Review
Biochemistry & Molecular Biology
Chaowei Li, Yue Cheng, Dawei Li, Qi An, Wei Zhang, Yu Zhang, Yijun Fu
Summary: Photothermal therapy (PTT) is a new tumor treatment strategy with the advantages of accuracy, ease of administration, high efficiency, and low side effects. This paper reviews the important role of photothermal transduction agents (PTAs) in PTT and discusses methods to improve photothermal conversion efficiency. The structure and characteristics of various PTAs are compared and analyzed, and the applications of photothermal synergistic therapies, including PTT combined with immunotherapy, chemotherapy, and photodynamic therapy, are reviewed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sorina Suarasan, Andreea Campu, Adriana Vulpoi, Manuela Banciu, Simion Astilean
Summary: This study evaluated the absorption properties of three different gold nanotriangular nanoparticles as photothermal agents and selected the most efficient one. It was found that gold nanoparticles which resonated with the 785 nm laser line showed the highest photothermal conversion efficacy and phototoxic effects, demonstrating their potential as a cancer treatment option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Andreia Granja, Marina Pinheiro, Celia T. Sousa, Salette Reis
Summary: Breast cancer is the leading cause of cancer-related deaths among women, and new treatment options are needed due to limitations of current therapeutics. Hyperthermia, particularly in combination with chemotherapy and radiotherapy, shows promise in improving breast cancer therapy. The association of hyperthermia with nanotechnology, such as photothermal therapy (PTT), has gained attention and gold nanostructures are emerging as excellent PTT agents for breast cancer management.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Dongya Liu, Lingyan Liu, Feiyang Liu, Mengfan Zhang, Peng Wei, Tao Yi
Summary: This study presents a tumor microenvironment-responsive nanodrug strategy based on reactive oxygen species (ROS) activation for imaging-guided precision therapy of tumors. The nanoplatform constructed from gold nanoparticles coated with an HOCl probe can adjust size in the tumor environment and inhibit tumor growth through combined photodynamic therapy (PDT) and photothermal therapy (PTT).
Article
Engineering, Environmental
Huajuan Wang, Jin Zhang, Zhiyong Song, Yongli Mu, Mohamed F. Foda, Yang Wu, Heyou Han
Summary: The intelligent antibacterial platform developed here utilizes the acidic environment of bacterial infection to trigger the aggregation of gold nanoparticles on the bacterial surface, with a charge-convertible property for precise targeting. This acidity-triggered aggregation strategy provides an excellent therapeutic mode for treating focal bacterial infections, achieving accurate bacterial killing under NIR irradiation light without causing critical damage to healthy tissues.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Varvara Athanasiou, Dimitra Stavroulaki, Foteini Arfara, Dimitrios Kampras, Ioannis Kleideris, Niki Roumelioti, Panagiota G. Fragouli, Georgios Patias, David Haddleton, Hermis Iatrou
Summary: A facile strategy for synthesizing hybrid nanoparticles with gold nanoshells that absorb NIR light was presented, allowing for fine-tuning of their optical properties. The nanoparticles showed significant temperature increase when irradiated with a low power laser, indicating their potential application in photothermal therapy.
ACS APPLIED NANO MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Agnieszka Pasciak, Aleksandra Pilch-Wrobel, Lukasz Marciniak, P. James Schuck, Artur Bednarkiewicz
Summary: Localized photothermal therapy is a promising method for combating cancer and enhancing other treatment modalities, but there is currently no consensus on how to accurately compare the light-to-heat conversion efficiency of different nanomaterials.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Theotim Lucas, Clement Linger, Thomas Naillon, Mahshid Hashemkhani, Lise Abiven, Bruno Viana, Corinne Chaneac, Gautier Laurent, Rana Bazzi, Stephane Roux, Sonia Becharef, Giulio Avveduto, Florence Gazeau, Jerome Gateau
Summary: Photoacoustic spectroscopy provides a precise and robust method of analyzing the photothermal capabilities of nanoagents in aqueous solutions, without the need for models.
