Article
Biochemistry & Molecular Biology
Juan Pablo Tosar, Maria Rosa Garcia-Silva, Alfonso Cayota
Summary: The study of piwi-interacting RNAs (piRNAs) in cancer research is gaining interest, as aberrant expression of piRNAs in cancer may indicate their involvement in tumorigenesis and potential for early cancer diagnosis. However, caution is needed as some somatic piRNAs reported may actually be fragments of other noncoding RNAs, leading to potential errors in research findings. Introducing the concept of miscellaneous-piRNAs (m-piRNAs) may help distinguish between canonical piRNAs and other small RNAs associated with PIWI proteins in somatic cells.
Article
Biochemistry & Molecular Biology
Byapti Ghosh, Arijita Sarkar, Sudip Mondal, Namrata Bhattacharya, Sunirmal Khatua, Zhumur Ghosh
Summary: piRNAQuest V.2 is an updated database with new features such as density-based cluster prediction, piRNA expression profile, and piRNA target prediction. It includes information on piRNAs for multiple species, allowing users to explore detailed information on piRNA, including their expression profiles in disease systems.
Review
Oncology
Fatemeh Sadoughi, Seyyed Mehdi Mirhashemi, Zatollah Asemi
Summary: Recent investigations have shown the important role of small non-coding RNAs, with a focus on piRNAs and their potential relationship to colorectal cancer (CRC). CRC, a common gastrointestinal malignancy, is believed to be linked to genetic and epigenetic alterations.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Jie Yao, Mei Xie, Xidong Ma, Jialin Song, Yuanyong Wang, Xinying Xue
Summary: This review focuses on the aberrant expression of piRNAs in cancer and their association with cancer hallmarks such as proliferation, invasion, and chemoresistance, and discusses their potential as biomarkers for cancer diagnosis and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nishant Chakravorty
Summary: This special issue compiles research and review articles on the involvement of ncRNAs (non-coding RNAs) in different pathophysiological conditions, including various types of cancers. It aims to motivate researchers to delve deeper into the world of ncRNAs and develop new diagnostic and therapeutic interventions for challenging clinical conditions.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Genetics & Heredity
Mohammad H. Ghazimoradi, Naeim Karimpour-Fard, Sadegh Babashah
Summary: Early identification of leukemia is crucial for disease management and survival improvement. Approaches based on accurate biomarkers in body fluids provide patients with high sensitivity and specificity for early diagnosis. Non-coding RNAs have shown potential as biomarkers and therapeutic targets in leukemia due to their involvement in crucial oncogenic processes and their presence in body fluids.
Review
Oncology
Leila Erfanparast, Mohammad Taghizadieh, Ali Akbar Shekarchi
Summary: Oral cancer is a significant public health concern with a negative impact on society. Despite advancements in treatment, the survival rate for oral cancer remains low, and the underlying molecular mechanisms of OSCC carcinogenesis are not fully understood. Noncoding RNAs, such as microRNAs and long ncRNAs, play important roles in cancer cell development. Understanding the relationship between ncRNAs and different types of cell death is essential. Manipulating ncRNA expression offers potential for controlling the occurrence and development of oral cancer. This review aims to explore the impact of ncRNAs on cell death and identify potential targets for oral cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Tanchun Cheng, Shouguo Huang
Summary: Metastasis in cervical cancer is not well understood, with non-coding RNAs playing diverse roles in this process. Dysregulation of miRNAs, lncRNAs, and circRNAs is associated with metastasis. They regulate metastasis by influencing metastasis-related genes, epithelial-mesenchymal transition, signaling pathways, and interactions with the tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Astrid D. Haase
Summary: PIWI proteins and piRNAs form an adaptive immune system that protects genome integrity by restricting the activity of mobile genetic elements. piRNAs can discriminate between self and nonself and adapt to novel genomic invaders. They originate from single-stranded RNA and require a unique set of processing factors.
Article
Cell Biology
Josien C. van Wolfswinkel
Summary: PIWI-interacting RNAs (piRNAs) play a crucial role in defending against transposons in animal germline and stem cells. The extent to which piRNAs also regulate other transcripts is a topic of ongoing debate, with the level of sequence complementarity between piRNA and target being a guiding factor in this discussion. This review summarizes findings from various studies and proposes a set of requirements for predicting targets based on current knowledge.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Biochemistry & Molecular Biology
Huimin Wang, Feng Jiang, Xiang Liu, Qing Liu, Yunyun Fu, Ran Li, Li Hou, Jie Zhang, Jing He, Le Kang
Summary: This study identifies a novel function of Piwi and piRNAs in regulating food intake in locusts. Knockdown of Piwi1 expression leads to reduced food consumption and body weight, potentially through decreased expression of neuropeptide NPF1. Mechanistically, intronic piRNAs may enhance RNA splicing of NPF1 by preventing hairpin formation at the branch point sites. This discovery reveals a novel nuclear PIWI/piRNA-mediated mechanism that controls food intake in the locust nervous system.
Review
Genetics & Heredity
Zhuang Jing, Yang Xi, Jin Yin, Han Shuwen
Summary: Colorectal cancer (CRC) is a common malignancy worldwide with piwi-interacting RNAs (piRNAs), a type of non-coding RNA, being closely linked to its occurrence and development. Studies have shown that piRNAs regulate CRC by modulating multiple molecular signaling pathways, suggesting their potential as molecular targets for CRC treatment.
Review
Biochemistry & Molecular Biology
Shusuke Toden, Timothy J. Zumwalt, Ajay Goel
Summary: Recent advances have highlighted the importance of non-coding RNAs, particularly microRNAs, in cancer pathogenesis. These ncRNAs have shown potential for therapeutic development in cancer, with early data from pre-clinical studies demonstrating promising results in human trials. While miRNAs have been extensively studied, there is ongoing research to uncover the molecular mechanisms and therapeutic targets of other lesser studied ncRNAs in cancer treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Biochemistry & Molecular Biology
Qun Lin, Yu Shi, Zihao Liu, Maryam Mehrpour, Ahmed Hamai, Chang Gong
Summary: Recent research has shown that non-coding RNAs play crucial roles in regulating both selective and non-selective autophagy, with abnormal expression impacting autophagy and contributing to carcinogenesis. Understanding the regulatory roles of ncRNAs in autophagy may offer valuable therapeutic targets for cancer management.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Oncology
Jialin Zhou, Han Xie, Jun Liu, Ruixiang Huang, Yufei Xiang, Dasheng Tian, Erbao Bian
Summary: P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a class of small regulatory RNAs that regulate transposons in germ cells and are associated with various malignant tumors. The functions and mechanisms of piRNAs in cancer are still unclear. This review summarizes the current findings on the biogenesis, function, and mechanisms of piRNAs and PIWI proteins in cancer, discusses their clinical significance as biomarkers and therapeutic tools, and presents critical questions for future research.
Article
Biology
Sanaz Dastghaib, Pooneh Mokarram, Mehran Erfani, Saeid Ghavami, Seyed Vahid Hosseini, Mozhdeh Zamani
Summary: The research investigated the role of ERMP1 in UPR activation in colorectal cancer, finding that silencing ERMP1 gene significantly decreased the expression of UPR-associated protein markers. This suggests that ERMP1 plays an important role in UPR activation in colorectal cancer.
Article
Transplantation
Marzieh Nemati, Narges Karbalaei, Pooneh Mokarram, Farzaneh Dehghani, Sanaz Dastghaib, Zohre Aghaei
Summary: Islet treatment with pancreatic islet homogenate improves islet survival and transplant function and outcomes, and reduces oxidative stress.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Leila Oudbor, Zohreh Mokhtari, Sanaz Dastghaib, Pooneh Mokarram, Huda Fatima Rajani, Mahdi Barazesh, Siamak Salami
Summary: This study evaluated the effects of stevia extract on gene expression in diabetic rats and pancreatic cell lines. The findings indicate that stevia extract upregulates antioxidative defense genes and downregulates genes associated with cell death, leading to clinical improvements in diabetes.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Saeid Ghavami, Mozhdeh Zamani, Mazaher Ahmadi, Mehran Erfani, Sanaz Dastghaib, Mahsa Darbandi, Sara Darbandi, Omid Vakili, Morvarid Siri, Beniamin Oskar Grabarek, Dariusz Boron, Maryam Zarghooni, Emilia Wiechec, Pooneh Mokarram
