Article
Clinical Neurology
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, JoAnn E. Manson, Kathryn M. Rexrode
Summary: In this study, supplementation with vitamin D or omega-3 fatty acids prior to stroke did not significantly improve post-stroke outcomes.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Obstetrics & Gynecology
Alayne D. Markland, Camille Vaughan, Alison Huang, Eunjung Kim, Vadim Y. Bubes, Vin Tangpricha, Julie Buring, I-Min Lee, Nancy Cook, JoAnn E. Manson, Francine Grodstein
Summary: This study found that vitamin D supplementation did not have a significant effect on the prevalence, incidence, or progression of urinary incontinence in older women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Are Annesonn Kalstad, Peder Langeland Myhre, Kristian Laake, Sjur Hansen Tveit, Erik Berg Schmidt, Paal Smith, Dennis Winston Trygve Nilsen, Arnljot Tveit, Morten Wang Fagerland, Svein Solheim, Ingebjorg Seljeflot, Harald Arnesen
Summary: The addition of 1.8g n-3 PUFA to standard care did not result in a significant reduction in cardiovascular events during a 2-year follow-up in elderly patients with recent AMI.
Article
Behavioral Sciences
Masoumeh Rajabi-Naeeni, Mahrokh Dolatian, Mostafa Qorbani, Amir Abbas Vaezi
Summary: This study aimed to evaluate the effectiveness of omega-3 and vitamin D co-supplementation on psychological distress in women of reproductive age with pre-diabetes and hypovitaminosis D. The results demonstrated a significant reduction in anxiety and improvement in sleep quality in the co-supplementation group compared with the other groups, as well as a significant decrease in depression and stress in the group receiving both supplements versus the placebo group.
BRAIN AND BEHAVIOR
(2021)
Review
Cardiac & Cardiovascular Systems
Shari S. Bassuk, JoAnn E. Manson
Summary: VITAL trial is the only large-scale randomized trial to investigate the preventive effects of marine omega-3 fatty acid supplementation on cardiovascular disease in a general population. The findings suggest that the intervention did not significantly reduce the primary endpoint of major CVD events, but did reduce the risk of total myocardial infarction, percutaneous coronary intervention, fatal myocardial infarction, and recurrent hospitalization for heart failure. Further research is needed to identify individuals who may benefit the most from this intervention.
CARDIOVASCULAR RESEARCH
(2023)
Review
Pediatrics
Gavriela Feketea, Maria Kostara, Roxana Silvia Bumbacea, Emilia Vassilopoulou, Sophia Tsabouri
Summary: The prevalence of food allergy (FA) has increased over the last decades, negatively impacting the quality of life of many children and their families. The development of FA involves both genetic and environmental factors, with genes such as SPINK5, STAT6, HLA, and FOXP3 implicated. The modification of pregnant women's dietary habits, particularly through Vitamin D and omega-3 supplementation, has been suggested to prevent FA development in offspring.
Article
Biochemistry & Molecular Biology
Liv Nesse Hande, Christian Kjellmo, Kristin Pettersen, Stefan Ljunggren, Helen Karlsson, Karin Cederbrant, Maritha Marcusson-Stahl, Anders Hovland, Knut Tore Lappegard
Summary: High-dose n-3 PUFAs supplements reduce atherogenic lipoproteins in FH subjects without affecting HDL-C function.
Article
Medicine, General & Internal
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, JoAnn E. Manson, Tobias Kurth
Summary: The study concluded that supplementation of vitamin D and marine omega-3 fatty acids did not reduce the frequency or severity of migraines in middle-aged or older adults, compared to a placebo.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Nutrition & Dietetics
Jae-Woo Lee, Yonghwan Kim, Taisun Hyun, Seunghye Song, Woojung Yang, Ye-Seul Kim, Hyo-Sun You, Young-Chang Chang, Seung-Ho Shin, Hee-Taik Kang
Summary: The study found that incorporating a low omega-6/omega-3 fatty acid ratio home meal replacement (HMR) can improve cardiometabolic parameters and reduce the prevalence of metabolic syndrome in obese individuals. This randomized crossover trial demonstrated significant reductions in BMI, weight, and MetS prevalence after a 4-week intervention with the HMR.
