CCR4 Antagonist (C021) Administration Diminishes Hypersensitivity and Enhances the Analgesic Potency of Morphine and Buprenorphine in a Mouse Model of Neuropathic Pain

Chronic constriction injury of the sciatic nerve in rats causes different activation modes of microglia between the anterior and posterior horns of the spinal cord

(2020) Tasuku Nishihara et al.   NEUROCHEMISTRY INTERNATIONAL

The release of exosomes in the medial prefrontal cortex and nucleus accumbens brain regions of chronic constriction injury (CCI) model mice could elevate the pain sensation

(2020) Xiaolu Yu et al.   NEUROSCIENCE LETTERS

CCR4 antagonist (C021) influences the level of nociceptive factors and enhances the analgesic potency of morphine in a rat model of neuropathic pain

(2020) Joanna Bogacka et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia

(2019) Klaudia Kwiatkowski et al.   CYTOKINE

CCR4 Is Critically Involved in Skin Allergic Inflammation of BALB/c Mice

(2018) Kazuhiko Matsuo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Activation of Astrocytes and Microglial Cells and CCL2/CCR2 Upregulation in the Dorsolateral and Ventrolateral Nuclei of Periaqueductal Gray and Rostral Ventromedial Medulla Following Different Types of Sciatic Nerve Injury

(2018) Petr Dubový et al.   Frontiers in Cellular Neuroscience

CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons

(2018) Lorenz Fülle et al.   GLIA

Membrane potential synchrony of neurons in anterior cingulate cortex plays a pivotal role in generation of neuropathic pain

(2018) Zhiyu Chen et al.   Scientific Reports

TLR4 Inhibits Spinal Gabaergic Activities via Microglial Activation in Chronic Constriction Injury Mice

(2018) Er liang Kong et al.   Neuropsychiatry

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

(2018) Gang Chen et al.   NEURON

The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity

(2017) Stefanie Scheu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats

(2017) Klaudia Kwiatkowski et al.   Journal of Neuroimmune Pharmacology

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic pain — In vivo and in vitro evidence

(2016) Anna Piotrowska et al.   JOURNAL OF NEUROIMMUNOLOGY

Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine

(2016) Dominika Pilat et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats

(2016) Klaudia Kwiatkowski et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

IL-1 receptor antagonist improves morphine and buprenorphine efficacy in a rat neuropathic pain model

(2015) Dominika Pilat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis

(2015) Lin Zhang et al.   YONSEI MEDICAL JOURNAL

Chemokine (C-C motif) Receptor 5 Is an Important Pathological Regulator in the Development and Maintenance of Neuropathic Pain

(2014) Katsuyuki Matsushita et al.   ANESTHESIOLOGY

CCR4 and its ligands: from bench to bedside

(2014) O. Yoshie et al.   INTERNATIONAL IMMUNOLOGY

Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline

(2014) Matthew McMillin et al.   Journal of Neuroinflammation

Contribution of Chemokine CCL2/CCR2 Signaling in the Dorsal Root Ganglion and Spinal Cord to the Maintenance of Neuropathic Pain in a Rat Model of Lumbar Disc Herniation

(2014) Xiang Zhu et al.   JOURNAL OF PAIN

Balance and coordination training and endurance training after nerve injury

(2014) Leandro Viçosa Bonetti et al.   MUSCLE & NERVE

Inhibition of intracellular signaling pathways NF-κB and MEK1/2 attenuates neuropathic pain development and enhances morphine analgesia

(2014) Katarzyna Popiolek-Barczyk et al.   Pharmacological Reports

Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain

(2014) Joanna Mika et al.   PLoS One

Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans

(2014) David Patsouris et al.   PLoS One

Minocycline Enhances the Effectiveness of Nociceptin/Orphanin FQ during Neuropathic Pain

(2014) Katarzyna Popiolek-Barczyk et al.   Biomed Research International

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

(2013) Francesco Ferrini et al.   NATURE NEUROSCIENCE

Morphine sensitivity of spinal neurons in the chronic constriction injury neuropathic rat pain model

(2013) Silke J. Hirsch et al.   NEUROSCIENCE LETTERS

A bivalent ligand targeting the putative mu opioid receptor and chemokine receptor CCR5 heterodimer: binding affinity versus functional activities

(2013) Yunyun Yuan et al.   MedChemComm

Altered profile of chemokines in fibromyalgia patients

(2013) J. J. Garcia et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Spinal MCP-1 Contributes to the Development of Morphine Antinociceptive Tolerance in Rats

(2012) Chun-mei Zhao et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Exercise Training Attenuates Neuropathic Pain and Cytokine Expression After Chronic Constriction Injury of Rat Sciatic Nerve

(2012) Yu-Wen Chen et al.   ANESTHESIA AND ANALGESIA

Design and synthesis of a bivalent ligand to explore the putative heterodimerization of the mu opioid receptor and the chemokine receptor CCR5

(2012) Yunyun Yuan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Microglia: A Promising Target for Treating Neuropathic and Postoperative Pain, and Morphine Tolerance

(2011) Yeong-Ray Wen et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain

(2009) Joanna Mika et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain

(2009) Y.-J. Gao et al.   JOURNAL OF NEUROSCIENCE

Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain

(2009) Ilona Obara et al.   PAIN

Attenuation of morphine tolerance by minocycline and pentoxifylline in naive and neuropathic mice

(2008) Joanna Mika et al.   BRAIN BEHAVIOR AND IMMUNITY

CCL2 is a key mediator of microglia activation in neuropathic pain states

(2008) Michael A. Thacker et al.   EUROPEAN JOURNAL OF PAIN

A novel role of minocycline: Attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia

(2007) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain

(2007) Stefania Echeverry et al.   PAIN