Article
Endocrinology & Metabolism
Yuting Wang, Song Li, Liming Zhao, Peng Cheng, Jian Liu, Fengjing Guo, Jun Xiao, Wentao Zhu, Anmin Chen
Summary: Progressive bone loss during aging leads to osteoporosis, which is a common and impactful condition in elderly populations. This study found that a metabolite called itaconate plays a crucial regulatory role during inflammaging, inhibiting osteoclast activity and maintaining bone homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Conelius Ngwa, Abdullah Al Mamun, Shaohua Qi, Romana Sharmeen, Yan Xu, Fudong Liu
Summary: This study found that aged microglia express higher levels of IRF5 and lower levels of IRF4 than young microglia after stroke. IRF5 conditional knockout improved stroke outcomes in aged mice, while worse outcomes were seen in IRF4 conditional knockout mice. The IRF5-IRF4 axis plays a role in regulating the pro- and anti-inflammatory responses of microglia in aged mice.
Review
Endocrinology & Metabolism
Fjorda Koromani, Nerea Alonso, Ines Alves, Maria Luisa Brandi, Ines Foessl, Melissa M. Formosa, Milana Frenkel Morgenstern, David Karasik, Mikhail Kolev, Outi Makitie, Evangelia Ntzani, Barbara Obermayer-Pietsch, Claes Ohlsson, Martina Rauner, Kent Soe, Ivan Soldatovic, Anna Teti, Amina Valjevac, Fernando Rivadeneira
Summary: Musculoskeletal research has been enriched in the past decade with new discoveries from GWAS and sequencing studies. However, the mechanisms by which these genes influence clinical traits are largely unknown. GEMSTONE aims to translate genomic discoveries into clinical applications to improve patient care.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Jiantuan Xiong, Fang Ma, Ning Ding, Lingbo Xu, Shengchao Ma, Anning Yang, Yinju Hao, Huiping Zhang, Yideng Jiang
Summary: This study revealed a novel mechanism by which homocysteine (Hcy) accelerates atherosclerosis by inhibiting the expression of miR-195-3p, inducing DNA hypermethylation and H3K9 deacetylation. Additionally, the interaction between Sp1 and DNMT3a promoted the binding of HDAC11 at the miR-195-3p promoter, providing a new target for the treatment of cardiovascular diseases.
Article
Medicine, General & Internal
Keiko Tanaka, Hitoshi Sugiyama, Hiroshi Morinaga, Masashi Kitagawa, Yuzuki Kano, Yasuhiro Onishi, Koki Mise, Katsuyuki Tanabe, Haruhito A. Uchida, Jun Wada
Summary: This study found that levels of soluble CD40L and IL-31 were higher in patients with IgA nephropathy, and were significantly associated with higher estimated glomerular filtration rate, lower urinary protein to creatinine ratio, and milder tubulointerstitial lesions (i.e., the early phase of IgA nephropathy). Multivariate analysis showed that serum sCD40L was an independent determinant of a lower urinary protein to creatinine ratio after adjusting for age, estimated glomerular filtration rate, and mean blood pressure. This study demonstrated the significance of serum sCD40L and IL-31 in the early phase of IgA nephropathy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ana Pinar-Gutierrez, Cristina Garcia-Fontana, Beatriz Garcia-Fontana, Manuel Munoz-Torres
Summary: Recent scientific evidence suggests that obese patients, especially those with higher visceral adipose tissue content, have an increased risk of fractures. This contradicts the belief that obesity offers protection against fractures. Obesity can accentuate age-related changes in older individuals, leading to a higher risk of falls and fractures. Factors such as chronic proinflammatory status, altered adipokine secretion, vitamin D deficiency, insulin resistance, and reduced mobility contribute to the greater risk in obese older individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Theresa Neuper, Daniel Neureiter, Muamera Sarajlic, Helen Strandt, Renate Bauer, Harald Schwarz, Patrick Suchanek, Evgeniia Korotchenko, Stacey R. Dillon, Peter Hammerl, Angelika Stoecklinger, Richard Weiss, Jutta Horejs-Hoeck
Summary: The study found that the IL-31/IL-31RA axis may regulate local, allergen-induced inflammation in the lungs.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Harry Wu, John Mach, Danijela Gnjidic, Vasi Naganathan, Fiona M. Blyth, Louise M. Waite, David J. Handelsman, David G. Le Couteur, Sarah N. Hilmer
Summary: Aging and multimorbidity are associated with inflammation, and polypharmacy is common in older adults. This study investigated the relationship between inflammation and polypharmacy in older adults with multimorbidity and in aging mice. The results showed that polypharmacy was associated with higher concentrations of certain cytokines in older adults, but no significant differences were observed in mice. This association may be related to underlying diseases.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Moeed Akbar, Lindsay A. N. Crowe, Michael McLean, Emma Garcia-Melchor, Lucy MacDonald, Kristyn Carter, Umberto G. Fazzi, David Martin, Angus Arthur, James H. Reilly, Iain B. McInnes, Neal L. Millar
Summary: Frozen shoulder is a common fibroproliferative disease with unclear pathophysiological mechanisms, but evidence suggests the involvement of dysregulated immunobiology. IL-17A plays a key role in inflammation and tissue remodeling in frozen shoulder, with potential as a therapeutic target for future management.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Laura Bonzano, Francesco Borgia, Rossella Casella, Andrea Miniello, Eustachio Nettis, Sebastiano Gangemi
Summary: Microbiome dysbiosis and cytokine alternations play crucial roles in the development of atopic dermatitis (AD) and psoriasis (PsO), two highly prevalent and burdensome pruritic skin conditions worldwide. Interleukin (IL)-33 and IL-31 are major drivers in the pathogenesis and maintenance of AD and PsO, and their potential as therapeutic targets is under extensive investigation. The relationship between dysbiosis and immunological changes has been studied extensively, with ongoing debate on the primary causative factor behind AD and PsO. This literature review aims to support the hypothesis that dysbiosis is the origin of IL-33/IL-31 dysregulation in AD and PsO, and discusses current therapeutic options targeting IL-31, IL-33, and/or the microbiome.