Article
Nutrition & Dietetics
Giulia Nuzzi, Maria Di Cicco, Irene Trambusti, Massimo Agosti, Diego G. Peroni, Pasquale Comberiati
Summary: Asthma, a common chronic disease in children, is influenced by various factors. Recent research has focused on the relationship between dietary factors during the first 1000 days of life and allergic outcomes in children. Vitamin D and omega-3 fatty acid supplementation during pregnancy and infancy may have a positive effect on preventing childhood wheeze. However, the quality of available evidence regarding nutritional interventions for preventing pediatric asthma is insufficient.
Article
Nutrition & Dietetics
Zuzana Paduchova, Barbora Katrencikova, Magdalena Vavakova, Lucia Laubertova, Zuzana Nagyova, Iveta Garaiova, Zdenka Durackova, Jana Trebaticka
Summary: In the DEPOXIN project, a high ω-6/ω-3 fatty acids ratio was associated with worsening of depressive symptoms in children and adolescents with depressive disorder. Supplementation with ω-3 fatty acids for 12 weeks significantly reduced plasma TXB levels and increased BDNF levels, indicating potential benefits in the pathophysiology of depressive disorder.
Article
Nutrition & Dietetics
Heike A. Bischoff-Ferrari, Gregor Freystatter, Bruno Vellas, Bess Dawson-Hughes, Reto W. Kressig, John A. Kanis, Walter C. Willett, JoAnn E. Manson, Rene Rizzoli, Robert Theiler, Lorenz C. Hofbauer, Gabriele Armbrecht, Jose A. P. da Silva, Michael Blauth, Caroline de Godoi Rezende Costa Molino, Wei Lang, Uwe Siebert, Andreas Egli, Endel J. Orav, Maud Wieczorek
Summary: Supplementing with omega-3 fatty acids may reduce the incidence of total falls among generally healthy and physically active older adults, while daily high doses of vitamin D or a home exercise program have no benefit.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Valentina De Cosmi, Alessandra Mazzocchi, Veronica D'Oria, Alessandro Re, Giulia Carla Immacolata Spolidoro, Gregorio P. Milani, Cristiana Berti, Silvia Scaglioni, Claudia Giavoli, Silvia Bergamaschi, Giulia Rodari, Eriselda Profka, Roberto Colombo, Carlo Agostoni
Summary: This study investigated the effect of vitamin D and DHA co-supplementation on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. The study found that more than 50% of the children improved their vitamin D status at the end of the study, but co-supplementation was not more effective than vitamin D plus wheat germ oil.
Review
Nutrition & Dietetics
Daniel Rodriguez, Carl J. Lavie, Andrew Elagizi, Richard V. Milani
Summary: This paper discusses the importance of using omega-3 fatty acids in cardiovascular diseases and summarizes related research and recommendations.
