Article
Biochemistry & Molecular Biology
Gysbert-Botho van Setten
Summary: The loss of ocular surface homeostasis characterizes the onset of dry eye disease. Resilience defines the ability to withstand this threat and bounce back, while cellular stress is central to the pathophysiology of dry eye disease. The proposed model suggests that the phase of heterostasis preceding the establishment of allostasis offers a better chance for therapeutic intervention and optimized recovery.
Article
Gastroenterology & Hepatology
Charles J. Cho, Dongkook Park, Jason C. Mills
Summary: This study identifies ELAPOR1 as an evolutionarily conserved, trans-Golgi/late endosome M6PR domain-containing protein that is specific to gastric zymogenic cells. It is required for normal secretory granule maturation in both human cell lines and mouse stomach.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Review
Immunology
Pavlina Spiliopoulou, S. Y. Cindy Yang, Jeff P. Bruce, Ben X. Wang, Hal K. Berman, Trevor J. Pugh, Lillian L. Siu
Summary: The cancer research community is searching for more biomarkers of response and resistance to immune checkpoint treatment, and analyzing the loss of the 9p21.3 locus may provide additional knowledge about immune evasion in cancer.
TRENDS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Samuel E. Redford, Siva Karthik Varanasi, Karina K. Sanchez, Natalia R. Thorup, Janelle S. Ayres
Summary: This study investigates the role of the adaptive immune response in adipose tissue wasting and cachexia. Findings suggest that fat wasting is induced by CD4+ T cells and has no impact on host antibody-mediated resistance or survival, whereas later-stage muscle wasting contributes to disease-tolerance defenses.
Article
Business
Joanna Santiago, Maria Teresa Borges-Tiago, Flavio Tiago
Summary: The study explores how Firm-Generated Content (FGC) influences customer purchase intention, finding that FGC has a negative impact on purchase intention and minimal effects on brand equity and attitude, challenging marketers to rethink their online marketing strategies.
JOURNAL OF BUSINESS RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yoshiaki Morishita, Aaron P. Kellogg, Dennis Larkin, Wei Chen, Suryakiran Vadrevu, Leslie Satin, Ming Liu, Peter Arvan
Summary: This study found that acute ER stress increases CIDE-A protein levels in thyroid cells, while chronic ER stress results in lower mRNA levels of CIDE-A. Furthermore, CIDE-A mRNA response to a new acute ER stress challenge is reduced in cells surviving chronic ER stress. CIDE-A may be a novel marker associated with a noncanonical ER stress response program.
Article
Neurosciences
Karin L. Meeker, Omar H. Butt, Brian A. Gordon, Anne M. Fagan, Suzanne E. Schindler, John C. Morris, Tammie L. S. Benzinger, Beau M. Ances
Summary: CSF NfL is a non-specific marker of aging and white matter integrity, and is more strongly associated with total white matter hyperintensity volume than with gray or white matter volume. Age and white matter hyperintensity volume are consistently more important predictors of CSF NfL than AD markers.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Plant Sciences
U. S. Sharath Chandran, Avijit Tarafdar, H. S. Mahesha, Mamta Sharma
Summary: Temperature and soil moisture content play a crucial role in influencing the progression of dry root rot disease in chickpea, with high temperature and low soil moisture leading to increased disease susceptibility. Host defense-related genes are found to be highly active in delaying the disease progression, especially under low soil moisture conditions.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Analytical
Julius Welzel, David Wendtland, Elke Warmerdam, Robbin Romijnders, Morad Elshehabi, Johanna Geritz, Daniela Berg, Clint Hansen, Walter Maetzler
Summary: Current research on Parkinson's disease is focusing on identifying objective markers for assessing therapy effects and disease progression. This study found that step length has a significant impact on PD progression, while step time shows minimal change, emphasizing the importance of evaluating quantitative gait parameters for making assumptions about disease progression in chronic progressive diseases like PD.
Article
Biology
Alexus McCue, Stephanie Munten, Karl-Heinz Herzig, Dominique D. Gagnon
Summary: During incremental maximal exercise to volitional fatigue in a cold environment, glucose ingestion led to increased glucose oxidation, while cold exposure increased lipid oxidation. However, metabolic flexibility was not altered in this context.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Biodiversity Conservation
O. Alejandro Aleuy, Stephanie J. Peacock, Peter K. Molnar, Kathreen E. Ruckstuhl, Susan J. Kutz
Summary: This study investigates the thermal responses of the parasitic nematode Marshallagia marshalli along a latitudinal gradient and finds that populations from northern locations show higher mortality and longer development time at higher temperatures. The research highlights the importance of considering location-specific climate change projections and parasite parameters in accurately predicting the impacts of climate change on broadly distributed species.
