How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings—A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae

In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures

(2019) Lea Wagmann et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes - A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae

(2019) Lilian H.J. Richter et al.   TOXICOLOGY LETTERS

New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites

(2019) Xingxing Diao et al.   Frontiers in Chemistry

Validation of an LC-MS/MS method for the quantitative analysis of 1P-LSD and its tentative metabolite LSD in fortified urine and serum samples including stability tests for 1P-LSD under different storage conditions

(2019) Christina Grumann et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Detection of the recently emerged synthetic cannabinoid 4F‐MDMB‐BINACA in “legal high” products and human urine specimens

(2019) Belal Haschimi et al.   Drug Testing and Analysis

Phenethylamine‐derived new psychoactive substances 2C‐E‐FLY, 2C‐EF‐FLY, and 2C‐T‐7‐FLY: Investigations on their metabolic fate including isoenzyme activities and their toxicological detectability in urine screenings

(2019) Lea Wagmann et al.   Drug Testing and Analysis

Pharmacokinetic study of xylazine in a zebrafish water tank, a human-like surrogate, by liquid chromatography Q-Orbitrap mass spectrometry

(2019) Rebecca Rodrigues Matos et al.   Forensic Toxicology

Toxicokinetic studies of the four new psychoactive substances 4-chloroethcathinone, N-ethylnorpentylone, N-ethylhexedrone, and 4-fluoro-alpha-pyrrolidinohexiophenone

(2019) Lea Wagmann et al.   Forensic Toxicology

4F-MDMB-BINACA: A New Synthetic Cannabinoid Widely Implicated in Forensic Casework

(2019) Alex J. Krotulski et al.   JOURNAL OF FORENSIC SCIENCES

In vitro toxicokinetics and analytical toxicology of three novel NBOMe derivatives: phase I and II metabolism, plasma protein binding, and detectability in standard urine screening approaches studied by means of hyphenated mass spectrometry

(2019) Lilian H. J. Richter et al.   Forensic Toxicology

Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of -lysergic acid diethylamide (LSD)

(2019) Adam L. Halberstadt et al.   NEUROPHARMACOLOGY

Nano liquid chromatography-high-resolution mass spectrometry for the identification of metabolites of the two new psychoactive substances N- ( ortho -methoxybenzyl)-3,4-dimethoxyamphetamine and N- ( ortho -methoxybenzyl)-4-methylmethamphetamine

(2018) Achim T. Caspar et al.   TALANTA

Human cytochrome P450 kinetic studies on six N -2-methoxybenzyl (NBOMe)-derived new psychoactive substances using the substrate depletion approach

(2018) Achim T. Caspar et al.   TOXICOLOGY LETTERS

The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics

(2018) Li Di   CURRENT DRUG METABOLISM

Metabolic fate of the new synthetic cannabinoid 4’N-5F-ADB in rat, human, and pooled human S9 studied by means of hyphenated high-resolution mass spectrometry

(2018) Lilian H.J. Richter et al.   Drug Testing and Analysis

Detection of metabolites of two synthetic cannabimimetics, MDMB-FUBINACA and ADB-FUBINACA, in authentic human urine specimens by accurate mass LC–MS: a comparison of intersecting metabolic patterns

(2017) Pierce Kavanagh et al.   Forensic Toxicology

Pooled human liver preparations, HepaRG, or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA, MDBD, butylone, MDPPP, MDPV, MDPB, 5-MAPB, and 5-API as examples

(2017) Lilian H.J. Richter et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

New psychoactive substances: Studies on the metabolism of XLR-11, AB-PINACA, FUB-PB-22, 4-methoxy-α-PVP, 25-I-NBOMe, and meclonazepam using human liver preparations in comparison to primary human hepatocytes, and human urine

(2017) Lilian H.J. Richter et al.   TOXICOLOGY LETTERS

Review: LC coupled to low- and high-resolution mass spectrometry for new psychoactive substance screening in biological matrices – Where do we stand today?

(2016) Markus R. Meyer et al.   ANALYTICA CHIMICA ACTA

High-resolution mass spectrometry in toxicology: current status and future perspectives

(2016) H. H. Maurer et al.   ARCHIVES OF TOXICOLOGY

New psychoactive substances: an overview on recent publications on their toxicodynamics and toxicokinetics

(2016) Markus R. Meyer   ARCHIVES OF TOXICOLOGY

What is the contribution of human FMO3 in the N -oxygenation of selected therapeutic drugs and drugs of abuse?

(2016) Lea Wagmann et al.   TOXICOLOGY LETTERS

Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD)

(2015) Simon D. Brandt et al.   Drug Testing and Analysis

Contribution of human esterases to the metabolism of selected drugs of abuse

(2015) Markus R. Meyer et al.   TOXICOLOGY LETTERS

The new drug phenomenon

(2014) Simon D. Brandt et al.   Drug Testing and Analysis

Recent developments in urinalysis of metabolites of new psychoactive substances using LC–MS

(2014) Frank T Peters   Bioanalysis

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Drugs of abuse screening in urine as part of a metabolite-based LC-MSn screening concept

(2011) Dirk K. Wissenbach et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Characterization of Recombinant Human Carboxylesterases: Fluorescein Diacetate as a Probe Substrate for Human Carboxylesterase 2

(2011) J. Wang et al.   DRUG METABOLISM AND DISPOSITION

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

(2010) Marc Lübberstedt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS