标题
A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex
作者
关键词
-
出版物
Cells
Volume 9, Issue 7, Pages 1678
出版商
MDPI AG
发表日期
2020-07-14
DOI
10.3390/cells9071678
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis
- (2020) Marcel Hohl et al. PLoS Genetics
- The ATP-bound conformation of the Mre11–Rad50 complex is essential for Tel1/ATM activation
- (2019) Corinne Cassani et al. NUCLEIC ACIDS RESEARCH
- MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer
- (2019) Yiling Situ et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- High expression of MRE11 correlates with poor prognosis in gastric carcinoma
- (2019) Junqing Li et al. Diagnostic Pathology
- Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex
- (2019) Lisa Käshammer et al. MOLECULAR CELL
- MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
- (2019) Lei Bian et al. Molecular Cancer
- Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas
- (2019) Robin Guo et al. Journal of Thoracic Oncology
- Adjacent mutations in the archaeal Rad50 ABC ATPase D-loop disrupt allosteric regulation of ATP hydrolysis through different mechanisms
- (2019) Zachary K Boswell et al. NUCLEIC ACIDS RESEARCH
- The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair
- (2018) Aleem Syed et al. Annual Review of Biochemistry
- Pancreatic cancer as a sentinel for hereditary cancer predisposition
- (2018) Erin L. Young et al. BMC CANCER
- RAD50 germline mutations are associated with poor survival in BRCA1/2 -negative breast cancer patients
- (2018) Cong Fan et al. INTERNATIONAL JOURNAL OF CANCER
- Breast cancer risk associated with genes encoding DNA repair MRN complex: a study from Punjab, Pakistan
- (2018) Rabbia Tariq Khan et al. Breast Cancer
- A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair
- (2018) Zachary K. Boswell et al. Scientific Reports
- Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas
- (2018) Theo A. Knijnenburg et al. Cell Reports
- Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis
- (2018) Vincent Ho et al. BMC CANCER
- 20 Years of Mre11 Biology: No End in Sight
- (2018) Tanya T. Paull MOLECULAR CELL
- Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development
- (2018) Luisa Maresca et al. Frontiers in Genetics
- Role of the Mre11 Complex in Preserving Genome Integrity
- (2018) Julyun Oh et al. Genes
- Spectrum and Prevalence of Pathogenic Variants in Ovarian Cancer Susceptibility Genes in a Group of 333 Patients
- (2018) Magdalena Koczkowska et al. Cancers
- Physiological protein blocks direct the Mre11–Rad50–Xrs2 and Sae2 nuclease complex to initiate DNA end resection
- (2017) Giordano Reginato et al. GENES & DEVELOPMENT
- Chromatin remodelling and DNA repair genes are frequently mutated in endometrioid endometrial carcinoma
- (2017) Pablo García-Sanz et al. INTERNATIONAL JOURNAL OF CANCER
- Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences
- (2017) Yasin Kaymaz et al. MOLECULAR CANCER RESEARCH
- Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair
- (2017) Logan R. Myler et al. MOLECULAR CELL
- The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression
- (2017) Jun Hyun Kim et al. Cell Reports
- Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer
- (2017) Fergus J. Couch et al. JAMA Oncology
- Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival
- (2017) Vincent Ho et al. Cancers
- Structural mechanism of ATP‐dependent DNA binding and DNA end bridging by eukaryotic Rad50
- (2016) Florian Ulrich Seifert et al. EMBO JOURNAL
- MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts
- (2016) Tomas Aparicio et al. JOURNAL OF CELL BIOLOGY
- Panel Testing for Familial Breast Cancer: Calibrating the Tension Between Research and Clinical Care
- (2016) Ella R. Thompson et al. JOURNAL OF CLINICAL ONCOLOGY
- Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes
- (2016) Nguyen Ngoc Hoa et al. MOLECULAR CELL
- Genomic landscape of DNA repair genes in cancer
- (2016) Young Kwang Chae et al. Oncotarget
- Metallophosphoesterases: structural fidelity with functional promiscuity
- (2015) Nishad Matange et al. BIOCHEMICAL JOURNAL
- ATP‐dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex
- (2015) Yaqi Liu et al. EMBO JOURNAL
- Mechanisms and Consequences of Double-Strand DNA Break Formation in Chromatin
- (2015) Wendy J. Cannan et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Genetic variations in the homologous recombination repair pathway genes modify risk of glioma
- (2015) Haishi Zhang et al. JOURNAL OF NEURO-ONCOLOGY
- Interdependence of the Rad50 Hook and Globular Domain Functions
- (2015) Marcel Hohl et al. MOLECULAR CELL
- Structure of the catalytic domain of Mre11 fromChaetomium thermophilum
- (2015) Florian Ulrich Seifert et al. Acta Crystallographica Section F-Structural Biology Communications
- A Rare Polymorphic Variant of NBS1 Reduces DNA Repair Activity and Elevates Chromosomal Instability
- (2014) Y. Yamamoto et al. CANCER RESEARCH
- Structure of the Rad50 DNA double‐strand break repair protein in complex with DNA
- (2014) Anna Rojowska et al. EMBO JOURNAL
- DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA
- (2014) S. Sung et al. EMBO JOURNAL
- ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling
- (2014) R. A. Deshpande et al. EMBO JOURNAL
- The functional polymorphism of NBS1 p.Glu185Gln is associated with an increased risk of lung cancer in Chinese populations: Case–control and a meta-analysis
