Article
Food Science & Technology
Shangyun Lu, Jiali Xu, Yang Xu, Yang Liu, Dongxing Shi, Jia Wang, Fubin Qiu
Summary: Maintaining the integrity and stability of the gut tract is crucial for overall body health. This study focused on using autophagy to balance gut homeostasis and found that glycyrol (GC), a coumarin compound from Glycyrrhiza uralensis Fisch, can activate autophagy and attenuate colon injury. By inhibiting the interaction between SQSTM1/p62 and ubiquitin-specific protease 8 (USP8), GC promotes the ubiquitination of p62 and activates autophagy. These findings suggest that GC has potential as a novel colon protector and should be further investigated.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Oncology
Sheng Wang, Wei Feng, Wulin Wang, Xiaoman Ye, Hao Chen, Chunzhao Yu
Summary: This study aims to increase the sensitivity of gemcitabine chemotherapy for pancreatic cancer by silencing the Girdin gene, showing that Girdin may enhance chemotherapy resistance to gemcitabine through regulating autophagy activity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Hong-Yan He, Zhi You, Ting Ouyang, Guangze Zhao, Qiong Wang, Jin-Yan Li, Xin Ye, Mary H. Zhang, Decheng Yang, Xing-Yi Ge, Ye Qiu
Summary: This study identified PCBP1 as a beneficial factor for CVB3 infection, demonstrating that it promotes viral replication by inhibiting the translation of p62/SQSTM1, an autophagy receptor protein. These findings enhance the understanding of host-virus interactions and may offer a potential target for intervention in CVB3 infection.
Article
Cell Biology
Yinfeng Xu, Yaosen Wu, Lei Wang, Zhuo Ren, Lijiang Song, Hui Zhang, Chuying Qian, Qian Wang, Zhengfu He, Wei Wan
Summary: The study uncovered a regulatory role of autophagy in RNA metabolism, showing that autophagy-deficient cells have higher levels of 47S precursor rRNA due to accumulation of SQSTM1. This accumulation potentiates MTORC1 signaling, leading to increased rRNA transcription from rDNA and promoting protein synthesis and cell proliferation.
Review
Cell Biology
Xiaolan Fan, Tiantian Huang, Yingdong Tong, Ziqiang Fan, Ziyue Yang, Deying Yang, Xueping Mao, Mingyao Yang
Summary: p62, also known as SQSTM1, is a crucial predictor of autophagic flux and plays a role in maintaining protein homeostasis in cells. It has the ability to resist oxidative stress, and its multiple domains allow it to interact with vital signaling pathways, influencing cell proliferation, apoptosis, and survival. Recent studies have also shown its involvement in the aging process.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Yasukazu Takanezawa, Ryohei Harada, Yoshio Shibagaki, Yui Kashiwano, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono
Summary: p62 interacts with NEDD4 to alleviate MeHg toxicity through the formation of a complex.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Toshinaru Fukae, Takeshi Miyatsuka, Miwa Himuro, Yuka Wakabayashi, Hitoshi Iida, Shuhei Aoyama, Tomoya Mita, Fuki Ikeda, Hidenori Haruna, Noriyuki Takubo, Yuya Nishida, Toshiaki Shimizu, Hirotaka Watada
Summary: Autophagy plays a crucial role in intracellular quality control, while the accumulation of p62 under autophagy-deficient conditions has little effect on 0 cell function.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Juncal Garcia-Garcia, Anne Kristin McLaren Berge, Katrine Stange Overa, Kenneth Bowitz Larsen, Zambarlal Bhujabal, Andreas Brech, Yakubu Princely Abudu, Trond Lamark, Terje Johansen, Eva Sjottem
Summary: TRIM27 is a multifunctional protein involved in various cellular functions. It has been found to facilitate mitochondrial clustering via SQSTM1/p62 and promote mitophagy by stabilizing phosphorylated TBK1 on mitochondria.
