Direct Targeting of CREB1 with Imperatorin Inhibits TGF β 2‐ERK Signaling to Suppress Esophageal Cancer Metastasis

Imperatorin as a Promising Chemotherapeutic Agent against Human Larynx Cancer and Rhabdomyosarcoma Cells

(2020) Aneta Grabarska et al.   MOLECULES

Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion

(2018) Yu Ren et al.   Molecular Cancer

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain

(2017) R. Aldrin Denny et al.   JOURNAL OF MEDICINAL CHEMISTRY

CREB1 regulates glucose transport of glioma cell line U87 by targeting GLUT1

(2017) Jiaying Chen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Metastasis: Lymphatic detours for cancer

(2017) Ayuko Hoshino et al.   NATURE

Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence

(2017) Benjamin Sunkel et al.   NUCLEIC ACIDS RESEARCH

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF

(2017) B Li et al.   ONCOGENE

Knockdown of CREB1 inhibits tumor growth of human gastric cancer in vitro and in vivo

(2017) Min Rao et al.   ONCOLOGY REPORTS

Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression

(2017) Wen Wen Xu et al.   Nature Communications

Endothelial angiogenesis is directed by RUNX1T1-regulated VEGFA, BMP4 and TGF-β2 expression

(2017) Ko-Hsun Liao et al.   PLoS One

Imperatorin exerts antiallergic effects in Th2-mediated allergic asthma via induction of IL-10-producing regulatory T cells by modulating the function of dendritic cells

(2016) Chu-Lun Lin et al.   PHARMACOLOGICAL RESEARCH

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma

(2015) Jin Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity

(2015) Fuchun Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma

(2014) Xia Li et al.   CANCER LETTERS

Id1-Induced IGF-II and Its Autocrine/Endocrine Promotion of Esophageal Cancer Progression and Chemoresistance--Implications for IGF-II and IGF-IR-Targeted Therapy

(2014) B. Li et al.   CLINICAL CANCER RESEARCH

TGF-beta Signaling in Cancer Treatment

(2014) Isabel Fabregat et al.   CURRENT PHARMACEUTICAL DESIGN

Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma

(2014) Deborah JL Wong et al.   Molecular Cancer

Novel Type of Prodrug Activation through a Long-Range O,N-Acyl Transfer: A Case of Water-Soluble CREB Inhibitor

(2014) Bingbing X. Li et al.   ACS Medicinal Chemistry Letters

Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription

(2013) Fuchun Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors

(2013) E. J. Morris et al.   Cancer Discovery

Structure–activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription

(2012) Bingbing X. Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Imperatorin Attenuates LPS-Induced Inflammation by Suppressing NF-κB and MAPKs Activation in RAW 264.7 Macrophages

(2012) Weixiao Guo et al.   INFLAMMATION

Regulatory Factor X1-induced Down-regulation of Transforming Growth Factor β2 Transcription in Human Neuroblastoma Cells

(2012) Chenzhuo Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Conformationally Constrained Analogues of Naphthol AS-E as Inhibitors of CREB-Mediated Gene Transcription

(2012) Min Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting CREB for Cancer Therapy: Friend or Foe

(2010) X. Xiao et al.   CURRENT CANCER DRUG TARGETS

Dual effects of TGF-β on ERα-mediated estrogenic transcriptional activity in breast cancer

(2009) Yongsheng Ren et al.   Molecular Cancer