A High-Throughput System for Cyclic Stretching of Precision-Cut Lung Slices During Acute Cigarette Smoke Extract Exposure

Biomechanical CT metrics are associated with patient outcomes in COPD

(2017) Sandeep Bodduluri et al.   THORAX

Predicting Structure-Function Relations and Survival following Surgical and Bronchoscopic Lung Volume Reduction Treatment of Emphysema

(2017) Jarred R. Mondoñedo et al.   PLoS Computational Biology

Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality

(2017) Vanessa Neuhaus et al.   Journal of Occupational Medicine and Toxicology

CT-derived Biomechanical Metrics Improve Agreement Between Spirometry and Emphysema

(2016) Surya P. Bhatt et al.   ACADEMIC RADIOLOGY

Influenza A virus infection and cigarette smoke impair bronchodilator responsiveness to  -adrenoceptor agonists in mouse lung

(2016) C. Donovan et al.   CLINICAL SCIENCE

Cigarette smoke extract alters the cell cycle via the phospholipid transfer protein/transforming growth factor-β1/CyclinD1/CDK4 pathway

(2016) Xue-Min Chai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Superoxide mediates tight junction complex dissociation in cyclically stretched lung slices

(2016) Min Jae Song et al.   JOURNAL OF BIOMECHANICS

Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity

(2016) A. Hess et al.   TOXICOLOGY IN VITRO

Mechanical Forces Accelerate Collagen Digestion by Bacterial Collagenase in Lung Tissue Strips

(2016) Eunice Yi et al.   Frontiers in Physiology

Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice

(2016) Jonathan E. Hiorns et al.   Frontiers in Physiology

Protease-Mediated Release of Chemotherapeutics from Mesoporous Silica Nanoparticles to ex Vivo Human and Mouse Lung Tumors

(2015) Sabine H. van Rijt et al.   ACS Nano

Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures

(2015) Franziska E. Uhl et al.   EUROPEAN RESPIRATORY JOURNAL

Design of a Novel Equi-Biaxial Stretcher for Live Cellular and Subcellular Imaging

(2015) Jasmin Imsirovic et al.   PLoS One

Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD

(2015) Kristoffer Ostridge et al.   THORAX

Screening for Chemical Toxicity Using Cryopreserved Precision Cut Lung Slices

(2015) Christa Y. Watson et al.   TOXICOLOGICAL SCIENCES

Comparison between cigarette smoke-induced emphysema and cigarette smoke extract-induced emphysema

(2015) Zhi-Hui He et al.   Tobacco Induced Diseases

Collagenolytic Matrix Metalloproteinases in Chronic Obstructive Lung Disease and Cancer

(2015) Denzel Woode et al.   Cancers

Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells

(2014) Korbinian Ballweg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Airway Contractility in the Precision-Cut Lung Slice after Cryopreservation

(2014) Sonia R. Rosner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Effects of cigarette smoke extract on human airway smooth muscle cells in COPD

(2014) L. Chen et al.   EUROPEAN RESPIRATORY JOURNAL

Assessment of immunotoxicity induced by chemicals in human precision-cut lung slices (PCLS)

(2014) L. Lauenstein et al.   TOXICOLOGY IN VITRO

Emphysema and Mechanical Stress-Induced Lung Remodeling

(2013) Béla Suki et al.   PHYSIOLOGY

Smad3 mediates cigarette smoke extract (CSE) induction of VEGF release by human fetal lung fibroblasts

(2013) Maha Farid et al.   TOXICOLOGY LETTERS

Reproducible uniform equibiaxial stretch of precision-cut lung slices

(2012) N. Davidovich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Dilatation of the Constricted Human Airway by Tidal Expansion of Lung Parenchyma

(2012) Tera L. Lavoie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Uses of Remnant Human Lung Tissue for Mechanical Stretch Studies

(2012) N. Davidovich et al.   Cellular and Molecular Bioengineering

Bacillus anthracis Lethal Toxin Reduces Human Alveolar Epithelial Barrier Function

(2012) Marybeth Langer et al.   INFECTION AND IMMUNITY

Neurally Mediated Airway Constriction in Human and Other Species: A Comparative Study Using Precision-Cut Lung Slices (PCLS)

(2012) Marco Schlepütz et al.   PLoS One

A therapeutic role for matrix metalloproteinase inhibitors in lung diseases?

(2011) R. E. Vandenbroucke et al.   EUROPEAN RESPIRATORY JOURNAL

Imbalance of Apoptosis and Cell Proliferation Contributes to the Development and Persistence of Emphysema

(2011) Ji-Hyun Lee et al.   LUNG

Exploring lung physiology in health and disease with lung slices

(2011) Michael J. Sanderson   PULMONARY PHARMACOLOGY & THERAPEUTICS

Influence of airway wall stiffness and parenchymal tethering on the dynamics of bronchoconstriction

(2010) Mohammad Afzal Khan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanical Forces Regulate Elastase Activity and Binding Site Availability in Lung Elastin

(2010) Rajiv Jesudason et al.   BIOPHYSICAL JOURNAL

Carbocisteine Protects Against Emphysema Induced by Cigarette Smoke Extract in Rats

(2010) Masayuki Hanaoka et al.   CHEST

Biaxial distension of precision-cut lung slices

(2010) C. Dassow et al.   JOURNAL OF APPLIED PHYSIOLOGY

Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices

(2010) S. Switalla et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Variable stretch pattern enhances surfactant secretion in alveolar type II cells in culture

(2009) Stephen P. Arold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Protective effect of beraprost sodium, a stable prostacyclin analog, in the development of cigarette smoke extract-induced emphysema

(2009) Yan Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats

(2009) Y. Chen et al.   EUROPEAN RESPIRATORY JOURNAL

Cigarette smoke extract reduces VEGF in primary human airway epithelial cells

(2009) J. V. Thaikoottathil et al.   EUROPEAN RESPIRATORY JOURNAL

Ex Vivo Lung Function Measurements in Precision-Cut Lung Slices (PCLS) from Chemical Allergen–Sensitized Mice Represent a Suitable Alternative to In Vivo Studies

(2008) M. Henjakovic et al.   TOXICOLOGICAL SCIENCES