Review
Biochemistry & Molecular Biology
Ruipeng Wang, Tiankang Guo, Junliang Li
Summary: Peritoneal adhesion (PA) is a fibrotic tissue that connects abdominal or visceral organs to the peritoneum, and its formation can lead to various clinical diseases. Damage to peritoneal mesothelial cells (PMCs) is believed to be one of the causes of PA. This review aims to understand the mechanism of action of PMCs in PA and provide a theoretical foundation for the treatment and prevention of PA.
Article
Cell Biology
Qiong Yang, Haosong Shi, Yizhou Quan, Qianqian Chen, Wang Li, Li Wang, Yonghui Wang, Zhongzhong Ji, Shan-Kai Yin, Hai-Bo Shi, Huiming Xu, Wei-Qiang Gao
Summary: The research provides a new method to induce mouse embryonic fibroblasts to differentiate into cells resembling inner ear hair cells in vitro, which is significant; these induced cells express multiple HC-specific proteins, exhibit structures and functions similar to inner ear hair cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jung-Yoon Heo, Jun-Young Do, Yunmee Lho, A-Young Kim, Sang-Woon Kim, Seok-Hui Kang
Summary: The study demonstrated that SB525334 effectively suppressed the epithelial-mesenchymal transition (EMT) induced by TGF-beta 1, reducing peritoneal fibrosis and thickness, and improving peritoneal membrane function in a peritoneal fibrosis mouse model.
Article
Biochemistry & Molecular Biology
Yoshiko Hashimoto, Tomoko Tsuzuki-Nakao, Naoko Kida, Yoshiyuki Matsuo, Tetsuo Maruyama, Hidetaka Okada, Kiichi Hirota
Summary: The endometrium undergoes repeated changes during the menstrual cycle, and chronic endometritis can lead to implantation failure and miscarriage. In this study, the effects of inflammatory cytokines, hypoxia-inducible factor (HIF), and inflammation on endometrial epithelial cells were investigated. The results showed that pro-inflammatory factors and hypoxia activated HIF-1 and promoted epithelial-mesenchymal transition (EMT) in endometrial epithelial cells.
Article
Pharmacology & Pharmacy
Yingfeng Shi, Min Tao, Jun Ni, Lunxian Tang, Feng Liu, Hui Chen, Xiaoyan Ma, Yan Hu, Xun Zhou, Andong Qiu, Shougang Zhuang, Na Liu
Summary: IL-6-induced HDAC6 not only regulated IL-6 downstream JAK2/STAT3 signaling, but also co-activated TGF-beta/Smad3 signaling, leading to changes in the phenotype and mobility of HPMCs. HDAC6 could be a potential therapeutic target for preventing and treating peritoneal fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Guya D. Marconi, Luigia Fonticoli, Thangavelu Soundara Rajan, Sante D. Pierdomenico, Oriana Trubiani, Jacopo Pizzicannella, Francesca Diomede
Summary: The epithelial-mesenchymal transition (EMT) is a crucial event in cell development, playing key roles in wound healing and organ fibrosis. EMT is classified into three types: type-1 EMT, type-2 EMT, and type-3 EMT, each with specific functions in embryogenesis, wound healing, and cancer progression respectively.
Article
Engineering, Biomedical
Adrian Cervero-Varona, Angelo Canciello, Alessia Peserico, Arlette Alina Haidar Montes, Maria Rita Citeroni, Annunziata Mauro, Valentina Russo, Samanta Moffa, Serena Pilato, Stefano Di Giacomo, Beatrice Dufrusine, Enrico Dainese, Antonella Fontana, Barbara Barboni
Summary: The use of biomaterials in immune regenerative strategies for unresolved pathologies is gaining attention in tissue engineering. Graphene oxide (GO) has been proposed as an immune-mimetic material for stem cell-based regenerative therapies, influencing stem cell behavior and immune response. Amniotic epithelial stem cells (AECs) are also of interest due to their plasticity and immunomodulatory paracrine activities, and the effects of GO on AECs are explored in this study. GO-coating induced and accelerated the Epithelial-Mesenchymal Transition (EMT) in AECs, leading to changes in cytokine secretion and enhanced activation of macrophages. Adhesion of AECs on GO-functionalized surfaces could create a tailored microenvironment for the regenerative process.
MATERIALS TODAY BIO
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fei Bi, Huilin Tang, Zhijun Zhang, Yun Lyu, Fangjun Huo, Guoqing Chen, Weihua Guo
Summary: Research has shown that using HERS cells for periodontal tissue regeneration has potential and can be used to repair severely damaged periodontal tissue.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Immunology
Junwei Zhao, Tianci Jiang, Pengfei Li, Lingling Dai, Guang Shi, Xiaogang Jing, Shuhui Gao, Liuqun Jia, Shujun Wu, Yu Wang, Youmei Peng, Zhe Cheng
Summary: The study showed that TF promotes airway pathological features by enhancing the EMT of bronchial epithelial cells in asthma, while downregulation of TF reduces airway hyperresponsiveness, eosinophil inflammation, and EMT process. TF downregulation also inhibits migration and invasion, and decreases fibronectin 1 and TGF-β1 expression while increasing E-cadherin expression in stimulated 16HBE cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Developmental Biology
M. Bourdon, P. Santulli, L. Doridot, M. Jeljeli, C. Chene, S. Chouzenoux, C. Nicco, L. Marcellin, C. Chapron, F. Batteux
Summary: The study showed that aberrant expression of immune cell markers, particularly increased inflammatory cell markers and decreased B cell markers, was observed during the development of adenomyosis. Additionally, activation of Notch1 signaling was associated with abnormal expression of immune and EMT markers in the early stages of adenomyosis development.
MOLECULAR HUMAN REPRODUCTION
(2021)
Review
Oncology
Junliang Li, Tiankang Guo
Summary: Peritoneal mesothelial cells (PMCs) play a crucial role in the progression of peritoneal tumors. In the past, PMCs were considered a barrier to tumor implantation and metastasis, but recent studies have shown that they can both inhibit and promote tumor progression.
Article
Medicine, Research & Experimental
Jin Qian, Bauer L. LeSavage, Kelsea M. Hubka, Chenkai Ma, Suchitra Natarajan, Joshua T. Eggold, Yiren Xiao, Katherine C. Fuh, Venkatesh Krishnan, Annika Enejder, Sarah C. Heilshorn, Oliver Dorigo, Erinn B. Rankin
Summary: Ovarian cancer-associated mesothelial cells play a critical role in promoting chemoresistance and stemness in ovarian cancer. The secreted factor osteopontin drives mesothelial-mediated chemoresistance and stemness, and therapeutic targeting of osteopontin may enhance platinum sensitivity in ovarian cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Hua Fu, Yong-Hong Gu, Juan Tan, Ye-Ning Yang, Guo-Hui Wang
Summary: The crosstalk between macrophages and tubular epithelial cells is important in the progression of renal fibrosis. In this study, the significance of circular RNA ACTR2 (circACTR2) in regulating macrophage inflammation, epithelial-mesenchymal transition (EMT) of tubular epithelial cells, and the development of renal fibrosis was revealed. circACTR2 promoted the activation of NLRP3 inflammasome, inflammation in macrophages, and stimulated EMT and fibrosis of tubular epithelial cells by sponging miR-561. Knocking down circACTR2 and overexpressing miR-561 may benefit the treatment of renal fibrosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Physiology
Young-Yeon Choo, Tsuyoshi Sakai, Satoshi Komatsu, Reiko Ikebe, Ann Jeffers, Karan P. Singh, Steven Idell, Torry A. Tucker, Mitsuo Ikebe
Summary: By investigating the mechanism of contractile myofibroblast differentiation of PMCs, this study found that calponin 1 plays a central role in the formation of stress fibers and focal adhesions, which contribute to the stiffness of scar tissue in the pleura and promote pleural fibrosis (PF).
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Valentina Russo, Annunziata Mauro, Alessia Peserico, Oriana Di Giacinto, Mohammad El Khatib, Maria Rita Citeroni, Emanuela Rossi, Angelo Canciello, Eleonora Mazzotti, Barbara Barboni
Summary: This research demonstrates the potential of amniotic epithelial stem cells (AECs) in promoting tendon regeneration. The study found that AECs can trans-differentiate into cell phenotypes with varying abilities to facilitate regeneration. The findings suggest that AECs with an epithelial phenotype have a greater impact on shifting the inflammatory response to a pro-regenerative response, while AECs with a tendon-like phenotype mainly affect the proliferative phase of regeneration. These results provide support for using AECs as a feasible and effective strategy for the treatment of acute tendinopathies.