Formyl peptide receptor type 2 agonists to kick‐start resolution pharmacology

Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation

(2020) Simon McArthur et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis of ligand binding modes at the human formyl peptide receptor 2

(2020) Tong Chen et al.   Nature Communications

The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer

(2020) Weiwei Liang et al.   Frontiers in Endocrinology

Dual modulation of formyl peptide receptor 2 by aspirin‐triggered lipoxin contributes to its anti‐inflammatory activity

(2020) Yunjun Ge et al.   FASEB JOURNAL

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure

(2020) Yoshikazu Asahina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization

(2019) Xiaofang Chen et al.   DIABETES

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair

(2019) Bartolo Ferraro et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

(2019) Stephen P H Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lipoxins Regulate the Early Growth Response–1 Network and Reverse Diabetic Kidney Disease

(2018) Eoin P. Brennan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis

(2018) E. P. Brennan et al.   DIABETES

Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)

(2018) Monica de Gaetano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications

(2018) Monica de Gaetano et al.   Frontiers in Pharmacology

The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1

(2017) Kátia M. Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune resolution mechanisms in inflammatory arthritis

(2017) Mauro Perretti et al.   Nature Reviews Rheumatology

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

(2017) Cheng Xue Qin et al.   Nature Communications

Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway

(2017) Giorgio Mottola et al.   PLoS One

Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949

(2016) Anna K. Stalder et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition

(2016) Benedict Wu et al.   FASEB JOURNAL

Formyl Peptide Receptor 2 Is Involved in Cardiac Repair After Myocardial Infarction Through Mobilization of Circulating Angiogenic Cells

(2016) Soon Chul Heo et al.   STEM CELLS

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

(2015) Emma Börgeson et al.   Cell Metabolism

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice

(2014) Irene Locatelli et al.   HEPATOLOGY

FPR2/ALXR Agonists and the Resolution of Inflammation

(2014) Olivier Corminboeuf et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis

(2014) Thomas Gobbetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

(2013) Rémi Mounier et al.   Cell Metabolism

Cutting Edge: A Critical Role for the G Protein-Coupled Receptor mFPR2 in Airway Inflammation and Immune Responses

(2010) K. Chen et al.   JOURNAL OF IMMUNOLOGY

Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation

(2010) Neil Dufton et al.   JOURNAL OF IMMUNOLOGY

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS