There and Back Again: Leptin Actions in White Adipose Tissue

A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

(2020) Putianqi Wang et al.   NATURE

Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway

(2019) Jie Wang et al.   Cells

White adipose tissue mitochondrial metabolism in health and in obesity

(2019) Sini Heinonen et al.   Obesity Reviews

Central nicotine induces browning through hypothalamic κ opioid receptor

(2019) Patricia Seoane-Collazo et al.   Nature Communications

Cold exposure induces dynamic, heterogeneous alterations in human brown adipose tissue lipid content

(2019) Crystal L. Coolbaugh et al.   Scientific Reports

Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease

(2019) Jörn F. Ziegler et al.   Nature Communications

Leptin Induces Proadipogenic and Proinflammatory Signaling in Adipocytes

(2019) Lohanna Palhinha et al.   Frontiers in Endocrinology

Source of dietary sucrose influences development of leptin resistance in male and female rats

(2018) Ruth B. S. Harris   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density

(2018) Jingyi Chi et al.   Cell Metabolism

Heterogeneity of adipose tissue in development and metabolic function

(2018) Theresa Schoettl et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis

(2018) Haitao Pan et al.   Marine Drugs

High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism

(2018) Miguel A. Lanaspa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxytocin Administration Alleviates Acute but Not Chronic Leptin Resistance of Diet-Induced Obese Mice

(2018) Mehdi Labyb et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adipokines and Their Role in Intestinal Inflammation

(2018) Carl Weidinger et al.   Frontiers in Immunology

Triglycerides cross the blood–brain barrier and induce central leptin and insulin receptor resistance

(2017) W A Banks et al.   INTERNATIONAL JOURNAL OF OBESITY

Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice

(2017) L Gan et al.   INTERNATIONAL JOURNAL OF OBESITY

Leptin in the interplay of inflammation, metabolism and immune system disorders

(2017) Vanessa Abella et al.   Nature Reviews Rheumatology

Hypothalamic Amenorrhea and the Long-Term Health Consequences

(2017) Tina Torbati et al.   SEMINARS IN REPRODUCTIVE MEDICINE

PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance

(2017) Takafumi Shintani et al.   Scientific Reports

Activation of β3-adrenoceptors increases in vivo free fatty acid uptake and utilization in brown but not white fat depots in high-fat-fed rats

(2016) Amy Warner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Liraglutide ameliorates palmitate-induced endothelial dysfunction through activating AMPK and reversing leptin resistance

(2016) Nana Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KBH-1, an herbal composition, improves hepatic steatosis and leptin resistance in high-fat diet-induced obese rats

(2016) Ji-Hye Lee et al.   BMC Complementary and Alternative Medicine

Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling

(2016) Salvatore Fabbiano et al.   Cell Metabolism

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals

(2016) Yi Zhu et al.   Cell Metabolism

Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity

(2016) Cristina Contreras et al.   DIABETES

Thyroid hormones induce browning of white fat

(2016) Noelia Martínez-Sánchez et al.   JOURNAL OF ENDOCRINOLOGY

Brain STAT5 signaling and behavioral control

(2016) Isadora C. Furigo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages

(2015) Yi Zhou et al.   Cell Metabolism

Regulation of energy balance by a gut–brain axis and involvement of the gut microbiota

(2015) Paige V. Bauer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human Brown Adipose Tissue: What We Have Learned So Far

(2015) Matthias J. Betz et al.   DIABETES

Lipolysis and lipases in white adipose tissue – An update

(2015) Andressa Bolsoni-Lopes et al.   Archives of Endocrinology Metabolism

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat

(2014) Hai-Bin Ruan et al.   CELL

Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4

(2014) Bing Luan et al.   Cell Metabolism

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

(2014) Matthew J. Harms et al.   Cell Metabolism

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice

(2014) A Rodríguez et al.   INTERNATIONAL JOURNAL OF OBESITY

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

(2014) Cristina Contreras et al.   Cell Reports

Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells

(2014) Anna Park   World Journal of Stem Cells

BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells

(2013) Manuela Elsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Bone Marrow Leptin Signaling Mediates Obesity-Associated Adipose Tissue Inflammation in Male Mice

