Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors

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ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade

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STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer

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PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness

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State-of-the-art strategies for targeting the DNA damage response in cancer

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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

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A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1

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Integrated genomic characterization of oesophageal carcinoma

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Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

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cGAS surveillance of micronuclei links genome instability to innate immunity

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Mitotic progression following DNA damage enables pattern recognition within micronuclei

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A STING-activating nanovaccine for cancer immunotherapy

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cGAS is essential for the antitumor effect of immune checkpoint blockade

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Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

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DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

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Intratumoral STING Activation with T-cell Checkpoint Modulation Generates Systemic Antitumor Immunity

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ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

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The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer

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Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

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Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type

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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

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ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

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Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells

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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

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Loss of ARID1A expression in colorectal carcinoma is strongly associated with mismatch repair deficiency

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STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

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Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy

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ARID1A loss correlates with mismatch repair deficiency and intact p53 expression in high-grade endometrial carcinomas

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Comprehensive molecular characterization of clear cell renal cell carcinoma

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cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

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Loss of ARID1A expression is uncommon in gastric, colorectal, and prostate cancers

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ARID1A Mutations in Cancer: Another Epigenetic Tumor Suppressor?

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Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

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Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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BRIT1/MCPH1 links chromatin remodelling to DNA damage response

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