Article
Biochemistry & Molecular Biology
Sabrina Folie, Bernhard Radlinger, Georg Goebel, Karin Salzmann, Gabriele Staudacher, Claudia Ress, Herbert Tilg, Susanne Kaser
Summary: The study suggests that switching from a metabolically harmful Western diet to a balanced standard diet can improve adipose tissue inflammation, while long-term consumption of a Western diet negatively impacts the thermogenic capacity of brown adipose tissue and inhibits beiging of white adipose tissue.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Nutrition & Dietetics
Xiujuan Wang, Meihong Xu, Yong Li
Summary: Adipose tissue, as the largest endocrine organ, plays a crucial role in regulating energy balance and immune function. Nutritional interventions have been proven effective in managing adipose tissue aging's adverse effects.
Article
Cell Biology
Patricia Corrales, Marina Martin-Taboada, Yurena Vivas-Garcia, Lucia Torres, Laura Ramirez-Jimenez, Yamila Lopez, Daniel Horrillo, Rocio Vila-Bedmar, Eloisa Barber-Cano, Adriana Izquierdo-Lahuerta, Maria Pena-Chilet, Carmen Martinez, Joaquin Dopazo, Manuel Ros, Gema Medina-Gomez
Summary: Caloric restriction is a non-pharmacological intervention that improves metabolic defects associated with aging. MiRNA expression levels can serve as predictive tools for aging-related alterations. Specific miRNAs contribute to impaired insulin-stimulated glucose metabolism in subcutaneous white adipose tissue, and their expression is modified by caloric restriction, suggesting their potential as biomarkers for age-related metabolic alterations.
Article
Biochemistry & Molecular Biology
Mariana Fraga Gauthier, Andressa Alves de Andrade, Joana Fisch, Vanessa Feistauer, Ana Moira Moras, Luiza Steffens Reinhardt, Ana Carolina de Moura, Dinara Jaqueline Moura, Silvana de Almeida, Renata Padilha Guedes, Marcia Giovenardi
Summary: Maternal diet has an impact on the progeny's health and adult life. This study reveals that maternal diet affects oxidative stress levels and gene expression related to energy metabolism in the adipose tissue and hypothalamus of the offspring.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Masaki Kobayashi, Yusuke Deguchi, Yuka Nozaki, Yoshikazu Higami
Summary: PGC-1 alpha plays a crucial role in regulating mitochondrial function and adipocyte-specific functions in white adipose tissue, with its function being affected by metabolic changes such as obesity and caloric restriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Lei Wang, Rong Wang, Xiaoyan Yu, Yuhuan Shi, Shengnan Li, Yongfang Yuan
Summary: This review summarizes the effects of energy restriction on macrophages in various diseases, offering valuable guidance for future research and insights into the clinical applications of calorie restriction and fasting.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Pieter de Lange, Assunta Lombardi, Elena Silvestri, Federica Cioffi, Antonia Giacco, Stefania Iervolino, Giuseppe Petito, Rosalba Senese, Antonia Lanni, Maria Moreno
Summary: The adipose organ plays a crucial role in metabolic functions and its aging process leads to metabolic disorders, impacting healthy aging. Cellular senescence in adipose tissue affects adipogenesis, inflammation, and adipocytokine production, leading to systemic inflammation, insulin resistance, and declined physiological features. Aging fat depots involve various cell types, highlighting their contribution to metabolic disorders. Targeting mitochondria may hold potential in managing adipose tissue senescence and treating age-related metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Manfred J. Mueller, Steven B. Heymsfield, Anja Bosy-Westphal
Summary: Adaptive thermogenesis is the mass-independent decrease in energy expenditure during caloric restriction and weight loss, which persists during weight maintenance. It occurs in resting and nonresting energy expenditure as AT(REE) and AT(NREE), respectively. AT(REE) has different mechanisms in different phases of weight loss, while AT(NREE) exceeds AT(REE) during weight maintenance. Some mechanisms of AT are known, but others remain unknown. Future studies on AT require an appropriate conceptual framework for experiment design and result interpretation.
Article
Medicine, Research & Experimental
Hye-Jin Lee, Bo-Yeong Jin, Mi-Rae Park, Nam Hoon Kim, Kwan Sik Seo, Yong Taek Jeong, Tsutomu Wada, Jun-Seok Lee, Sang-Hyun Choi, Dong-Hoon Kim
Summary: This study investigated the role of modulation of the WAT vasculature in regulating RWG after CR and found that it can attenuate RWG by suppressing hyperphagia and increasing BAT thermogenesis and WAT browning.
