Article
Endocrinology & Metabolism
Michael A. Rotondi, Octavia Wong, Michael Riddell, Bruce Perkins
Summary: Universal use of CGM or isCGM in the Canadian T1D population is expected to reduce diabetes-related complications and mortality at an acceptable cost-effectiveness threshold.
Article
Nutrition & Dietetics
Franklin R. Muntis, Elizabeth J. Mayer-Davis, Saame R. Shaikh, Jamie Crandell, Kelly R. Evenson, Abbie E. Smith-Ryan
Summary: This study evaluated the role of post-exercise protein intake on post-exercise glycemia and found that increasing protein intake after moderate-intensity continuous training may help reduce the risk of hypoglycemia.
Article
Endocrinology & Metabolism
David N. O'Neal, Ohad Cohen, Sara Vogrin, Robert A. Vigersky, Alicia J. Jenkins
Summary: This study aimed to evaluate the relationships between continuous glucose monitoring (CGM) time in range (TIR), time below range (TBR), time above range (TAR), and glucose coefficient of variation (CV) in older people with type 1 diabetes. The results showed strong correlations between TIR and TAR, weak correlation between TBR and TIR, and no significant correlation between CV and glucose variability. It is recommended to prioritize TBR targets to reduce hypoglycemic risk in older individuals and address TBR independently of TIR.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Georges Jabbour, Nicola Luigi Bragazzi
Summary: This study found that CGM use may be associated with increased vigorous physical activity among youth with T1D, while higher levels of hypoglycemia fear in children were correlated with activity level and episodes of hypoglycemia.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pediatrics
Francesco Vinci, Giuseppe d'Annunzio, Flavia Napoli, Marta Bassi, Carolina Montobbio, Giulia Ferrando, Nicola Minuto
Summary: Continuous glucose monitoring (CGM) can play a crucial role in detecting potential adrenal insufficiency in patients with type 1 diabetes, especially when recurrent hypoglycemic trends are observed. Addison's disease, a rare autoimmune condition, may present initially asymptomatic in young patients and progress slowly to acute adrenal crisis if not promptly recognized. Regular evaluation of CGM data can help to identify underlying conditions like Addison's disease in type 1 diabetes patients.
Article
Biochemistry & Molecular Biology
Valeria Calcaterra, Pietro Bosoni, Lucia Sacchi, Gian Vincenzo Zuccotti, Savina Mannarino, Riccardo Bellazzi, Cristiana Larizza
Summary: Combining blood glucose and heart rate measurements, this study investigated heart rate changes related to nocturnal hypoglycemia episodes in pediatric patients with type 1 diabetes. The results showed that specific heart rate patterns during hypoglycemia could improve hypoglycemia detection and prevention of fatal events.
Article
Medicine, General & Internal
C. Liu, Q. Meng, C. Zu, R. Li, S. Yang, P. He, H. Li, Y. Y. Zhang, C. Zhou, M. Liu, Z. Ye, Q. Wu, Y. J. Zhang, X. Gan, X. Qin
Summary: The study found a U-shape association between dietary thiamine intake and new-onset diabetes, with a minimal risk at 0.75-1.10 mg/day.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Erik H. Serne, Ingrid Kirsten van den Berg, Caterina Racca, Daniel H. van Raalte, Mark H. H. Kramer, Maartje de Wit, Frank J. Snoek
Summary: A study compared the effectiveness of immediate continuous glucose monitoring (CGM) and a stepped-care approach for diabetes patients. The results showed that immediate CGM was more effective in reducing the risk of severe hypoglycemic events and achieving glycemic targets.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Lalantha Leelarathna, Mark L. L. Evans, Sankalpa Neupane, Gerry Rayman, Sarah Lumley, Iain Cranston, Parth Narendran, Katharine Barnard-Kelly, Christopher J. J. Sutton, Rachel A. A. Elliott, Vicky P. P. Taxiarchi, Georgios Gkountouras, Matthew Burns, Womba Mubita, Naresh Kanumilli, Maisie Camm, Hood Thabit, Emma G. G. Wilmot
Summary: This study investigated the efficacy of intermittently scanned continuous glucose monitoring in patients with type 1 diabetes. The results showed that compared to traditional fingerstick testing, the use of intermittently scanned continuous glucose monitoring significantly reduced glycated hemoglobin levels and improved blood glucose control.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nutrition & Dietetics
Nadia Kheriji, Wided Boukhalfa, Faten Mahjoub, Meriem Hechmi, Thouraya Dakhlaoui, Mehdi Mrad, Afef Hadj Salah Bahlous, Nadia Ben Amor, Henda Jamoussi, Rym Kefi
Summary: The prevalence of Type 2 diabetes is increasing globally. Genetics and lifestyle, especially diet, play a role in its development. Analyzing the intake of macronutrients and micronutrients in global populations can help understand their impact on glucose homeostasis and disease development.