Review
Endocrinology & Metabolism
Kari Martyniak, Fei Wei, Amelia Ballesteros, Teerin Meckmongkol, Ashley Calder, Timothy Gilbertson, Nina Orlovskaya, Melanie J. Coathup
Summary: Age-related bone loss is inevitable and osteoporosis is projected to increase with the growing elderly population. Obesity and osteoporosis are closely related, and diet plays a significant role in bone regeneration and repair. Dietary polyunsaturated fats, particularly omega-3 fatty acids, have been associated with increased bone regeneration and improved strength, while omega-6 fatty acids may increase fracture risk. This suggests a potential role for omega-3 fatty acids in reducing bone loss in the aging population, indicating a need for amendments to nutritional recommendations.
Review
Cell Biology
Harper S. Kim, Andrew M. Pickering
Summary: Protein translation, a crucial process in cellular growth and development, declines with age in various animal species. Surprisingly, lifelong reductions in protein translation have been found to extend lifespan and healthspan in multiple animal models. This article explores the protein synthesis paradox and presents evidence supporting protein translation as a modulator of lifespan and healthspan.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Enrico Gugliandolo, Francesco Macri, Roberta Fusco, Rosalba Siracusa, Marika Cordaro, Ramona D'amico, Alessio Filippo Peritore, Daniela Impellizzeri, Tiziana Genovese, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalia Crupi
Summary: Pulmonary arterial hypertension (PAH) is a chronic, progressive disease characterized by increased blood pressure in the lungs' arteries. IL-6, a pleiotropic cytokine, plays a key role in the immune response, inflammation, and tissue remodeling. This study found that using an IL-6 receptor antagonist had a significant protective effect in a rat model of PAH, improving haemodynamic parameters, lung and cardiac function, tissue remodeling, and inflammation associated with the disease. These results suggest that inhibiting IL-6 could be a potential pharmacological strategy for treating PAH in both humans and animals.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Jeremy A. Whitson, Miguel Martin-Perez, Tong Zhang, Matthew J. Gaffrey, Gennifer E. Merrihew, Eric Huang, Collin C. White, Terrance J. Kavanagh, Wei-Jun Qian, Matthew D. Campbell, Michael J. MacCoss, David J. Marcinek, Judit Villen, Peter S. Rabinovitch
Summary: Research has shown that elamipretide can rescue age-related functional deficits in the heart by reversing increased oxidation of protein thiols and changes in the phosphoproteome associated with aging. This suggests that changes in thiol redox state and phosphorylation status are two ways in which age may affect mouse heart function, which can be restored by treatment with elamipretide.
Review
Immunology
Umberto Tarantino, Chiara Greggi, Ida Cariati, Virginia Veronica Visconti, Monica Gasparini, Marco Cateni, Elena Gasbarra, Annalisa Botta, Antonietta Salustri, Manuel Scimeca
Summary: PTX3 is a multifunctional glycoprotein involved in acute inflammatory response and plays a key role in bone matrix deposition and remodeling. Recent studies suggest its involvement in breast cancer disease and age-related bone diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Maddalena Sirufo, Francesca De Pietro, Lia Ginaldi, Massimo De Martinis
Summary: Gender differences are increasingly recognized in medicine, but specific gender-targeted studies are lacking. Considering gender pharmacology is crucial for optimizing drug therapies. Further development of gender research can identify potential risks and benefits between genders and enable personalized medicine.
Letter
Chemistry, Applied
Nicola Cicero, Sebastiano Gangemi, Alessandro Allegra
NATURAL PRODUCT RESEARCH
(2023)
Letter
Oncology
Maria Maddalena Sirufo, Lina Maria Magnanimi, Lia Ginaldi, Massimo De Martinis
CURRENT PROBLEMS IN CANCER
(2023)
Review
Chemistry, Applied
Eleonora Di Salvo, Francesca Conte, Marco Casciaro, Sebastiano Gangemi, Nicola Cicero
Summary: Mammalian milk contains various components that have chemical and functional activities, which positively impact human health. In addition to their nutritional value, the biologically active compounds in milk play important roles in physiological and biochemical functions in the human body. Donkey and camel milk contain bioactive molecules that have the potential to benefit human health.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Luca Gammeri, Claudia Panzera, Fabrizio Calapai, Nicola Cicero, Sebastiano Gangemi
Summary: Chronic urticaria is a pathological condition characterized by wheals and angioedema lasting for more than six weeks. Treatment commonly involves antihistamines, but corticosteroids and monoclonal antibodies can also be used. Herbal medicine is an alternative approach, with some herbs possessing anti-inflammatory, anti-allergic, and antioxidant properties.
NATURAL PRODUCT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Francesco Borgia, Paolo Custurone, Federica Li Pomi, Mario Vaccaro, Clara Alessandrello, Sebastiano Gangemi
Summary: IL-37 and IL-33 are newly identified cytokines that play a role in various inflammatory conditions. This review aims to collect and organize data from multiple studies to establish a comprehensive understanding of their role. The studies assessed mainly focused on atopic dermatitis and immunologic pathways. The collective data suggests a pro-inflammatory role for IL-33 and an anti-inflammatory role for IL-37, potentially linked in an IL-33/IL-37 axis. Early results indicate that both cytokines may serve as markers of disease activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alessandro Allegra, Giuseppe Murdaca, Luca Gammeri, Roberta Ettari, Sebastiano Gangemi
Summary: It is known that airway inflammation plays a crucial role in various respiratory diseases. This review focuses on the changes in respiratory diseases related to alarmins, such as HMGB1 and IL-33, and their relationships with genetic non-coding material like microRNAs. The role of these alarmins in certain pathophysiological processes confirms the existence of an axis composed of HMGB1 and IL-33, which are implicated in ferroptosis, type 2 inflammation, and airway alterations. Additionally, both factors can influence non-coding genetic material that affects respiratory function. Finally, the review outlines alarmins and RNA-based therapeutics proposed for the treatment of respiratory pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Oncology
Maria Maddalena Sirufo, Lia Ginaldi, Massimo De Martinis
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Letter
Allergy
Maria Maddalena Sirufo, Lia Ginaldi, Massimo De Martinis
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Oncology
Alessandro Allegra, Claudia Petrarca, Mario Di Gioacchino, Giuseppe Mirabile, Sebastiano Gangemi
Summary: Early diagnosis of leukemia is crucial for effective treatment. DNA biosensors, specifically electrochemical biosensors, can help identify specific genetic alterations and improve diagnostic accuracy. This review evaluates the potential use of electrochemical biosensors in diagnosing hematological neoplasms, with a focus on leukemias.
Editorial Material
Biochemistry & Molecular Biology
Giuseppe Murdaca, Sebastiano Gangemi
Article
Biochemistry & Molecular Biology
Marco Calapai, Luisa Puzzo, Giuseppe Bova, Daniele Alfio Vecchio, Rosario Blandino, Alessia Barbagallo, Ilaria Ammendolia, Luigi Cardia, Maria De Pasquale, Fabrizio Calapai, Emanuela Esposito, Fabio Trimarchi, Debora Di Mauro, Gioacchino Calapai, Carmen Mannucci
Summary: The aim of this study was to evaluate the effects of physical activity on chronic pain in post-mastectomy women. The results showed that adequate physical activity can reduce pain intensity and interference, and is associated with a reduction in blood biomarkers of inflammation.
Letter
Health Care Sciences & Services
Lia Ginaldi, Massimo De Martinis
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Letter
Endocrinology & Metabolism
Maria Maddalena Sirufo, Lina Maria Magnanimi, Lia Ginaldi, Massimo De Martinis
ACTA DIABETOLOGICA
(2022)
Article
Medicine, General & Internal
Gianluca Bagnato, Egidio Imbalzano, Caterina Oriana Aragona, Carmelo Ioppolo, Pierpaolo Di Micco, Daniela La Rosa, Francesco Costa, Antonio Micari, Simona Tomeo, Natalia Zirilli, Angela Sciacqua, Tommaso D'Angelo, Irene Cacciola, Alessandra Bitto, Natasha Irrera, Vincenzo Russo, William Neal Roberts, Sebastiano Gangemi, Antonio Giovanni Versace
Summary: New-onset atrial fibrillation is common in COVID-19 patients and is associated with increased IL-6 serum levels and early mortality.
MEDICINA-LITHUANIA
(2022)