Article
Biology
Karla J. Suchacki, Benjamin J. Thomas, Yoshiko M. Ikushima, Kuan-Chan Chen, Claire Fyfe, Adriana A. S. Tavares, Richard J. Sulston, Andrea Lovdel, Holly J. Woodward, Xuan Han, Domenico Mattiucci, Eleanor J. Brain, Carlos J. Alcaide-Corral, Hiroshi Kobayashi, Gillian A. Gray, Phillip D. Whitfield, Roland H. Stimson, Nicholas M. Morton, Alexandra M. Johnstone, William P. Cawthorn
Summary: Studies have shown that caloric restriction (CR) can reduce the risk of age-related diseases in various species, including humans. However, there are sex and age-dependent differences in the metabolic effects of CR. Young female mice showed less improvement in fat loss, glucose tolerance, and insulin sensitivity compared to young males, which may be due to differences in lipolysis, energy expenditure, and fatty acid oxidation. Furthermore, the sex differences in glucose homeostasis were associated with altered hepatic ceramide content and substrate metabolism. In aged mice and overweight/obese humans, the sex differences in CR's effects were reduced or absent. These findings highlight the importance of adipose tissue, the liver, and estrogen as key determinants of CR's metabolic benefits.
Article
Cell Biology
Joana Fisch, Ana Carolina de Moura, Vanessa Feistauer, Luiza Steffens Reinhardt, Patricia Molz, Ana Moira Moras, Dinara Jaqueline Moura, Priscila Oliveira de Souza, Elizandra Braganhol, Silvana Almeida, Renata Padilha Guedes, Alethea Gatto Barschak, Marcia Giovenardi
Summary: This study investigated the effects of different maternal diets during pregnancy and lactation on adipose tissue inflammation and liver tissue oxidative stress in both mothers and their female offspring. The results showed that a hypercaloric diet led to non-alcoholic steatohepatitis (NASH) and increased inflammation in mothers. A restricted diet caused increased inflammation in the offspring. In conclusion, maternal diet during pregnancy and lactation affects the liver and adipose tissues in both mothers and their offspring.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Alistaire D. D. Ruggiero, Ravichandra Vemuri, Megan Blawas, Masha Long, Darla DeStephanis, Abigail G. G. Williams, Haiying Chen, Jamie N. N. Justice, Shannon I. L. Macauley, Steven M. M. Day, Kylie Kavanagh
Summary: Cellular senescence increases with aging and leads to the secretion of pro-inflammatory factors, causing local and systemic tissue dysfunction. In a preclinical trial with middle-aged nonhuman primates, the effects of the senolytic combination dasatinib (D) and quercetin (Q), with and without caloric restriction (CR), were investigated. The study found that D + Q reduced senescence markers, improved immune cell types, reduced microbial translocation biomarkers, and showed renal and metabolic health benefits. The results suggest that intermittent D + Q exposure may combat inflammaging and improve intestinal barrier function.
Article
Nutrition & Dietetics
Jennifer M. Monk, Wenqing Wu, Dion Lepp, K. Peter Pauls, Lindsay E. Robinson, Krista A. Power
Summary: Cooked common beans can improve intestinal health and inflammation in obese mice, with greater benefits compared to weight loss through diet control alone. This suggests that incorporating beans into the diet can have a positive impact on obesity-related health issues beyond just weight loss.
Article
Multidisciplinary Sciences
Byoung Kook Lee, Jun Hyeok Lee, Jeongmin Shin, Young Hwa Jung, Chang Won Choi
Summary: The study found that low BMI at birth was associated with an increased risk of bronchopulmonary dysplasia and necrotizing enterocolitis in preterm infants, while high BMI was not associated with adverse neonatal outcomes.
SCIENTIFIC REPORTS
(2021)
Review
Nutrition & Dietetics
Julia Voglhuber, Senka Ljubojevic-Holzer, Mahmoud Abdellatif, Simon Sedej
Summary: Global life expectancy is increasing, as is the burden of cardiovascular disease. Dietary restriction can improve cardiovascular risk factors, but challenges in adherence have led to the investigation of alternative eating patterns and pharmacological alternatives.
FRONTIERS IN NUTRITION
(2021)