标题
The Role of Smoothened in Cancer
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 18, Pages 6863
出版商
MDPI AG
发表日期
2020-09-18
DOI
10.3390/ijms21186863
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Colorectal cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Cancer statistics, 2020
- (2020) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Analysis of vismodegib resistance in D473G and W535L mutants of SMO receptor and design of novel drug derivatives using molecular dynamics simulations
- (2020) Siyan Liao et al. LIFE SCIENCES
- Safety and Tolerability of Sonic Hedgehog Pathway Inhibitors in Cancer
- (2019) Richard L. Carpenter et al. DRUG SAFETY
- Role of Protein Kinases in Hedgehog Pathway Control and Implications for Cancer Therapy
- (2019) Valentina Montagnani et al. Cancers
- Nuclear localization and Overexpression of Smoothened in Pancreatic and Colorectal Cancers
- (2019) Madiha Niyaz et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway
- (2019) Hyuk Moon et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures
- (2019) Christian Espinosa-Bustos et al. Future Medicinal Chemistry
- Genomic testing, tumor microenvironment and targeted therapy of Hedgehog-related human cancers
- (2019) Masaru Katoh CLINICAL SCIENCE
- Biochemical mechanisms of vertebrate hedgehog signaling
- (2019) Jennifer H. Kong et al. DEVELOPMENT
- Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies
- (2019) Ilya Galperin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy
- (2019) Elisabeth Peer et al. Cancers
- Targeting Hedgehog (Hh) Pathway for the Acute Myeloid Leukemia Treatment
- (2019) Toshiki Terao et al. Cells
- Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
- (2019) Natalia A. Riobo-Del Galdo et al. Cells
- Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer
- (2019) Hao Xie et al. Cells
- Hedgehog signaling inhibitors in solid and hematological cancers
- (2019) Jorge E. Cortes et al. CANCER TREATMENT REVIEWS
- Role of Hedgehog Signaling in Vasculature Development, Differentiation, and Maintenance
- (2019) Candice Chapouly et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting cancer stem cells in drug discovery: Current state and future perspectives
- (2019) Fang-Yu Du et al. World Journal of Stem Cells
- Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)
- (2019) Kuo‑Shyang Jeng et al. Oncology Letters
- The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective
- (2019) Yan Xu et al. Cell Communication and Signaling
- Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells
- (2019) Nihal AlMuraikhi et al. Stem Cells International
- Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update
- (2019) Joseph A. Clara et al. Nature Reviews Clinical Oncology
- Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers
- (2018) Qing-rou Li et al. ACTA PHARMACOLOGICA SINICA
- Involvement of hedgehog pathway in early onset, aggressive molecular subtypes and metastatic potential of breast cancer
- (2018) Syeda Kiran Riaz et al. Cell Communication and Signaling
- Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays
- (2018) Wenfeng Lu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A phase Ib study of sonidegib (LDE225), an oral small molecule inhibitor of smoothened or Hedgehog pathway, in combination with docetaxel in triple negative advanced breast cancer patients: GEICAM/2012–12 (EDALINE) study
- (2018) Manuel Ruiz-Borrego et al. INVESTIGATIONAL NEW DRUGS
- Hedgehog signalling in liver pathophysiology
- (2018) Mariana Verdelho Machado et al. JOURNAL OF HEPATOLOGY
- Strategies to target the Hedgehog signaling pathway for cancer therapy
- (2018) Minhang Xin et al. MEDICINAL RESEARCH REVIEWS
- Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway (Review)
- (2018) Dengliang Huang et al. Oncology Letters
- SMO Inhibition Modulates Cellular Plasticity and Invasiveness in Colorectal Cancer
- (2018) Paolo Magistri et al. Frontiers in Pharmacology
- Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration
- (2018) Giuditta Guerrini et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Signaling pathway inhibitors target breast cancer stem cells in triple-negative breast cancer
- (2018) Wenlong Li et al. ONCOLOGY REPORTS
- Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells
- (2018) Ita Novita Sari et al. Cells
- Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines
- (2017) Chuanqing Wu et al. Experimental and Therapeutic Medicine
- Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells
- (2017) Joseph L. Regan et al. Cell Reports
- Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer
- (2017) Vinod Kumar et al. Scientific Reports
- GDC-0449 improves the antitumor activity of nano-doxorubicin in pancreatic cancer in a fibroblast-enriched microenvironment
- (2017) Quan Zhou et al. Scientific Reports
- Chemotherapy curable malignancies and cancer stem cells: a biological review and hypothesis
- (2016) Philip Savage BMC CANCER
- Cancer statistics in China, 2015
- (2016) Wanqing Chen et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar–ductal metaplasia
- (2016) Xin Liu et al. GENES & DEVELOPMENT
- Epidemiology of Hepatocellular Carcinoma in the Asia-Pacific Region
- (2016) Ran Xu Zhu et al. Gut and Liver
- Smoothened Regulation: A Tale of Two Signals
- (2016) Angela M. Arensdorf et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Sonic hedgehog signaling pathway mediates development of hepatocellular carcinoma
- (2016) Heng Cai et al. TUMOR BIOLOGY
- Significance of the hedgehog pathway-associated proteins Gli-1 and Gli-2 and the epithelial-mesenchymal transition-associated proteins Twist and E-cadherin in hepatocellular carcinoma
- (2016) Hyung Wook Chun et al. Oncology Letters
- Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
- (2016) Marco Gerling et al. Nature Communications
- In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors
- (2016) Monica Benvenuto et al. Oncotarget
- Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells
- (2016) Mingjuan Sun et al. Cell and Bioscience
- Hedgehog Signaling Regulates Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem-Like Cells
- (2016) Feng Wang et al. Journal of Cancer
- Hedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma
- (2016) Yuqiong Wang et al. Journal of Cancer
- Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
- (2016) Tadas Rimkus et al. Cancers
- Sonic hedgehog pathway inhibitor mitigates mouse hepatocellular carcinoma
- (2015) Kuo-Shyang Jeng et al. AMERICAN JOURNAL OF SURGERY
- Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma
- (2015) Hayley J. Sharpe et al. CANCER CELL
- Sonic hedgehog-glioma associated oncogene homolog 1 signaling enhances drug resistance in CD44+/Musashi-1+ gastric cancer stem cells
- (2015) Min Xu et al. CANCER LETTERS
- Heterogeneity of hepatocellular carcinoma contributes to cancer progression
- (2015) Kuo-Shyang Jeng et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Alcoholic liver disease: mechanisms of injury and targeted treatment
- (2015) Alexandre Louvet et al. Nature Reviews Gastroenterology & Hepatology
- Association between donor and recipient smoothened gene polymorphisms and the risk of hepatocellular carcinoma recurrence following orthotopic liver transplantation in a Han Chinese population
- (2015) Pusen Wang et al. TUMOR BIOLOGY
- Triple-negative breast cancer: new perspectives for targeted therapies
- (2015) Silverio Tomao et al. OncoTargets and Therapy
- Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells
- (2015) Maria Peiris-Pagès et al. Oncotarget
- Hedgehog Signaling in the Maintenance of Cancer Stem Cells
- (2015) Catherine Cochrane et al. Cancers
- The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis
- (2015) Arwa Flemban et al. Cancers
- SMO Expression in Colorectal Cancer: Associations with Clinical, Pathological, and Molecular Features
- (2014) Tingting Li et al. ANNALS OF SURGICAL ONCOLOGY
- Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells
- (2014) C D’Amato et al. BRITISH JOURNAL OF CANCER
