Article
Clinical Neurology
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, JoAnn E. Manson, Kathryn M. Rexrode
Summary: In this study, supplementation with vitamin D or omega-3 fatty acids prior to stroke did not significantly improve post-stroke outcomes.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Obstetrics & Gynecology
Alayne D. Markland, Camille Vaughan, Alison Huang, Eunjung Kim, Vadim Y. Bubes, Vin Tangpricha, Julie Buring, I-Min Lee, Nancy Cook, JoAnn E. Manson, Francine Grodstein
Summary: This study found that vitamin D supplementation did not have a significant effect on the prevalence, incidence, or progression of urinary incontinence in older women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Pamela M. Rist, Julie E. Buring, Nancy R. Cook, JoAnn E. Manson, Tobias Kurth
Summary: The study concluded that supplementation of vitamin D and marine omega-3 fatty acids did not reduce the frequency or severity of migraines in middle-aged or older adults, compared to a placebo.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Behavioral Sciences
Masoumeh Rajabi-Naeeni, Mahrokh Dolatian, Mostafa Qorbani, Amir Abbas Vaezi
Summary: This study aimed to evaluate the effectiveness of omega-3 and vitamin D co-supplementation on psychological distress in women of reproductive age with pre-diabetes and hypovitaminosis D. The results demonstrated a significant reduction in anxiety and improvement in sleep quality in the co-supplementation group compared with the other groups, as well as a significant decrease in depression and stress in the group receiving both supplements versus the placebo group.
BRAIN AND BEHAVIOR
(2021)
Article
Medicine, Research & Experimental
Saeid Doaei, Somayeh Gholami, Samira Rastgoo, Maryam Gholamalizadeh, Fatemeh Bourbour, Seyedeh Elaheh Bagheri, Forough Samipoor, Mohammad Esmail Akbari, Mahdi Shadnoush, Fereshteh Ghorat, Seyed Alireza Mosavi Jarrahi, Narjes Ashouri Mirsadeghi, Azadeh Hajipour, Parvin Joola, Alireza Moslem, Mark O. Goodarzi
Summary: This study investigated the effects of n3-PUFA supplementation on critically ill patients with COVID-19. The results suggest that Omega-3 supplementation can improve certain biochemical and inflammatory markers, as well as increase survival rates in critically ill patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Valentina De Cosmi, Alessandra Mazzocchi, Veronica D'Oria, Alessandro Re, Giulia Carla Immacolata Spolidoro, Gregorio P. Milani, Cristiana Berti, Silvia Scaglioni, Claudia Giavoli, Silvia Bergamaschi, Giulia Rodari, Eriselda Profka, Roberto Colombo, Carlo Agostoni
Summary: This study investigated the effect of vitamin D and DHA co-supplementation on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. The study found that more than 50% of the children improved their vitamin D status at the end of the study, but co-supplementation was not more effective than vitamin D plus wheat germ oil.
Review
Psychiatry
Katherine H. O. Deane, Oluseyi F. Jimoh, Priti Biswas, Alex O'Brien, Sarah Hanson, Asmaa S. Abdelhamid, Chris Fox, Lee Hooper
Summary: The study found that increasing long-chain Omega-3 has little or no effect on preventing depression and anxiety symptoms, while increasing alpha-linolenic acid may slightly increase the risk of depression symptoms, but with low-quality evidence.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
Zuzana Paduchova, Barbora Katrencikova, Magdalena Vavakova, Lucia Laubertova, Zuzana Nagyova, Iveta Garaiova, Zdenka Durackova, Jana Trebaticka
Summary: In the DEPOXIN project, a high ω-6/ω-3 fatty acids ratio was associated with worsening of depressive symptoms in children and adolescents with depressive disorder. Supplementation with ω-3 fatty acids for 12 weeks significantly reduced plasma TXB levels and increased BDNF levels, indicating potential benefits in the pathophysiology of depressive disorder.
