Article
Chemistry, Multidisciplinary
Man-Di Wang, Gan-Tian Lv, Hong-Wei An, Ni-Yuan Zhang, Hao Wang
Summary: This study reports a programmable peptide molecule that enables specific and efficient assembly by binding to targeting receptor proteins. By designing different peptide sequences and receptor bindings, it is possible to promote oligomerization and functional regulation of protein complexes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Environmental
Gaizhen Kuang, Qingfei Zhang, Yunru Yu, Xiaoya Ding, Weijian Sun, Xian Shen, Yuanjin Zhao
Summary: Immunotherapy is important for treating malignant tumors. A sponge-nanofiber Janus scaffold has been developed for tumor postoperative immuno-chemotherapy, containing lyophilization-inactivated cancer cells, immune adjuvant imiquimod, and 5-fluorouracil (5-FU). The scaffold exhibits excellent anti-recurrence and anti-metastasis efficiency in a mouse breast tumor model, making it a promising option for combination therapy after tumor surgery.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Georgia Gomatou, Nikolaos Syrigos, Ioannis A. Vathiotis, Elias A. Kotteas
Summary: Tumor dormancy is a critical stage of cancer development where tumor cells are present but cancer does not progress. It involves both cellular and tumor mass dormancy, which are fundamental in preventing recurrence and maximizing therapeutic benefit.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Rebecca G. Zitnay, Michael R. Herron, Keith R. Carney, Scott Potter, Lyska L. Emerson, Jeffrey A. Weiss, Michelle C. Mendoza
Summary: In this study, the researchers developed a finite element model of lung tissue to investigate the effect of early tumor lesions on respiration-induced strain. The results showed that early tumors amplified the strain experienced in the adjacent alveolar walls, and tumor stiffening further increased the amplitude of the strain. Simulations and experimental measurements also suggested that tumor-adjacent alveolar walls exhibited thickening, indicating cellular response to strain.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Eleonora Tassara, Boaz Orel, Micha Ilan, Dario Cavallo, Andrea Dodero, Maila Castellano, Silvia Vicini, Marco Giovine, Marina Pozzolini
Summary: This study investigates the molecular and chemical-physical properties of collagen extracted from Chondrosia reniformis sponges collected in different seasons to evaluate the potential impact of sea temperature. The results show that collagen fibrils extracted from samples at 17 degrees C have lower lysyl-hydroxylation level, thermal stability, and protein glycosylation level compared to those extracted from samples at 27 degrees C. Membranes made from 17 degrees C fibrils exhibit higher stiffness than those made from 27 degrees C fibrils. The differences in collagen properties are important in guiding the use of the biomaterial.
Article
Biochemistry & Molecular Biology
Guanghui Hou, Tiantian Sun, Junmin Qian, Yaping Zhang, Min Guo, Weijun Xu, Jinlei Wang, Aili Suo
Summary: Hydroxyethyl chitosan (HECS) hydrogels can mimic the structure and composition characteristics of the extracellular matrix in breast tumors, with highly porous structure, stiffness comparable to breast tissue, and great potential for constructing breast tumor models as a biomimetic ECM.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Yaoyi Xiong, Lingao Ju, Lushun Yuan, Liang Chen, Gang Wang, Huimin Xu, Tianchen Peng, Yongwen Luo, Yu Xiao, Xinghuan Wang
Summary: This study identified an oncogene KNSTRN that promotes tumorigenesis and gemcitabine resistance by activating AKT phosphorylation. KNSTRN interacts with PTEN and AKT at the cell membrane, facilitating AKT movement to PIP3 for activation. The findings suggest that KNSTRN may serve as a potential therapeutic target for bladder cancer.
Article
Genetics & Heredity
Xiaomeng Sun, Huilin Xu, Gang Liu, Jiani Chen, Jinrong Xu, Mingming Li, Lei Liu
Summary: By analyzing 1370 NMIBC transcript data from nine public databases, this study identified nine tumor-infiltrating marker cells highly related to the survival of NMIBC, and established an immune-prognostic model to distinguish high-risk and low-risk progression groups. The study suggests that evaluating tumor progression should consider various components in the tumor immune microenvironment instead of a single marker.
FRONTIERS IN GENETICS
(2022)
Review
Immunology
Maoyu Wang, Zhensheng Zhang, Zhizhou Li, Yasheng Zhu, Chuanliang Xu
Summary: With the increasing incidence of bladder cancer, there has been a focus on understanding its mechanism and developing new treatment strategies. The introduction of immune checkpoint inhibitor-based immunotherapy has shown great promise in treating advanced bladder cancer and improving patients' survival. The ubiquitin-proteasome system, which plays a crucial role in various biological processes, has been found to be involved in bladder cancer. This review summarizes the recent progress in understanding the role of E3 ubiquitin ligases and deubiquitinases in bladder cancer tumorigenesis and highlights their implications for bladder cancer immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jae-Won Cho, Hyo Sup Shim, Chang Young Lee, Seong Yong Park, Min Hee Hong, Insuk Lee, Hye Ryun Kim
Summary: This study performed a genome-wide analysis of DNA methylation in tumor and normal tissues from LUSC patients, and found that methylation of enhancer regions plays a more important role in the epigenetic regulation of tumorigenesis and immune infiltration in LUSC.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Medicine, Research & Experimental
Shihui Guo, Xiao Zhu, Ziyuan Huang, Chuzhong Wei, Jiaao Yu, Lin Zhang, Jinghua Feng, Mingdong Li, Zesong Li
Summary: Genetic instability can be caused by external factors and is related to intracellular damage. Research has shown the connection between genomic stability and tumors, which is a crucial factor in tumor treatment. The mechanisms of genomic stability and tumorigenesis development are complex, but researchers have been making progress in these areas. This review introduces various aspects related to genomic stability, tumor development drivers, characteristics of tumor cells, tumor metastasis, and tumor treatment. Immunotherapy plays a significant role in tumor treatment as it can effectively inhibit tumor spread and eliminate tumor cells. Advances in tumorigenesis development studies and discoveries in tumor metastasis provide new therapeutic techniques that can prevent tumor spread and improve the cure rate of tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Juan Zhang, Wenjing Zhang, Mengsi Yang, Weiwei Zhu, Ming Li, Ao Liang, Hui Zhang, Ti Fang, Xian-En Zhang, Feng Li
Summary: This study explored the impact of tumor progression stages on the targeting efficiency of PEGylated viral nanoparticles using a colorectal cancer model. The results showed a decrease in tumor targeting efficiency with tumor progression.
Article
Cell Biology
Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang, Jinjian Yang
Summary: The study revealed that exosomes released by bladder cancer cells can promote the immunosuppressive polarization of macrophages, facilitating tumor growth. This process is mediated by down-regulation of PTEN and activation of AKT/STAT3/6 signaling. Inhibiting the generation or secretion of exosomes can suppress the immunosuppressive transformation of macrophages, thereby inhibiting tumor growth.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Engineering, Biomedical
Xu Huang, Lei Ding, Xingkai Liu, Rongsheng Tong, Jianxun Ding, Zhiyong Qian, Lulu Cai, Ping Zhang, Di Li
Summary: Pancreatic cancer is a deadly malignancy worldwide due to its insidious symptoms, early metastasis, and poor responses to treatment. Researchers are focusing on the tumor microenvironment as a key factor in treatment effectiveness and prognosis. Biomaterials are being developed to target components of the TME to inhibit cancer growth and metastasis.
Review
Cell Biology
Fajuan Cheng, Bin Zheng, Shubin Si, Jianwei Wang, Guiting Zhao, Zhongshun Yao, Zhihong Niu, Wei He
Summary: Bladder cancer (BCa) is the most common malignancy of the urinary system. CircRNAs, a subtype of non-coding RNAs, play a crucial role in physiological and developmental processes. Dysregulated circRNAs associated with BCa contribute to abnormalities in biological, genetic, and epigenetic information.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Urology & Nephrology
Xinyang Liao, Shi Qiu, Yige Bao, Wanyu Wang, Lu Yang, Qiang Wei
WORLD JOURNAL OF UROLOGY
(2019)
Review
Urology & Nephrology
Xiang Tu, Tiancong Chang, Ling Nie, Shi Qiu, He Xu, Yin Huang, Yige Bao, Zhenhua Liu, Lu Yang, Qiang Wei
UROLOGIA INTERNATIONALIS
(2019)
Article
Urology & Nephrology
Thomas Tailly, Brandon R. Nadeau, Philippe D. Violette, Yige Bao, Justin Amann, Linda Nott, John D. Denstedt, Hassan Razvi
JOURNAL OF ENDOUROLOGY
(2020)
Article
Urology & Nephrology
Xiang Tu, Zhenhua Liu, Chichen Zhang, Tiancong Chang, He Xu, Yige Bao, Jiakun Li, Kun Jin, Qiming Yuan, Shi Qiu, Lu Yang, Qiang Wei
UROLOGIA INTERNATIONALIS
(2020)
Article
Oncology
Xingyuan Wang, Zeyu Chen, Shi Qiu, Dehong Cao, Kun Jin, Jin Li, Bo Chen, Yin Huang, Yige Bao, Liangren Liu, Qiang Wei
CANCER MANAGEMENT AND RESEARCH
(2020)
Review
Oncology
Xiang Tu, Chichen Zhang, Zhenhua Liu, Guohua Shen, Xiaoai Wu, Ling Nie, Tiancong Chang, He Xu, Yige Bao, Lu Yang, Qiang Wei
FRONTIERS IN ONCOLOGY
(2020)
Letter
Urology & Nephrology
Yi Sun, Fengxiang Sun, Qiang Wei, Jin Huang, Ruiqi Duan
Review
Chemistry, Medicinal
Jinjiang Jiang, Bo Chen, Bo Tang, Qiang Wei
Summary: Selenium plays a crucial role in prostate cancer research, involving prevention, development, and treatment. It has shown promise in combinatorial therapy and is associated with various cellular processes. Selenium holds potential as a trace mineral for prostate cancer prevention, development, treatment, and exploration of novel agents.
Article
Chemistry, Multidisciplinary
Ping Tan, Weihua Zhuang, Shufen Li, Jiapeng Zhang, Hang Xu, Lu Yang, Yanbiao Liao, Mao Chen, Qiang Wei
Summary: A one-step synthesized LD specific fluorescent probe TTIE is designed and synthesized for LD specific image-guided photodynamic therapy with high specificity, good photostability and great capacity in generating cytotoxic reactive oxygen species (ROS) under low powered white light irradiation in human clear cell renal cell carcinoma primary cells and tissues.
CHEMICAL COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Yige Bao, Xiang Tu, Qiang Wei
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2020)
Review
Urology & Nephrology
Shi Qiu, Siwei Bi, Tianhai Lin, Zhuheng Wu, Qi'an Jiang, Jiwen Geng, Liangren Liu, Yige Bao, Xiang Tu, Mingjing He, Lu Yang, Qiang Wei
ASIAN JOURNAL OF UROLOGY
(2019)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.