Re-purposing Chloroquine for Glioblastoma: Potential Merits and Confounding Variables

GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis

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NF-κB Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance

(2017) Seungwon Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Study protocol of a phase IB/II clinical trial of metformin and chloroquine in patients with IDH1 -mutated or IDH2 -mutated solid tumours

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Oxidative stress, mitochondrial abnormalities and antioxidant defense in Ataxia-telangiectasia, Bloom syndrome and Nijmegen breakage syndrome

(2017) Mateusz Maciejczyk et al.   Redox Biology

Chloroquine, an autophagy inhibitor, potentiates the radiosensitivity of glioma initiating cells by inhibiting autophagy and activating apoptosis

(2016) Hongxing Ye et al.   BMC Neurology

The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair

(2016) Diana H. Liang et al.   CANCER LETTERS

Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells

(2016) M A King et al.   ONCOGENE

Effects of primaquine and chloroquine on oxidative stress parameters in rats

(2015) FRANCIANNE GIOVANELLA et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells

(2015) Seung Woo Lee et al.   CANCER LETTERS

Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells

(2015) S. U. Ahmed et al.   CANCER RESEARCH

Impact of Autophagy Inhibition at Different Stages on Cytotoxic Effect of Autophagy Inducer in Glioblastoma Cells

(2015) Chenguang Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

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(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Impact of nuclear factor erythroid-derived 2–like 2 and p62/sequestosome expression on prognosis of patients with gliomas

(2015) Mingfei Zhao et al.   HUMAN PATHOLOGY

Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases

(2015) M. A. A. Al-Bari   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nuclear factor-κB in glioblastoma: insights into regulators and targeted therapy

(2015) Kirk E. Cahill et al.   NEURO-ONCOLOGY

Loss of autophagy causes a synthetic lethal deficiency in DNA repair

(2015) Emma Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

(2015) Christina H. Eng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner

(2015) Sung-Hak Kim et al.   Stem Cell Reports

How to teach an old dog new tricks: Autophagy-independent action of chloroquine on the tumor vasculature

(2014) Hannelore Maes et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

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Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Chloroquine potentiates temozolomide cytotoxicity by inhibiting mitochondrial autophagy in glioma cells

(2014) Yusuke S. Hori et al.   JOURNAL OF NEURO-ONCOLOGY

EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma

(2014) Michael Weller et al.   LANCET ONCOLOGY

Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy

(2014) Encouse B. Golden et al.   Neurosurgical Focus

Hominoid-specific enzyme GLUD2 promotes growth ofIDH1R132Hglioma

(2014) Ruihuan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FET-PET-based reirradiation and chloroquine in patients with recurrent glioblastoma

(2014) Angelika Bilger et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging

(2013) Valentina Gambino et al.   AGING CELL

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

(2013) T. Kimura et al.   CANCER RESEARCH

Chloroquine: Modes of action of an undervalued drug

(2013) Rodolfo Thomé et al.   IMMUNOLOGY LETTERS

Molecular neuro-oncology in clinical practice: a new horizon

(2013) Michael Weller et al.   LANCET ONCOLOGY

EGFR overexpressing cells and tumors are dependent on autophagy for growth and survival

(2013) Barry Jutten et al.   RADIOTHERAPY AND ONCOLOGY

The ATM signaling network in development and disease

(2013) Travis H. Stracker et al.   Frontiers in Genetics

The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosisviamitochondrial-lysosomal cross-talk

(2012) Christian Seitz et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy and cancer - issues we need to digest

(2012) E. Y. Liu et al.   JOURNAL OF CELL SCIENCE

Chloroquine or Chloroquine-PI3K/Akt Pathway Inhibitor Combinations Strongly Promote γ-Irradiation-Induced Cell Death in Primary Stem-Like Glioma Cells

(2012) Elke Firat et al.   PLoS One

Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor

(2011) Yoko Hirata et al.   JOURNAL OF NEUROCHEMISTRY

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

(2011) E. L. Kim et al.   NEURO-ONCOLOGY

Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

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The induction of autophagy by γ-radiation contributes to the radioresistance of glioma stem cells

(2009) Stephanie L. Lomonaco et al.   INTERNATIONAL JOURNAL OF CANCER

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection

(2008) Theophilus S. Vijaykumar et al.   VIROLOGY