Review
Endocrinology & Metabolism
Meghali Joshi, Shruti Sethi, Poonam Mehta, Anamika Kumari, Singh Rajender
Summary: Small non-coding RNAs (sncRNAs) play crucial roles in male reproduction, especially in spermatogenesis. miRNAs, piRNAs, and tsRNAs are the most commonly studied sncRNAs. Dysregulation of miRNAs is highly correlated with infertility. Sperm-borne small RNAs have the potential to act as biomarkers of sperm quality and fertility.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yu Wang, Tianhua Liu, Wenying Xiao, Yanyan Bai, Dandan Yue, Liuliu Feng
Summary: Atherosclerosis (AS) is a common cardiovascular disease characterized by endothelial cell injury and dysfunction. Oxidative low-density lipoprotein (Ox-LDL) is a key risk factor for AS development. This study identified the expression changes of small non-coding RNAs (sncRNAs) in Ox-LDL-treated endothelial cells, providing new markers for the diagnosis and treatment of endothelial cell injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Songqian Huang, Shinya Nishiumi, Md Asaduzzaman, Yida Pan, Guanting Liu, Kazutoshi Yoshitake, Kaoru Maeyama, Shigeharu Kinoshita, Kiyohito Nagai, Shugo Watabe, Tetsuhiko Yoshida, Shuichi Asakawa
Summary: This study discovered abundant miRNAs and piRNAs in exosomes of the pearl oyster during graft transplantation, and found that they are related to immune response and transposon silencing. This work provides insights into the function of exosome-derived sncRNAs and the PIWI/piRNA pathway in molluscs.
Review
Plant Sciences
K. Bharathan Sruthi, Athira Menon, P. Akash, Eppurath Soniya
Summary: Long non-coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides without coding potential. Recent research shows that lncRNAs can code for micropeptides, which are generated from small open reading frames (smORFs) and found in short mRNAs and non-coding RNAs. Although micropeptides play critical roles in plant development and stress, only a few functions have been verified so far.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Oncology
Leila Erfanparast, Mohammad Taghizadieh, Ali Akbar Shekarchi
Summary: Oral cancer is a significant public health concern with a negative impact on society. Despite advancements in treatment, the survival rate for oral cancer remains low, and the underlying molecular mechanisms of OSCC carcinogenesis are not fully understood. Noncoding RNAs, such as microRNAs and long ncRNAs, play important roles in cancer cell development. Understanding the relationship between ncRNAs and different types of cell death is essential. Manipulating ncRNA expression offers potential for controlling the occurrence and development of oral cancer. This review aims to explore the impact of ncRNAs on cell death and identify potential targets for oral cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Pooneh Mokarram, Maryam Niknam, Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Morvarid Siri, Sanaz Dastghaib, Hassan Brim, Hassan Ashktorab
Summary: PIWI-interacting RNAs (piRNAs), identified as a category of small non-coding RNAs, play crucial roles in cell biology and show potential value in cancer research. Identifying cancer-related piRNAs and assessing their target genes could help in developing better cancer prevention and treatment strategies.
Review
Neurosciences
Omid Mohamadzadeh, Mahsasadat Hajinouri, Farzaneh Moammer, Seyed Saeed Tamehri Zadeh, Ghoncheh Omid Shafiei, Ameneh Jafari, Amirreza Ostadian, Sayyed Alireza Talaei Zavareh, Michael R. Hamblin, Arezoo Jafarian Yazdi, Amirhossein Sheida, Hamed Mirzaei
Summary: Nowadays, traumatic brain injury (TBI) is a global concern due to its significant morbidity and long-term consequences that are not fully understood. Cellular pathways such as free radical production, excitotoxicity, apoptosis, and neuroinflammatory responses have been identified in TBI. Non-coding RNAs (ncRNAs) have been found to play a crucial role in post-transcriptional regulation in the brain, and altered levels of ncRNA expression have been observed in both traumatic and non-traumatic brain injuries. This review provides an overview of the primary molecular mechanisms involved in TBI and discusses the latest findings on changes and the role of ncRNAs in TBI from both clinical and experimental research.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nishant Chakravorty
Summary: This special issue compiles research and review articles on the involvement of ncRNAs (non-coding RNAs) in different pathophysiological conditions, including various types of cancers. It aims to motivate researchers to delve deeper into the world of ncRNAs and develop new diagnostic and therapeutic interventions for challenging clinical conditions.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Genetics & Heredity
Mohammad H. Ghazimoradi, Naeim Karimpour-Fard, Sadegh Babashah
Summary: Early identification of leukemia is crucial for disease management and survival improvement. Approaches based on accurate biomarkers in body fluids provide patients with high sensitivity and specificity for early diagnosis. Non-coding RNAs have shown potential as biomarkers and therapeutic targets in leukemia due to their involvement in crucial oncogenic processes and their presence in body fluids.
Review
Neurosciences
Amber Penning, Giorgia Tosoni, Oihane Abiega, Pascal Bielefeld, Caterina Gasperini, Davide De Pietri Tonelli, Carlos P. Fitzsimons, Evgenia Salta
Summary: The adult neurogenic niches are complex multicellular systems where adult neural stem cells generate astrocytic and neuronal progeny, functionally linked to memory, cognition, and mood regulation. Deregulation of aNSCs and their progeny can impact aging and various brain pathologies. Non-coding RNAs have emerged as key regulators in NSC fate determination, providing potential therapeutic avenues for neurological diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Emilie Boutet, Samia Djerroud, Jonathan Perreault
Summary: Small RNAs (sRNAs) are essential regulators in bacterial adaptation to environmental changes, and approximately 550 distinct families of sRNAs have been identified. They are found in various bacterial phyla, with higher prominence in highly researched model organisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Natalya Frolows, Alyson Ashe
Summary: In recent years, research has shown that in addition to the information encoded in DNA sequences, molecules within the cytoplasm of the gamete play a significant role in heritability. RNA molecules are crucial in transmitting transgenerational responses, while the role of histone modifications in epigenetic inheritance is increasingly recognized.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Review
Cell Biology
Nasrin Ahangar Davoodi, Sajad Najafi, Zari Naderi Ghale-Noie, Ashkan Piranviseh, Samaneh Mollazadeh, Sahar Ahmadi Asouri, Zatollah Asemi, Mohammadamin Morshedi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Amirhossein Sheida, Hamed Mirzaei
Summary: Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that can have severe consequences. Non-coding RNAs (ncRNAs) play important roles in the pathogenesis and development of RB, with different ncRNAs acting as either tumor promoters or suppressors. Understanding the regulatory mechanisms of ncRNAs provides new opportunities for RB therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Genetics & Heredity
Huifen Cao, Philipp Kapranov
Summary: This article reviews the significant progress made in the past decade in mapping RNA interactions, validating novel interactions, and interpreting the data obtained using interactome mapping methods.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Ida Manna, Francesco Fortunato, Selene De Benedittis, Ilaria Sammarra, Gloria Bertoli, Angelo Labate, Antonio Gambardella
Summary: Temporal lobe epilepsy is the most common form of focal epilepsy, considered a network disorder associated with structural changes. Non-coding RNAs, acting as epigenetic factors, participate in the regulation of the pathophysiological processes of epilepsy and can be used as biomarkers for diagnosis and treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Entomology
M. K. Mills, D. Nayduch, D. S. McVey, K. Michel
JOURNAL OF MEDICAL ENTOMOLOGY
(2017)
Article
Biology
Mary K. Mills, Kristin Michel, Robert S. Pfannenstiel, Mark G. Ruder, Eva Veronesi, Dana Nayduch
CURRENT OPINION IN INSECT SCIENCE
(2017)
Article
Biochemistry & Molecular Biology
M. K. Mills, D. Nayduch, K. Michel
INSECT MOLECULAR BIOLOGY
(2015)
Article
Multidisciplinary Sciences
Chester Joyner, Mary Katherine Mills, Dana Nayduch
Article
Multidisciplinary Sciences
Mary K. Mills, Mark G. Ruder, Dana Nayduch, Kristin Michel, Barbara S. Drolet
Article
Genetics & Heredity
William Bart Bryant, Mary Katherine Mills, Bradley J. S. C. Olson, Kristin Michel
G3-GENES GENOMES GENETICS
(2019)
Article
Virology
Dana Nayduch, Vijay Shankar, Mary K. Mills, Tanner Robl, Barbara S. Drolet, Mark G. Ruder, Erin D. Scully, Christopher A. Saski
Article
Virology
Sandra Y. Mendiola, Mary K. Mills, Elin Maki, Barbara S. Drolet, William C. Wilson, Roy Berghaus, David E. Stallknecht, Jonathan Breitenbach, D. Scott McVey, Mark G. Ruder
Article
Entomology
Mary Katherine Mills, Paula Rozo-Lopez, William Bart Bryant, Barbara S. Drolet
Summary: Culicoides sonorensis midges are capable of transmitting pathogenic viruses to livestock, which can result in significant economic losses. Understanding midge physiology is crucial for controlling virus transmission due to the relationship between blood feeding, egg development, and pathogen infection. MicroRNAs (miRNAs) have been found to play a role in these processes.