Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol

Trapped! A critical evaluation of methods for measuring total cellular uptake versus cytosolic localization

(2019) Kirsten Deprey et al.   BIOCONJUGATE CHEMISTRY

Progress in targeting RAS with small molecule drugs

(2019) Frank McCormick   BIOCHEMICAL JOURNAL

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

(2019) Nadine Eliane Schmit et al.   ACS Chemical Biology

Cell‐penetrable nanobodies (transbodies) that inhibit the tyrosine kinase activity of EGFR leading to the impediment of human lung adenocarcinoma cell motility and survival

(2019) Lueacha Tabtimmai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe

(2019) Nicolas Bery et al.   Nature Communications

Bacterial type III secretion system as a protein delivery tool for a broad range of biomedical applications

(2018) Fang Bai et al.   BIOTECHNOLOGY ADVANCES

Protein-Injection Machines in Bacteria

(2018) Jorge E. Galán et al.   CELL

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery

(2018) Samuel A. Smith et al.   BIOCONJUGATE CHEMISTRY

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells

(2017) Henry D. Herce et al.   Nature Chemistry

Monobodies and other synthetic binding proteins for expanding protein science

(2017) Fern Sha et al.   PROTEIN SCIENCE

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange

(2017) Sandrine Guillard et al.   Nature Communications

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Delivery of Non-Native Cargo into Mammalian Cells Using Anthrax Lethal Toxin

(2016) Amy E. Rabideau et al.   ACS Chemical Biology

A Bacterial Pathogen Targets a Host Rab-Family GTPase Defense Pathway with a GAP

(2016) Stefania Spanò et al.   Cell Host & Microbe

Targeted release of transcription factors for cell reprogramming by a natural micro-syringe

(2016) Lionel Berthoin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Inhibition of RAS function through targeting an allosteric regulatory site

(2016) Russell Spencer-Smith et al.   Nature Chemical Biology

Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells

(2016) Ruth Röder et al.   PHARMACEUTICAL RESEARCH

Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS–p110 crosstalk

(2016) Rastislav Tamaskovic et al.   Nature Communications

Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy

(2015) Andreas Plückthun   Annual Review of Pharmacology and Toxicology

A bacterial type III secretion-based protein delivery tool for broad applications in cell biology

(2015) Simon J. Ittig et al.   JOURNAL OF CELL BIOLOGY

Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems

(2015) Wouter P.R. Verdurmen et al.   JOURNAL OF CONTROLLED RELEASE

Efficient Gene Editing in Pluripotent Stem Cells by Bacterial Injection of Transcription Activator-Like Effector Nuclease Proteins

(2015) Jingyue Jia et al.   Stem Cells Translational Medicine

Bacterial Type III Secretion Systems: Specialized Nanomachines for Protein Delivery into Target Cells

(2014) Jorge E. Galán et al.   Annual Review of Microbiology

Delivery of Antibody Mimics into Mammalian Cells via Anthrax Toxin Protective Antigen

(2014) Xiaoli Liao et al.   CHEMBIOCHEM

Protein interference applications in cellular and developmental biology using DARPins that recognize GFP and mCherry

(2014) M. Brauchle et al.   Biology Open

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Knowledge-Based Design of a Biosensor to Quantify Localized ERK Activation in Living Cells

(2013) Lutz Kummer et al.   CHEMISTRY & BIOLOGY

Salmonella enterica Serovar Typhimurium Skills To Succeed in the Host: Virulence and Regulation

(2013) A. Fabrega et al.   CLINICAL MICROBIOLOGY REVIEWS

From DARPins to LoopDARPins: Novel LoopDARPin Design Allows the Selection of Low Picomolar Binders in a Single Round of Ribosome Display

(2013) Johannes Schilling et al.   JOURNAL OF MOLECULAR BIOLOGY

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

Structure of a pathogenic type 3 secretion system in action

(2013) Julia Radics et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

Regulation of chaperone/effector complex synthesis in a bacterial type III secretion system

(2011) Julie E. Button et al.   MOLECULAR MICROBIOLOGY

Three-Dimensional Model of Salmonella's Needle Complex at Subnanometer Resolution

(2011) O. Schraidt et al.   SCIENCE

Discovery of Novel Secreted Virulence Factors fromSalmonella entericaSerovar Typhimurium by Proteomic Analysis of Culture Supernatants

(2010) George S. Niemann et al.   INFECTION AND IMMUNITY

Direct Injection of Functional Single-Domain Antibodies from E. coli into Human Cells

(2010) Ana Blanco-Toribio et al.   PLoS One

Engineering the Salmonella type III secretion system to export spider silk monomers

(2009) Daniel M Widmaier et al.   Molecular Systems Biology

Folding and Unfolding Mechanism of Highly Stable Full-Consensus Ankyrin Repeat Proteins

(2007) Svava K. Wetzel et al.   JOURNAL OF MOLECULAR BIOLOGY