Article
Chemistry, Multidisciplinary
Feiyi Sun, Hanchen Shen, Qinghu Yang, Zhaoyue Yuan, Yuyang Chen, Weihua Guo, Yu Wang, Liang Yang, Zhantao Bai, Qingqing Liu, Ming Jiang, Jacky W. Y. Lam, Jianwei Sun, Ruquan Ye, Ryan T. K. Kwok, Ben Zhong Tang
Summary: Researchers have developed PT-UCNP-B/G nanoparticles that can modulate neuronal activities through both light and heat stimulation, addressing the issues of invasive brain implants and thermal effects in optogenetics.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Asher L. Siegel, Luis Polo-Parada, Gary A. Baker
Summary: Tunable gold nanostars were successfully synthesized in this study, with the morphology and size of nanoparticles easily adjusted through reaction conditions, showing great potential for biomedical applications.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Kailash P. Prajapati, Ayoushna Panigrahi, Sampreeta Purohit, Masihuzzaman Ansari, Kriti Dubey, Rajendra Kumar Behera, Bibin G. Anand, Karunakar Kar
Summary: The study synthesized gold nanoparticles coated with osmolytes, which were found to inhibit temperature-induced amyloid aggregation of insulin. The nanoparticles interacted directly with insulin, protecting it from aggregation-prone domains under extreme conditions, suggesting potential for antiamyloid nanoformulations.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Spectroscopy
Meng Zhang, Xiangyu Zhang, Kai Zhao, Yunxia Dong, Wenrong Yang, Jingquan Liu, Da Li
Summary: The assembly of gold nanorods with reduced graphene oxide (AuNR@Lcyst-rGO) demonstrates high therapeutic efficiency and excellent biocompatibility in tumor photothermal therapy. The assembly shows high photothermal effect, stability, and suitability for human tissue applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Oncology
Ahmed A. Abdulhussein Al-Ali, Nameer Al Ward, Mohammad A. Obeid, Carsten Uhd Nielsen, Paul A. Mulheran, Mohammed M. Al Qaraghuli
Summary: Recently, research has been focused on the use of photothermal therapy (PTT) as an advanced method to treat various types of cancer. The PTT approach primarily utilizes nanoparticles (NPs) made from metals, carbon, or semiconductors that can convert near-infrared laser irradiation into local heat, inducing cancer cell death. An alternative approach is to utilize NPs like liposomes to carry suitable dye molecules to achieve the same effect.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Article
Engineering, Environmental
Xiaodong He, Gnanasekar Sathishkumar, Kasi Gopinath, Kai Zhang, Zhisong Lu, Changming Li, En-Tang Kang, Liqun Xu
Summary: This study developed a novel biomaterial for medical devices with excellent antibacterial and antifouling properties, providing an effective strategy to combat medical device-associated infections.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Jinwoo Shin, Nayeon Kang, Byungkook Kim, Hyunsik Hong, Le Yu, Jungryun Kim, Heemin Kang, Jong Seung Kim
Summary: One-dimensional (1-D) nanomaterials, classified according to their shape, have unique physicochemical properties and promising applications in nanotechnology. In cancer therapy and diagnosis, the biological characteristics of 1-D nanomaterials have extended their potential, including high drug loading efficiency, prolonged blood circulation, cancer cell capture, unique cellular uptake mechanisms, efficient photothermal conversion, and material tunability. This review presents an overview of emerging 1-D nanomaterials in cancer therapy and diagnosis, discussing their definition, shape-dependent physicochemical properties, biomedical applications, recent advances, and unexplored potential.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Chenchen Wang, Wei Du, Chenfan Wu, Shan Dan, Miao Sun, Tong Zhang, Bin Wang, Yue Yuan, Gaolin Liang
Summary: CTSB is overexpressed in many types of cancer in the early stage, and the smart photoacoustic probe Cypate-CBT can achieve sensitive and specific detection of CTSB activity, showing intracellular accumulation after self-assembly initiated by CTSB. It is expected to be an effective PA imaging agent for early cancer diagnosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Rui Luo, Chunqing Ou, Xinchao Li, Yanfang Wang, Wei Du, Gaolin Liang, Changyang Gong
Summary: In this study, a molecular probe was synthesized using a CBT-Cys click condensation reaction to initiate the disassembly of self-assembled nanoparticles in response to tumor acidity, achieving tumor-targeted imaging.
Article
Medicine, Research & Experimental
Huan Li, Zijuan Hai, Liwei Zou, Lele Zhang, Lulu Wang, Longsheng Wang, Gaolin Liang
Summary: This study found that a gadolinium nanoparticle, instructed by gamma-glutamyl transpeptidase (GGT) and formed intracellularly, exhibits different magnetic resonance properties at low and high magnetic fields, making it suitable for enhancing T-1 and T-2 MRI imaging of liver tumors respectively.
Article
Chemistry, Multidisciplinary
Xiang Shi, Ge Gao, Xiaoyang Liu, Lingling Xu, Yu Deng, Rui Wang, Gaolin Liang
Summary: Lipid droplet (LD) fluorescent imaging plays an important role in the detection of lipid-related diseases. However, currently available LD imaging fluorophores have limitations in terms of photostability and hydrophobicity. This study introduces a highly lipophilic compound, Cou-Flu, which exhibits excellent photostability and excimer-monomer transition property. Cou-Flu enables high contrast LD imaging and LD movement tracing in cells, and it is also suitable for in vivo LD detection with excellent sensitivity.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biophysics
Zhen Zheng, Tiantian Xia, Tao Wang, Deying Jia, Ziye Wu, Jun Jiang, Gaolin Liang
Summary: By realizing the firefly bioluminescence cycle in vitro and in cells, researchers have identified the optimal chemical route to achieve the highest light intensity. This pioneering study provides the opportunity to design tunable, economical, biomimetic cold light devices in the near future.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Xianbao Sun, Tiantian Xia, Lingling Xu, Wenjun Zhan, Gaolin Liang
Summary: Featuring molecule-level data encryption, molecular keypad locks offer attractive advantages in information security. Previous multiple-input locks using fluorescence as the output have encountered challenges due to inefficient prequenching or the synthetic complexity of fluorophore-containing processor molecules. In this study, we propose a simple and label-free three-input molecular keypad lock, capable of generating fluorescent readout without background interference. The correct password leads to the generation of a fluorescent product, while incorrect inputs fail to open the lock. This device shows potential for further development into an advanced and secure keypad lock.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yu Deng, Xiang Shi, Xinyi Hu, Lingling Xu, Xiaoyang Liu, Ge Gao, Rui Wang, Gaolin Liang
Summary: Peroxynitrite (ONOO-) is an important reactive oxygen/nitrogen species (ROS/RNS) that plays a vital role in physiological activities. Excessive ONOO- is associated with various diseases, including inflammation, arthritis, inflammatory bowel disease, cancer, and neurodegenerative diseases. In this study, a chemiluminescent probe, B-PD, was designed and synthesized to detect endogenous ONOO-. The probe showed a quick response and a detection limit of 201 nM. In vivo imaging results demonstrated that B-PD could effectively locate early stage inflammation tissue with a high imaging contrast of up to 6.2. These findings suggest that B-PD holds great promise for highly sensitive diagnosis of inflammation-related diseases in the future.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyang Liu, Wenjun Zhan, Ge Gao, Qiaochu Jiang, Xinping Zhang, Hongbo Zhang, Xianbao Sun, Wei Han, Fu-Gen Wu, Gaolin Liang
Summary: Researchers enhance the assembly of porphyrin nanofibers through apoptosis, improving the effectiveness of photodynamic therapy (PDT) for oral squamous cell carcinoma (OSCC).
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Mengxing Wei, Lulu Wang, Yanfang Wang, Tong Zhang, Chenchen Wang, Chengfan Wu, Changlin Tian, Gaolin Liang, Yue Yuan
Summary: Magnetic resonance imaging (MRI) is an excellent imaging technique with unlimited tissue penetration depth and superb spatiotemporal resolution. However, the use of intracellular self-assembled Gd-containing nanoparticles to enhance T-2-weighted MR contrast in vivo for precise tumor MRI is rarely reported. This study developed a CTSB-responsive small molecular contrast agent VC-Gd-CBT, which can self-assemble into large intracellular Gd-containing nanoparticles, and it has the potential to be used as a T-2 contrast agent for early-stage cancer diagnosis.
Article
Chemistry, Multidisciplinary
Guangqiong Xu, Qiao Weng, Lei Zhang, Yaye Song, Wenjun Zhan, Yuan Yin, Gaolin Liang, Fuqiang Wang
Summary: This study reports an AURKB-responsive hydrogel, Gel S/AZD, which enhances cervical tumor suppression by controlled release of AZD1152. Cell assays show that Gel S/AZD induces growth arrest and apoptosis of cervical cancer cells by downregulating the expression of AURKB downstream protein pH3. In vivo studies demonstrate that Gel S/AZD exhibits superior tumor suppressive effect in orthotropic cervical tumor models.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Xinyi Hu, Xianbao Sun, Xiaoyang Liu, Hai-Dong Xu, Liang Yang, Songqin Liu, Rui Wang, Gaolin Liang
Summary: This study introduces a new molecular probe for photoacoustic imaging, which shows promising results for early diagnosis of breast cancer. The experimental results demonstrate that the molecular probe enhances the activity of urokinase-type plasminogen activator and holds great potential for application in both in vitro and in vivo settings.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Hai-Dong Xu, Xiaotong Cheng, Xianbao Sun, Peiyao Chen, Wenjun Zhan, Xiaoyang Liu, Xinliang Wang, Bing Hu, Gaolin Liang
Summary: A self-assembling probe for apoptosis imaging was designed, which underwent a Caspase-3 cleavage and CBT-Cys click reaction to form Gd nanoparticles. This probe achieved enhanced MR imaging of apoptosis in vitro, in apoptotic cells, and in zebrafish.
Review
Chemistry, Analytical
Ying Xu, Qiaochu Jiang, Xianbao Sun, Gaolin Liang
Summary: Stimuli-triggered in-situ morphological transformation of peptide nanomaterials can enhance the on-site accumulation and retention of imaging agent cargos, enabling precise, sensitive, and prolonged disease imaging. This strategy allows for the co-delivery of contrast agents and drugs with smart turn-on ability, facilitating efficient disease theranostics. This review highlights the bioimaging applications of these smart morphological transformation-based peptide materials, and discusses the challenges in this field.
ANALYSIS & SENSING
(2023)
Review
Nanoscience & Nanotechnology
Xinyi Hu, Runqun Tang, Lin Bai, Songqin Liu, Gaolin Liang, Xianbao Sun
Summary: Derived from the D-luciferin regeneration pathway in firefly body, the CBT-Cys click reaction possesses unique advantages and has been used to fabricate stimuli-activatable imaging probes with self-assembling behaviors in physiological context. The in situ formed nanostructures enable precise and enhanced in vivo imaging of diseases, especially tumors.
Article
Chemistry, Multidisciplinary
Lingling Xu, Hang Gao, Wenjun Zhan, Yu Deng, Xiaoyang Liu, Qiaochu Jiang, Xianbao Sun, Jing-Juan Xu, Gaolin Liang
Summary: This study successfully achieves enhanced imaging of Alzheimer's disease by designing a near-infrared AIEgen with dual aggregation properties.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