Review
Food Science & Technology
Valentina Stacchiotti, Serge Rezzi, Manfred Eggersdorfer, Francesco Galli
Summary: The gut microbiota acts as an important metabolic interface in the human body, interacting with dietary nutrients and affecting human health. Understanding the complex interactions between fat-soluble vitamins and the gut microbiota is crucial for developing new strategies for disease prevention and therapy, and personalized nutrition.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Nutrition & Dietetics
Mingjin Cheng, Shengqiang Zhang, Chengdong Ning, Qianlun Huo
Summary: This study confirmed the efficacy of omega-3 fatty acid supplementation in improving the nutritional status and suppressing systemic inflammatory response in patients with lung cancer. Compared to the placebo group, the omega-3 group showed significant improvements in weight, albumin, and triglyceride levels, as well as reductions in inflammatory markers.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Article
Cardiac & Cardiovascular Systems
Are Annesonn Kalstad, Peder Langeland Myhre, Kristian Laake, Sjur Hansen Tveit, Erik Berg Schmidt, Paal Smith, Dennis Winston Trygve Nilsen, Arnljot Tveit, Morten Wang Fagerland, Svein Solheim, Ingebjorg Seljeflot, Harald Arnesen
Summary: The addition of 1.8g n-3 PUFA to standard care did not result in a significant reduction in cardiovascular events during a 2-year follow-up in elderly patients with recent AMI.
Article
Agriculture, Multidisciplinary
Xue Chen, Kehong Liang, Hong Zhu
Summary: This study compared the nutritional composition of omega-3 enriched eggs with regular eggs, finding higher levels of omega-3 polyunsaturated fatty acids and alpha-tocopherol in the former. Boiling omega-3 enriched eggs for 20 minutes at 75 degrees Celsius resulted in higher levels of omega-3 PUFAs, total tocopherol, and essential amino acids compared to other conditions.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Pediatrics
Gavriela Feketea, Maria Kostara, Roxana Silvia Bumbacea, Emilia Vassilopoulou, Sophia Tsabouri
Summary: The prevalence of food allergy (FA) has increased over the last decades, negatively impacting the quality of life of many children and their families. The development of FA involves both genetic and environmental factors, with genes such as SPINK5, STAT6, HLA, and FOXP3 implicated. The modification of pregnant women's dietary habits, particularly through Vitamin D and omega-3 supplementation, has been suggested to prevent FA development in offspring.
Article
Nutrition & Dietetics
Angus G. Scrimgeour, Michelle L. Condlin, Andrei Loban, James C. DeMar
Summary: This study found that an anti-inflammatory diet can affect plasma biomarker levels following mild TBI, and voluntary exercise can counteract cognitive deficits associated with TBI. The combination of an Omega-3 fatty acid and vitamin D diet not only increased docosahexaenoic acid levels in plasma and brain tissue, but also increased serum levels of vitamin D.
FRONTIERS IN NUTRITION
(2021)
Article
Medicine, Research & Experimental
Hongjin Li, Judith M. Schlaeger, Crystal L. Patil, Oana Danciu, Zhengjia Chen, Natalie Lif, Shuang Gao, Ardith Z. Doorenbos
Summary: Nearly 94% of breast cancer survivors experience symptoms or side effects during or after endocrine therapy, and acupuncture offers a comprehensive solution to address these issues. However, medically underserved breast cancer survivors often lack access to acupuncture. To promote equal access and evidence-based treatment, a randomized controlled trial is being conducted to investigate the effectiveness of acupuncture for symptom management among this population.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
JoAnn M. Sperl-Hillen, Jacob L. Haapala, Steven P. Dehmer, Lilian N. Chumba, Heidi L. Ekstrom, Anjali R. Truitt, Stephen E. Asche, Ann M. Werner, Dan J. Rehrauer, Melissa A. Pankonin, Pamala A. Pawloski, Patrick J. O'Connor
Summary: This article describes the original and adapted protocols of a randomized trial to improve medication adherence for cardiometabolic conditions. Protocol adaptation became imperative in response to major implementation challenges.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
Connor Celum, Bethany Jablonski Horton, Mark Conaway
Summary: This paper proposes a phase-I clinical trial design that uses ordinal toxicity to locate group-specific doses. The proposed method avoids dose-reversals and is compared with two other methods through simulations.
CONTEMPORARY CLINICAL TRIALS
(2024)
Article
Medicine, Research & Experimental
Tanya Knutzen, Eileen Bulger, Matt Iles-Shih, Alexandra Hernandez, Allison Engstrom, Lauren Whiteside, Navneet Birk, Khadija Abu, Jake Shoyer, Cristina Conde, Paige Ryan, Jin Wang, Joan Russo, Patrick Heagerty, Larry Palinkas, Douglas Zatzick
Summary: This study aims to investigate how trauma centers in the US can effectively conduct mental health screening, intervention, and referral services to help injured patients recover. The study will randomly assign patients to different intervention groups and compare the impact of different interventions on PTSD symptoms and emergency department/inpatient utilization.
CONTEMPORARY CLINICAL TRIALS
(2024)