Article
Anatomy & Morphology
Joe Iwanaga, Soichiro Ibaragi, Yohei Takeshita, Junichi Asaumi, Keith Horner, Thomas R. Gest, R. Shane Tubbs
Summary: The study used the Delphi method to explore the appropriate naming of the mandibular canal, finding varying opinions across different fields of expertise but ultimately suggesting it should be called the inferior alveolar canal.
Article
Endocrinology & Metabolism
S. Taschieri, C. Vitelli, D. Albano, L. Sconfienza, M. Del Fabbro, L. Francetti, M. Parrini, S. Corbella
Summary: The research used cone-beam CT to evaluate the features of the mental foramen (MF) and inferior alveolar nerve canal (IAN), finding significant morphological variability and individual differences among subjects. An increase in the width of MF was correlated to its oval shape, and there was a low but significant correlation between the round shape of MF and the size of the IAN. Individual anatomical variability of this structure is an important consideration in mandibular surgery.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ali Fahd, Ahmed Talaat Temerek, Sarah Mohammed Kenawy
Summary: The study aimed to evaluate, compare, and validate different protocols for inferior alveolar canal tracing. The results showed that the hybrid protocol was the most accurate, while the automatic protocol was the least accurate.
DENTOMAXILLOFACIAL RADIOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Uma Maheswari Pandyan, Banumathi Arumugam, Ulaganathan Gurunathan, Shahul Hameed Kopuli Ashkar Ali
Summary: This research proposes a method for IAC localization in dental panoramic images using image processing techniques. The method achieves automated localization and reduces the complexity of the procedure. The results show higher accuracy and improved image enhancement compared to recent techniques. It provides guidance for successful localization and minimizes the complexities in oral surgery and implantology.
SIGNAL IMAGE AND VIDEO PROCESSING
(2022)
Article
Dentistry, Oral Surgery & Medicine
C. Brent Haeberle, Amara Abreu, Kurt Metzler, Marlen Robles-Moreno
Summary: In cases of severe alveolar resorption in the posterior mandible, implant placement is challenging due to inadequate bone and the position of the inferior alveolar nerve. This report discusses a mandibular fracture following inferior alveolar nerve transposition and simultaneous implant placement, with prosthodontic reconstruction achieved using a fixed dental prosthesis.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Michelle Kher Wei Chua, Wen Jiong Koh, Smita Nimbalkar, Pravinkumar G. Patil
Summary: The study aimed to identify the buccolingual orientation of the inferior alveolar nerve in the posterior mandible among the Malaysian population for implant planning. Significant differences were found in the buccolingual position of the nerve between sexes, variations in bone width between sexes and ethnic groups, and differences in canal thickness between sides. Overall, there were variations in bone width from second molar to second premolar regions, underscoring the importance of considering ethnicity, sex, and side in implant procedures.
INTERNATIONAL JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Daniah M. Alhazmi, Christina L. Nicholas, Siddharth R. Vora, Trishul V. Allareddy, Shankar Rengasamy Venugopalan
Summary: The objective of this study was to test for morphological integration between the mandible and the inferior alveolar nerve, and determine if there were shape variations in different skeletal classes. CBCT scans of 80 subjects were analyzed, showing strong integration between the inferior alveolar nerve and the posterior/inferior border of the mandible, as well as the overall mandibular shape. Significant shape variations were also found among different skeletal classes.
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2023)
Article
Anatomy & Morphology
Caitlin Yoakum, Claire Terhune
Summary: Previous studies have mainly focused on the mandibular canal, mental foramen, and mandibular foramen in humans and a few non-primate mammals, but there is limited research on these structures in primates. Understanding the relationship between the inferior alveolar nerve (IAN) and mandibular canal is crucial due to their involvement in teeth and mastication. This study used microCT and diceCT scans to create 3D models of the IAN and mandibular canal in primates, revealing that the mandibular canal is often not a well-defined canal and the IAN does not occupy most of the space within it. The study also found significant relationships between the IAN and corresponding canals, with the mental foramen/nerve showing negative allometry.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
E. Paasky, A. Suomalainen, I Venta
Summary: This study analyzed retrospective register data from Finland and found that women are more likely to experience inferior alveolar nerve injuries (IANIs) in dental implant procedures compared to men. The results also showed that women are at a higher risk for IANI and implant malposition than men.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Iris Burck, Rania A. Helal, Nagy N. N. Naguib, Nour-Eldin A. Nour-Eldin, Jan-Erik Scholtz, Simon Martin, Martin Leinung, Silke Helbig, Timo Stoever, Annette Lehn, Thomas J. Vogl
Summary: The study found that postoperative facial nerve stimulation was not significantly correlated with mastoid facial canal diameter, wall thickness, distance to CI cable, and angle with chorda tympani, but significantly associated with a history of meningitis/encephalitis, extracochlear-electrode-contacts, scala-vestibuli position, younger patient age, lateral-wall-electrode type, and early onset hearing loss.