Review
Biochemistry & Molecular Biology
Giulia Orlandi, Luca Roncucci, Gianluca Carnevale, Paola Sena
Summary: Colorectal cancer remains a major threat to life, despite attempts at therapeutic and screening. Apoptosis and autophagy share signaling pathways and protein components. In cancer development, these processes can interact and inhibit each other. Understanding the regulation and molecular mechanisms behind this duality is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Hainan He, Junling Wang, Xingmei Mou, Xin Liu, Qiao Li, Mingyue Zhong, Bingbing Luo, Zhisheng Yu, Jingjing Zhang, Tian Xu, Chengli Dou, Danya Wu, Wei Qing, Linhui Wu, Kai Zhou, Zhengang Fan, Tingting Wang, Taotao Hu, Xia Zhang, Jilong Zhou, Yi-Liang Miao
Summary: This study shows that reduced autophagy in granulosa cells is negatively correlated with oocyte quality. Inhibition or genetic ablation of autophagy in granulosa cells impairs oocyte quality and fertilization ability. The adverse impact of autophagy impairment on oocyte quality is mediated by downregulated citrate levels, which can be restored by exogenous supplementation.
Article
Cell Biology
Paivi Yla-Anttila, Soham Gupta, Maria G. Masucci
Summary: Macroautophagy plays a critical role in controlling viral infections, with viruses evolving strategies to interfere with this process. The Epstein-Barr virus-encoded BPLF1 protein regulates selective autophagy, promoting infection and viral production by targeting the cellular defense mechanism.
Article
Oncology
Fangqin Yu, Runsheng Ma, Chenguang Liu, Lele Zhang, Kaixiang Feng, Meiqi Wang, Detao Yin
Summary: The study investigated the effect of SQSTM1/p62 on papillary thyroid cancer (PTC) cells, finding that p62 expression was higher in tumor tissues compared to normal tissues. Knockout of p62 inhibited cell proliferation, cell cycle, and induced apoptosis in PTC cells. The AMPK/AKT/mTOR pathway was found to be involved in mediating these effects, suggesting p62 as a potential therapeutic target for PTC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Young Rae Jo, Yuna Oh, Young Hee Kim, Yoon Kyung Shin, Hye Ran Kim, Hana Go, Jaekyoon Shin, Hye Ji Park, Hyongjong Koh, Jong Kuk Kim, Jung Eun Shin, Kyung Eun Lee, Hwan Tae Park
Summary: DSCs utilize autophagy-related genes to form secretory phagophores and tubular phagophores, enabling the exocytosis of large myelin chambers. This autophagy-mediated myelin clearance mechanism is a novel response of DSCs to nerve damage.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lanxin Bao, Jing Ye, Nannan Liu, Yubao Shao, Wenhao Li, Xuefei Fan, Dahai Zhao, Hongzhi Wang, Xiaoyu Chen
Summary: Resveratrol has been found to improve the progression of rheumatoid arthritis (RA) by regulating autophagy. In patients with RA-associated interstitial lung disease (RA-ILD), autophagy is enhanced in the early stage but inhibited in the late stage. However, treatment with resveratrol can improve autophagy levels, reverse the inhibition, and attenuate fibrosis.
Article
Cell Biology
David S. Schussele, Patricia K. Haller, Maximilian L. Haas, Catherine Hunter, Katharina Sporbeck, Tassula Proikas-Cezanne
Summary: This paper presents a method for single cell-based analysis of autophagy using open source CellProfiler software. The method utilizes fluorescence microscopy to detect autophagy-related proteins and provides a reliable and automated analysis of the number and size of recognized puncta. The method can be easily adapted for different autophagy markers or cell types and is suitable for high-throughput studies.
Article
Biochemistry & Molecular Biology
Wenliang Zhang, Guocai Yao, Jianbo Wang, Minglei Yang, Jing Wang, Haiyue Zhang, Weizhong Li
Article
Oncology
Hui Li, Mingming Zhang, Yanli Wei, Farhan Haider, Yitong Lin, Wen Guan, Yanbin Liu, Shaoyang Zhang, Ronghua Yuan, Xia Yang, Shulan Yang, Haihe Wang
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Yanbin Liu, Zhicong Huang, Yanli Wei, Mingming Zhang, Xingzhi Li, Shulan Yang, Haihe Wang
Summary: The research identified a novel positive feedback loop between STXBP6 and IRF1 in regulating PD-L1 expression, which affects the response to immunotherapy targeting PD-L1 in cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Dade Rong, Changwei Wang, Xiaomei Zhang, Yanli Wei, Mingming Zhang, Daiyuan Liu, Haider Farhan, Saleh Abdul Momen Ali, Yanbin Liu, Adam Taouil, Wanrong Guo, Yican Wang, Iwao Ojima, Shulan Yang, Haihe Wang
Article
Biochemistry & Molecular Biology
Wenliang Zhang, Binghui Zeng, Minglei Yang, Huan Yang, Jianbo Wang, Yongjie Deng, Haiyue Zhang, Guocai Yao, Song Wu, Weizhong Li
Summary: ncRNAVar is the first database providing association data between validated ncRNA variants and human diseases, curated manually and computationally. It offers various web applications including association prioritization, network visualization, and relationship mapping, serving as a useful resource for understanding relationships between ncRNA variants and human health.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Genetics & Heredity
Guocai Yao, Wenliang Zhang, Minglei Yang, Huan Yang, Jianbo Wang, Haiyue Zhang, Lai Wei, Zhi Xie, Weizhong Li
GENOMICS PROTEOMICS & BIOINFORMATICS
(2020)
Article
Biochemistry & Molecular Biology
Wenliang Zhang, Yan Zhang, Zhuochao Min, Jing Mo, Zhen Ju, Wen Guan, Binghui Zeng, Yang Liu, Jianliang Chen, Qianshen Zhang, Hanguang Li, Chunxia Zeng, Yanjie Wei, Godfrey Chi-Fung Chan
Summary: In this study, the researchers developed the COVID19db platform, which provides a user-friendly platform for researchers to analyze transcriptomic data of coronavirus disease 2019 (COVID-19). The platform standardized and annotated each dataset and offers multiple analytical applications and a drug discovery tool to help researchers better understand the mechanisms underlying COVID-19 and identify potential drugs and targets.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wenliang Zhang, Yang Liu, Zhuochao Min, Guodong Liang, Jing Mo, Zhen Ju, Binghui Zeng, Wen Guan, Yan Zhang, Jianliang Chen, Qianshen Zhang, Hanguang Li, Chunxia Zeng, Yanjie Wei, Godfrey Chi-Fung Chan
Summary: The study introduces circMine as a tool to assist researchers in investigating circRNA transcriptome data. CircMine provides a large amount of data and online analytical functions to assess the clinical and biological significance of circRNA, and additional tools to systematically discover circRNA-miRNA interactions and circRNA translatability.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shaoyang Zhang, Xueming Guo, Xiufeng Liu, Zhixiong Zhong, Shulan Yang, Haihe Wang
Summary: Metastatic recurrence in breast cancer patients is associated with upregulated expression of SH3BGRL, which affects tumor development by regulating the protein level of PFN1. Loss of PFN1 leads to activation of downstream signaling pathways, while forced expression of PFN1 can neutralize SH3BGRL-induced metastasis and tumorigenesis, suggesting SH3BGRL as a potential therapeutic target for breast cancer.
Correction
Biochemistry & Molecular Biology
Shaoyang Zhang, Xuemin Guo, Xiufeng Liu, Zhixiong Zhong, Shulan Yang, Haihe Wang
Article
Neurosciences
Li-Kang Zhang, Jia-Hui Sun, Sheng Liu, Wen-Liang Zhang, Jian-Long Zou
Summary: In this study, we developed an in vitro model called SCWR to mimic the tissue-specific differences between motor and sensory nerve regeneration. The model demonstrated asymmetric regeneration of the ventral and dorsal roots in response to growth factors and exhibited motor and sensory Schwann cell phenotypes. Additionally, we identified a targeted effect of collagen VI on sensory nerve bundle formation and characterized the protein expression profiles associated with motor/sensory-specific nerve regeneration.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ziwei Jin, Dongxia Wang, Haimei Lv, Bo Wu, Zhe Li, Xiaoling Guo, Haihe Wang, Shulan Yang
Summary: Ovarian fibrosis is a reproductive obstacle causing female infertility in vertebrates. A study in zebrafish found that a small adaptor protein called SH3-domain-binding glutamate-rich protein like (Sh3bgrl) plays an important role in female reproduction. Knockout of the sh3bgrl gene leads to upregulation of genes associated with extracellular matrix (ECM) and fiber generation in the fish's ovary, resulting in accumulation of ECM or fibers and eventual spawning inability.
Article
Oncology
Wenliang Zhang, Binghui Zeng, Huancai Lin, Wen Guan, Jing Mo, Song Wu, Yanjie Wei, Qianshen Zhang, Dongsheng Yu, Weizhong Li, Godfrey Chi-Fung Chan
Summary: CanImmunother presents a comprehensive and high-quality database of experimental cancer immunotherapy association data, which will assist clinicians and researchers in identifying and discovering better immunotherapy options, as well as their respective biomarkers and targets.