GLOBAL CHANGE BIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Farzaneh Nikparast, Zohreh Ganji, Mohammad Danesh Doust, Reyhane Faraji, Hoda Zare
Summary: This narrative review discusses the use of quantitative susceptibility mapping (QSM), a magnetic resonance imaging (MRI) based method, for assessing iron deposition in the brain. The article provides an overview of the role of iron in neurodegenerative diseases, current methods for examining iron deposition, and the advantages and disadvantages of QSM. It suggests that QSM can be introduced as a reliable technique for clinical evaluations.
INSIGHTS INTO IMAGING
(2022)
Article
Neurosciences
Andreas B. Wulff, Phylicia Cooper, Emmanuela Kodjo, Eliana Abel, Scott M. Thompson
Summary: The sucrose preference test is widely used to study stress-sensitive reward behaviors and antidepressant treatments in rodents. Our analysis of licking microstructure in mice during the test revealed that stress-naive mice showed longer and more frequent bouts of drinking at the sucrose bottle compared to the water bottle. Manipulations of caloric content and need did not affect preference or drinking behavior. Chronic stress impaired sucrose location memory and reduced the number of drinking bouts, explaining the loss of sucrose preference in stress susceptible mice. Female mice showed similar drinking behavior to males but may be less susceptible to chronic stress and have better memory performance.
Article
Multidisciplinary Sciences
Alan Benard, Anne Jacobsen, Maximilian Brunner, Christian Krautz, Bettina Kloesch, Izabela Swierzy, Elisabeth Naschberger, Malgorzata J. Podolska, Dina Kouhestani, Paul David, Torsten Birkholz, Ixchel Castellanos, Denis Trufa, Horia Sirbu, Marcel Vetter, Andreas E. Kremer, Kai Hildner, Andreas Hecker, Fabian Edinger, Matthias Tenbusch, Petra Muehl-Zuerbes, Alexander Steinkasserer, Enrico Richter, Hendrik Streeck, Marc M. Berger, Thorsten Brenner, Markus A. Weigand, Filip K. Swirski, Georg Schett, Robert Gruetzmann, Georg F. Weber
Summary: Researchers identify IL-3 as an independent prognostic marker for the outcome of SARS-CoV-2 infections, with low IL-3 levels being associated with increased severity, viral load, and mortality. Additionally, patients with severe COVID-19 have reduced levels of circulating plasmacytoid dendritic cells compared to non-severe cases.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Nana Wang, Zhenyu Lu, Wei Zhang, Yu Bai, Dongmei Pei, Ling Li
Summary: This study explored the association between serum Cystatin C trajectory and diabetic kidney disease, finding that patients with type 2 diabetes had a higher velocity of increase in Cysc compared to healthy subjects. Patients with high baseline Cysc values and high latent increasing velocity of Cysc had a higher risk of developing diabetic kidney disease in later life.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Adam C. Mumford, Denise M. Akob, J. Grace Klinges, Isabelle M. Cozzarelli
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Rebecca L. Maher, Mallory M. Rice, Ryan McMinds, Deron E. Burkepile, Rebecca Vega Thurber
SCIENTIFIC REPORTS
(2019)
Article
Ecology
J. Grace Klinges, Stephanie M. Rosales, Ryan McMinds, Elizabeth C. Shaver, Andrew A. Shantz, Esther C. Peters, Michael Eitel, Gert Woerheide, Koty H. Sharp, Deron E. Burkepile, Brian R. Silliman, Rebecca L. Vega Thurber
Article
Biochemistry & Molecular Biology
Serge Planes, Denis Allemand, Sylvain Agostini, Bernard Banaigs, Emilie Boissin, Emmanuel Boss, Guillaume Bourdin, Chris Bowler, Eric Douville, J. Michel Flores, Didier Forcioli, Paola Furla, Pierre E. Galand, Jean-Francois Ghiglione, Eric Gilson, Fabien Lombard, Clementine Moulin, Stephane Pesant, Julie Poulain, Stephanie Reynaud, Sarah Romac, Matthew B. Sullivan, Shinichi Sunagawa, Olivier P. Thomas, Romain Trouble, Colomban de Vargas, Rebecca Vega Thurber, Christian R. Voolstra, Patrick Wincker, Didier Zoccola, S. Planes, D. Allemand, S. Agostini, E. Armstrong, S. Audrain, J-M Aury, B. Banaig, V Barbe, C. Belser, E. Beraud, E. Boissin, E. Bonnival, E. Boss, G. Bourdin, E. Bourgois, C. Bowler, Q. Carradec, N. Cassar, N. R. Cohen, P. Conan, D. R. Cronin, O. da Silva, C. de Vargas, N. Djerbi, J. R. Dolan, Dominguez G. Herta, E. Douville, Du J, J. Filee, J. M. Flores, D. Forcioli, R. Friedrich, P. Furla, P. E. Galand, J-F Ghiglione, E. Gilson, G. Gorsky, M. Guinther, N. Haentjens, N. Henry, M. Hertau, C. Hochart, B. C. C. Hume, G. Iwankow, S. G. John, L. Karp-Boss, R. L. Kelly, Y. Kitano, G. Klinges, I Koren, K. Labadie, J. Lancelot, N. Lang-Yona, J. Le-Hoang, R. Lemee, Y. Lin, F. Lombard, D. Marie, R. McMind, M. Miguel-Gordo, M. Trainic, D. Monmarche, C. Moulin, Y. Mucherie, B. Noel, A. Ottaviani, L. Paoli, M-L Pedrotti, S. Pesant, C. Pogoreutz, J. Poulain, M. Pujo-Pay, G. Reverdin, S. Reynaud, S. Romac, T. Rothig, E. Rottinger, A. Rouan, H-J Ruscheweyh, G. Salazar, M. B. Sullivan, S. Sunagawa, O. P. Thomas, R. Trouble, A. Vardi, R. Vega-Thunder, C. R. Voolstra, P. Wincker, A. Zahed, T. Zamoum, M. Ziegler, D. Zoccola
Article
Ecology
Leila Ezzat, Thomas Lamy, Rebecca L. Maher, Katrina S. Munsterman, Kaitlyn Landfield, Emily R. Schmeltzer, Christopher A. Gaulke, Deron E. Burkepile, Rebecca Vega Thurber
MARINE ECOLOGY PROGRESS SERIES
(2019)
Article
Multidisciplinary Sciences
Mallory M. Rice, Rebecca L. Maher, Rebecca Vega Thurber, Deron E. Burkepile
Article
Marine & Freshwater Biology
Mallory M. Rice, Rebecca L. Maher, Adrienne M. S. Correa, Holly Moeller, Nathan P. Lemoine, Andrew A. Shantz, Deron E. Burkepile, Nyssa J. Silbiger
Article
Ecology
Lydia J. Baker, Hannah G. Reich, Sheila A. Kitchen, J. Grace Klinges, Hanna R. Koch, Iliana B. Baums, Erinn M. Muller, Rebecca Vega Thurber
Summary: This study investigated the infection and ecology of the symbiont Candidatus Aquarickettsia rohweri in threatened Acropora corals, finding that the infection magnitude is influenced by coral host and geographic location. Phylogenomic analysis showed clustering by geographic region, with positive selection observed in Florida populations due to greater nutrient stress. Aquarickettsia was not found to codiversify significantly with coral animal or algal symbiont, suggesting horizontal transmission as the likely route of infection.
Article
Microbiology
Adriana Messyasz, Rebecca L. Maher, Sonora S. Meiling, Rebecca Vega Thurber
Summary: Studies show that nutrient pollution affects the microbiome dynamics of corals, fish, and macroalgae differently, with coral microbiomes being less resistant to nutrient pollution. There are 51 common amplicon sequence variants (ASVs) shared among the three hosts, including potentially pathogenic Vibrionaceae bacteria that may be transmitted between these organisms.
Article
Ecology
Dakota M. Lewis, Tali Vardi, Rebecca L. Maher, Adrienne M. S. Correa, Geoffrey S. Cook
Summary: Disturbances of coral reefs are becoming more frequent, intense, and long-lasting, leading to demographic shifts in reef-building coral populations and uncertain consequences for ongoing coral restoration efforts. Using stage-based matrix population models, this study predicts the changes in population and areal coverage of Orbicella franksi under simulated disturbance and restoration scenarios. The results show that simulated restoration can greatly increase the number of O. franksi colonies and overall estimated areal coverage compared to baseline population estimates. However, even with restoration efforts, there is a projected loss of O. franksi areal coverage in both mild and severe disturbance scenarios.