EUROPEAN RADIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jae-Young Kim, Michael D. Han, Kug Jin Jeon, Jong-Ki Huh, Kwang-Ho Park
Summary: The study found differences in the configuration and dimensions of the anterior loop of the inferior alveolar nerve (ALIAN) between patients with and without mandibular asymmetry. Surgeons should take this into consideration during surgery for patients with mandibular asymmetry.
Review
Dentistry, Oral Surgery & Medicine
James Robbins, Katelyn Rene Smalley, Pamela Ray, Kamran Ali
Summary: This systematic review examines the impact of cone-beam CT (CBCT) assessment on the incidence of nerve injury following high-risk mandibular third molar (MTM) surgery. The included seven randomized controlled trials provide moderate quality evidence that CBCT does not reduce the occurrence of nerve injury in MTM removal.
Article
Health Care Sciences & Services
Swati Srivastava, Hanan M. Alharbi, Afnan S. Alharbi, Mai Soliman, Elzahraa Eldwakhly, Manal M. Abdelhafeez
Summary: This study analyzed the relationships between the inferior alveolar canal and the root apices of mandibular teeth, as well as the mandibular cortical plates. The results showed that the inferior alveolar canal was in close proximity to the roots of mandibular canines anteriorly, and to the distal roots of mandibular second molars posteriorly.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
George Deryabin, Simonas Grybauskas
Summary: This study investigated the medium-to-long-term success and survival rates of dental implants placed simultaneously with inferior alveolar nerve repositioning. The results showed that this technique is effective and reliable for severely resorbed mandibles, although neurosensory disturbances are a common complication that tends to resolve over time. Advanced surgical skills are required for this procedure.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2021)
Article
Medicine, General & Internal
Liang-Wen Chen, Xiao-E Zhao, Qi Yan, Hai-Bin Xia, Quan Sun
Summary: This article introduces a trans-IAN implant placement technique guided by a dynamic navigation system, which can successfully treat posterior mandibular dentition defects with a bone height of only 4.5 mm, and the restoration outcome is stable.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Neurosciences
Harsh Goel, Keshav Goyal, Avanish Kumar Pandey, Mercilena Benjamin, Fahad Khan, Pratibha Pandey, Sandeep Mittan, Danish Iqbal, Mohammed Alsaweed, Wael Alturaiki, Yahya Madkhali, Mohammad Amjad Kamal, Pranay Tanwar, Tarun Kumar Upadhyay
Summary: Due to environmental contamination, humans are exposed to physical and chemical mutagens, which cause a variety of neurological disorders through neuroinflammation, genetic instability, oxidative stress, and mitochondrial damage. This review summarizes the molecular mechanisms and effects of mutagens in the environment on neurological disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Neurosciences
Md. Mominur Rahman, Sadia Afsana Mim, Md. Rezaul Islam, Nasrin Sultana, Muniruddin Ahmed, Mohammad Amjad Kamal
Summary: G-protein-coupled receptors (GPCRs) are activated by neurotransmitters and play a crucial role in psychiatric and neurological disorders. GPCRs show potential as therapeutic targets for obesity, diabetes, Alzheimer's disease, and other central nervous system disorders. Orphan GPCRs, such as GPR52, GPR6, and GPR8, are of particular interest and may have therapeutic implications for psychiatric disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Pediatrics
Mohammed G. Sghaireen, Deepti Shrivastava, Mohammed O. Alnusayri, Abdulmajeed D. Alahmari, Ali M. Aldajani, Kumar C. Srivastava, Mohammad K. Alam
Summary: The success of implant dentistry is closely linked to the quality and quantity of bone at the implant site. With the growing popularity of dental implants, there is an increased interest in bone reconstruction for the oral cavity. Many patients requesting implant rehabilitation may require additional procedures to improve the quantity and quality of the bone.