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Abstract LB-380: Direct targeting of the Hedgehog pathway in primary chondrosarcoma xenografts with the Smoothened inhibitor IPI-926
- (2014) V. T. Campbell et al. CANCER RESEARCH
- A Phase I Study of PF-04449913, an Oral Hedgehog Inhibitor, in Patients with Advanced Solid Tumors
- (2014) A. J. Wagner et al. CLINICAL CANCER RESEARCH
- Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
- (2014) E. J. Kim et al. CLINICAL CANCER RESEARCH
- CD44 Expression Denotes a Subpopulation of Gastric Cancer Cells in Which Hedgehog Signaling Promotes Chemotherapy Resistance
- (2014) C. Yoon et al. CLINICAL CANCER RESEARCH
- Roles for Hedgehog signaling in adult organ homeostasis and repair
- (2014) R. Petrova et al. DEVELOPMENT
- Hedgehog pathway as a potential treatment target in human cholangiocarcinoma
- (2014) Dorothee Riedlinger et al. Journal of Hepato-Biliary-Pancreatic Sciences
- Hepatocellular carcinoma: A comprehensive overview of surgical therapy
- (2014) Annabelle L. Fonseca et al. JOURNAL OF SURGICAL ONCOLOGY
- Transcriptomic Characterization of Hepatocellular Carcinoma with CTNNB1 Mutation
- (2014) Xiao Ding et al. PLoS One
- Targeting stem cell signaling pathways for drug discovery: advances in the Notch and Wnt pathways
- (2014) Songzhu Michael An et al. Science China-Life Sciences
- Canonical and non-canonical Hedgehog signalling and the control of metabolism
- (2014) Raffaele Teperino et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Tumor Microenvironment and Metabolic Synergy in Breast Cancers: Critical Importance of Mitochondrial Fuels and Function
- (2014) Ubaldo Martinez-Outschoorn et al. SEMINARS IN ONCOLOGY
- Targeting of Smoothened for therapeutic gain
- (2014) Martial Ruat et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers
- (2014) Armel Hervé Nwabo Kamdje World Journal of Clinical Cases
- Expression of Smoothened Protein in Colon Cancer and its Prognostic Value for Postoperative Liver Metastasis
- (2013) Yin-Lu Ding et al. Asian Pacific Journal of Cancer Prevention
- Smoothened is a master regulator of adult liver repair
- (2013) Gregory A. Michelotti et al. JOURNAL OF CLINICAL INVESTIGATION
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- NPV-LDE-225 (Erismodegib) inhibits epithelial mesenchymal transition and self-renewal of glioblastoma initiating cells by regulating miR-21, miR-128, and miR-200
- (2013) J. Fu et al. NEURO-ONCOLOGY
- Activation of the sonic hedgehog signaling pathway occurs in the CD133 positive cells of mouse liver cancer Hepa 1–6 cells
- (2013) Wen-Juei Jeng et al. OncoTargets and Therapy
- The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells
- (2013) Jun Shi et al. OncoTargets and Therapy
- High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma
- (2013) Kuo-Shyang Jeng et al. OncoTargets and Therapy
- Cyclopamine is a novel Hedgehog signaling inhibitor with significant anti-proliferative, anti-invasive and anti-estrogenic potency in human breast cancer cells
- (2013) JUN CHE et al. Oncology Letters
- NVP-LDE-225 (Erismodegib) inhibits epithelial–mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128
- (2013) R Nanta et al. Oncogenesis
- High Expression of Patched Homolog-1 Messenger RNA and Glioma-Associated Oncogene-1 Messenger RNA of Sonic Hedgehog Signaling Pathway Indicates a Risk of Postresection Recurrence of Hepatocellular Carcinoma
- (2012) Kuo-Shyang Jeng et al. ANNALS OF SURGICAL ONCOLOGY
- Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: Modification of the core skeleton for improved solubility
- (2012) Tomohiro Ohashi et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
- (2012) Douglas Hanahan et al. CANCER CELL
- KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma
- (2012) Jianhua Ling et al. CANCER CELL
- Hedgehog Signaling Blockade Delays Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein
- (2012) A. Arzumanyan et al. CANCER RESEARCH
- A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer
- (2012) J. Berlin et al. CLINICAL CANCER RESEARCH