Article
Nutrition & Dietetics
Jyrki K. Virtanen, Tarja Nurmi, Antti Aro, Elizabeth R. Bertone-Johnson, Elina Hypponen, Heikki Kroger, Christel Lamberg-Allardt, JoAnn E. Manson, Jaakko Mursu, Pekka Mantyselka, Sakari Suominen, Matti Uusitupa, Ari Voutilainen, Tomi-Pekka Tuomainen, Sari Hantunen
Summary: A 5-year randomized trial found that vitamin D-3 supplementation did not reduce the incidences of major cardiovascular events or invasive cancer among older adults.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Zareen M. Farukhi, Olga Demler, Michael P. Caulfield, Krishnaji Kulkarni, Jay Wohlgemuth, Michael Cobble, Heike Luttmann-Gibson, Chunying Li, John R. Nelson, Nancy R. Cook, Julie E. Buring, Ronald M. Krauss, JoAnn E. Manson, Samia Mora
JOURNAL OF CLINICAL LIPIDOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Brendan M. Everett, M. V. Moorthy, Jani T. Tikkanen, Nancy R. Cook, Christine M. Albert
Article
Endocrinology & Metabolism
Meryl S. LeBoff, Elle M. Murata, Nancy R. Cook, Peggy Cawthon, Sharon H. Chou, Gregory Kotler, Vadim Bubes, Julie E. Buring, JoAnn E. Manson
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Rheumatology
Lindsey A. MacFarlane, Nancy R. Cook, Eunjung Kim, I-Min Lee, Maura D. Iversen, David Gordon, Julie E. Buring, Jeffrey N. Katz, JoAnn E. Manson, Karen H. Costenbader
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Kathryn Foti, Randi E. Foraker, Pamela Martyn-Nemeth, Cheryl A. M. Anderson, Nancy R. Cook, Alice H. Lichtenstein, Sarah D. de Ferranti, Deborah Rohm Young, Marie-France Hivert, Robert Ross, Prakash Deedwania, Laurie P. Whitsel, Lawrence J. Appel
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2020)
Article
Medicine, General & Internal
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, JoAnn E. Manson, Tobias Kurth
Summary: The study concluded that supplementation of vitamin D and marine omega-3 fatty acids did not reduce the frequency or severity of migraines in middle-aged or older adults, compared to a placebo.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Sharon H. Chou, Elle M. Murata, Cindy Yu, Jacqueline Danik, Gregory Kotler, Nancy R. Cook, Vadim Bubes, Samia Mora, Paulette D. Chandler, Deirdre K. Tobias, Trisha Copeland, Julie E. Buring, JoAnn E. Manson, Meryl S. LeBoff
Summary: This study aimed to investigate the effects of vitamin D-3 supplementation on weight and body composition, and the results showed that there were no significant effects on weight, BMI, or measures of adiposity and lean tissue. However, it did slightly improve body fat percentage in participants with normal BMI at baseline, indicating a potential benefit for individuals with normal weight.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Samia Mora, Patrick R. Lawler, Nancy R. Cook, Paul M. Ridker, Julie E. Buring, I-Min Lee, JoAnn E. Manson, Deirdre K. Tobias
Summary: The study found that higher plasma BCAA concentrations are associated with adverse profiles of biomarkers of inflammation and dyslipidemia, reflecting poorer cardiometabolic health.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2021)
Article
Obstetrics & Gynecology
Alayne D. Markland, Camille Vaughan, Alison Huang, Eunjung Kim, Vadim Y. Bubes, Vin Tangpricha, Julie Buring, I-Min Lee, Nancy Cook, JoAnn E. Manson, Francine Grodstein
Summary: This study found that vitamin D supplementation did not have a significant effect on the prevalence, incidence, or progression of urinary incontinence in older women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Baris Gencer, Luc Djousse, Omar T. Al-Ramady, Nancy R. Cook, JoAnn E. Manson, Christine M. Albert
Summary: In randomized controlled trials examining cardiovascular outcomes, supplementation of marine -3 fatty acids was associated with an increased risk of atrial fibrillation (AF). The risk appeared to be greater in trials testing >1 g/d.
Article
Cardiac & Cardiovascular Systems
Rosangela A. Hoshi, Yanyan Liu, Heike Luttmann-Gibson, Saumya Tiwari, Franco Giulianini, Allen M. Andres, Jeramie D. Watrous, Nancy R. Cook, Karen H. Costenbader, Olivia Okereke, Paul M. Ridker, JoAnn E. Manson, I-Min Lee, Manickavasagar Vinayagamoorthy, Susan Cheng, Trisha Copeland, Mohit Jain, Daniel Chasman, Olga Demler, Samia Mora
Summary: This study identified a profile of bioactive lipids associated with physical activity, and 12 of these lipids were found to have opposite associations with incident cardiovascular disease events.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Alvin Chandra, Michael H. Picard, Shi Huang, Deepak K. Gupta, Kartik Agusala, Julie E. Buring, I-Min Lee, Nancy R. Cook, JoAnn E. Manson, Ravi Thadhani, Thomas J. Wang
Summary: In a study lasting 2 years, supplementation with vitamin D3 and n-3 fatty acids did not have significant effects on cardiac structure and function in middle-aged/older individuals.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Yanbin Dong, Haidong Zhu, Li Chen, Ying Huang, William Christen, Nancy R. Cook, Trisha Copeland, Samia Mora, Julie E. Buring, I-Min Lee, Karen H. Costenbader, JoAnn E. Manson
Summary: In the VITAL study, vitamin D-3 supplementation reduced hs-CRP levels at year 2, but had no significant effects on other inflammatory biomarkers. Marine n-3 FAs supplementation did not significantly affect these biomarkers at either time point.