(2013) Lea H. Dib et al.   ENDOCRINOLOGY

Participation of leptin in the determination of the macrophage phenotype: an additional role in adipocyte and macrophage crosstalk

(2013) Simone Coghetto Acedo et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Waist circumference, ghrelin and selected adipose tissue-derived adipokines as predictors of insulin resistance in obese patients: Preliminary results

(2013) Mariusz Stepien et al.   MEDICAL SCIENCE MONITOR

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

(2012) Joseph Tam et al.   Cell Metabolism

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Leptin, a neuroendocrine mediator of immune responses, inflammation, and sickness behaviors

(2012) Elizabeth D. Carlton et al.   HORMONES AND BEHAVIOR

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Dendritically targeted Bdnf mRNA is essential for energy balance and response to leptin

(2012) Guey-Ying Liao et al.   NATURE MEDICINE

Rapid Nitration of Adipocyte Phosphoenolpyruvate Carboxykinase by Leptin Reduces Glyceroneogenesis and Induces Fatty Acid Release

(2012) Anne-Marie Jaubert et al.   PLoS One

Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction

(2012) Christa M. Patterson et al.   Molecular Metabolism

Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity

(2011) Javier Conde et al.   BIOFACTORS

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

(2011) Kim Loh et al.   Cell Metabolism

Lipodystrophies: Genetic and Acquired Body Fat Disorders

(2011) Abhimanyu Garg   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity

(2011) Dario A Gutierrez et al.   JOURNAL OF ENDOCRINOLOGY

Long-term metreleptin treatment increases bone mineral density and content at the lumbar spine of lean hypoleptinemic women

(2011) Elizabeth Sienkiewicz et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Leptin as an immunomodulator

(2011) Claudio Procaccini et al.   MOLECULAR ASPECTS OF MEDICINE

Leptin is an effective treatment for hypothalamic amenorrhea

(2011) S. H. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of Leptin Receptor Bone Marrow Chimeras: Recovery From Irradiation, Immune Cellularity, Cytokine Expression, and Metabolic Parameters

(2010) Melissa E. Gove et al.   Obesity

Hyperleptinemia Is Required for the Development of Leptin Resistance

(2010) Zachary A. Knight et al.   PLoS One

Leptin therapy in insulin-deficient type I diabetes

(2010) M.-y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

(2010) T. Fujikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

(2010) Eduardo R. Ropelle et al.   PLOS BIOLOGY

The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo

(2009) Jiejin Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

(2009) Seongjin Seo et al.   HUMAN MOLECULAR GENETICS

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

(2009) E. Maury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

(2009) Jian Liu et al.   NATURE MEDICINE

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

(2009) Jong Chul Won et al.   Obesity

Lipolysis and lipid mobilization in human adipose tissue

(2009) Max Lafontan et al.   PROGRESS IN LIPID RESEARCH

Regional Anatomic and Age Effects on Cell Function of Human Adipose-Derived Stem Cells

(2008) Bret M. Schipper et al.   ANNALS OF PLASTIC SURGERY

White Adipose Tissue as Endocrine Organ and Its Role in Obesity

(2008) Maria Eugenia Frigolet Vázquez-Vela et al.   ARCHIVES OF MEDICAL RESEARCH

Effects of Leptin on Lipid Metabolism and Gene Expression of Differentiation-Associated Growth Factors and Transcription Factors during Differentiation and Maturation of 3T3-L1 Preadipocytes

(2008) Won Kon KIM et al.   ENDOCRINE JOURNAL

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

(2008) Jennifer W. Hill et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome

(2008) Kamal Rahmouni et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic Reticulum Stress Induces Leptin Resistance

(2008) T. Hosoi et al.   MOLECULAR PHARMACOLOGY

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

(2008) Christoph Buettner et al.   NATURE MEDICINE

Mechanisms of Leptin Action and Leptin Resistance

(2007) Martin G. Myers et al.   Annual Review of Physiology

Type 1 Diabetes Associated with Acquired Generalized Lipodystrophy and Insulin Resistance: The Effect of Long-Term Leptin Therapy

(2007) Jean Y. Park et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM