New insights into the role of co-receptor neuropilins in tumour angiogenesis and lymphangiogenesis and targeted therapy strategies

Design, synthesis, and evaluation of a novel benzamidine-based inhibitor of VEGF-C binding to Neuropilin-2

(2020) Ahmed M. Said et al.   BIOORGANIC CHEMISTRY

Construction of novel procoagulant protein targeting neuropilin-1 on tumour vasculature for tumour embolization therapy

(2019) Mingyuan Zou et al.   JOURNAL OF DRUG TARGETING

Podoplanin in Inflammation and Cancer

(2019) Miguel Quintanilla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Roles of Neuropilin 2/VEGF-C Axis in a Series of Recurrent Lymphangioma

(2019) Xueqiang Yan et al.   EUROPEAN JOURNAL OF PEDIATRIC SURGERY

Discovery of novel nonpeptide small-molecule NRP1 antagonists: Virtual screening, molecular simulation and structural modification

(2019) Kewen Peng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interactions between NRP1 and VEGFR2 molecules in the plasma membrane

(2018) Christopher King et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Neuropilin 1 (NRP1) is a novel tumor marker in hepatocellular carcinoma

(2018) Jiafei Lin et al.   CLINICA CHIMICA ACTA

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2

(2018) Chloe Peach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nanodisk-based glioma-targeted drug delivery enabled by a stable glycopeptide

(2018) Huan Wang et al.   JOURNAL OF CONTROLLED RELEASE

Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells

(2018) Jonathan Powell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Prognostic Biomarkers by Combined mRNA and miRNA Expression Microarray Analysis in Pancreatic Cancer

(2018) Bin Liu et al.   Translational Oncology

Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A

(2018) Daniëlle de Ridder et al.   Scientific Reports

Neuropilin-1 expression is associated with lymph node metastasis in breast cancer tissues

(2018) Mahnaz Seifi-Alan et al.   Cancer Management and Research

CCBE1 is required for coronary vessel development and proper coronary artery stem formation in the mouse heart

(2018) Fernando Bonet et al.   DEVELOPMENTAL DYNAMICS

Tumor and endothelial cells collaborate via transcellular receptor complexes

(2018) Sarvenaz Sarabipour et al.   JOURNAL OF PATHOLOGY

Cytoplasmic neuropilin 2 is associated with metastasis and a poor prognosis in early tongue cancer patients

(2017) H.S. Ong et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation

(2017) Alessandro Fantin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R

(2017) Anna Niescioruk et al.   JOURNAL OF NANOPARTICLE RESEARCH

Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality

(2017) B W C Tse et al.   ONCOGENE

Neuropilin-1 modulates TGFβ signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy

(2017) Sam C. Kwiatkowski et al.   PLoS One

Stabilized Heptapeptide A7R for Enhanced Multifunctional Liposome-Based Tumor-Targeted Drug Delivery

(2016) Man Ying et al.   ACS Applied Materials & Interfaces

Bevacizumab changes vascular structure and modulates the expression of angiogenic factors in recurrent malignant gliomas

(2016) Saori Okamoto et al.   Brain Tumor Pathology

Pathway-related molecules of VEGFC/D-VEGFR3/NRP2 axis in tumor lymphangiogenesis and lymphatic metastasis

(2016) Jingwen Wang et al.   CLINICA CHIMICA ACTA

The implication of microRNAs and endo-siRNAs in animal germline and early development

(2016) Alexandra Dallaire et al.   DEVELOPMENTAL BIOLOGY

131I-labeled monoclonal antibody targeting neuropilin receptor type-2 for tumor SPECT imaging

(2016) Lichun Chen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

(2016) Hung M. Bui et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuropilin-2 promotes melanoma growth and progression in vivo

(2016) Whei F. Moriarty et al.   MELANOMA RESEARCH

Crystal Structure of the Neuropilin-1 MAM Domain: Completing the Neuropilin-1 Ectodomain Picture

(2016) Tamas Yelland et al.   STRUCTURE

Concurrent Expression of VEGF-C and Neuropilin-2 Is Correlated with Poor Prognosis in Glioblastoma

(2016) Haiqing Zhao et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-9 suppresses the growth, migration, and invasion of malignant melanoma cells via targeting NRP1

(2016) Dan Xu et al.   OncoTargets and Therapy

Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFC/VEGFR3 independent signaling

(2015) Juan-Juan Ou et al.   CANCER LETTERS

Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

(2015) Matthew W. Parker et al.   STRUCTURE

A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors

(2014) Amita Patnaik et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis

(2014) A. Fantin et al.   DEVELOPMENT

Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting

(2014) J. W. Astin et al.   DEVELOPMENT

Neuropilin-2 and its ligand VEGF-C predict treatment response after transurethral resection and radiochemotherapy in bladder cancer patients

(2014) B. Keck et al.   INTERNATIONAL JOURNAL OF CANCER

A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors

(2014) Colin D. Weekes et al.   INVESTIGATIONAL NEW DRUGS

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells

(2014) Claudio Raimondi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-320 regulates tumor angiogenesis driven by vascular endothelial cells in oral cancer by silencing neuropilin 1

(2013) Yi-Ying Wu et al.   ANGIOGENESIS

Mechanism of Dimerization of a Recombinant Mature Vascular Endothelial Growth Factor C

(2013) Joyce Chiu et al.   BIOCHEMISTRY

Polycyclic Peptide Therapeutics

(2013) Vanessa Baeriswyl et al.   ChemMedChem

The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

(2013) Anthony Lanahan et al.   DEVELOPMENTAL CELL

The Propeptides of VEGF-D Determine Heparin Binding, Receptor Heterodimerization, and Effects on Tumor Biology

(2013) Nicole C. Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-331-3p regulates expression of neuropilin-2 in glioblastoma

(2013) Michael R. Epis et al.   JOURNAL OF NEURO-ONCOLOGY

Sequence dependence of C-end rule peptides in binding and activation of neuropilin-1 receptor

(2013) David Zanuy et al.   JOURNAL OF STRUCTURAL BIOLOGY

Neuropilin signalling in vessels, neurons and tumours

(2013) Claudio Raimondi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations

(2012) Taina A. Partanen et al.   ANGIOGENESIS

MiR-15b and miR-152 reduce glioma cell invasion and angiogenesis via NRP-2 and MMP-3

(2012) Xuguang Zheng et al.   CANCER LETTERS

Neuropilin-2 expression in cancer

(2012) Adrian M Jubb et al.   HISTOPATHOLOGY

Neuropilins: expression and roles in the epithelium

(2012) Jonathan R. L. Wild et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Contactin-1 (CNTN-1) Overexpression is Correlated with Advanced Clinical Stage and Lymph Node Metastasis in Oesophageal Squamous Cell Carcinomas

(2012) Pengfei Liu et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer

(2012) Hira Lal Goel et al.   Cancer Discovery

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

VEGF-C promotes the development of esophageal cancer via regulating CNTN-1 expression

(2011) Pengfei Liu et al.   CYTOKINE

The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins

(2011) A. Fantin et al.   DEVELOPMENT

Monoclonal Antibody Against NRP-1 b1b2

(2011) Xiang Li et al.   HYBRIDOMA

Neuropilin-1 expression in cancer and development

(2011) Adrian M Jubb et al.   JOURNAL OF PATHOLOGY

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation

(2011) Birger Herzog et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of Akt and ERK1/2 Is Required for VEGF-A/VEGFR2-Induced Proliferation and Migration of Lymphatic Endothelium

(2011) Michael T. Dellinger et al.   PLoS One

Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity

(2010) H Jia et al.   BRITISH JOURNAL OF CANCER

Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta

(2010) Yelena Glinka et al.   CARCINOGENESIS

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

(2010) Ashley Jarvis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE

Cytoplasmic CXCR4 expression in breast cancer: induction by nitric oxide and correlation with lymph node metastasis and poor prognosis

(2009) Hironao Yasuoka et al.   BMC CANCER

Neuropilin-2 expression in breast cancer: correlation with lymph node metastasis, poor prognosis, and regulation of CXCR4 expression

(2009) Hironao Yasuoka et al.   BMC CANCER

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Vascular Endothelial Growth Factor (VEGF) Receptor-2 Tyrosine 1175 Signaling Controls VEGF-induced von Willebrand Factor Release from Endothelial Cells via Phospholipase C-γ1- and Protein Kinase A-dependent Pathways

(2009) Yan Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

αvβ3 Integrin Limits the Contribution of Neuropilin-1 to Vascular Endothelial Growth Factor-induced Angiogenesis

(2009) Stephen D. Robinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigating the differential activation of vascular endothelial growth factor (VEGF) receptors

(2009) Bruno Araújo Cautiero Horta et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

(2009) Donatella Valdembri et al.   PLOS BIOLOGY

Neuropilins: structure, function and role in disease

(2008) Caroline Pellet-Many et al.   BIOCHEMICAL JOURNAL

Distinct heparin binding sites on VEGF165 and its receptors revealed by their interaction with a non sulfated glycoaminoglycan (NaPaC)

(2008) Mélanie Di Benedetto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

(2008) H. Kawamura et al.   BLOOD

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

(2008) Maresa Caunt et al.   CANCER CELL

Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos

(2008) E. A. V. Jones et al.   DEVELOPMENT

Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity

(2008) Yelena Glinka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos

(2008) P. Haiko et al.   MOLECULAR AND CELLULAR BIOLOGY