Role of HMGB1 in the Interplay between NETosis and Thrombosis in Ischemic Stroke: A Review

Neutrophil Extracellular Traps and Cardiovascular Diseases: An Update

(2020) Aldo Bonaventura et al.   Cells

Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction

(2020) Julia Novotny et al.   NEUROLOGY

Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke

(2020) Lijing Kang et al.   Nature Communications

Neutrophil Extracellular Traps

(2019) Charlotte Thålin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis after Vessel Injury

(2019) Nicoletta Sorvillo et al.   CIRCULATION RESEARCH

ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology

(2019) Yongliang Cao et al.   PLOS BIOLOGY

Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain

(2019) Seung-Woo Kim et al.   Acta Neuropathologica Communications

ATP amplifies NADPH-dependent and -independent neutrophil extracellular trap formation

(2019) Aderonke Sofoluwe et al.   Scientific Reports

Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation

(2019) Binita Shrestha et al.   Frontiers in Immunology

DAMPs and NETs in Sepsis

(2019) Naomi-Liza Denning et al.   Frontiers in Immunology

Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation

(2019) Stefanie Gößwein et al.   Frontiers in Immunology

Inhibition of peptidyl arginine deiminase-4 protects against myocardial infarction induced cardiac dysfunction

(2019) Mingjun Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

(2018) Han Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA

(2018) Tineke Kraaij et al.   KIDNEY INTERNATIONAL

Association of circulating blood HMGB1 levels with ischemic stroke: a systematic review and meta-analysis

(2018) Kai Le et al.   NEUROLOGICAL RESEARCH

Thrombus Neutrophil Extracellular Traps Content Impair tPA-Induced Thrombolysis in Acute Ischemic Stroke

(2018) Celina Ducroux et al.   STROKE

Alarmin HMGB1 induces systemic and brain inflammatory exacerbation in post-stroke infection rat model

(2018) Il-Doo Kim et al.   Cell Death & Disease

Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA

(2018) Mitchell R. Dyer et al.   Scientific Reports

Markers of neutrophil extracellular traps are associated with adverse clinical outcome in stable coronary artery disease

(2018) Miriam Sjåstad Langseth et al.   European Journal of Preventive Cardiology

Peptidylarginine deiminase 4 concentration, but not PADI4 polymorphisms, is associated with ICU mortality in septic shock patients

(2018) Nara Aline Costa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Elevated Serum High-Mobility Group Box-1 Protein Level Is Associated with Poor Functional Outcome in Ischemic Stroke

(2017) Toshiyuki Tsukagawa et al.   Journal of Stroke & Cerebrovascular Diseases

Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI

(2017) Daigo Nakazawa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Release of extracellular DNA influences renal ischemia reperfusion injury by platelet activation and formation of neutrophil extracellular traps

(2017) Marcel P.B. Jansen et al.   KIDNEY INTERNATIONAL

Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance

(2017) Juana Vallés et al.   THROMBOSIS AND HAEMOSTASIS

Elevated Serum High-Mobility Group Box-1 Protein Level Is Associated with Poor Functional Outcome in Ischemic Stroke

(2017) Toshiyuki Tsukagawa et al.   Journal of Stroke & Cerebrovascular Diseases

Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice

(2016) K. Stark et al.   BLOOD

Human plasma platelet-derived exosomes: effects of aspirin

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation

(2016) Payel Sil et al.   INFLAMMATION RESEARCH

P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals

(2016) Payel Sil et al.   JOURNAL OF IMMUNOLOGY

Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms

(2016) Xiaoxing Xiong et al.   Journal of Neuroinflammation

Recombinant human soluble thrombomodulin ameliorates cerebral ischemic injury through a high-mobility group box 1 inhibitory mechanism without hemorrhagic complications in mice

(2016) Yoshihiko Nakamura et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Incidence and Predictors of Early Recanalization After Intravenous Thrombolysis

(2016) Pierre Seners et al.   STROKE

Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1

(2016) Jung Ho Lee et al.   Molecular Brain

Low ADAMTS13 activity is associated with an increased risk of ischemic stroke

(2015) M. A. H. Sonneveld et al.   BLOOD

Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals

(2015) J. Cedervall et al.   CANCER RESEARCH

Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation

(2015) Erin Witalison et al.   CURRENT DRUG TARGETS

Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction

(2015) Dimitrios A. Stakos et al.   EUROPEAN HEART JOURNAL

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

Platelet-derived HMGB1 is a critical mediator of thrombosis

(2015) Sebastian Vogel et al.   JOURNAL OF CLINICAL INVESTIGATION

At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases

(2015) Peter C. Grayson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN

(2015) S. V. R. Kumar et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies

(2015) M. Jiménez-Alcázar et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

(2015) Michael Bode et al.   THROMBOSIS AND HAEMOSTASIS

Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid

(2015) Julia Spengler et al.   Arthritis & Rheumatology

Neutrophil recruitment to the brain in mouse and human ischemic stroke

(2014) Isabel Perez-de-Puig et al.   ACTA NEUROPATHOLOGICA

Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome

(2014) Nelly Sapojnikova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activated Platelets Interfere with Recruitment of Mesenchymal Stem Cells to Apoptotic Cardiac Cells via High Mobility Group Box 1/Toll-like Receptor 4-mediated Down-regulation of Hepatocyte Growth Factor Receptor MET

(2014) Sebastian Vogel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host-Derived Extracellular Nucleic Acids Enhance Innate Immune Responses, Induce Coagulation, and Prolong Survival upon Infection in Insects

(2014) B. Altincicek et al.   JOURNAL OF IMMUNOLOGY

Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates

(2014) Sigrun Lange et al.   JOURNAL OF NEUROCHEMISTRY

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Molecular dialogs between the ischemic brain and the peripheral immune system: Dualistic roles in injury and repair

(2014) Chengrui An et al.   PROGRESS IN NEUROBIOLOGY

Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

(2013) Konstantinos Kambas et al.   ANNALS OF THE RHEUMATIC DISEASES

Oxidative Stress Elicits Platelet/Leukocyte Inflammatory Interactions via HMGB1: A Candidate for Microvessel Injury in Sytemic Sclerosis

(2013) Norma Maugeri et al.   ANTIOXIDANTS & REDOX SIGNALING

Functional Role of Soluble Receptor for Advanced Glycation End Products in Stroke

(2013) Sung-Chun Tang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation

(2013) Yasuyuki Arai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

(2013) A. S. Savchenko et al.   BLOOD

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation

(2013) J. Rossaint et al.   BLOOD

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones

(2013) Colin Longstaff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomonitoring and prognostic relevance of neutrophils in clinical trials

(2013) Frede Donskov   SEMINARS IN CANCER BIOLOGY

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

(2012) Gaby Enzmann et al.   ACTA NEUROPATHOLOGICA

Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

(2012) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating platelets as a source of the damage-associated molecular pattern HMGB1 in patients with systemic sclerosis

(2012) Norma Maugeri et al.   AUTOIMMUNITY

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Detection of Extracellular Genomic DNA Scaffold in Human Thrombus: Implications for the Use of Deoxyribonuclease Enzymes in Thrombolysis

(2012) Rahmi Oklu et al.   JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY

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(2012) Jean-Marc Tadie et al.   MOLECULAR MEDICINE

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(2012) Huan Yang et al.   MOLECULAR MEDICINE

Intranasal Delivery of HMGB1 siRNA Confers Target Gene Knockdown and Robust Neuroprotection in the Postischemic Brain

(2012) Il-Doo Kim et al.   MOLECULAR THERAPY

Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion

(2012) Seung-Woo Kim et al.   NEUROBIOLOGY OF DISEASE

ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia–reperfusion injury

(2012) Masayuki Fujioka et al.   NEUROLOGICAL SCIENCES

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis

(2012) Konstantinos Kambas et al.   PLoS One

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe Stroke Induces Long-Lasting Alterations of High-Mobility Group Box 1

(2012) Juliane Schulze et al.   STROKE

Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction

(2012) Xiaofei Li et al.   THROMBOSIS AND HAEMOSTASIS

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Bonding the foe – NETting neutrophils immobilize the pro-inflammatory monosodium urate crystals

(2012) Christine Schorn et al.   Frontiers in Immunology

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus

(2011) V. Urbonaviciute et al.   JOURNAL OF INTERNAL MEDICINE

Breast cancer chemotherapy induces the release of cell-free DNA, a novel procoagulant stimulus

(2011) L. L. SWYSTUN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation

(2011) C. T. AMMOLLO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats

(2011) X. Ye et al.   NEUROSCIENCE

Porphyromonas gingivalis Participates in Pathogenesis of Human Abdominal Aortic Aneurysm by Neutrophil Activation. Proof of Concept in Rats

(2011) Sandrine Delbosc et al.   PLoS One

Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

(2011) Ioannis Mitroulis et al.   PLoS One

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats

(2011) Jiyong Zhang et al.   STROKE

The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke

(2010) Nai-Wen Tsai et al.   CLINICA CHIMICA ACTA

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

HMBG1 Mediates Ischemia—Reperfusion Injury by TRIF-Adaptor Independent Toll-Like Receptor 4 Signaling

(2010) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy

(2010) Gregory C. Connolly et al.   THROMBOSIS RESEARCH

von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke

(2009) B.-Q. Zhao et al.   BLOOD

Increased PADI4 expression in blood and tissues of patients with malignant tumors

(2009) Xiaotian Chang et al.   BMC CANCER

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE