Update on GNA Alterations in Cancer: Implications for Uveal Melanoma Treatment

GNAQ and GNA11 mutant non‐uveal melanoma, a subtype distinct from both cutaneous and uveal melanoma

(2020) E. Livingstone et al.   BRITISH JOURNAL OF DERMATOLOGY

Heterotrimeric Gq proteins as therapeutic targets?

(2020) Evi Kostenis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells

(2019) Suvi Annala et al.   Science Signaling

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

(2019) Xiaodong Feng et al.   CANCER CELL

Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives

(2019) Croce et al.   Cancers

GNAQ Q209L expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system

(2019) Oscar Urtatiz et al.   Pigment Cell & Melanoma Research

Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study

(2019) Markus V. Heppt et al.   Journal for ImmunoTherapy of Cancer

Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma

(2019) Francesca Piaggio et al.   Cancers

Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP

(2018) Qi Hu et al.   CELL

DNMT1 mediated promoter methylation of GNAO1 in hepatoma carcinoma cells

(2018) Diannan Xu et al.   GENE

Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized Trial (SUMIT)

(2018) Richard D. Carvajal et al.   JOURNAL OF CLINICAL ONCOLOGY

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

(2018) Krushna C. Patra et al.   NATURE CELL BIOLOGY

Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology

(2018) Dahlia E. Perez et al.   Pigment Cell & Melanoma Research

G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog

(2018) Ganesh V. Pusapati et al.   Science Signaling

GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma

(2018) Amanda R. Moore et al.   Cell Reports

G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog

(2018) Ganesh V. Pusapati et al.   Science Signaling

GNAS, GNAQ, and GNA11 Alterations in Patients With Diverse Cancers

(2018) Austin J. Parish et al.   CANCER

Novel role of Giα2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells

(2018) Silvia Caggia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

(2018) Michael D. Onken et al.   Science Signaling

Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins

(2018) Rodolfo Daniel Cervantes-Villagrana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal Melanoma

(2018) Dominic Lapadula et al.   MOLECULAR CANCER RESEARCH

Anti-PD1 treatment in metastatic uveal melanoma in the Netherlands

(2016) M. K. van der Kooij et al.   ACTA ONCOLOGICA

A dual CysLT1/2antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma

(2016) G. M. Gauvreau et al.   ALLERGY

Comprehensive Genetic Landscape of Uveal Melanoma by Whole-Genome Sequencing

(2016) Beryl Royer-Bertrand et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and ThrombosisSignificance

(2016) M. Keegan Delaney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Uveal melanoma: From diagnosis to treatment and the science in between

(2016) Chandrani Chattopadhyay et al.   CANCER

Clinical outcomes in metastatic uveal melanoma treated with PD-1 and PD-L1 antibodies

(2016) Alain P. Algazi et al.   CANCER

ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma

(2016) Jae Hyuk Yoo et al.   CANCER CELL

Regulation of cellular oxidative stress and apoptosis by G protein-coupled receptor kinase-2; The role of NADPH oxidase 4

(2016) Tiju Theccanat et al.   CELLULAR SIGNALLING

Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma

(2016) Amanda R Moore et al.   NATURE GENETICS

Driver Mutations in Uveal Melanoma

(2016) Christina L. Decatur et al.   JAMA Ophthalmology

Bile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett’s Esophageal Adenocarcinoma Cells

(2016) Dan Li et al.   Scientific Reports

Oncogenic G Protein GNAQ Induces Uveal Melanoma and Intravasation in Mice

(2015) J. L.-Y. Huang et al.   CANCER RESEARCH

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase II DeCOG-Study of Ipilimumab in Pretreated and Treatment-Naïve Patients with Metastatic Uveal Melanoma

(2015) Lisa Zimmer et al.   PLoS One

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

Deep sequencing of uveal melanoma identifies a recurrent mutation in PLCB4

(2015) Peter Johansson et al.   Oncotarget

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα

(2015) Naadiya Carrim et al.   Redox Biology

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair

(2014) I. H. Ismail et al.   CANCER RESEARCH

Novel insights into G protein and G protein-coupled receptor signaling in cancer

(2014) Morgan O’Hayre et al.   CURRENT OPINION IN CELL BIOLOGY

Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons

(2013) Adam J. Case et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NADPH Oxidase Biology and the Regulation of Tyrosine Kinase Receptor Signaling and Cancer Drug Cytotoxicity

(2013) Rafael Paletta-Silva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Ultradeep sequencing detectsGNAQandGNA11mutations in cell-free DNA from plasma of patients with uveal melanoma

(2013) Claudia H. D. Metz et al.   Cancer Medicine

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

A Genome-wide RNAi Screen Reveals a Trio-Regulated Rho GTPase Circuitry Transducing Mitogenic Signals Initiated by G Protein-Coupled Receptors

(2012) Jose P. Vaqué et al.   MOLECULAR CELL

Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4

(2012) G. Fazeli et al.   MUTAGENESIS

Angiotensin II-Induced Mitochondrial Nox4 Is a Major Endogenous Source of Oxidative Stress in Kidney Tubular Cells

(2012) Su-Mi Kim et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Ipilimumab in pretreated patients with metastatic uveal melanoma: safety and clinical efficacy

(2011) Riccardo Danielli et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II

(2011) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

Calcium/Calmodulin-Dependent Kinase II Mediates the Phosphorylation and Activation of NADPH Oxidase 5

(2011) D. Pandey et al.   MOLECULAR PHARMACOLOGY

Germline mutations in BAP1 predispose to melanocytic tumors

(2011) Thomas Wiesner et al.   NATURE GENETICS

Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis

(2010) Heidi V. N. Küsters-Vandevelde et al.   ACTA NEUROPATHOLOGICA

Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT2) receptor

(2010) F Wunder et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells

(2010) Augusto C. Montezano et al.   CIRCULATION RESEARCH

Regulation of Coronary Arterial BK Channels by Caveolae-Mediated Angiotensin II Signaling in Diabetes Mellitus

(2010) Tong Lu et al.   CIRCULATION RESEARCH

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

Heterotrimeric G Protein Signaling Outside the Realm of Seven Transmembrane Domain Receptors

(2010) C. Marty et al.   MOLECULAR PHARMACOLOGY

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Influence of Immune Privilege on Ocular Tumor Development

(2010) Kyle C. McKenna et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

The activating mutation R201C in GNAS promotes intestinal tumourigenesis in ApcMin/+ mice through activation of Wnt and ERK1/2 MAPK pathways

(2010) C H Wilson et al.   ONCOGENE

The Hypoxia-Inducible Factor-2α Is Stabilized by Oxidative Stress Involving NOX4

(2009) Isabel Diebold et al.   ANTIOXIDANTS & REDOX SIGNALING

A Differential Role for Endocytosis in Receptor-Mediated Activation of Nox1

(2009) Francis J. Miller et al.   ANTIOXIDANTS & REDOX SIGNALING

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE