Review
Biochemistry & Molecular Biology
Anwarul Hasan, Bilal Ahamad Paray, Arif Hussain, Fikry Ali Qadir, Farnoosh Attar, Falah Mohammad Aziz, Majid Sharifi, Hossein Derakhshankhah, Behnam Rasti, Masoumeh Mehrabi, Koorosh Shahpasand, Ali Akbar Saboury, Mojtaba Falahati
Summary: This review discusses the interactions between the novel coronavirus SARS-CoV-2 and human cells, highlighting the role of important receptors like ACE-2 and furin in the virus invasion. It explores the potential inhibitory effects of compounds on the virus, as well as future prospects for drug development.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Medicine, General & Internal
Mahdie Rahban, Agata Stanek, Amirreza Hooshmand, Yasaman Khamineh, Salma Ahi, Syed Naqui Kazim, Faizan Ahmad, Vladimir Muronetz, Mohamed Samy Abousenna, Samaneh Zolghadri, Ali A. Saboury
Summary: The gastrointestinal tract plays a crucial role in SARS-CoV-2 infection due to the overexpression of ACE2 cell receptors, which increases intestinal permeability to pathogens. Unlike liver cells, the gut has lower expression of ACE2, reducing the likelihood of liver infection by SARS-CoV-2. Additionally, there is an interconnected relationship between the lungs, brain, and gastrointestinal tract during severe COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Urology & Nephrology
Jordana B. Cohen, Andrew M. South, Hossam A. Shaltout, Matthew R. Sinclair, Matthew A. Sparks
Summary: During the early months of the COVID-19 pandemic, controversy arose over the hypothesis that pharmacologic inhibitors of the renin-angiotensin system (RAS) may exacerbate COVID-19 severity. While some evidence suggests potential protective effects of ACE2 and RAS blockade on acute lung injury, there are risks associated with discontinuing these medications. Further research and examination of this topic are warranted to improve understanding of these complex relationships.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Endocrinology & Metabolism
Yue Hu, Lihuan Liu, Xifeng Lu
Summary: ACE2, a negative regulator of the renin-angiotensin system, is the receptor for SARS-CoV-2 and plays a crucial role in the pathophysiology of COVID-19. It is implicated in tissue injury, chronic conditions such as hypertension, diabetes, and cardiovascular disease, and may be a potential therapeutic target for COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Peripheral Vascular Disease
Yasushi Matsuzawa, Kazuo Kimura, Hisao Ogawa, Kouichi Tamura
Summary: This article summarizes the potential effects of RAS inhibitors and their impact on COVID-19, indicating that further research is needed to confirm their role.
HYPERTENSION RESEARCH
(2022)
Article
Biology
Hristo L. Svilenov, Florent Delhommel, Till Siebenmorgen, Florian Ruehrnoessl, Grzegorz M. Popowicz, Alwin Reiter, Michael Sattler, Carsten Brockmeyer, Johannes Buchner
Summary: The solution structure, stability, and dynamics of a broadly-acting antiviral ACE2-IgG-Fc fusion protein are determined. Small chemical compounds binding to ACE2 can be used to drastically increase the thermal stability of the ACE2 domain. Our findings reveal a general concept for stabilizing the labile receptor segments of therapeutic antiviral fusion proteins by chemical compounds.
COMMUNICATIONS BIOLOGY
(2023)
Article
Virology
Annika Lundstrom, Louise Ziegler, Sebastian Havervall, Ann-Sofie Rudberg, Fien von Meijenfeldt, Ton Lisman, Nigel Mackman, Per Sanden, Charlotte Thalin
Summary: The study found that levels of sACE2 were higher in COVID-19 patients compared to healthy controls, but decreased over time while remaining higher than in controls. The correlations of sACE2 and sACE levels with markers of inflammation and endothelial dysfunction were different, suggesting release from different cell types and/or vascular beds.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Endocrinology & Metabolism
Joshua R. Cook, John Ausiello
Summary: SARS-CoV-2 virus primarily uses ACE2 as its main receptor, associated with the renin-angiotensin system. ACE2 deficiency may contribute to the multisystem dysfunction of COVID-19, leading to angiotensin imbalance.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Obstetrics & Gynecology
Darshan P. Patel, Nahid Punjani, Jingtao Guo, Joseph P. Alukal, Philip S. Li, James M. Hotaling
Summary: Many couples initially delayed fertility care due to COVID-19 concerns, but later resumed services despite uncertainties related to male reproductive health. Ongoing research on COVID-19 and male sexual and reproductive health has limited definitive evidence, making it challenging for patients and physicians to provide the best clinical care.
FERTILITY AND STERILITY
(2021)
Review
Physiology
Nayara Azinheira Nobrega Cruz, Lilian Caroline Goncalves de Oliveira, Helio Tedesco Silva Junior, Jose Osmar Medina Pestana, Dulce Elena Casarini
Summary: COVID-19, caused by SARS-CoV-2, has led to a major pandemic with a wide range of clinical manifestations, including severe respiratory syndrome and kidney injury. The high affinity of SARS-CoV-2 for ACE2 may contribute to the severity of the disease by depleting its biological activity and affecting renal physiology.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Immunology
Jieqiong Wang, Huiying Zhao, Youzhong An
Summary: ACE2 is a crucial component of the RAS and serves as the receptor for SARS-COV-2. The role of sACE2 in the pathology of the disease is not completely understood. Recent studies have shown that sACE2 also acts as a receptor for SARS-COV-2 and elevated concentrations of sACE2 are associated with the disease. Recombinant human ACE2 may be a potential treatment for COVID-19, but further research is needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Physiology
Shah-Abas Muhamad, Azizah Ugusman, Jaya Kumar, Dominik Skiba, Adila A. Hamid, Amilia Aminuddin
Summary: Observational studies globally have shown that most COVID-19 patients have preexisting hypertension, raising questions about the potential relationship between COVID-19 and hypertension. This review summarizes the current understanding of the link between hypertension and COVID-19, as well as its underlying mechanisms.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tomokazu Yamaguchi, Midori Hoshizaki, Takafumi Minato, Satoru Nirasawa, Masamitsu N. Asaka, Mayumi Niiyama, Masaki Imai, Akihiko Uda, Jasper Fuk-Woo Chan, Saori Takahashi, Jianbo An, Akari Saku, Ryota Nukiwa, Daichi Utsumi, Maki Kiso, Atsuhiro Yasuhara, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Yuji Fujino, Satoru Motoyama, Satoshi Nagata, Josef M. Penninger, Haruhiko Kamada, Kwok-Yung Yuen, Wataru Kamitani, Ken Maeda, Yoshihiro Kawaoka, Yasuhiro Yasutomi, Yumiko Imai, Keiji Kuba
Summary: Endogenous ACE2 is a receptor for SARS-CoV-2 and a recombinant soluble ACE2 protein can act as a decoy to inhibit virus infection. The ACE2-like enzyme B38-CAP is shown to be protective against SARS-CoV-2-induced lung injury, providing potential therapeutic strategies for COVID-19 patients.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Gavin Y. Oudit, Kaiming Wang, Anissa Viveiros, Max J. Kellner, Josef M. Penninger
Summary: ACE2 is the essential entry receptor for SARS-CoV and SARS-CoV-2, and it has become one of the most targeted human molecules in biomedicine due to the COVID-19 pandemic. ACE2 plays two crucial physiological roles: it alters peptide cascade balance as an enzyme and controls intestinal amino acid uptake as a chaperone. The tissue distribution of ACE2, influenced by comorbidities and sex, explains the wide range of coronaviruses' tropism and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics offer a universal strategy for preventing and treating SARS-CoV-2 infections, applicable to all SARS-CoV-2 variants and other emerging zoonotic coronaviruses that exploit ACE2 as their cellular receptor.
Article
Urology & Nephrology
Ander Vergara, Kaiming Wang, Daniele Colombo, Mahmoud Gheblawi, Jaslyn Rasmuson, Rupasri Mandal, Franca Del Nonno, Brian Chiu, James W. Scholey, Maria Jose Soler, David S. Wishart, Gavin Y. Oudit
Summary: This study found that the urinary ACE2 levels are elevated in COVID-19 patients and are associated with the occurrence of acute kidney injury (AKI). The loss of tubular ACE2 during SARS-CoV-2 infection may be linked to aminoaciduria and proximal tubular injury.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Medicine, Research & Experimental
Yazdan Naderi, Sara Khosraviani, Saba Nasiri, Fahimeh Hajiaghaei, Ehsan Aali, Tannaz Jamialahmadi, Maciej Banach, Amirhossein Sahebkar
Summary: The study evaluated the cardioprotective effects of minocycline against doxorubicin-induced cardiotoxicity in adult male rats. Results showed that minocycline significantly decreased the activity of lactate dehydrogenase and creatine kinase MB, while increasing the activity of catalase and superoxide dismutase in cardiac tissue. Minocycline also reduced the levels of malondialdehyde, TNF-alpha, and IL-18 in cardiac tissue, and alleviated the tissue damage caused by doxorubicin.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Amir Abbas Momtazi-Borojeni, Maciej Banach, Sayed Abbas Tabatabaei, Amirhossein Sahebkar
Summary: The antiPCSK9 vaccine is safe and does not have adverse effects on the function of different organs and blood levels of cellular and biochemical biomarkers in healthy mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Sebastiano Cicco, Marco D'Abbondanza, Marco Proietti, Vincenzo Zaccone, Chiara Pes, Federica Caradio, Massimo Mattioli, Salvatore Piano, Alberto Maria Marra, Alessandro Nobili, Pier Mannuccio Mannucci, Antonello Pietrangelo, Giorgio Sesti, Elena Buzzetti, Andrea Salzano, Antonio Cimellaro
Summary: This study investigated the determinants and outcomes of antihypertensive drug prescription in older hospitalized patients. The findings suggest that adherence to guideline-recommended antihypertensive treatment is associated with a lower risk of adverse clinical outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Chemistry, Multidisciplinary
Chenoor Poorshamohammad, Luguang Liu, Xurui Cheng, Amir Abbas Momtazi-Borojeni, Jie Chai
Summary: In this study, gold nanoparticles (AuNPs) were synthesized using plant extract and characterized by physical and chemical techniques. The quasi-spherical nanoparticles of mean diameter 20-50 nm were observed through SEM imaging. The XRD pattern confirmed the metallic gold composition of the nanoparticles. The biologically synthesized AuNPs showed cytotoxic and anti-gastric carcinoma effects against cancer cell lines, indicating their potential in cancer treatment.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Panagiotis Anagnostis, Vasileios Kotsis, Maciej Banach, Dimitri P. P. Mikhailidis
Summary: Plant sterols, similar to cholesterol, can only be obtained through dietary sources and have the potential to lower cholesterol levels. However, high concentrations of phytosterols may increase the risk of atherosclerosis. Medications like ezetimibe can effectively reduce cholesterol and phytosterol absorption, but it is yet to be determined if this translates into a reduction in residual cardiovascular risk for patients.
Review
Biochemistry & Molecular Biology
Rosaria Vincenza Giglio, Angelo Maria Patti, Ali Abbas Rizvi, Anca Panta Stoian, Marcello Ciaccio, Nikolaos Papanas, Andrej Janez, Alper Sonmez, Maciej Banach, Amirhossein Sahebkar, Manfredi Rizzo
Summary: Diabetic nephropathy is the leading cause of end-stage renal disease globally, and its pathogenesis involves increased pressure, activity of the renin-angiotensin system, and oxidative stress. Current treatment options focus on optimizing blood pressure and blood glucose targets, but new drug classes such as GLP-1 RAs, SGLT-2is, and inhibitors of mineralocorticoid receptor-mediated sodium reabsorption show positive effects on kidney function in individuals with type 2 diabetes mellitus. This review aims to provide an update on therapeutic options for preventing or slowing the onset and progression of diabetic nephropathy.
