期刊
BIOMATERIALS SCIENCE
卷 2, 期 2, 页码 203-211出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3bm60126a
关键词
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资金
- UK EPSRC [EP/H005625/1, EP/G042462/1, EP/H028277/1, EP/E021042/1]
- University of Nottingham
- EPSRC [EP/H005625/1, EP/G042462/1, EP/H028277/1, EP/E021042/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H028277/1, 1094922, EP/H005625/1, EP/G042462/1, EP/E021042/1] Funding Source: researchfish
Combination switchable polymer-DNA hydrogels have been synthesized to respond to both a specific oligonucleotide recognition signal and a non-specific but biorelevant environmental trigger. The hydrogels exhibit rheological properties that can be modulated through interaction with complementary DNA strands and/or reduction. Furthermore, individual and combined oligonucleotide recognition and reduction responses allow control over pore sizes in the gel, enabling programmable release and transport of objects ranging from the nano-to micro-scale.
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