CURRENT PEDIATRIC REVIEWS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Tanima Bhattacharya, Nigel H. Greig, Bairong Shen, Mohammad Amjad Kamal
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Neurosciences
Aziz Unnisa, Nigel H. Greig, Mohammad Amjad Kamal
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by underdeveloped brain and impaired social interaction. Recent research suggests that disturbances in neuron-glia interactions play a significant role in the pathophysiology of ASD. Glial cells, in addition to neurons, are essential for mental activities, and a new strategy emphasizing neuron-glia interactions should be applied. Dysfunctional neuron-glia connections result in abnormal neural network formation and neurotransmission, leading to the malfunctioning of brain circuits and behavioral issues. Reactive glial cells and dysfunction in microglia have been associated with autism, and various approaches involving glial cell treatment are being explored.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mirra Edreena Sallehudin, Nor Dalila Nor Affandi, Ahmad Mukifza Harun, Mohammad Khursheed Alam, Liliana Indrie
Summary: This study aimed to investigate the effects of washing cycles on nano-TiO2 coated cotton yarn with the aid of succinic acid on the morphological structures and self-cleaning properties. It was found that the washing cycles changed the morphological structure of the nano-TiO2 coated cotton yarn, with a decrease in photocatalytic activity and an increase in stain absorption after 20 wash cycles. However, the coating maintained good photocatalytic activity and self-cleaning properties up to 15 wash cycles when succinic acid was present.
Review
Medicine, General & Internal
Mohammad Khursheed Alam, Huda Abutayyem, Bushra Kanwal, Maher A. L. Shayeb
Summary: This study reviewed recent technological trends in orthodontics and speculated on future developments. Through a comprehensive search of online journals, important areas of development were found to be 3D printing, computer-aided design and manufacturing, biopolymers, and teleorthodontics. The selected studies revealed aspects of orthodontics that were influenced by rapid technological changes and could become mainstream in the future. However, caution is needed in the adoption of certain trends, such as social media usage among patients and orthodontists.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Mohammad Khursheed Alam, Kumar Chandan Srivastava, Mohd Fadhli Khamis, Adam Husein
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Infectious Diseases
Osama Abu-Hammad, Abdalla Abu-Hammad, Abdul-Raheem Jaber, Abdel Rahman Jaber, Najla Dar-Odeh
Summary: This review aimed to examine patient factors associated with the geographic variation in monkeypox cases during the 2022 outbreak. The study found that in Europe, the Americas, and Southeast Asia, cases were primarily observed among men who have sex with men (MSM), with a high proportion of HIV and sexually transmitted diseases. The Eastern Mediterranean region had the lowest number of cases, likely due to conservative social behaviors. The detection of cases among women and children highlights the importance of implementing appropriate preventive public health measures.
NEW MICROBES AND NEW INFECTIONS
(2023)
Article
Medicine, General & Internal
Md Mehedy Hasan Miraz, Md Afif Ullah, Abdullah Al Nayem, Brototi Chakrobortty, Sanjoy Deb, Anee Laskar, Nishita Umaya Tithi, Nilay Saha, Anita Rani Chowdhury, K. M. Khairul Alam, Tania Binte Wahed, Mohammad Khursheed Alam, Sukalyan Kumar Kundu
Summary: This study investigates the potential of phytochemical compounds from Nigella sativa to inhibit the spike protein and main protease of the Omicron variant of SARS-CoV-2. Among the tested compounds, Nigelladine A showed the highest binding affinity with both targets. Further research is needed to validate this compound as a potential drug against the selected variant of SARS-CoV-2.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2023)
Article
Anatomy & Morphology
Joao Armando Brancher, Rodrigo Schuh, Maria Fernanda Pioli Torres, Jordanna de Melo Teixeira do Brasil, Maria Angelica Hueb, Carlos Alexandre dos Santos Haemmerle, Peter Proff, Mohammad Khursheed Alam, Christian Kirschneck, Erika Calvano Kuechler
Summary: This study aimed to evaluate if SNPs in WNT6 (rs6754599) and WNT10A (rs10177996 and rs3806557) genes are associated with the calcification and patterns of the sella turcica. The results showed that individuals carrying the TT genotype in rs10177996 were more likely to have partially calcified sella turcica (p = 0.047). Therefore, the SNP in WNT10A is associated with the calcification phenotype of the sella turcica.