Article
Endocrinology & Metabolism
Ben Broos, Sara Charleer, Nancy Bolsens, Carolien Moyson, Chantal Mathieu, Pieter Gillard, Christophe De Block
Summary: The study found that diabetes knowledge and health literacy impact glycemic control, with higher diabetes knowledge and health literacy scores associated with improved glycemic control.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Akemi Tokutsu, Yosuke Okada, Keiichi Torimoto, Yoshiya Tanaka
Summary: The study found that HbA1c variability is associated with hypoglycemia, suggesting the need to evaluate low blood sugar in patients with high HbA1c variability and reconsider their treatment regimen.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Rose A. Gubitosi-Klug, Barbara H. Braffett, Ionut Bebu, Mary L. Johnson, Kaleigh Farrell, David Kenny, Victoria R. Trapani, Lynne Meadema-Mayer, Elsayed Z. Soliman, Rodica Pop-Busui, John M. Lachin, Richard M. Bergenstal, William Tamborlane
Summary: This study evaluated continuous glucose monitoring data in adults with type 1 diabetes and found frequent nocturnal hypoglycemia and daytime hyperglycemia. The use of insulin pumps and continuous glucose monitoring reduced the occurrence of hypoglycemia and hyperglycemia.
Article
Endocrinology & Metabolism
Parizad Avari, Alice O'Regan, Lukana Preechasuk, Nick Oliver, Rochan Agha-Jaffar
Summary: Retrospective analysis of data from 20 women with type 1 diabetes during peripartum period showed the feasibility and accuracy of continuous glucose monitoring (CGM) adjustment of variable rate intravenous insulin infusion (VRIII). Further prospective studies are needed to confirm the safety and potential efficacy of CGM-based insulin titration.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Bingkun Huang, Qiuhui Jiang, Ting Wu, Qingbao Shen, Wengui Wang, Shoubi Wang, Yinxiang Huang, Shunhua Wang, Peiying Huang, Mingzhu Lin, Xiulin Shi, Xuejun Li
Summary: This study investigated the prevalence and influencing factors of asymptomatic hypoglycemia in outpatients with type 2 diabetes. The results showed that younger age, lower hemoglobin A1c levels, and higher systolic blood pressure levels were associated with an increased risk of asymptomatic hypoglycemia. The study also found that male sex and Dipeptidylpeptidase-4 inhibitors treatment were associated with a lower risk of more severe asymptomatic hypoglycemia.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Endocrinology & Metabolism
Laya Ekhlaspour, Dan Raghinaru, Gregory P. Forlenza, Elvira Isganaitis, Yogish C. Kudva, David W. Lam, Camilla Levister, Grenye O'Malley, Mei Mei Church, John W. Lum, Bruce Buckingham, Sue A. Brown
Summary: The study investigated the potential benefits of automated insulin delivery among individuals with type 1 diabetes, regardless of their baseline device use or CGM status. The results showed that the closed-loop control system significantly improved glycemic outcomes in both insulin pump and MDI users with or without CGM.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Moshe Phillip, Revital Nimri, Richard M. Bergenstal, Katharine Barnard-Kelly, Thomas Danne, Roman Hovorka, Boris P. Kovatchev, Laurel H. Messer, Christopher G. Parkin, Louise Ambler-Osborn, Stephanie A. Amiel, Lia Bally, Roy W. Beck, Sarah Biester, Torben Biester, Julia E. Blanchette, Emanuele Bosi, Charlotte K. Boughton, Marc D. Breton, Sue A. Brown, Bruce A. Buckingham, Albert Cai, Anders L. Carlson, Jessica R. Castle, Pratik Choudhary, Kelly L. Close, Claudio Cobelli, Amy B. Criego, Elizabeth Davis, Carine de Beaufort, Martin de Bock, Daniel J. DeSalvo, J. Hans DeVries, Klemen Dovc, Francis J. Doyle, Laya Ekhlaspour, Naama Fisch Shvalb, Gregory P. Forlenza, Geraldine Gallen, Satish K. Garg, Dana C. Gershenoff, Linda A. Gonder-Frederick, Ahmad Haidar, Sara Hartnell, Lutz Heinemann, Simon Heller, Irl B. Hirsch, Korey K. Hood, Diana Isaacs, David C. Klonoff, Olga Kordonouri, Aaron Kowalski, Lori Laffel, Julia Lawton, Rayhan A. Lal, Lalantha Leelarathna, David M. Maahs, Helen R. Murphy, Kirsten Norgaard, David O'Neal, Sean Oser, Tamara Oser, Eric Renard, Michael C. Riddell, David Rodbard, Steven J. Russell, Desmond A. Schatz, Viral N. Shah, Jennifer L. Sherr, Gregg D. Simonson, R. Paul Wadwa, Candice Ward, Stuart A. Weinzimer, Emma G. Wilmot, Tadej Battelino
Summary: The global prevalence of diabetes continues to be a challenge and the advances in automated insulin delivery (AID) technologies have shown to be safe and effective in helping patients achieve their glycemic goals. However, there is a lack of guidance for clinicians on using AID systems in clinical settings.
Article
Endocrinology & Metabolism
Soohee Cho, Tim Vigers, Laura Pyle, Anna Franklin, Jenna Sopfe, Frankie Jeney, Gregory Forlenza
Summary: Malglycemia in pediatric, adolescent, and young adult patients undergoing hematopoietic stem cell transplant is associated with increased infection and mortality rate. Most patients in this study had suboptimal glycemic control in the peri-HSCT period. Further research is needed to develop screening and treatment strategies to improve glycemic control and clinical outcomes.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Jenna Demedis, Sharon Scarbro, Krithika Suresh, Kelly Maloney, Gregory P. Forlenza
Summary: Transient hyperglycemia during induction chemotherapy in patients with acute lymphoblastic leukemia (ALL) is associated with increased morbidity and mortality. Glucocorticoids, asparaginase, and stress are proposed causal factors. This study aimed to characterize glycemic control throughout ALL therapy and evaluate risk factors and outcomes associated with increased mean glucose and glucose variability during induction chemotherapy. Retrospective review of pediatric/young adult patients treated for ALL from 2010 to 2014 identified high mean glucose levels during induction, pretreatment, delayed intensification, and maintenance cycles. Factors such as Down syndrome, age, and overweight/obesity were associated with higher mean glucose or glucose variability during induction. However, these glycemic measures were not associated with increased risk of infection, relapse, or death.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Daria Igudesman, Jamie Crandell, Karen D. Corbin, Dessi P. Zaharieva, Ananta Addala, Joan M. Thomas, Cynthia M. Bulik, Brian W. Pence, Richard E. Pratley, Michael R. Kosorok, David M. Maahs, Ian M. Carroll, Elizabeth J. Mayer-Davis
Summary: This study aimed to evaluate the association between disordered eating and gut microbiota-derived short chain fatty acids (SCFA) in individuals with type 1 diabetes. The results showed that disordered eating and insulin restriction were associated with a reduced abundance of gut microbes that produce SCFA.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Endocrinology & Metabolism
Tadej Battelino, Charles M. Alexander, Stephanie A. Amiel, Guillermo Arreaza-Rubin, Roy W. Beck, Richard M. Bergenstal, Bruce A. Buckingham, James Carroll, Antonio Ceriello, Elaine Chow, Pratik Choudhary, Kelly Close, Thomas Danne, Sanjoy Dutta, Robert Gabbay, Satish Garg, Julie Heverly, Irl B. Hirsch, Tina Kader, Julia Kenney, Boris Kovatchev, Lori Laffel, David Maahs, Chantal Mathieu, Didac Mauricio, Revital Nimri, Rimei Nishimura, Mauro Scharf, Stefano Del Prato, Eric Renard, Julio Rosenstock, Banshi Saboo, Kohjiro Ueki, Guillermo E. Umpierrez, Stuart A. Weinzimer, Moshe Phillip
Summary: Randomised controlled trials and other prospective clinical studies have traditionally used HbA1c as a measure of average blood glucose levels, but with the increasing use of continuous glucose monitoring (CGM), CGM-derived metrics are being considered for use in these studies. This consensus statement recommends the use of CGM data in clinical studies to provide additional clinical information beyond HbA1c. Standardizing the collection and reporting of CGM data in clinical trials can enhance the interpretability of the data and inform therapeutic decisions related to hypoglycaemia, postprandial hyperglycaemia, and glucose variability.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Eugene M. Lewit, Lauren E. Figg, Ananta Addala, Stephanie L. Filipp, Rayhan Lal, Matthew J. Gurka, Jill Boylston Herndon, Michael J. Haller, David M. L. Maahs, Ashby F. J. Walker
Summary: Project ECHO Diabetes is a tele-education learning model that aims to improve care for marginalized communities with diabetes. It utilizes expert hub teams and primary care providers to provide additional diabetes support. The costs of operating a Project ECHO Diabetes hub, including personnel and diabetes support coach costs, were estimated.
Article
Endocrinology & Metabolism
Dessi P. Zaharieva, Ransalu Senanayake, Conner Brown, Brendan Watkins, Glenn Loving, Priya Prahalad, Johannes O. Ferstad, Carlos Guestrin, Emily B. Fox, David M. Maahs, David Scheinker
Summary: Stanford University has utilized algorithm-enabled patient prioritization and remote patient monitoring to improve clinical workflows and glucose control in youth with type 1 diabetes. The care model integrates continuous glucose monitoring data and aims to incorporate exercise data to better manage patients' needs and help healthcare professionals make informed decisions. Regular exercise is crucial for cardiovascular fitness and overall well-being, but can impact blood glucose levels. By integrating physical activity metrics, the model aims to identify whether patients are meeting exercise guidelines and provide clinically relevant information.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Laurel H. Messer, Paul F. Cook, Stephen Voida, Casey Fiesler, Emily Fivekiller, Chinmay Agrawal, Tian Xu, Gregory P. Forlenza, Sriram Sankaranarayanan
Summary: The study aims to assess the situational awareness of adolescents regarding glucose control and their engagement with the Control-IQ system. The results show that situational awareness is an independent predictor of time in range, with proactive engagement predicting better control and reactive engagement predicting lower control.
PEDIATRIC DIABETES
(2023)
Article
Medicine, General & Internal
Ananta Addala, Victoria Ding, Dessi P. Zaharieva, Franziska K. Bishop, Alyce S. Adams, Abby C. King, Ramesh Johari, David Scheinker, Korey K. Hood, Manisha Desai, David M. Maahs, Priya Prahalad
Summary: Continuous glucose monitoring (CGM) is associated with improved HbA(1c) in youths with type 1 diabetes, but minority groups and those with public insurance face more barriers to access. Early initiation of CGM can reduce disparities and improve outcomes.
Review
Endocrinology & Metabolism
Grazia Aleppo, Irl B. Hirsch, Christopher G. Parkin, Janet McGill, Rodolfo Galindo, Davida F. Kruger, Carol J. Levy, Gregory P. Forlenza, Guillermo E. Umpierrez, George Grunberger, Richard M. Bergenstal
Summary: Numerous studies have shown the clinical benefits of continuous glucose monitoring (CGM) in individuals with type 1 and type 2 diabetes who receive intensive insulin treatment. Despite the increasing evidence, insurance coverage for CGM is limited or nonexistent for individuals treated with less-intensive insulin therapy or noninsulin medications.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Korey K. Hood, William H. Polonsky, Sarah A. MacLeish, Carol J. Levy, Gregory P. Forlenza, Amy B. Criego, Bruce A. Buckingham, Bruce W. Bode, David W. Hansen, Jennifer L. Sherr, Sue A. Brown, Daniel J. DeSalvo, Sanjeev N. Mehta, Lori M. Laffel, Anuj Bhargava, Lauren M. Huyett, Todd E. Vienneau, Trang T. Ly
Summary: The study evaluated the impact of a tubeless insulin delivery system on psychosocial outcomes in children and adolescents with type 1 diabetes. The results showed significant improvements in diabetes-related distress, insulin delivery satisfaction, and system usability after using the system. Caregivers of children also experienced improved well-being, confidence in managing hypoglycemia, and sleep quality.
PEDIATRIC DIABETES
(2023)
Article
Medicine, General & Internal
Ananta Addala, Melanie Hechavarria, Lauren Figg, Xanadu Roque, Stephanie L. Filipp, Claudia Anez-Zabala, Rayhan Lal, Matthew J. Gurka, Michael J. Haller, David M. Maahs, Ashby F. Walker
Summary: The study aims to explore the recruitment and retention issues of under-represented populations in diabetes research and provides some solutions. The findings suggest that collaborations with trusted healthcare centers in local communities can effectively improve recruitment and retention rates. In addition, flexible consent processes, adequate funding, and analogue communication methods are also helpful in addressing recruitment and retention barriers.
Article
Endocrinology & Metabolism
Anna Casu, Yury O. Nunez O. Lopez, Gongxin Yu, Christopher Clifford, Anika Bilal, Alejandra M. Petrilli, Heather Cornnell, Elvis Alvarez Carnero, Ananya Bhatheja, Karen D. Corbin, Anton Iliuk, David M. Maahs, Richard E. Pratley
Summary: This pilot study aimed to characterize the proteomic and phosphoproteomic landscape of circulating extracellular vesicle (EV)-enriched preparations in individuals with type 1 diabetes (T1D) and healthy controls. The study found differential abundances of proteins and phosphoproteins in participants with T1D compared to controls, including some well-known EV proteins. The analysis also revealed protein modules associated with pancreas size, inflammation, and immune response.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Joseph E. Biskupiak, Mafalda Ramos, Carol J. Levy, Greg Forlenza, Colin Hopley, Jennifer Boyd, Dan Swift, Mark Lamotte, Diana Brixner
Summary: A tubeless, on-body automated insulin delivery system has shown to improve glycated hemoglobin A1c levels and blood glucose range in both adults and children with type 1 diabetes. Cost-effectiveness analyses suggest that this system is a cost-effective treatment option for type 1 diabetes from a US payer's perspective.
JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY
(2023)