Sex-specific genetic effects across biomarkers

Using human genetics to understand the disease impacts of testosterone in men and women

(2020) Katherine S Ruth et al.   NATURE MEDICINE

Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects

(2019) Mathias Rask-Andersen et al.   Nature Communications

Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction: mendelian randomisation study in UK Biobank

(2019) Shan Luo et al.   BMJ-British Medical Journal

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology

(2019) Yosuke Tanigawa et al.   Nature Communications

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

(2018) Guiyan Ni et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome

(2018) Ferdinando Bonfiglio et al.   GASTROENTEROLOGY

Serum testosterone and non-alcoholic fatty liver disease in men and women in the US

(2018) Jeong Yoon Yim et al.   LIVER INTERNATIONAL

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

(2018) Fredrick R. Schumacher et al.   NATURE GENETICS

Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study

(2018) Christopher DeBoever et al.   Nature Communications

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics

(2018) Gregory McInnes et al.   BIOINFORMATICS

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

SumHer better estimates the SNP heritability of complex traits from summary statistics

(2018) Doug Speed et al.   NATURE GENETICS

The role of sex in the genomics of human complex traits

(2018) Ekaterina A. Khramtsova et al.   NATURE REVIEWS GENETICS

Author Correction: Majority of human traits do not show evidence for sex-specific genetic and environmental effects

(2018) Sven Stringer et al.   Scientific Reports

Concepts, estimation and interpretation of SNP-based heritability

(2017) Jian Yang et al.   NATURE GENETICS

Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis

(2017) Joel Eriksson et al.   PLoS One

A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization

(2017) Jack Bowden et al.   STATISTICS IN MEDICINE

Low-frequency and common genetic variation in ischemic stroke

(2016) Rainer Malik et al.   NEUROLOGY

Age-specific population centiles for androgen status in men

(2015) D J Handelsman et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

STAG3 truncating variant as the cause of primary ovarian insufficiency

(2015) Polona Le Quesne Stabej et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Associations Between Sex Steroids and the Development of Metabolic Syndrome: A Longitudinal Study in European Men

(2015) Leen Antonio et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

New genetic loci link adipose and insulin biology to body fat distribution

(2015) Dmitry Shungin et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

(2015) Felix R Day et al.   NATURE GENETICS

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

(2015) Thomas W. Winkler et al.   PLoS Genetics

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Cell Type-Specific Expression Analysis to Identify Putative Cellular Mechanisms for Neurogenetic Disorders

(2014) X. Xu et al.   JOURNAL OF NEUROSCIENCE

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

(2014) John R. B. Perry et al.   NATURE

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

(2013) Joshua C. Randall et al.   PLoS Genetics

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

Large-scale association analysis identifies new risk loci for coronary artery disease

(2012) Panos Deloukas et al.   NATURE GENETICS

Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women

(2012) Jennifer Prescott et al.   PLoS One

Genetic Determinants of Serum Testosterone Concentrations in Men

(2011) Claes Ohlsson et al.   PLoS Genetics

Linkage analysis of obesity phenotypes in pre- and post-menopausal women from a United States mid-western population

(2010) Linda E Kelemen et al.   BMC Medical Genetics

Prospective association of low total testosterone concentrations with an adverse lipid profile and increased incident dyslipidemia

(2010) Robin Haring et al.   EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

Sex-specific genetic architecture of human disease

(2008) Carole Ober et al.   NATURE REVIEWS GENETICS