- (2014) Wenxiang Fang et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Synthetic Lethality in ATM-Deficient RAD50-Mutant Tumors Underlies Outlier Response to Cancer Therapy
- (2014) H. Al-Ahmadie et al. Cancer Discovery
- Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms
- (2013) Joshua A. Regal et al. HUMAN MOLECULAR GENETICS
- Ataxia Telangiectasia-Mutated (ATM) Kinase Activity Is Regulated by ATP-driven Conformational Changes in the Mre11/Rad50/Nbs1 (MRN) Complex
- (2013) Ji-Hoon Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional variants in NBS1 and cancer risk: evidence from a meta-analysis of 60 publications with 111 individual studies
- (2013) P. Gao et al. MUTAGENESIS
- Mutation Inactivation of Nijmegen Breakage Syndrome Gene (NBS1) in Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
- (2013) Yan Wang et al. PLoS One
- Significant association between Nijmegen breakage syndrome 1 657del5 polymorphism and breast cancer risk
- (2013) Guofeng Zhang et al. TUMOR BIOLOGY
- NBS1 Glu185Gln polymorphism and cancer risk: update on current evidence
- (2013) Ya-Zhou He et al. TUMOR BIOLOGY
- Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling
- (2012) Christian B Schiller et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair
- (2012) Oliver Limbo et al. NUCLEIC ACIDS RESEARCH
- Nijmegen breakage syndrome (NBS)
- (2012) Krystyna H Chrzanowska et al. Orphanet Journal of Rare Diseases
- MRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers
- (2011) E. Vilar et al. CANCER RESEARCH
- The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair
- (2011) Katja Lammens et al. CELL
- The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation
- (2011) Zhenbao Yu et al. CELL RESEARCH
- Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly
- (2011) Yoshiyuki Matsumoto et al. DNA REPAIR
- Crystal structure of the Mre11-Rad50-ATP S complex: understanding the interplay between Mre11 and Rad50
- (2011) H. S. Lim et al. GENES & DEVELOPMENT
- Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma
- (2011) Jian Zheng et al. MOLECULAR CARCINOGENESIS
- NBS1 Recruits RAD18 via a RAD6-like Domain and Regulates Pol η-Dependent Translesion DNA Synthesis
- (2011) Hiromi Yanagihara et al. MOLECULAR CELL
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
- (2011) Ignacio Varela et al. NATURE
- The Rad50 coiled-coil domain is indispensable for Mre11 complex functions
- (2011) Marcel Hohl et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair
- (2011) Gareth J Williams et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex
- (2011) Carolin Möckel et al. NUCLEIC ACIDS RESEARCH
- Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations
- (2011) Young Bong Park et al. STRUCTURE
- Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks
- (2011) Petra Langerak et al. PLoS Genetics
- The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
- (2010) Michael R. Lieber Annual Review of Biochemistry
- Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks
- (2010) Gareth J. Williams et al. DNA REPAIR
- Biochemical Characterization of Bacteriophage T4 Mre11-Rad50 Complex
- (2010) Timothy J. Herdendorf et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder
- (2009) Regina Waltes et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2French Canadian families with high risk of breast cancer
- (2009) Sylvie Desjardins et al. BMC CANCER
- Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair
- (2009) R. Scott Williams et al. CELL
- A Supramodular FHA/BRCT-Repeat Architecture Mediates Nbs1 Adaptor Function in Response to DNA Damage
- (2009) Janette Lloyd et al. CELL
- MRN and the race to the break
- (2009) Agnieszka Rupnik et al. CHROMOSOMA
- Mutational Inactivation of the Nijmegen Breakage Syndrome Gene (NBS1) in Glioblastomas Is Associated With Multiple TP53 Mutations
- (2009) Takuya Watanabe et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Two Brothers with Ataxia-Telangiectasia-like Disorder with Lung Adenocarcinoma
- (2009) Naoki Uchisaka et al. JOURNAL OF PEDIATRICS
- Role of mammalian Mre11 in classical and alternative nonhomologous end joining
- (2009) Anyong Xie et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells
- (2009) Emilie Rass et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The R215W mutation in NBS1 impairs γ-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients
- (2008) Alessandra di Masi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair
- (2008) R. Scott Williams et al. CELL
- Mutations in the Nijmegen Breakage Syndrome Gene in Medulloblastomas
- (2008) J. Huang et al. CLINICAL CANCER RESEARCH
- NBS1 Heterozygosity and Cancer Risk
- (2008) Alessandra Masi et al. CURRENT GENOMICS
- Forkhead-Associated Domain of Yeast Xrs2, a Homolog of Human Nbs1, Promotes Nonhomologous End Joining Through Interaction With a Ligase IV Partner Protein, Lif1
- (2008) K. Matsuzaki et al. GENETICS
- A Field Synopsis on Low-Penetrance Variants in DNA Repair Genes and Cancer Susceptibility
- (2008) Paolo Vineis et al. JNCI-Journal of the National Cancer Institute
- A Glycine-Arginine Domain in Control of the Human MRE11 DNA Repair Protein
- (2008) U. Dery et al. MOLECULAR AND CELLULAR BIOLOGY
- A Mutant Allele of MRE11 Found in Mismatch Repair-deficient Tumor Cells Suppresses the Cellular Response to DNA Replication Fork Stress in a Dominant Negative Manner
- (2008) Qin Wen et al. MOLECULAR BIOLOGY OF THE CELL
- Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene
- (2008) Jirina Bartkova et al. Molecular Oncology
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