Summary: This article discusses the association between autophagy and epigenetics in gastrointestinal cancers (GICs), including their interplay, how epigenetic modifications affect cancer cell behavior, and how epigenetic drugs modulate autophagy to overcome chemoresistance in GICs.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Pharmacology & Pharmacy
Mehdi Eshraghi, Mazaher Ahmadi, Saeid Afshar, Shahrokh Lorzadeh, Aida Adlimoghaddam, Nahid Rezvani Jalal, Ryan West, Sanaz Dastghaib, Somayeh Igder, Seyed Reza Naeimi Torshizi, Amir Mahmoodzadeh, Pooneh Mokarram, Tayyebeh Madrakian, Benedict C. Albensi, Marek J. Los, Saeid Ghavami, Stevan Pecic
Summary: Alzheimer's disease is a significant threat to global health due to an aging population. Current drugs for AD are not very effective, making the targeting of autophagy an attractive therapeutic approach. Drug repositioning is being considered as a time-efficient and cost-effective strategy for developing new therapies.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Hamidreza Totonchi, Pooneh Mokarram, Saeed Karima, Ramazan Rezaei, Sanaz Dastghaib, Farhad Koohpeyma, Shokoofe Noori, Negar Azarpira
Summary: This study found that low-dose resveratrol (0.02 and 0.2 mg/kg) treatment after ischemia significantly reduced ALT and AST levels. Additionally, the expression of UPR pathway genes was significantly reduced in the resveratrol group compared to the control group. The histopathological changes induced by I/R were significantly improved in mice receiving lower doses of resveratrol.
BMC PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Oncology
Marziyeh Babazadeh, Mozhdeh Zamani, Parvaneh Mehrbod, Pooneh Mokarram
Summary: This study investigated the effects of 5-Fluorouracil (5-FU) and bovine alpha-lactalbumin made lethal to tumor cells (BAMLET) on colon cancer cells, focusing on the Wnt signaling pathway. The results showed that BAMLET downregulated the expression of β-catenin and upregulated the expression of E-cadherin, while also reducing the expression of VEGF. Bovine alpha-lactalbumin made lethal to tumor cells can be considered as a potential strategy in the treatment of colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER MANAGEMENT
(2022)
Article
Immunology
Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Tania Dehesh, Nima Taefehshokr, Adel Sadeghdoust, Katarzyna Kotfis, Amirhossein Hashemiattar, Amir Ravandi, Neda Aligolighasemabadi, Omid Vakili, Beniamin Grabarek, Rafal Staszkiewicz, Marek J. J. Los, Pooneh Mokarram, Saeid Ghavami
Summary: The aim of this prospective cohort study was to investigate the impact of statins on long-term respiratory symptoms and pulmonary fibrosis in COVID-19 patients with diabetes mellitus. The study found that the Non-statin group had significantly higher odds of cough and dyspnea compared to the Statin group during the follow-up period. Although there was no significant difference in pulmonary fibrosis score change between the groups, Non-statin patients with > 5 years of DM were more likely to exhibit higher fibrosis scores during follow-up.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Article
Biochemistry & Molecular Biology
Marziyeh Babazadeh, Mozhdeh Zamani, Parvaneh Mehrbod, Pooneh Mokarram
Summary: This study investigated the effects of bovine alpha-lactalbumin made lethal to tumor cells and 5-Flourouracil on the stemness of colorectal cancer cells. The results showed that BAMLET and 5-Flourouracil treatment led to decreased expression levels of stemness-related genes and surface markers, with BAMLET being more effective than 5-Flourouracil in inhibiting stemness.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hamid Behrouj, Omid Vakili, Adel Sadeghdoust, Neda Aligolighasemabadi, Parnian Khalili, Mozhdeh Zamani, Pooneh Mokarram
Summary: The COVID-19 pandemic is a serious global public health issue that requires effective therapeutic strategies. Autophagy plays a significant role in the growth and replication of coronaviruses, and epigenetic alterations are also involved in COVID-19. Understanding the epigenetic pathways linked with autophagy could provide novel therapeutic targets for COVID-19 eradication.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Biology
Sanaz Dastghaib, Farhad Koohpeyma, Saeed Khazayel, Fatemeh Gholizadeh, Soheila Mansoor Pour, Pooneh Mokaram, Ali Noorafshan
Summary: This study investigated the protective and preventive effects of oral extracts of Stevia on the pancreas in streptozocin-induced diabetic rats. The results showed that treatment with Stevia significantly reduced fasting blood sugar levels and MDA levels, increased the weight and volume of the pancreas, and increased the volume density of the pancreatic islands and the number of beta cells.
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
