Article
Chemistry, Physical
Zhaojie Wang, Nuo Yu, Jiulong Zhang, Qian Ren, Maoquan Li, Zhigang Chen
Summary: A hafnium-hemoporfin framework (HfHFs) has been developed as a multifunctional theranostic nanoplatform for synergistic sonodynamic therapy (SDT) and radiation therapy (RT) of deep-seated tumors. The HfHFs show promising results in suppressing deep-seated tumors and can be monitored through CT imaging.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Shuang Liu, Mei Wen, Mengmeng Huang, Haifeng Wang, Zhigang Chen, Nuo Yu
Summary: This study presents the synthesis of nanoscale hematoporphrin-based frameworks with Al3+ ions as metal nodes for enhanced photo-sono therapy of malignant tumors. The AlHFs-PEG exhibits high biocompatibility and can produce more 1O2 species than traditional metal-organic frameworks, inhibiting the growth rate of tumors in mice significantly when exposed to both light and ultrasound. This research provides insights for developing nanoscale frameworks with light metal ions as metal nodes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xiangdan Meng, Sirong Sun, Chenchen Gong, Junyan Yang, Zhou Yang, Xueji Zhang, Haifeng Dong
Summary: In this study, we report the design of a Ti-based metal-organic framework (MIL) and silver nanoparticles (Ag NPs) heterostructure, MIL@Ag. It is found that the introduction of Ag NPs significantly improves the electron transfer efficiency and O2 adsorption capacity of MIL, leading to enhanced reactive oxygen species (ROS) generation for sonodynamic therapy (SDT). Under ultrasound irradiation, the activated electrons and holes from MIL and Ag NPs produce superoxide radicals and hydroxyl radicals, respectively, improving the therapeutic efficiency of SDT. MIL@Ag-PEG-mediated SDT demonstrates effective cancer cell killing and bacterial infection eradication. Thus, MIL@Ag-PEG provides a promising strategy for enhancing SDT performance through rational heterostructure design of sonosensitizers.
Article
Engineering, Environmental
Jiulong Zhang, Chunzi Shi, Fei Shan, Nannan Shi, Wen Ye, Yaoyao Zhuo, Yijun Zhang, Zhiyong Zhang, Yuxin Shi, Chen Peng
Summary: The study utilized biologically modified HMNCs as multifunctional nanoagents for efficient cancer therapy through sonodynamic therapy and photothermal therapy, exhibiting high biocompatibility and biosafety in vivo. HMNCs also showed advantages in tumor imaging and inhibiting tumor growth.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Pai Liu, Tianyue Yang, Yaning Li, Jun Guo, Shulan Li, Hongli Chen, Yi Liu
Summary: Sonodynamic therapy (SDT) is a novel therapeutic method with deep penetration, good cell membrane permeability, and the ability to be exposed to light. However, the hypoxic tumor microenvironment and poor targeting of sonosensitizers limit the treatment efficiency of SDT. Therefore, constructing sonosensitizer-based nanoplatforms is crucial for achieving a more comprehensive therapeutic effect.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Naeimeh Hassanzadeh Goji, Mohammad Ramezani, Amir Sh Saljooghi, Mona Alibolandi
Summary: Metal organic frameworks (MOFs) as hybrid materials possess unique characteristics for biomedical applications, and porphyrin, as an organic linker with interesting photochemical and photophysical properties, has been studied for engineering potent multifunctional porphyrinic metal organic frameworks (PMOFs). This review introduces MOFs and coordination polymers constructed from porphyrinic linkers, with a special focus on those synthesized by meso-tetrakis (4-carboxyphenyl) porphyrin (TCPP), and summarizes the different types of PMOFs and their biomedical applications as diagnostic agents, therapeutic platforms, and drug delivery vehicles.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Lichang Zhong, Tian Yang, Pei Li, Lin Shi, JinYu Lai, Liping Gu
Summary: Hypoxia, a characteristic of cancer, affects the efficacy of chemotherapy and other oxygen-dependent treatments. This study reports a nanotherapeutic based on metal-organic frameworks that can deliver two drugs simultaneously for synergistic sonodynamic therapy and chemotherapy.
FRONTIERS IN MATERIALS
(2022)
Article
Chemistry, Physical
Qian Ren, Nuo Yu, Leyi Wang, Mei Wen, Peng Geng, Qin Jiang, Maoquan Li, Zhigang Chen
Summary: Sonodynamic therapy (SDT) holds great potential in cancer treatment, but faces limitations. This study addresses the limitations by preparing a nanoarchitectonics based on metal-organic frameworks (MOFs) containing platinum (Pt) nanozymes. The results demonstrate that the nanoplatform effectively alleviates tumor hypoxia and enhances the sensitivity of SDT and chemotherapy, leading to remarkable inhibition of tumor growth.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoying Wang, Liyun Zhu, Jianhui Zhou, Lingzhou Zhao, Jingchao Li, Changcun Liu
Summary: This study presents an injectable drug-loaded hybrid hydrogel, AMPS, that enables sonodynamic therapy and chemodyanmic therapy combined action, as well as suppression of tumor metastasis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Jianming Zhao, Jirong Shi, Xiangdan Meng, Chenchen Gong, Peng Wu, Zhou Yang, Haifeng Dong
Summary: Stimuli-responsive nanoplatforms have great potential for delivering drugs to kill cancer cells with high accuracy and minimal invasiveness. In this study, ROS-responsive nanoscale coordination polymers were designed, and the release of drugs was enhanced under ultrasound stimulation. The nanoplatform achieved the synergistic effect of sonodynamic therapy and chemotherapy, and showed good targeting ability to cancer cells.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Yinying Pu, Haohao Yin, Caihong Dong, Huijing Xiang, Wencheng Wu, Bangguo Zhou, Dou Du, Yu Chen, Huixiong Xu
Summary: A sono-controllable and ROS-sensitive nanomedicine, P/M@CasMTH1, has been developed for enhanced sonodynamic therapy by disrupting MTH1 gene in tumor cells, leading to cellular apoptosis and tumor suppression.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Applied
Wenbin Hu, Sanying Wang, Chenyi Jiang, Minbin Zheng, Zhi Bai, Devyani Srivastava, Abhinav Kumar, Jianqiang Liu
Summary: Sonodynamic therapy (SDT) is a new treatment method that combines low-intensity ultrasound with sonosensitizers. Metal-organic frameworks (MOFs) have shown potential as efficient carriers for sono-sensitizers in SDT. This review discusses the use of different types of MOFs as carriers for sono-sensitizers and the latest research progress in enhancing SDT.
Article
Chemistry, Multidisciplinary
Tao Jia, Jiarui Du, Jiani Yang, Yang Li, Tymish Y. Ohulchanskyy, Xikui Fang, Guanying Chen
Summary: Noninvasive sonodynamic therapy (SDT) has potential for brain glioma treatment, but is hindered by challenges such as the hypoxic tumor microenvironment (TME), high levels of ROS scavenger glutathione (GSH), and the inability to visualize glioma in vivo. To address these challenges, researchers fabricated a core-shell heterostructure sonosensitizer that effectively inhibits GSH synthesis and provides precise optical imaging for treatment management and monitoring. The sonosensitizer showed efficient ROS generation and resulted in a significant reduction in glioma volume in experiments.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Yuqin Zeng, Can Zhang, Dou Du, Ya Li, Lu Sun, Yuanyuan Han, Xiaoxiao He, Jianwu Dai, Liyang Shi
Summary: Metal-organic framework (MOF) is a porous biomaterial that can be used as a drug carrier. Researchers have designed an MOF-based hydrogel with self-healing and shear-thinning properties for localized drug delivery. The hydrogel exhibits pH and ATP-responsive drug release characteristics and efficiently kills cancer cells in vitro, showing enhanced tumor growth suppression compared to other drug delivery methods.
ACTA BIOMATERIALIA
(2022)
Review
Pharmacology & Pharmacy
Donghui Liao, Jiefeng Huang, Chenyi Jiang, Luyi Zhou, Mingbin Zheng, Alireza Nezamzadeh-Ejhieh, Na Qi, Chengyu Lu, Jianqiang Liu
Summary: Metal-organic frameworks (MOFs) combined with sonodynamic therapy (SDT) have been introduced as a new and efficient treatment method, with the critical advantage of penetrating deep tissues and concentrating energy on tumor sites. SDT uses a sonosensitizer to generate reactive oxygen species (ROS) under ultrasound, resulting in a more lethal effect on tumors. The fast development of micro/nanotechnology has improved the efficiency of SDT, and MOFs have been widely evaluated for their easy synthesis, high porosity, and biocompatibility.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.