19 F NMR‐Based Fragment Screening for 14 Different Biologically Active RNAs and 10 DNA and Protein Counter‐Screens

Measuring RNA–Ligand Interactions with Microscale Thermophoresis

(2018) Michelle H. Moon et al.   BIOCHEMISTRY

The domain architecture of the PtkA, the first tyrosine kinase fromMycobacterium tuberculosisdiffers from the conventional kinase architecture.

(2018) Anna Niesteruk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current NMR Techniques for Structure-Based Drug Discovery

(2018) Toshihiko Sugiki et al.   MOLECULES

Principles for targeting RNA with drug-like small molecules

(2018) Katherine Deigan Warner et al.   NATURE REVIEWS DRUG DISCOVERY

High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble

(2018) Laura R. Ganser et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes

(2018) Amparo Garcia-Lopez et al.   Nature Communications

High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble

(2018) Laura R. Ganser et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting RNA in mammalian systems with small molecules

(2018) Anita Donlic et al.   Wiley Interdisciplinary Reviews-RNA

Medicinal chemistry of acridine and its analogues

(2018) Parteek Prasher et al.   MedChemComm

Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding

(2018) Wenting Liu et al.   Nature Communications

Combined smFRET and NMR analysis of riboswitch structural dynamics

(2018) Jasleen Kaur Bains et al.   METHODS

Molecular dynamics simulations and novel drug discovery

(2017) Xuewei Liu et al.   Expert Opinion on Drug Discovery

Evaluation of 15N-detected H–N correlation experiments on increasingly large RNAs

(2017) Robbin Schnieders et al.   JOURNAL OF BIOMOLECULAR NMR

NMR Structural Profiling of Transcriptional Intermediates Reveals Riboswitch Regulation by Metastable RNA Conformations

(2017) Christina Helmling et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

(2017) J. R. Stagno et al.   NATURE

Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR

(2017) Neeraj N. Patwardhan et al.   MedChemComm

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

(2017) Manaswini Sivaramakrishnan et al.   Nature Communications

Discovery of Inhibitors of MicroRNA-21 Processing Using Small Molecule Microarrays

(2016) Colleen M. Connelly et al.   ACS Chemical Biology

Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs

(2016) Stephanie Heinzlmeir et al.   ACS Chemical Biology

Non-coding RNAs as drug targets

(2016) Masayuki Matsui et al.   NATURE REVIEWS DRUG DISCOVERY

Studying a Drug-like, RNA-Focused Small Molecule Library Identifies Compounds That Inhibit RNA Toxicity in Myotonic Dystrophy

(2015) Suzanne G. Rzuczek et al.   ACS Chemical Biology

May the Best Molecule Win: Competition ESI Mass Spectrometry

(2015) Sarah Laughlin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapid NMR screening of RNA secondary structure and binding

(2015) Christina Helmling et al.   JOURNAL OF BIOMOLECULAR NMR

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

(2015) James Palacino et al.   Nature Chemical Biology

Global RNA Fold and Molecular Recognition for a pfl Riboswitch Bound to ZMP, a Master Regulator of One-Carbon Metabolism

(2015) Aiming Ren et al.   STRUCTURE

Structural Basis for Molecular Discrimination by a 3′,3′-cGAMP Sensing Riboswitch

(2015) Aiming Ren et al.   Cell Reports

Discovery of Selective Ligands for Telomeric RNA G-quadruplexes (TERRA) through 19F-NMR Based Fragment Screening

(2014) Miguel Garavís et al.   ACS Chemical Biology

Resonance assignment of the ribosome binding domain of E. coli ribosomal protein S1

(2014) Pierre Giraud et al.   Biomolecular NMR Assignments

Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR

(2014) Mirco Zeiger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MicroScale Thermophoresis: Interaction analysis and beyond

(2014) Moran Jerabek-Willemsen et al.   JOURNAL OF MOLECULAR STRUCTURE

Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

(2014) Joanna Sztuba-Solinska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dramatic Improvement of Crystals of Large RNAs by Cation Replacement and Dehydration

(2014) Jinwei Zhang et al.   STRUCTURE

Three-state mechanism couples ligand and temperature sensing in riboswitches

(2013) Anke Reining et al.   NATURE

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Rationally Designed Small Molecules Targeting the RNA That Causes Myotonic Dystrophy Type 1 Are Potently Bioactive

(2012) Jessica L. Childs-Disney et al.   ACS Chemical Biology

Screening Strategies to Identify New Antibiotics

(2012) Mark S. Butler et al.   CURRENT DRUG TARGETS

The Apo-structure of the Low Molecular Weight Protein-tyrosine Phosphatase A (MptpA) fromMycobacterium tuberculosisAllows for Better Target-specific Drug Development

(2012) Tanja Stehle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Application of high-resolution ESI and MALDI mass spectrometry to metabolite profiling of small interfering RNA duplex

(2012) Hisao Shimizu et al.   JOURNAL OF MASS SPECTROMETRY

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation

(2012) D. Wei et al.   NUCLEIC ACIDS RESEARCH

Development of a high-throughput G4-FID assay for screening and evaluation of small molecules binding quadruplex nucleic acid structures

(2011) Eric Largy et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Ligand-Assisted Complex Formation of Two DNA Hairpin Loops

(2011) Changfeng Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Topological constraints: using RNA secondary structure to model 3D conformation, folding pathways, and dynamic adaptation

(2011) Maximillian H Bailor et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

(2011) Jixun Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble

(2011) Andrew C Stelzer et al.   Nature Chemical Biology

Widespread Genetic Switches and Toxicity Resistance Proteins for Fluoride

(2011) J. L. Baker et al.   SCIENCE

A modified fluorescent intercalator displacement assay for RNA ligand discovery

(2010) Papa Nii Asare-Okai et al.   ANALYTICAL BIOCHEMISTRY

Structural and Biochemical Determinants of Ligand Binding by the c-di-GMP Riboswitch,

(2010) Kathryn D. Smith et al.   BIOCHEMISTRY

Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors

(2010) Yu-Sen Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Roseoflavin is a natural antibacterial compound that binds to FMN riboswitches and regulates gene expression

(2010) Elaine R. Lee et al.   RNA Biology

Thermodynamic characterization of naturally occurring RNA tetraloops

(2010) J. P. Sheehy et al.   RNA

Regulatory RNAs in Bacteria

(2009) Lauren S. Waters et al.   CELL

Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch

(2009) Nadia Kulshina et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of ligand binding by a c-di-GMP riboswitch

(2009) Kathryn D Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Constructing RNA dynamical ensembles by combining MD and motionally decoupled NMR RDCs: new insights into RNA dynamics and adaptive ligand recognition

(2009) Aaron T. Frank et al.   NUCLEIC ACIDS RESEARCH

Probing the relationship between Gram-negative and Gram-positive S1 proteins by sequence analysis

(2009) Philippe Salah et al.   NUCLEIC ACIDS RESEARCH

A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding

(2009) J. F. Arambula et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins

(2008) Cheol-Min Park et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity†

(2008) Steven Howard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Perspectives on NMR in drug discovery: a technique comes of age

(2008) Maurizio Pellecchia et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

(2008) J. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

(2007) Paul A. Brough et al.   JOURNAL OF MEDICINAL CHEMISTRY