- Molecular Mechanisms Underlying Occult Hepatitis B Virus Infection
- (2012) J. Samal et al. CLINICAL MICROBIOLOGY REVIEWS
- Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer
- (2012) R. F. Hwang et al. MOLECULAR CANCER RESEARCH
- Abstract B192: Preclinical characterization of BMS-833923 (XL139), a hedgehog (HH) pathway inhibitor in early clinical development
- (2012) S. B. Gendreau et al. MOLECULAR CANCER THERAPEUTICS
- Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
- (2012) Wan Zhang et al. NATURE CELL BIOLOGY
- Blockade of the sonic hedgehog pathway effectively inhibits the growth of hepatoma in mice: An in vivo study
- (2012) KUO-SHYANG JENG et al. Oncology Letters
- Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer
- (2011) Hideya Onishi et al. CANCER SCIENCE
- Understanding the metabolic basis of drug resistance
- (2011) Ubaldo E. Martinez-Outschoorn et al. CELL CYCLE
- Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines
- (2011) Yeon-Jin Kwon et al. CLINICAL & EXPERIMENTAL METASTASIS
- Polymeric Nanoparticle-Encapsulated Hedgehog Pathway Inhibitor HPI-1 (NanoHHI) Inhibits Systemic Metastases in an Orthotopic Model of Human Hepatocellular Carcinoma
- (2011) Yang Xu et al. CLINICAL CANCER RESEARCH
- Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened
- (2011) T. Tang et al. CLINICAL CANCER RESEARCH
- Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened
- (2011) Adriana P. Visbal et al. DEVELOPMENTAL BIOLOGY
- Mechanisms of Hedgehog signalling in cancer
- (2011) Kieren D. Marini et al. GROWTH FACTORS
- Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration
- (2011) Ariel H. Polizio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effective Targeting of Hedgehog Signaling in a Medulloblastoma Model with PF-5274857, a Potent and Selective Smoothened Antagonist That Penetrates the Blood-Brain Barrier
- (2011) A. Rohner et al. MOLECULAR CANCER THERAPEUTICS
- Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
- (2011) Kristin M Nieman et al. NATURE MEDICINE
- Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells
- (2011) X Cao et al. ONCOGENE
- Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61
- (2011) L G Harris et al. ONCOGENE
- Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord
- (2011) Y. H. Belgacem et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Overexpression of Hedgehog signaling molecules and its involvement in triple-negative breast cancer
- (2011) Lianhong Li Oncology Letters
- Expression of Sonic Hedgehog Signaling Components in Hepatocellular Carcinoma and Cyclopamine-induced Apoptosis Through Bcl-2 Downregulation In Vitro
- (2010) Xi-lin Chen et al. ARCHIVES OF MEDICAL RESEARCH
- Differential impact of fibroblasts on the efficient cell death of lung cancer cells induced by paclitaxel and cisplatin
- (2010) Babett Bartling et al. CANCER BIOLOGY & THERAPY
- Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer
- (2010) Masae Souzaki et al. CANCER SCIENCE
- Overexpression of Smoothened Activates the Sonic Hedgehog Signaling Pathway in Pancreatic Cancer-Associated Fibroblasts
- (2010) K. Walter et al. CLINICAL CANCER RESEARCH
- Hedgehog Signaling Induced by Breast Cancer Cells Promotes Osteoclastogenesis and Osteolysis
- (2010) Shamik Das et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Viral hepatocarcinogenesis
- (2010) W-L Tsai et al. ONCOGENE
- Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
- (2009) Frédéric Varnat et al. EMBO Molecular Medicine
- Role of Hedgehog signaling pathway in proliferation and invasiveness of hepatocellular carcinoma cells
- (2009) Tian INTERNATIONAL JOURNAL OF ONCOLOGY
- Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
- (2009) J M Bailey et al. ONCOGENE
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Liver Transplantation for Hepatocellular Carcinoma
- (2008) Julie K. Heimbach CANCER JOURNAL
- An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
- (2008) G. Feldmann et al. MOLECULAR CANCER THERAPEUTICS
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started