Article
Urology & Nephrology
Christine P. Limonte, Leila R. Zelnick, Andrew N. Hoofnagle, Ravi Thadhani, Michal L. Melamed, Samia Mora, Nancy R. Cook, Heike Luttmann-Gibson, Howard D. Sesso, I-Min Lee, Julie E. Buring, JoAnn E. Manson, Ian H. de Boer
Summary: Based on the results of the Vitamin D and Omega-3 Trial (VITAL), there is no difference in the effects of vitamin D3 supplementation on cardiovascular and cancer outcomes based on baseline estimated glomerular filtration rate (eGFR). The effects on serum 25(OH)D and parathyroid hormone (PTH) concentrations also did not differ at different eGFR levels.
Article
Cardiac & Cardiovascular Systems
Neal A. Chatterjee, Jani T. Tikkanen, Gopi K. Panicker, Dhiraj Narula, Daniel C. Lee, Tuomas Kentta, Juhani M. Junttila, Nancy R. Cook, Alan Kadish, Jeffrey J. Goldberger, Heikki Huikuri, Christine M. Albert
EUROPEAN HEART JOURNAL
(2020)
Article
Medicine, Research & Experimental
Hongjin Li, Judith M. Schlaeger, Crystal L. Patil, Oana Danciu, Zhengjia Chen, Natalie Lif, Shuang Gao, Ardith Z. Doorenbos
Summary: Nearly 94% of breast cancer survivors experience symptoms or side effects during or after endocrine therapy, and acupuncture offers a comprehensive solution to address these issues. However, medically underserved breast cancer survivors often lack access to acupuncture. To promote equal access and evidence-based treatment, a randomized controlled trial is being conducted to investigate the effectiveness of acupuncture for symptom management among this population.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
JoAnn M. Sperl-Hillen, Jacob L. Haapala, Steven P. Dehmer, Lilian N. Chumba, Heidi L. Ekstrom, Anjali R. Truitt, Stephen E. Asche, Ann M. Werner, Dan J. Rehrauer, Melissa A. Pankonin, Pamala A. Pawloski, Patrick J. O'Connor
Summary: This article describes the original and adapted protocols of a randomized trial to improve medication adherence for cardiometabolic conditions. Protocol adaptation became imperative in response to major implementation challenges.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
Connor Celum, Bethany Jablonski Horton, Mark Conaway
Summary: This paper proposes a phase-I clinical trial design that uses ordinal toxicity to locate group-specific doses. The proposed method avoids dose-reversals and is compared with two other methods through simulations.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
Tanya Knutzen, Eileen Bulger, Matt Iles-Shih, Alexandra Hernandez, Allison Engstrom, Lauren Whiteside, Navneet Birk, Khadija Abu, Jake Shoyer, Cristina Conde, Paige Ryan, Jin Wang, Joan Russo, Patrick Heagerty, Larry Palinkas, Douglas Zatzick
Summary: This study aims to investigate how trauma centers in the US can effectively conduct mental health screening, intervention, and referral services to help injured patients recover. The study will randomly assign patients to different intervention groups and compare the impact of different interventions on PTSD symptoms and emergency department/inpatient utilization.
CONTEMPORARY CLINICAL TRIALS
(2024)