ECOLOGICAL MODELLING
(2022)
Article
Ecology
Lauren I. Howe-Kerr, Carsten G. B. Grupstra, Kristen M. Rabbitt, Dennis Conetta, Samantha R. Coy, J. Grace Klinges, Rebecca L. Maher, Kaitlin M. McConnell, Sonora S. Meiling, Adriana Messyasz, Emily R. Schmeltzer, Sarah Seabrook, Jordan A. Sims, Alex J. Veglia, Andrew R. Thurber, Rebecca L. Vega Thurber, Adrienne M. S. Correa
Summary: This study examined the viral dynamics of positive-sense single-stranded RNA viruses that infect symbiotic dinoflagellates in reef-building corals. The researchers analyzed the viral major capsid protein (mcp) gene sequences of these viruses in Porites lobata corals sampled from different reef zones over a 3-year period. They found that dinoRNAV infections in corals respond to environmental fluctuations and the reef-wide thermal stress event, which could have implications for coral reef ecosystems.
ISME COMMUNICATIONS
(2023)
Article
Microbiology
Leila Ezzat, Thomas Lamy, Rebecca L. Maher, Katrina S. Munsterman, Kaitlyn M. Landfield, Emily R. Schmeltzer, Cody S. Clements, Rebecca L. Vega Thurber, Deron E. Burkepile
Article
Environmental Sciences
Gabriel Gorsky, Guillaume Bourdin, Fabien Lombard, Maria Luiza Pedrotti, Samuel Audrain, Nicolas Bin, Emmanuel Boss, Chris Bowler, Nicolas Cassar, Loic Caudan, Genevieve Chabot, Natalie R. Cohen, Daniel Cron, Colomban De Vargas, John R. Dolan, Eric Douville, Amanda Elineau, J. Michel Flores, Jean Francois Ghiglione, Nils Haentjens, Martin Hertau, Seth G. John, Rachel L. Kelly, Ilan Koren, Yajuan Lin, Dominique Marie, Clementine Moulin, Yohann Moucherie, Stephane Pesant, Marc Picheral, Julie Poulain, Mireille Pujo-Pay, Gilles Reverdin, Sarah Romac, Mathew B. Sullivan, Miri Trainic, Marc Tressol, Romain Trouble, Assaf Vardi, Christian R. Voolstra, Patrick Wincker, Sylvain Agostini, Bernard Banaigs, Emilie Boissin, Didier Forcioli, Paola Furla, Pierre E. Galand, Eric Gilson, Stephanie Reynaud, Shinichi Sunagawa, Olivier P. Thomas, Rebecca Lisette Vega Thurber, Didier Zoccola, Serge Planes, Denis Allemand, Eric Karsenti, S. Planes, B. Banaig, E. Boissin, G. Iwankow, D. Allemand, D. Zoccola, S. Reynaud, E. Beraud, N. Djerbi, D. Forcioli, P. Furla, E. Gilson, R. McMind, A. Ottaviani, E. Rottinger, A. Rouan, T. Zamoum, B. C. C. Flume, C. Pogoreutz, C. R. Voolstra, T. Rothig, M. Ziegler, L. Paoli, H-J Ruscheweyh, G. Salazar, S. Sunagawa, J. M. Flores, I Koren, M. Trainic, N. Lang-Yona, A. Vardi, P. Conan, J-F Ghiglione, M. Pujo-Pay, P. E. Galand, C. Hochart, S. Audrain, E. Bourgois, M. Hertau, J. Lancelot, D. Monmarche, C. Moulin, Y. Moucherie, R. Trouble, E. Boss, G. Bourdin, N. Haentjens, L. Karp-Boss, E. Douville, S. Agostini, G. Mitsuhashi, Y. Kitano, O. da Silva, J. R. Dolan, G. Gorsky, R. Lemee, F. Lombard, M-L Pedrotti, D. Cronin, M. Sullivan, E. Armstrong, J-M Aury, V Barbe, C. Belser, Q. Carradec, K. Labadie, J. Le-Hoang, B. Noel, J. Poulain, P. Wincker, G. Klinges, R. Vega-Thunder, E. Bonnival, C. de Vargas, N. Henry, D. Marie, S. Romac, S. Pesant, M. Miguel-Gorda, O. P. Thomas, C. Bowler, R. Friedrich, N. Cassar, Y. Lin, S. G. John, R. L. Kelly, N. R. Cohen, G. Reverdin, J. Filee
FRONTIERS IN MARINE SCIENCE
(2019)