW ENGLAND JOURNAL OF MEDICINE