Editorial Material
Medicine, General & Internal
Maciej Banach, Stanislaw Surma
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Agata Bielecka-Dabrowa, Maciej Banach, Andrzej Wittczak, Arrigo F. G. Cicero, Amani Kallel, Raimondas Kubilius, Dimitri P. Mikhailidis, Amirhossein Sahebkar, Anca Pantea Stoian, Dragos Vinereanu, Peter E. Penson, Stephan von Haehling, ILEP
Summary: Sarcopenia has a prevalence of at least 20% in patients with heart failure, and heart failure patients often have subclinical systemic inflammation. Therefore, evaluating the patients' nutrition intake carefully and selecting appropriate diet and nutraceuticals to stimulate muscle growth is important.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Review
Chemistry, Medicinal
Sahar Dadkhah Tehrani, Mehrnaz Shojaei, Mohammad Bagherniya, Matteo Pirro, Amirhossein Sahebkar
Summary: This systematic review aimed to evaluate the efficacy of phytochemicals on lipid parameters in patients with hypertriglyceridemia (HTG). Forty-eight RCTs including 53 arms and comprising 3,478 HTG patients met the eligibility criteria. Phytochemicals significantly reduced the serum levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B, while increasing high-density lipoprotein cholesterol levels in HTG patients.
PHYTOTHERAPY RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Maciej Banach, Peter E. Penson, Michel Farnier, Zlatko Fras, Gustavs Latkovskis, Ulrich Laufs, Francesco Paneni, Paolo Parini, Matteo Pirro, Zeljko Reiner, Michal Vrablik, Carlos Escobar
Summary: Cardiovascular disease (CVD) is a chronic non-communicable disease and the leading cause of disability and mortality worldwide. The current lipid-lowering treatments need improvement, and bempedoic acid, as a new approach to reduce lipid levels, has the potential to lower the risk of CVD.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Review
Endocrinology & Metabolism
Laszlo Rosta, Adrienn Menyhart, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Alberto Firenze, Massimo Galia, Su-Yen Goh, Andrej Janez, Sanjay Kalra, Nitin Kapoor, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Amirhossein Sahebkar, Raul D. Santos, Anca Pantea Stoian, Peter P. Toth, Vijay Viswanathan, Peter Kempler, Manfredi Rizzo
Summary: Over the past two decades, telemedicine has become an important part of healthcare, particularly in the field of diabetes care. The COVID-19 pandemic has further highlighted the need for remote medical services, as they provide a convenient and effective way to communicate with and care for patients. The strategies developed during the pandemic have shown the wide applicability of telemedicine in diabetes care and can continue to benefit clinical practice in the future.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Mohsen Mazidi, Niki Katsiki, Maciej Banach
Summary: This study used Mendelian Randomization (MR) analysis to investigate the relationship between plasma short chain fatty acids (SCFA), renal function, and risk of chronic kidney disease (CKD). The results showed that there was no significant association between plasma valerate (an SCFA) and CKD, but there was a positive correlation between plasma valerate and estimated glomerular filtration rate (eGFR) in the total population and among non-diabetic individuals.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2023)
Article
Medicine, General & Internal
Mateusz Babicki, Damian Kolat, Joanna Kapusta, Zaneta Kaluzinska-Kolat, Piotr Jankowski, Agnieszka Mastalerz-Migas, Maciej Banach, Robert Mordaka, Michal Chudzik
Summary: The aim of this study was to assess the prevalence, the most common symptoms, and the risk factors for development of post-COVID syndrome in patients during a 12-month follow-up after recovery from COVID-19. After 12 months, 65.7% of the patients still experienced persistent symptoms, with the most common symptoms being fatigue and neurocognitive symptoms. Female sex and severe COVID-19 course were associated with the persistence of clinical symptoms.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
