A Novel Small-Molecule Inhibitor of Endosomal TLRs Reduces Inflammation and Alleviates Autoimmune Disease Symptoms in Murine Models

A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice

(2019) Hyuk-Kwon Kwon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Toll-like receptor-induced cytokines as immunotherapeutic targets in cancers and autoimmune diseases

(2019) Mahesh Chandra Patra et al.   SEMINARS IN CANCER BIOLOGY

Linear and Rationally Designed Stapled Peptides Abrogate TLR4 Pathway and Relieve Inflammatory Symptoms in Rheumatoid Arthritis Rat Model

(2019) Asma Achek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chembench: A Publicly Accessible, Integrated Cheminformatics Portal

(2017) Stephen J. Capuzzi et al.   Journal of Chemical Information and Modeling

Discovery of Small Molecules as Multi-Toll-like Receptor Agonists with Proinflammatory and Anticancer Activities

(2017) Lei Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-molecule inhibition of TLR8 through stabilization of its resting state

(2017) Shuting Zhang et al.   Nature Chemical Biology

Identification of an optimized 2′- O -methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8

(2017) Felix C.F. Schmitt et al.   RNA

Drugging Membrane Protein Interactions

(2016) Hang Yin et al.   Annual Review of Biomedical Engineering

Recent progress in the development of Toll-like receptor (TLR) antagonists

(2016) Mahesh Chandra Patra et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA

(2016) Zhikuan Zhang et al.   IMMUNITY

The delivery of therapeutic oligonucleotides

(2016) Rudolph L. Juliano   NUCLEIC ACIDS RESEARCH

Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis

(2015) Dorothea Terhorst et al.   JOURNAL OF IMMUNOLOGY

What is the future of targeted therapy in rheumatology: biologics or small molecules?

(2014) Attila Mócsai et al.   BMC Medicine

The BAFF/APRIL system in SLE pathogenesis

(2014) Fabien B. Vincent et al.   Nature Reviews Rheumatology

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection

(2014) S. M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dihydropyrrolo[2,3-d]pyrimidines: Selective Toll-Like Receptor 9 Antagonists from Scaffold Morphing Efforts

(2014) Manabu Watanabe et al.   ACS Medicinal Chemistry Letters

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

(2013) Barry Flutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

RNA recognition by human TLR8 can lead to autoimmune inflammation

(2013) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Toll-Like Receptor 7, 8, and 9 Antagonist Inhibits Th1 and Th17 Responses and Inflammasome Activation in a Model of IL-23-Induced Psoriasis

(2013) Weiwen Jiang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9

(2013) Ekambar R. Kandimalla et al.   NUCLEIC ACIDS RESEARCH

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

(2013) H. Tanji et al.   SCIENCE

Aldara activates TLR7-independent immune defence

(2013) Anne Walter et al.   Nature Communications

Nucleic acids and endosomal pattern recognition: how to tell friend from foe?

(2013) Eva Brencicova et al.   Frontiers in Cellular and Infection Microbiology

Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system

(2012) Nobutaka Hanagata   International Journal of Nanomedicine

Structure–Activity Relationships in Human Toll-like Receptor 8-Active 2,3-Diamino-furo[2,3-c]pyridines

(2012) Deepak B. Salunke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

(2012) S. Jensen et al.   JOURNAL OF VIROLOGY

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

Dissecting negative regulation of Toll-like receptor signaling

(2012) Takeshi Kondo et al.   TRENDS IN IMMUNOLOGY

Potential role of IFNα in adult lupus

(2012) Lars Rönnblom   ARTHRITIS RESEARCH & THERAPY

Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists

(2011) Nikunj M. Shukla et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small-Molecule Inhibitors of the TLR3/dsRNA Complex

(2011) Kui Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TCM Database@Taiwan: The World's Largest Traditional Chinese Medicine Database for Drug Screening In Silico

(2011) Calvin Yu-Chian Chen   PLoS One

Lupus nephritis: current update

(2011) Ramesh Saxena et al.   ARTHRITIS RESEARCH & THERAPY

Chembench: a cheminformatics workbench

(2010) Theo Walker et al.   BIOINFORMATICS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

TLR8 deficiency leads to autoimmunity in mice

(2010) Olivier Demaria et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues

(2010) Nikunj M. Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline

(2009) Nikunj M. Shukla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE