Phenotypic Profiling of Reference Chemicals across Biologically Diverse Cell Types Using the Cell Painting Assay

The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals using High-throughput Transcriptomics and Benchmark Concentration Modeling

(2019) Sreenivasa C Ramaiahgari et al.   TOXICOLOGICAL SCIENCES

The next generation blueprint of computational toxicology at the U.S. Environmental Protection Agency

(2019) Russell S Thomas et al.   TOXICOLOGICAL SCIENCES

Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains

(2019) Fatima Naaz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biophysical comparison of four silver nanoparticles coatings using microscopy, hyperspectral imaging and flow cytometry

(2019) Robert M. Zucker et al.   PLoS One

High content phenotypic screening identifies serotonin receptor modulators with selective activity upon breast cancer cell cycle and cytokine signaling pathways

(2019) Scott J. Warchal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling

(2019) Johanna Nyffeler et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq

(2018) Alice Limonciel et al.   ARCHIVES OF TOXICOLOGY

BMDExpress 2: enhanced transcriptomic dose-response analysis workflow

(2018) Jason R Phillips et al.   BIOINFORMATICS

A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

(2017) Mark-Anthony Bray et al.   GigaScience

A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling

(2017) Joanne M. Yeakley et al.   PLoS One

Development of the Theta Comparative Cell Scoring Method to Quantify Diverse Phenotypic Responses Between Distinct Cell Types

(2016) Scott J. Warchal et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

(2016) Ann M. Richard et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

(2016) Fabian A. Grimm et al.   GREEN CHEMISTRY

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

(2016) Mark-Anthony Bray et al.   Nature Protocols

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

(2015) Imran Shah et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Short-term exposure to low doses of rotenone induces developmental, biochemical, behavioral, and histological changes in fish

(2015) Karina Motta Melo et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

The position of mitochondria and ER in relation to that of the secretory sites in chromaffin cells

(2014) J. Villanueva et al.   JOURNAL OF CELL SCIENCE

Anthelmintic resistance in equine nematodes

(2014) Jacqueline B. Matthews   International Journal for Parasitology-Drugs and Drug Resistance

Multiplex Cytological Profiling Assay to Measure Diverse Cellular States

(2013) Sigrun M. Gustafsdottir et al.   PLoS One

Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson’s disease models

(2012) Nian Xiong et al.   CRITICAL REVIEWS IN TOXICOLOGY

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Mitochondrial inhibitor as a new class of insulin sensitizer

(2012) Yong Zhang et al.   Acta Pharmaceutica Sinica B