Linking epigenetic dysregulation, mitochondrial impairment, and metabolic dysfunction in SBMA motor neurons

Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease

(2019) Jacqueline M. Ward et al.   Cell Reports

Elevated Exogenous Pyruvate Potentiates Mesodermal Differentiation through Metabolic Modulation and AMPK/mTOR Pathway in Human Embryonic Stem Cells

(2019) Chengcheng Song et al.   Stem Cell Reports

Modulation of HSF1 Activity Through Silencing of Ser303/Ser307 Phosphorylation Supports A Metabolic Program Leading to Age-related Obesity and Insulin Resistance

(2018) Xiongjie Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation

(2018) Hao Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative epigenetic taxonomy of primary prostate cancer

(2018) Suzan Stelloo et al.   Nature Communications

AMP-activated protein kinase–mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β

(2017) Akihiro Nakanishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

(2017) Philipp Mews et al.   NATURE

Nonalcoholic fatty liver disease in spinal and bulbar muscular atrophy

(2017) Robert D. Guber et al.   NEUROLOGY

GLUT4 Mobilization Supports Energetic Demands of Active Synapses

(2017) Ghazaleh Ashrafi et al.   NEURON

Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases

(2017) Pierre Theurey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet

(2016) Anna Rocchi et al.   ACTA NEUROPATHOLOGICA

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The phosphorylation-dependent regulation of nuclear SREBP1 during mitosis links lipid metabolism and cell growth

(2016) Maria Teresa Bengoechea-Alonso et al.   CELL CYCLE

ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks

(2016) Ritchie Ho et al.   NATURE NEUROSCIENCE

Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain

(2016) Feng Tie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing

(2016) Elisa Giorgetti et al.   Cell Reports

Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

(2016) Xinde Zheng et al.   eLife

Protein Lysine Acetylation by p300/CBP

(2015) Beverley M. Dancy et al.   CHEMICAL REVIEWS

Chromatin deregulation in disease

(2015) Anne C. Mirabella et al.   CHROMOSOMA

Neuronal identity genes regulated by super-enhancers are preferentially down-regulated in the striatum of Huntington's disease mice

(2015) M. Achour et al.   HUMAN MOLECULAR GENETICS

H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription

(2015) Sankari Nagarajan et al.   Oncotarget

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients

(2014) Christopher Grunseich et al.   NEUROBIOLOGY OF DISEASE

Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapy

(2013) Bilal Malik et al.   BRAIN

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

Spinal and bulbar muscular atrophy: pathogenesis and clinical management

(2013) C Grunseich et al.   ORAL DISEASES

Targeting H3K4 trimethylation in Huntington disease

(2013) M. Vashishtha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

(2012) Yossi Dagon et al.   Cell Metabolism

Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development

(2012) Stefan Bonn et al.   NATURE GENETICS

Ca2+Regulation of Mitochondrial ATP Synthesis Visualized at the Single Cell Level

(2011) Masahiro Nakano et al.   ACS Chemical Biology

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease

(2011) Tz-Chuen Ju et al.   JOURNAL OF CELL BIOLOGY

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

Histone H3K27ac separates active from poised enhancers and predicts developmental state

(2010) M. P. Creyghton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of IGF-1 in Muscle Attenuates Disease in a Mouse Model of Spinal and Bulbar Muscular Atrophy

(2009) Isabella Palazzolo et al.   NEURON

Mitochondrial abnormalities in spinal and bulbar muscular atrophy

(2008) Srikanth Ranganathan et al.   HUMAN MOLECULAR GENETICS