JOURNAL OF ANATOMY
(2023)
Article
Medicine, General & Internal
Mohammed G. Sghaireen, Kiran Kumar Ganji, Kumar Chandan Srivastava, Mohammad Khursheed Alam, Shadi Nashwan, Fayeq Hasan Migdadi, Ahmad Al-Qerem, Yousef Khader
Summary: This clinical study evaluated the correlation between Vitamin D (Vit D), cholesterol levels, and T- and Z-scores of dual-energy X-ray absorptiometry (DXA) scans with cone beam computed tomography values in the maxillary and mandibular jaws. A total of 187 patients aged between 45 and 65 were included in the study, divided into control (non-osteoporosis) and case (osteoporosis) groups. The results showed a significant inverse relationship between Vit D and cholesterol in the case group, and a positive relationship between Vit D and cone beam computed tomography values in all regions of the jaws except the mandibular posterior region. Pearson correlation analysis revealed an insignificant negative association between Vit D, cholesterol levels, and cone beam computed tomography values in all regions of the jaws, while Z-values were highly correlated with the cone beam computed tomography values in all regions of the jaws. Vit D, cholesterol levels, and Z-values were found to be related to the cone beam computed tomography values of the jaws in women and men aged 45-65.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Multidisciplinary
Rehana Basri, Vigneswaran Dhasarathan, G. Palai, Mohammad Khursheed Alam, Kiran Kumar Ganji, Manay Srinivas Munisekhar, Anil Kumar Nagarajappa
Summary: The neuron connections in the central nervous system are crucial for the structure and function of the human body. Any slight variation or deformation of neurons can lead to serious complications like brain hemorrhage. By using a one-dimensional photonic structure and infrared signals, the amount of neuron deformation in the brain can be measured, providing early detection and prevention of brain hemorrhage.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Medicine, General & Internal
Asma Kassab, Yassine Khalij, Yosra Ayed, Najla Dar-Odeh, Amal A. Kokandi, Meriam Denguezli, Monia Youssef
Summary: Background: Vitiligo is a common chronic hypomelanotic skin disorder. The study investigates the important markers associated with vitiligo pathogenesis, including redox status, inflammation, and immune profile, in patients with vitiligo.
Methods: The study included 96 subjects: 30 patients with active non-segmental vitiligo, 30 patients with stable non-segmental vitiligo, and 36 controls. Various serum parameters were assessed.
Results: Antioxidant status, catalase activity, glutathione peroxidase activity, and glutathione-S-transferase activity were significantly lower in vitiligo patients than in controls. Superoxide dismutase activity was significantly higher in vitiligo patients. Malondialdehyde and advanced oxidation protein products levels were significantly higher in vitiligo patients. C reactive protein and interleukin-15 were significantly higher in vitiligo patients. Chemokines CXCL9 and CXCL10 were significantly higher in vitiligo patients.
Conclusions: In vitiligo, oxidative damage induces an increase in pro-inflammatory IL-15, which in turn promotes IFN-gamma-inducible chemokines such as CXCL9 and CXCL10. The VASI score is linked to IL-15 levels. Inhibiting IL-15 could be a potential targeted treatment for suppresses the early interplay between oxidant stress and IL-15 keratinocyte production, as well as between resident and recirculating memory T cells.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Saad Mohammad Alqahtani, Shankar T. Gokhale, Mohamed Fadul A. Elagib, Deepti Shrivastava, Raghavendra Reddy Nagate, Badar Awadh Mohammad Alshmrani, Abduaziz Mohammed Abdullah Alburade, Fares Mufreh Abdullah Alqahtani, Anil Kumar Nagarajappa, Valentino Natoli, Kumar Chandan Srivastava
Summary: The aim of this study was to assess the salivary calcium, magnesium, and pH levels in smokers compared with non-smokers with chronic periodontitis. The results showed that smokers had significantly higher levels of periodontal disease indices and salivary calcium compared to non-smokers. These findings suggest that salivary calcium level can be a potential biochemical parameter to assess the progression of periodontal disease in smokers and non-smokers.
MEDICINA-LITHUANIA
(2023)
